Browsing by Author "Aras, I."

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Analysis of Incidental Thyroid Cancers in Surgically Treated Toxic Goiter Patients
(Yuzuncu Yil Universitesi Tip Fakultesi, 2025) Aras, A.; Karayil, A.R.; Yilmaz, Ö.; Aras, I.; Toktaş, O.; Kotan, Ç.
Differentiated Thyroid Cancer (DTC) is the most common endocrine cancer and the frequency of DTC detection in histopathological examinations in thyroid surgeries performed for non-cancer indications is increasing. The aim of this study is to investigate the rate of incidentally detected thyroid cancer in patients who underwent surgery for toxic goiter in our clinic. Histopathological data of patients who underwent surgery with a diagnosis of toxic goiter were retrospectively reviewed. Patients were divided into 3 groups as toxic adenoma (TA), toxic multinodular goiter (MNG) and Basedow-Graves disease. The presence of malignancy and clinicopathological features were investigated RESULTS: 84% of the cases were female and 16% were male, and the mean age was 43. 202 (65%) of the toxic goiter cases had TMG, 8 (3%) had TA, and 101 (32%) had Graves' disease. Histopathologically, the malignant/benign ratio was 65 (21%)/ 246 (79%). Malignancy was detected in 3 of the 15 patients with a family history of thyroid cancer Incidental thyroid cancer was detected in 65 (21%) of the patients with toxic goiter. Thyroid carcinoma was present in 45 (22%) of the patients with toxic MNG, 1 (12.5%) of the patients with TA and 19 (19%) of the patients with Graves. Histopathological examination revealed 62 papillary (38 microcarcinoma), 2 Non-invasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP) and 1 medullary microcarcinoma. The incidence of incidental thyroid cancer in the patients with toxic goiter treated with surgery was found to be consistent with the literature. © 2025, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Effect of Safran, Safranal and Crocin Which Are Active Ingredients of Saffron (Crocus) on Erythrocyte Fragility and Hematological Parameters in Carbon Tetrachloride Intoxicated Rats
(Yuzuncu Yil Universitesi Tip Fakultesi, 2016) Arihan, O.; Oto, G.; Bayram, I.; Aras, I.
Carbon tetrachloride is a toxic chemical and well known for its carcinogenic property. Intoxication with carbon tetrachloride causes serious liver injury and it is used as an experimental model for triggering liver related diseases. Saff ron (Crocus) species are well known bulbous ornamental and aromatic plants. Many of the saffron species are used in ethnomedicinal practices. In addition both saffron species and their ingredients are also subject to scientific research. In this study 72 rats were divided into 9 groups (n=8 in each group). Groups were set as control, olive oil, carbon tetrachloride, safran, safranal, crocin, carbon tetrachloride + safranal, carbon tetrachloride + crocin. Administrations were conducted for 7 days. Erythrocyte osmotic fragility and some selected hematological parameters were assessed. Results state significant increase in erythrocyte fragility due to carbon tetrachloride and amelioration due to active ingredients of saffron. Among hematocrit, hemoglobin and red blood cell count parameters only significant alteration was observed in safran with an increase in red blood cell count. Different administration schemes can be evaluated in future studies in order to assess detailed impact of saffron constituents on hematological parame ters and erythrocyte integrity. © 2017 Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Investigation of the Neuro-Regenerative Effects of Bioresonance and Magnetotherapy in Sciatic Nerve Damage-Induced Rats
(Universidad de la Frontera, 2023) Tas, A.; Nalci, K.A.; Sincan, S.; Özdemir, H.; Üstün, R.; Aras, I.; Tuncer, M.C.
Peripheral nerve damage is a significant clinical problem that can lead to severe complications in patients. Regarding the regeneration of peripheral nerves, it is crucial to use experimental animals' nerves and use different evaluation methods. Epineural or perineural suturing is the gold standard in treating sciatic nerve injury, but nerve repair is often unsuccessful. This study aimed to investigate the neuroregenerative effects of magnetotherapy and bioresonance in experimental animals with sciatic nerve damage. In this study, 24 female Wistar rats were divided into 7 groups (n=6) as follows: Group 1 (Control), Group 2 (Axonotmesis control), Group 3 (Anastomosis control), Group 4 (Axonotmesis + magnetotherapy), Group 5 (Anastomosis + magnetotherapy), Group 6 (Axonotmesis + bioresonance), Group 7 (Anastomosis + bioresonance). Magnetotherapy and bioresonance treatments were applied for 12 weeks. Behavioural tests and EMG tests were performed at the end of the 12th week. Then the rats were sacrificed, and a histopathological evaluation was made. The statistical significance level was taken as 5% in the calculations, and the SPSS (IBM SPSS for Windows, ver.21) statistical package program was used for the calculations. Statistically significant results were obtained in animal behaviour tests, EMG, and pathology groups treated with magnetotherapy. There was no statistically significant difference in the groups treated with bioresonance treatment compared to the control groups. Muscle activity and nerve repair occurred in experimental animals with acute peripheral nerve damage due to 12 weeks of magnetotherapy, and further studies should support these results. © 2023, Universidad de la Frontera. All rights reserved.
Saffron and Saffron Ingredients Like Safranal and Crocin’s Cytoprotective Effects on Carbon Tetrachloride Induced Liver Damage
(Yuzuncu Yil Universitesi Tip Fakultesi, 2022) Aras, I.; Bayram, I.; Oto, G.; Erten, R.; Almali, A.Ö.; Ilik, Z.A.
This study aims to investigate the liver-protective effects of saffron and saffron components like crocin and safranal against acute liver injury induced by carbon tetrachloride (CCI4) in rats. 72 male Wistar Albino rats were used in the study. The rats were divided into nine groups: 8 in each group. The rats were sacrificed at the end of the seventh day with high excretion (exsanguina tion). The protective effect of saffron, safranal, and crocin against CCI4-induced acute liver injury was evaluated histopathologically. In the study, balloon degeneration, apoptotic cells, and sub-massive necrosis were seen in hepatocytes as a result of-the effect of CCI4. These histopathological changes were hardly seen in groups in which CCI4 was administered with crocin and saffron. On the other hand, in the group where safranal and CCI4 were given together, changes similar to the histopathological changes seen in the CCI4 group were observed. It was concluded that crocin and saffron have a hepatoprotective effect in the experimental ac ute liver injury caused by CCI4, but the safranal has no protective effect on the liver. © 2022, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.