Browsing by Author "Aras, A."

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Analysis of Incidental Thyroid Cancers in Surgically Treated Toxic Goiter Patients
(Yuzuncu Yil Universitesi Tip Fakultesi, 2025) Aras, A.; Karayil, A.R.; Yilmaz, Ö.; Aras, I.; Toktaş, O.; Kotan, Ç.
Differentiated Thyroid Cancer (DTC) is the most common endocrine cancer and the frequency of DTC detection in histopathological examinations in thyroid surgeries performed for non-cancer indications is increasing. The aim of this study is to investigate the rate of incidentally detected thyroid cancer in patients who underwent surgery for toxic goiter in our clinic. Histopathological data of patients who underwent surgery with a diagnosis of toxic goiter were retrospectively reviewed. Patients were divided into 3 groups as toxic adenoma (TA), toxic multinodular goiter (MNG) and Basedow-Graves disease. The presence of malignancy and clinicopathological features were investigated RESULTS: 84% of the cases were female and 16% were male, and the mean age was 43. 202 (65%) of the toxic goiter cases had TMG, 8 (3%) had TA, and 101 (32%) had Graves' disease. Histopathologically, the malignant/benign ratio was 65 (21%)/ 246 (79%). Malignancy was detected in 3 of the 15 patients with a family history of thyroid cancer Incidental thyroid cancer was detected in 65 (21%) of the patients with toxic goiter. Thyroid carcinoma was present in 45 (22%) of the patients with toxic MNG, 1 (12.5%) of the patients with TA and 19 (19%) of the patients with Graves. Histopathological examination revealed 62 papillary (38 microcarcinoma), 2 Non-invasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP) and 1 medullary microcarcinoma. The incidence of incidental thyroid cancer in the patients with toxic goiter treated with surgery was found to be consistent with the literature. © 2025, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Are Appendix Weight and Length Related To Inflammatory Parameters and Alvarado Score in Acute Appendicitis
(Yuzuncu Yil Universitesi Tip Fakultesi, 2021) Kiziltan, R.; Çalli, I.; Karayil, A.R.; Aras, A.; Kotan, Ç.
We aimed to investigate if appendix weight and length affects clinical presentation. This study prospectively enrolled 50 patients who were operated with the diagnosis of acute appendicitis. The appendix material was weighed in milligram. Then, the diameter of the appendix was measured in millimeter from its widest point using a surgical ruler. The length of the appendix was measured in millimeter using the same ruler. As appendix length may have influenced its weight, weight in milligram per millimeter was used for standardization. The obtained value was expressed as the unit weight (mg/mm). In order to make a comparison by the obtained unit weight, the patients were divided into two groups. Among 50 patients enrolled in the present study, 24 (48%) were men and 26 (52%) were women. The mean CRP level of the study population was 29.4 (3-160). The mean appendix diameter measured with ultrasonography at the preoperative period was 8.49 mm (range 6-13 mm), and the mean appendix diameter measured with a ruler at the postoperative period was 10.3 mm (range 8-20 mm). There was approximately a 2 mm difference between these measurements which were made from the widest points. In conclusion, it was found that the unit weight of the appendix increased proportionally to the CRP level. The appendix would be more edematous, have a greater diameter and weight, and be more likely to perforate in patients with a higher unit weight. © 2021, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Colonoscopic Perforations, What Is Our Experience in a Training Hospital
(Lippincott Williams and Wilkins, 2016) Aras, A.; Oran, E.; Seyit, H.; Karabulut, M.; Gök, I.; Aliş, H.
The aim of this study was to describe our experience in patients treated with the diagnosis of colonoscopic perforation. A retrospective institutional computer-based search of the patients treated with the diagnosis of colonoscopic perforation between July 2009 and May 2014 was undertaken. Our study included 16 patients. In 9 (56%) patients, perforations occurred during the diagnostic colonoscopy. Snare polypectomy was the causative factor in 5 patients associated with therapeutic colonoscopy. The perforation was significantly higher in patients who underwent therapeutic colonoscopy than those had diagnostic colonoscopy (P<0.007). The sigmoid colon was the most common perforation site (62.5%). Twelve patients (75%) were treated by surgically, 3 (19%) patients by conservatively, and 1 (6%) by endoscopic clipping. Early recognition of the perforation is critical. Therefore, a high index of suspicion is essential for the prompt and accurate diagnosis. Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.
Comparison of Icodextrin With Thymoquinone: a New Hope for Postoperative Adhesions
(Medknow Publications & Media Pvt Ltd, 2017) Yilmaz, O.; Kiziltan, R.; Celik, S.; Yildirm, S.; Alp, H. H.; Aras, A.; Kotan, C.
Objective: The purpose of this study was to compare the effects of thymoquinone and icodextrin in rats within the framework of an experimental adhesion model. Materials and Methods: Rats were separated into three groups: (1) a control group consisting of rats that had 2 ml of isotonic solution administered intraperitoneally, (2) an ICO group administered with 2 ml of 4% icodextrin, and (3) a TQ group administered thymoquinone (10 mg/kg), all following cecal abrasion. The three groups underwent a reoperation on the 7th postoperative day. Hydroxyproline levels were analyzed in the resected adhesive tissues, and histopathological investigations were conducted. Blood samples were collected for biochemical analyses. Results: Fewer postoperative adhesions were observed in the ICO and TQ groups compared with the control group. A comparison of the TQ and ICO groups revealed lowers levels of postoperative adhesions in the TQ group. Compared with the control group, malondialdehyde, 8-OH-deoxyguanosine/deoxyguanosine (8-OHdG/10dG), Coenzyme Q10 (CoQ10), and CoenzymeQ10/reduced CoenzymeQ10 (CoQ10/CoQ10H) values were found to be lower in the TQ and ICO groups. When the TQ and ICO groups were compared with respect to their biochemical parameters, the results for all of the four parameters were found to be statistically significantly lower in the TQ group (P < 0.000). The levels of hydroxyproline in the control, ICO, and TQ groups were found to be (mean +/- standard deviation) 502.25 +/- 90.39 mu g/g, 342.13 +/- 66.61 mu g/g, and 287.88 +/- 49.59 mu g/g, respectively. Conclusions: A comparison of the antiadhesive effects of thymoquinone and icodextrin revealed thymoquinone to be more effective. These results indicate that thymoquinone is an efficient and strong antiadhesive molecule.
Correlatıon of the Results of Fnac and Hıstopathologıcal Examınatıons İn Thyroıd Nodules
(Yuzuncu Yil Universitesi Tip Fakultesi, 2024) Aras, A.; Karayıl, A.R.; Çallı, I.; Toktas, O.; Kiziltan, R.; Kotan, Ç.
We aimed to evaluate the effectiveness of Fine Needle Aspiration Cytology(FNAC) in thyroid nodules by comparing the thyroid FNAC results and histopathological results of patients who underwent thyroidectomy surgery in our clinic. FNAC results of 1229 patients who underwent thyroidectomy for various indications in the General Surgery Clinic at Van Yuzuncu Yil University, Faculty of Medicine Hospital between January 2014 and December 2020 were categorized according to the Bethesda reporting system and compared with histopathological results. The cases were between ages of 18-78 with the mean age of 45.22 years and the female/male ratio was 1032(%84) /197(%16). According to the FNAC results, 8% of the patients were Bethesda-3, 12% were Bethesda-4, 33% were Bethesda-5, and 47% were Bethesda-6. According to histopathological results, malignancy was detected in 9.2% of patients in Bethesda-3, 22.8% of patients in Bethesda-4, 78.8% of patients in Bethesda-5, and 97.9% of patients in Bethesda-6. Malignancy detection rates were compatible with Bethesda 4, 5 and 6, but were incompatible with the Bathesda 3 category. We found a sensitivity of 95.4%, a specificity rate of 67%, a positive predictive value of 90% and a negative predictive value of 82%, and an accuracy rate of 89%. FNAC is an effective and reliable method in the evaluation of thyroid nodule. © 2024, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
The Effect of Super-Oxidized Water on the Tissues of Uterus and Ovary: an Experimental Rat Study
(Yuzuncu Yil Universitesi Tip Fakultesi, 2017) Aras, A.; Karaman, E.; Çim, N.; Yıldırım, S.; Kızıltan, R.; Yılmaz, Ö.
Super-oxidized solutions are known to be potent disinfectants for external surfaces and also for wound care. There are limited data about the use of superoxidized water in the intraperitoneal organs. The aim of the present study was to evalaute its effect on the uterus and ovary when applied via intraperitoneal infusion in a rat model. Thirty Wistar-Albino rats weighing 250-300 g were randomly divided into three groups (10 rats/group). Group1(control group) rats received single dose of 10 mg/kg saline solution intraperitoneally. Group 2(single dose group) rats received single dose of 10 mg/kg pH-neutral SOW intraperitoneally. Group 3(multiple doses group) rats received multiple doses of 10 mg/kg pH-neutral SOW intraperitoneall at first, third and fifth days. All animals were sacrificed at one week after infusion. The macro- and microscopic histopathological examinations were performed for each rat. All rats remained healthy follow up of one week. The macroscopic examinations of the three groups showed no significant differences. No toxicity findings were found in three groups. The microscopic examinations revealed active endometial glandular structures in uterus and functional follicules at different stages of maturation in ovary. There were no significant differences with regards to the microscopic findings between three groups. Intraperitoneal infusion of pH-neutral SOW does not result in any significant toxicity and complications on the tissues of uterus and ovary. © 2017, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Evaluation of Effectiveness of Hemogram Parameters in Colorectal Cancer Screening
(Yuzuncu Yil Universitesi Tip Fakultesi, 2025) Aras, A.; Oğuz, E.
Colorectal cancer (CRC) frequency and cancer-related death rates can be reduced with screening methods. Due to the invasiveness of the colonoscopy procedure and the high rate of false positivity of stool-based tests, it was aimed to investigate whether hemogram parameters could be a potential alternative to assist screening methods. Between January 2023 and December 2024 at Van YYU Faculty of Medicine Hospital, 605 patients who underwent colonoscopy for various indications were divided into groups and the age, gender, hemogram parameters taken before colonoscopy, such as RBC Count, Hb, Hct, WBC Count, Platelet Count, MPV, MC V, RDW, NLR, PLR, MLR, MPV/PLT ratio, Hb/PLT ratio, Lymphocyte/Monocyte ratio and the Hb/RDW ratio were investigated and then the usability of these hemogram parameters in colorectal cancer screening was studied. Statistical differences were observed in WBC, Hemoglobin, hematocrit, MCV, RDW, lymphocyte, MPV/PLT, Hb/PLT, Lymphocyte/monocyte and Hb/RDW ratios with T Test between cancer patients and patients with normal colonoscopy findings. Additionally, in multiple group comparisons, a statistically significant difference was detected in age, WBC, RBC and MCV parameters. This study is the most comprehensive study ever conducted with 18 hemogram parameters. As a result of binary and multivariate analysis, a statistically significant difference was detected in 10 parameters with T Test and in 4 parameters with multivariate analysis. It was concluded that hemogram parameters will be used alone or in addition to existing screening methods in colorectal cancer screening through prospective studies with the appropri ate combination of these parameters. © 2025, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Factors Affecting Mortality in Emergency Surgery in Cases of Complicated Colorectal Cancer
(Medical Association of Zenica-Doboj Canton, 2016) Kızıltan, R.; Yılmaz, Ö.; Aras, A.; Çelik, S.; Kotan, Ç.
Aim To evaluate retrospectively demographic, clinical and histopathological variables effective on mortality in patients who had undergone emergency surgery due to complicated colorectal cancer. Methods A total of 39 patients underwent urgent surgical interventions due to complicated colorectal cancer at the Department of General Surgery, Dursun Odabaş Medical Center, between January 2010 and January 2015. Thirty three of these were included in the study. Six patients were excluded because complete medical records had been missing. Medical records of the 33 cases were retrospectively reviewed. Results There were 14 (42.5%) male and 19 (57.5%) female patients. Mean age was 60 years (range: 32- 83 years); 14 (42.5%) patients were less than 60 years old, while 19 (57.5%) were 60 years old or older. Operations were performed due to perforation (39.3%) and obstruction (60.6%) in 13 and 20 patients, respectively. Tumor localization was in the right and transverse colon in nine (21.2%) and in the left colon in 24 cases (72.7%). Eleven (33.3%) patients underwent resection and anastomosis, 13 (39.3%) resection and ostomy, and nine (27.2%) patients underwent ostomy alone without any resection. Postoperative mortality occurred in nine cases (27.2%). Conclusions High mortality should be expected in females older than 60 years with a left sided colon tumor or with another synchronous tumor and in perforated tumors. Unnecessary major resections should be avoided and primary pathology should be in the focus of treatment in order to decrease the mortality and morbidity rates. © 2016, Medical Association of Zenica-Doboj Canton. All rights reserved.
Intraoperatively Testing the Anastomotic Integrity of Esophagojejunostomy Using Methylene Blue
(Sage Publications Ltd, 2017) Celik, S.; Almali, N.; Aras, A.; Yilmaz, O.; Kiziltan, R.
Background: Intraoperative testing of gastrointestinal anastomosis effectively ensures anastomotic integrity. This study investigated whether the routine use of methylene blue intraoperatively identified leaks to reduce the postoperative proportion of clinical leaks. Methods: This study retrospectively analyzed consecutive total gastrectomies performed from January 2007 to December 2014 in a university hospital setting by a general surgical group that exclusively used the methylene blue test. All surgeries were performed for gastric or junctional cancers (n = 198). All reconstructions (Roux-en Y esophagojejunostomy) were performed using a stapler. The methylene blue test was used in 108 cases (group 1) via a nasojejunal tube. No test was performed for the other 90 cases (group 2). Intraoperative leakage rate, postoperative clinical leakage rate, length of hospitalization, and mortality rate were the outcome measures. Results: The intraoperative leakage rate was 7.4% in group 1. The postoperative clinical leakage rate was 8.6%. The postoperative clinical leakage rate was 3.7% in group 1 and 14.4% in group 2 (p = 0.007). There were no postoperative clinical leaks when an intraoperative leak led to concomitant intraoperative repair. The median length of hospital stay was 6 days in group 1 and 8 days in group 2 (p<0.001). One death occurred in each group. No test-related complications were observed. Conclusion: The methylene blue test for esophagojejunostomy is a safe and reliable method for the assessment of anastomosis integrity, especially in cases with difficult esophagojejunostomic construction.
The Mineralogy and Firing Behaviour of Pottery Clays of the Lake Van Region, Eastern Turkey
(Mineralogical Soc, 2017) Aras, A.; Kilic, S.
The present study focused on the mineralogical and chemical characterization and firing behaviour of clays from the Lake Van region and compared them with the same characteristics established for two ancient pot sherds. Four pottery clays collected from Kutki and Kusluk in the Kesan Valley to the south, from Kavakbasi to the southwest and from Bardakci village on the east coast of Lake Van were analysed by X-ray diffraction to identify mineralogical composition (bulk clays and <2 mu m fractions after heating at 300-500 degrees C and ethylene glycol solvation). Further analyses were conducted to determine the size distribution, chemical composition and physical properties of test bodies derived from these clays. The in situ weathered schist forming the primary micaceous red clays which are suitable for local pottery production are characterized by large muscovite-sericite-illite and small calcite contents. In contrast, the Bardakci clays are dominated by large smectite contents and are only used sparingly in mixtures of local pottery production because they undergo firing shrinkage and present drying and firing flaws in the fired bodies. Firing ranges of similar to 800-900 degrees C were inferred from the mineralogy and colours of the two ancient sherds from Kutki. As a result of mineralogical analysis of fired and unfired test bodies of these pottery clays and pot sherds, two different types of pastes were determined for pottery production in the Lake Van region: metamorphic and volcanic paste, the former characterized by a calcite-poor and mica-sericite-rich matrix and the latter by large smectite and small calcite contents.
Portal Venous Thrombosis Developing After Torsion of a Wandering Spleen
(Medknow Publications & Media Pvt Ltd, 2017) Yilmaz, O.; Kiziltan, R.; Almali, N.; Aras, A.
Torsion of a wandering spleen is a rare disease. The symptoms and signs of this condition are only present when the splenic pedicle torts. The etiological factors are the congenital absence of the ligaments that hold the spleen in its normal anatomic position, or the relaxation of these ligaments resulting from conditions like trauma and abdominal surgery. We aimed to present a rare case with torsion of wandering spleen that consequently developed thrombosis of portal vein and its branches, taking into consideration the relevant literature.