Browsing by Author "Arslan, Ayse"

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Change of Antioxidant Enzyme Activities, Some Metals and Lipid Peroxidation in Alzheimer's Disease
(Carbone Editore, 2016) Arslan, Ayse; Tuzun, Fatma Aykan; Tamer, Sibel; Demir, Halit; Aycan, Abdurrahman; Demir, Canan; Gonullu, Edip
Introduction: Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive cognitive regression and memory loss. It has been claimed that oxidative stress and factors such as metal accumulation in the brain play important roles in the etiopathogenesis of the disease. Material and methods: The subjects of this study consisted of 24 individuals with Alzheimer's disease and 15 healthy agematched controls. Blood samples were withdrawn from the patients and healthy controls, and the activities of antioxidant enzymes SOD (Superoxide Dismutase), GSH (Glutathion), GSHPx (Glutathion peroxidase), GST (Glutathion S-Transferase) and MDA (Malondialdehyde) levels were determined by Spectrometer. Some metals and heavy metals were measured by atomic absorption spectrometry (AAS). Results: Biochemical analyses showed a significant decrease of the main enzymatic antioxidant defences (SOD, GSH, GST and GSHPx) and increased production of lipid peroxidation marker (MDA) in the serum of AD patients, compared to age-matched control group (p< 0.001). Also the levels of Zn, Mg, and Mn was lower and Fe, Pb, and Cd was higher in the patient group, compared to the control group. Serum Cu and Co levels did not differ significantly between the patient and control groups (p> 0.001). Conclusion: These results supports the theory that in AD there is a defect in the antioxidant defense system, which may lead to oxidative damage. Also alterations in some trace metals and their related enzymes may play a role of etiopathogenesis in AD.
Change of the Levels of Trace Elements and Heavy Metals in Threatened Abortion
(Lippincott Williams & Wilkins, 2019) Turan, Kasim; Arslan, Ayse; Uckan, Kazim; Demir, Halit; Demir, Canan
Backround: This study aimed to investigate the impact of changes in the serum levels of trace elements and heavy metals in threatened abortion, which is a common complication in early pregnancy. Earlier studies have shown that changes in the serum levels of some trace elements and increased serum concentrations of heavy metals are associated with spontaneous abortion; however, this relationship has not been fully clarified. Methods: The patient group consisted of 45 pregnant women diagnosed with threatened abortion. There were 40 healthy nonpregnant women in the control group. Blood samples were obtained from the patients and the healthy controls, and the concentrations of serum trace elements and heavy metals were measured using atomic absorption spectrophotometry. Results: Statistically significant decreases were found in the serum zinc (Zn), iron (Fe), magnesium (Mg) and manganese (Mn) levels, and significant increases were found in the serum copper (Cu), cadmium (Cd) and lead (Pb) levels in cases of threatened abortion in comparison to the controls (p < 0.001). However, there was no difference between the groups in terms of the serum cobalt (Co) levels (p > 0.001). Conclusion: Changes in the balance of some essential trace elements (especially decreases in Fe and Zn) and elevated concentrations of some toxic heavy metals in the blood may be important diagnostic and prognostic parameters for threatened abortion
Determination of Maternal Lipid Peroxidation and Antioxidant Activities in Term and Preterm Birth in Different Weeks
(Bayrakol Medical Publisher, 2021) Arslan, Ayse; Uckan, Kazurn; Turan, Kasurn; Demir, Halit; Demir, Canan
Aim: It has been suggested that oxidative stress may be associated with various pregnancy complications, including preterm birth (PTB). However, the rote of oxidative stress in preterm births and its effects on the pregnancy process are not conclusive. Material and Method: In this study, oxidative stress parameters were investigated in maternal blood samples who delivered at preterm and term. One hundred twelve mothers (<37 gestational weeks) diagnosed with preterm delivery were included in the study as a patient group. Also, sixty-four women who delivered at term as a control group were included in the study. Serum antioxidant enzymes (CAT (Catalase), SOD (Superoxide dismutase), GSHPx (Glutathione peroxidase), GSH (Glutathione) and MDA (Malondialdehyde) levels were determined spectrophotometrically. Results: Serum antioxidant activity was lower in the preterm groups than in the control group. Also, serum lipid peroxidation levels were higher in the preterm groups than the control group (p< 0.05). Discussion: Our findings show that women with preterm birth have higher levels of oxidative stress. These results suggest that oxidative stress is associated with preterm labor. However, It is still unclear whether oxidative stress is a cause or a result of preterm birth.
The Effect of Computed Tomography on Oxidative Stress Level and Some Antioxidant Parameters
(Sage Publications Ltd, 2021) Gunduz, Ali Mahir; Demir, Halit; Toprak, Nursen; Akdeniz, Huseyin; Demir, Canan; Arslan, Ayse; Goya, Cemil
Background X-rays are defined as ionizing radiation and hydrolyze the water, causing free radical formation. Oxidative stress is the damage that occurs in cells due to the lack of antioxidants, which detoxifies them, with the increased production of free radicals that occur during normal cellular metabolism. Purpose To examine the acute effects of computed tomography (CT), i.e. ionizing radiation, on oxidative stress and antioxidant defense mechanisms. Material and Methods The study included a total of 53 patients that were selected among the patients that underwent non-contrast full-body CT. Malondialdehyde (MDA) and reduced glutathione (GSH) levels and superoxide dismutase (SOD) and catalase (CAT) activities were investigated in blood samples taken from patients. Results The post-scan levels of MDA increased significantly while the post-scan levels of GSH, SOD, and CAT decreased significantly compared to their pre-scan levels. Conclusion CT, which is a widely used X-ray imaging technique and has numerous known side effects, was found to increase the levels of MDA, which is an indicator of oxidative stress, and to decrease the levels of some antioxidants including GSH, SOD, and CAT.
Evaluation of Cholinergic Enzymes and Selected Biochemical Parameters in the Serum of Patients With a Diagnosis of Acute Subarachnoid Hemorrhage
(de Gruyter Poland Sp Z O O, 2023) Aycan, Abdurrahman; Tas, Abdurrahim; Yeltekin, Asli Cilingir; El-Tekreti, Sama Amer Abbas; Arslan, Ayse; Arslan, Mustafa; Aycan, Nur
Background: Spontaneous subarachnoid hemorrhage (SAH) is the most severe form of hemorrhagic stroke and accounts for 5-7% of all strokes. Several chemical enzymes and cytokines are thought to cause reactions that may affect the mortality and morbidity of SAH patients. This study aimed to examine the possible relationships between these parameters and the occurrence of SAH and the clinical-radiological parameters in patients with acute SAH. Methods: This study evaluated 44 patients, including 20 with SAH and 24 controls. We obtained blood from the patients and control groups, which was stored in heparinized tubes and used in determining tumor necrosis factor alpha (TNF-alpha), brain-derived neurotrophic factor (BDNF), acetylcholinesterase (AChE), caspase-3, and butyrylcholinesterase (BChE) enzymes. Results: TNF-alpha, BDNF, AChE, and BChE enzyme levels were not related to the Glasgow Coma scale (GCS) score in the patient group (p > 0.05), whereas higher enzyme levels of caspase-3 were associated with lower GCS scores (p < 0.05). The difference between the control and patient groups in terms of mean TNF-alpha levels was statistically significant (p < 0.01). The BDNF levels were statistically insignificant in the patient groups (p > 0.05). Caspase-3, AChE, and BChE levels were significantly different between the control and patient groups (p < 0.01). Conclusions: Our results may be valuable for predicting the prognosis, diagnosis, and follow-up of patients with SAH. However, further studies are required to elucidate the relationship between the clinical and radiological results in patients with SAH and certain enzymes, cytokines, and growth factors.
Oxidative Stress in Patients With Thyroidectomy and Thyroparathyroidectomy Under Replacement Therapy
(Springer, 2015) Kacmaz, Murat; Atmaca, Murat; Arslan, Ayse; Demir, Halit; Ozbay, Mehmet Fatih
Several studies have demonstrated an imbalance between free radicals and the antioxidative system in individuals with thyroid dysfunction. However, oxidative stress has not been evaluated in patients with thyroidectomy and thyroparathyroidectomy, who are under replacement therapy. The objective of this study was to evaluate the oxidative stress using malondialdehyde, nitric oxide, and catalase levels in patients with thyroidectomy and thyroparathyroidectomy. Nineteen patients with thyroidectomy, 20 patients with thyroparathyroidectomy, and 20 controls with no history of thyroid or parathyroid disease or surgery were included in the study. Serum malondialdehyde, nitric oxide, and catalase levels were examined. Levels of nitric oxide and malondialdehyde were elevated, and catalase levels decreased in patients with thyroidectomy and thyroparathyroidectomy compared with controls (p value for all the parameters: p < 0.001). Free tetraiodothyronine was a potential predictor of malondialdehyde in the patient groups (p: 0.002). Catalase was negatively correlated with nitric oxide (p < 0.01) and malondialdehyde (p < 0.01). The results of the current study demonstrated that oxidative stress increased in patients with thyroidectomy and thyroparathyroidectomy despite the application of replacement therapies.
Posterior Reversible Encephalopathy Syndrome in Iga Vasculitis: Neuroimaging of a 14-Year Child
(Elsevier Urban & Partner Sp Z O O, 2018) Arslan, Harun; Yavuz, Alpaslan; Arslan, Ayse; Aycan, Abdurrahman
IgA vasculitis (IgAV) is a leukocytoclastic vasculitis and characterized by involvement of small vessels in skin, gastrointestinal system, joints, kidneys, and less frequently other organs. It is the commonest vasculitis in childhood and etiology is not completely known. Neurological manifestations of IgAV are very rare and usually seen in patients with severe hypertension or as an uncommon feature such as peripheral neuropathy. Posterior reversible encephalopathy syndrome (PRES) is a clinic-radiologic entity characterized with temporary vasogenic edema developing typically in posterior circulation of the brain and has been reported as a rare manifestation of IgAV. In this paper, a PRES case of 14-year-old male with IgAV is reported and etiopathogenesis was discussed with literature. Diagnosis was made by magnetic resonance imaging because of the existence of neurological symptoms (headache and visual loss) during the course of disease. His radiological findings have resolved with therapy. Although neurological involvement is a rare manifestation in IgAV, we recommend magnetic resonance imaging in such patients for diagnosis and evaluation of complications. (c) 2017 Published by Elsevier Sp. z o.o. on behalf of Polish Neurological Society.
The Relationship Between Serum Paraoxonase Levels and Carotid Atherosclerotic Plaque Formation in Alzheimer's Patients
(Termedia Publishing House Ltd, 2016) Arslan, Ayse; Tuzun, Fatma Aykan; Arslan, Harun; Demir, Halit; Tamer, Sibel; Demir, Canan; Tasin, Muhterem
Low paraoxonase 1 (PON1) activity and carotid atherosclerosis have been suggested to be important risk factors for dementia. However, the studies to date could not fully clarify the relationship between PON1, carotid atherosclerosis and dementia. The present study aimed to measure carotid atherosclerosis and PON1 activity in Alzheimer's Disease and to evaluate the relationship between them. The study included 25 Alzheimer's patients and 25 control subjects, for a total of 50 individuals. The study measured the serum PON1 activity and other biochemical parameters and carotid atherosclerotic plaque values of the participants. The mean paraoxonase activity (31.06 +/- 2.31 U/L) was significantly lower in the Alzheimer's group compared to the control group (59.05 +/- 7.05 U/L) (P < 0.001). Nonetheless, the carotid plaque values were significantly higher in the patient group (3.02 +/- 0.52 mm) compared to the control group (1.84 +/- 0.45 mm) (P < 0.001). Furthermore, there was a negative correlation (81.0%) between PON1 activity and carotid plaque in the overall study group (P < 0.05). Also serum homocystein level was higher in the patient group (22.15 +/- 7.05) compared to the control group (13.30 +/- 3.32). In conclusion, our findings show inverse association between PON1 activity and carotid atherosclerosis in Alzheimer patients: the lower the PON1 activity the more progressed the atherosclerotic process in AD. (C) 2016 Polish Neurological Society. Published by Elsevier Sp. z o.o. All rights reserved.
Reply To: "is Serum Level of Trace Elements and Heavy Metals Associated With Threatened Abortion
(Lippincott Williams & Wilkins, 2019) Turan, Kasim; Arslan, Ayse; Uckan, Kazim; Demir, Halit; Demir, Canan
Smoking-Related Alterations in Serum Levels of Thyroid Hormones and Insulin in Female and Male Students
(innovision Communications, 2015) Meral, Ismail; Arslan, Ayse; Him, Aydin; Arslan, Harun
Context Cigarette smoking has large-scale and complex effects on the endocrine system. Various studies related to cigarette smoking have provided differing results. Therefore, more research is needed to determine the effects on the body that are created by cigarette smoking. Objectives The study was designed, to investigate the effects of cigarette smoking, primarily on thyroid hormones in serum, such as on levels of total triiodothyronine (tT(3)), free triiodothyronine (fT(3)), total thyroxine (tT(4)), free thyroxine (fT(4)), thyroid-stimulating hormone (TSH) (ie, thyrotropin), and insulin of young students aged 18-25 y. Design This study was a randomized, controlled trial. Setting The study was performed in the Department of Physiology, School of Medicine, Yuzuncu Yil University (Van, Turkey). Participants Eighty healthy students, 40 females and 40 males, were included in the study. Intervention Of the 40 female participants, 25 were smokers, and 15 were nonsmokers. Of the 40 male participants, 25 were smokers; and 15 were nonsmokers. The intervention (smoking) group, therefore, consisted of 50 participants, and the control (nonsmoking) group consisted of 30 participants. Outcome Measures Serum concentrations of thyroid hormones and insulin were determined by enzyme-linked immunesorbent assays (ELISAs), using monoclonal antibodies; and by measurement of blood glucose, using a glucometer. Results The study found that both female and male smokers had higher levels of serum tT(3) and insulin hormone than nonsmokers had. A positive correlation was found between age and insulin resistance in male smokers. The study also found that male smokers had higher levels of serum tT(3) and fT(4) hormone than female smoken had. Conclusions Smoking may be associated with an increased Secretion of thyroid hormones and the development of insulin resistance. With aging, insulin resistance may increase more in male smokers than in female smokers.