Browsing by Author "Arslan, Ş."

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Beta-Thalassemia Mutations in the East of Turkey
(2001) Öner, A.F.; Özer, R.; Üner, A.; Arslan, Ş.; Gümrük, F.
This study was planned to determine the frequency of β-thalassemia trait and mutations in Van Lake region, which is in the eastern part of Turkey, surrounded by Iran in the east and by Iraq in the south. This study consist of 1014 healthy students, between the age of 12 and 18 years who are studying in boarding schools in Van city and cities surrounding Van Lake that includes Van, Aǧri, Hakkari, Bitlis, Muş and Siirt. The students were randomly selected according to their school numbers. Their origin was not taken into consideration in selection. Complete blood counts were performed on all donors. The accepted lower limit of mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH) were 78 fL and 27 pg respectively. HbA2 was measured by DE-52 microcolumn chromatography method. β-Thalassemia trait with high HbA2 was found in 6 children. β-Thalassemia homozygous form of -30 (T-A) mutation was determined in one child and HbD-Los Angeles heterozygous in another. The β-thalassemia homozygous individual was accepted as two cases in prevalence calculation. We found that the prevalence of β-thalassemia trait was 0.78% in this area. In DNA analyses, there were β-thalassemia gene mutations of FSC 8/9 (+G), -30 (T-A), IVS I-110 (G-A), IVS II-1 (G-A) and IVS I-130 (G-A) in 3, 2, 1, 1 and 1 individuals, respectively. We conclude that although five different β-thalassemia mutation exist in Van Lake region, β-thalassemia is not a potential risk in the east of Turkey.
A Case of Nephrotic Syndrome Associated With Relapsing Hepatitis A
(IOS Press, 2007) Ataş, B.; Tuncer, O.; Çaksen, H.; Arslan, Ş.
Viral hepatitis A infection is a self-limited infection occurring predominantly among children usually as an anicteric often-subclinical illness. Almost all patients with hepatitis A virus infection recover completely. However, a relapsing course can occur with clinical signs, symptoms and biochemical findings of hepatic inflammation one or four months after the acute phase. In this article, we report a case of nephrotic syndrome associated with relapsing hepatitis A. Although it has been reported that hepatitis A can lead to nephrotic syndrome, an association of relapsing hepatitis A and nephrotic syndrome has not been reported in the literature to the best of our knowledge. © 2007 IOS Press. All rights reserved.
Effects of High-Dose Methylprednisolone Therapy on Lymphocyte Subtypes in Patients With Acute Immune Thrombocytopenic Purpura
(2005) Öner, A.F.; Bay, A.; Kuru, M.; Üner, A.; Arslan, Ş.; Dilek, I.
The aim of this study was to determine the effect of high-dose methylprednisolone (HDMP) on lymphocyte subtypes, CD4/CD8 ratio and clinical efficacy of the treatment in children with acute immune thrombocytopenic purpura (ITP). The study consisted of 21 children (aged between 1.5-14 years) with ITP treated with HDMP for 7 days. Absolute lymphocyte count, CD4+ and CD8+ T lymphocyte levels were examined on peripheral blood and CD4/CD8 ratio was calculated before and after HMTP treatment (on 0 and 8th days) in all subjects. There was no statistically significant difference for age and sex between the study and the control group. A significant reduction was observed in the percentage of CD4+ lymphocyte (39.0 ± 7.5% vs 29.3 ± 8.1%, p= 0.001), CD8+ lymphocyte (27.1 ± 7.2% vs 23.7 ± 8.3%, p= 0.03), CD4+/CD8+ (1.5 ± 0.5 vs 1.3 ± 0.4, p= 0.02) and the absolute number of CD4+ lymphocyte count (1694.99 ± 1019 vs 1199.12 ± 612, p= 0.038). These findings indicated that HDMP treatment may cause a decrease in the percentage of CD4+ and CD8+ T-lymphocyte and ratio of CD4+/CD8+ lymphocyte in patients with acute ITP. We suggest that the effectiveness of steroids may depended upon the suppression of CD4 T-lymphocyte and sequential monitoring of circulating lymphocyte subtypes may be used to predict the clinical effects of steroid treatment.
The Prevalence of Urinary Lithiasis in Children in Van Region, Turkey
(2009) Akgün, C.; Kayan, M.; Tuncer, O.; Arslan, Ş.; Çaksen, H.; Ataş, B.; Akbayram, S.
We aimed to determine the prevalence and etiology of urinary lithiasis in childhood in our region, Van, Turkey. A total of 1120 children were included in the study. Urinary ultrasonography was performed in all the children between April 2003 and June 2003. During the study, the kidneys were examined longitudinally and transversally using a 3.75 MHz convex probe in a Hitachi EUB -315 ultrasonography machine. The children's ages ranged from 7 years to 14 years (10.16 ±1.92 years) and 572 (51.1%) were males and 548 (48.9%) females. Urinary ultrasonography showed that 19 (1.7%) children had urinary lithiasis, which was in the right kidney in 15 children and in the left kidney in four children. Urinary lithiasis was in the upper urinary tract in all children. The etiological studies showed metabolic disorder in 14 children, and congenital renal anomaly in one child, but no underlying cause was diagnosed in four children. In conclusion, we found that was the prevalence of urinary lithiasis was 1.7% in school-aged children in our region. It was also noted that all urinary lithiasis was in the upper urinary system and its most common cause was metabolic disorder.
Relapsing Hepatitis a in Children: Report of Two Cases
(2002) Arslan, Ş.; Çaksen, H.; Öner, A.F.; Odabaş, D.; Rastgeldi, L.
Viral A hepatitis is a self-limited infection occurring predominantly among children usually as an anicteric often subclinical illness. After a stage of typical hepatitis A, a biphasic or relapsing form of viral hepatitis A (R-HA) may occur. Although relapse occurs in 3 to 21% of patients with acute hepatitis A, the patients with R-HA have been unusually reported in the literature. In this article, we report two children with R-HA because of unusual presentation and to draw attention to the importance of R-EA.
Splenic Abscess, Pleural Effusion and Severe Anemia Caused by Salmonella Typhi
(2000) Çaksen, H.; Öner, A.F.; Arslan, Ş.; Köseoǧlu, B.; Harman, M.; Ataš, B.; Abuhandan, M.
Various complications related to gastrointestinal system, central nervous system, and skeletal system may be observed during typhoid fever, but splenic abscess and pleural effusion are rarely encountered. A 12-year-old boy was admitted with fever, fatigue and pallor. On examination he had hepatosplenomegaly and severe anemia. He was diagnosed as having Salmonella typhi infection complicating with splenic abscess, pleural effusion and severe anemia, and successfully treated with percutaneous drainage with ultrasonography and antibiotics. In conclusion we would like to emphasize that typhoid fever should also be considered in patients with hepatosplenomegaly and severe anemia, and percutaneous drainage with ultrasonography may successfully be used in management of splenic abscess in typhoid fever.
Use of Intravenous Megadose Corticosteroid in a Child With Thrombocytopenic Purpura Due To Mumps
(2001) Öner, A.F.; Çaksen, H.; Arslan, Ş.; Odabas, D.; Özer, R.; Ceylan, A.