Browsing by Author "Arslan, A."

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Evaluation of Il-17a Expressions in High-Grade Glial Tumors Receiving Radiotherapy
(Wolters Kluwer Medknow Publications, 2022) Karaca, F.; Keskin, S.; Mentes, S.; Okten, A., I; Cavus, G.; Arslan, A.; Koksal, F.
Aim: In this study, we aimed to investigate the interleukin-17A (IL-17A) levels in patients with high-grade glial tumors before receiving radiotherapy, immediately after radiotherapy, and 3 months after radiotherapy. Patients and Methods: A total of 33 patients who applied to Adana City Training and Research Hospital, Department of Radiation Oncology between December 2016 and May 2018 was included in this study. A total of three blood samples was taken from each patient to assess IL-17A levels before and after radiotherapy and 3 months after the completion of radiotherapy. Results: The differences in IL-17A levels between genders were not statistically significant. IL-17A levels progressively decreased after the radiotherapy and 3 months after the radiotherapy as compared to the levels before radiotherapy. However, this was not statistically significant. IL-17A levels in the non-surviving patients were high before and after radiotherapy as compared to the surviving ones, but this was also not statistically significant. Conclusion: As compared to the period before radiotherapy, IL-17A levels tend to decrease in the period of acute and chronic phases of radiotherapy in all patient groups.
Relationship Between Biomass Exposure, Chronic Headache and Brain Damage in Young Women
(Yuzuncu Yil Universitesi Tip Fakultesi, 2020) Arslan, A.; Tüzün, F.A.; Arslan, H.
Biomass, an energy source, is the general name of all non-fossilized biological material obtained from living or recently living organism. Household use of solid biomass fuels is the most common cause of indoor air pollution (IAP) worldwide. The aim of this study was to investigate the relationship between biomass exposure and the presence of headache and brain damage in young women. This cross-sectional study included patient group consisted of 69 women who applied to the neurology outpatient clinic with complaints of chronic headache and fatigue and the control group consisted of 26 healthy volunteer women who were not exposed to tandir smoke. In all subjects, blood samples were obtained for biochemical analysis and brain Magnetic Resonance Imaging (MRI) scan was performed to evaluate brain damage. In the patient group, ischemic gliotic foci were detected in 56 patient (81.2%) while in the control group, gliotic foci was detected in 3 subjects (11.5%). The prevalence of gliotic foci was almost 8 times higher in subjects with a history of biomass smoke exposure than in subjects without a history of biomass smoke exposure (81.2% vs. 11.5%). These findings suggest that indoor air pollution may have an effect on the risk of headache and brain damage. However additional studies with larger sample sizes and including other ethnic or environmental communities are needed to determine in detail the role of indoor air pollution in the occurrence of headaches and brain damage. © 2020, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Serum Ischemia Modified Albumin and Oxidative Stress Levels in Patients With Gestational Diabetes Mellitus
(Yuzuncu Yil Universitesi Tip Fakultesi, 2022) Arslan, A.
Gestational Diabetes Mellitus (GDM) is a metabolic condition that develops during pregnancy and is associated with complications. This studies aim was to evaluate and measure the oxidative stress markers and antioxidants levels in women with gestational diabetes and compare them with healthy pregnant women. There were 77 pregnant women who participated in this case-control study. Forty female patients diagnosed with GDM participated in the study as the case group and 37 healthy women as the control group. All biochemical analyzes (IMA, MDA, GSH, CAT) were performed using the spectrophotometric method. When comparing the two groups, the patients group’s serum IMA levels (1.531±0.407 AbsU) were higher than those of the control group’s (0.863 ±0.092 AbsU) (p<0.001). Similarly, the patient group’s MDA levels (1.769 ±0.357 μmol/L) were higher than the control group’s (1.025 ±0.018 μmol/L) (p<0.001). Conversly, the patient group’s GSH levels (0.023 ±0.014 mmol/g) were lower than those of the control group’s (0.186 ±0.012 mmol/g) (p<0.001). This study als o found that both groups’ CAT activity levels had no significant statistical difference (GDM-0.072±0.019 and Control-0.075±0.013 U/L) (p<0.395). These results suggest that while the oxidative stress increased, the antioxidant defense levels decreased in wo men with GDM. It is recommended that patients with GDM are strictly monitored throughout pregnancy, which may help in the management of oxidative stress together with glycemic control. © 2022, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Silibinin and Ellagic Acid Increase the Expression of Insulin Receptor Substrate 1 Protein in Ultraviolet Irradiated Rat Skin
(Taylor & Francis Ltd, 2020) Gorgisen, G.; Ozkol, H.; Tuluce, Y.; Arslan, A.; Ecer, Y.; Keskin, S.; Ragbetli, M. C.
Daily exposure to ultraviolet (UV) light induces inflammation and tumorigenesis in the skin. Silibinin and ellagic acid are natural products that exhibit anti-inflammatory and anti-tumorigenic properties. Insulin receptor substrate protein 1 (IRS1) is important for skin homeostasis and physiology, but its activity following UV radiation remains unclear. We investigated the effects of ellagic acid and silibinin on IRS1 expression in ultraviolet A (UVA) and ultraviolet B (UVB) irradiated rat skin. Forty-two female Wistar rats were divided randomly into six groups of seven animals. The dorsal skin of rats was exposed to UVA + UVB, then treated with ellagic acid and silibinin by gavage. IRS1 expression in skin tissues was determined by western blot analysis. IRS1 expression increased significantly following treatment with ellagic acid and silibinin in UVA + UVB irradiated skin compared to the UVA + UVB only group. After UVA + UVB treatment, ellagic acid effected greater induction of IRS1 expression than silibinin. Our findings suggest that the photoprotective roles of ellagic acid and silibinin may be due to induction of IRS1 expression in UVA + UVB treated rat skin.
Western Blot Analysis of the Igg-Antibody Response To Acid-Glycine Antigens From Campylobacter Fetus Subsp. Fetus and C-Jejuni in Naturally Infected Sheep
(veterinarni A Farmaceuticka Univerzita Brno, 2007) Gurturk, K.; Ekin, I. H.; Arslan, A.
IgG-antibody response in aborting sheep and in apparently healthy sheep in a flock against acid-glycine-extracted antigens from three strains for each C fetus subsp. fetus and C jejuni were analysed by Western blot. One strain of C fetus subsp. fetus was isolated from aborting sheep. Western blot analysis of the sera revealed the presence of IgG antibody binding to the common antigens including proteins with the Mw of 63 kDa and 54 kDa in extracts from both C. fetus subsp. fetus and C. jejuni strains. In addition, IgG antibodies in sera from aborting sheep reacted more strongly with the antigens from C. fetus subsp. fetus strains with Mw of approximately 100, 95 and 86.5 kDa than those of apparently healthy sheep. The binding profile of the antibodies with these antigens appeared to be unique for each C. fetus subsp. fetus strain. On the other hand, IgG antibodies only in sera from aborting sheep recognized strongly the antigens of each C. fetus subsp. fetus strain at the Mw ranged from approximately 26 to 22 kDa. However, the antigenic components between 26 and 22 kDa were not detectable in coomassie blue stained gel and thought to have non-protein nature. These low molecular weight antigens of C. fetus subsp. fetus may be related to a recent infection in aborting sheep. These observations indicate that such species-specific antigens or conjugated protein antigens could be used for improving the specificity of the serological tests to detect C. fetus antibodies in sheep sera, and may be the candidates for subunit vaccines against ovine abortion.