Browsing by Author "Arslan, D."

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Alström Syndrome Associated With Cerebral Involvement: an Unusual Presentation
(TIP ARASTIRMALARI DERNEGI, 2006) Yilmaz, C.; Çaksen, H.; Yilmaz, N.; Güven, A.S.; Arslan, D.; Cesur, Y.
Alström syndrome (AS) is a rare autosomal recessive disorder, characterized by retinal degeneration, progressive hearing impairment, truncal obesity and non-insulin dependent diabetes mellitus. A 6-year-old girl was admitted with aphasia, deafness, strabismus, abdominal distention, and weakness on the right body side. The physical and laboratory examination revealed psychomotor retardation, right hemiparesis, sensorioneural hearing loss, aphasia, eye and teeth abnormalities, hyperpigmentation, truncal obesity, hepatosplenomegaly, severe iron deficiency anemia, delayed bone age, and cerebral hemiatrophy. Based on these abnormal findings she was diagnosed as AS. According to our knowledge this is the first case of AS with cerebral involvement. This last finding may be a component of the syndrome.
Ellis-Van Creveld Syndrome
(TIP ARASTIRMALARI DERNEGI, 2008) Cesur, Y.; Yuca, S.A.; Üner, A.; Yuca, K.; Arslan, D.
Ellis-van Creveld syndrome (EVCS) or chondroectodermal dysplasia is a rare autosomal recessive disorder characterized by a variable spectrum of clinical findings. Classical EVC syndrome comprises a tetrad of clinical manifestations of chondrodystrophy, polydactyly, ectodermal dysplasia, and cardiac defects. The patient presented with short stature, polydactyly, triangular face and dental dismorphism was found appropriately as radiographic with ectodermal dysplasia. In addition to the presence of single atrium, mitral, tricuspid and pulmonary valve insufficiency and pulmonary hypertension wererevealed by echocardiography. Her history involved a sister who was dead in 3-month-ages.
Enzyme Inhibition Properties of Calendula Officinalis, Matricaria Chamomilla, and Anthemis Pseudocotula: Kinetics and Molecular Docking Studies
(ACG Publications, 2025) Aslan, K.; Kiziltas, H.; Guven, L.; Karagecili, H.; Arslan, D.; Gulcin, İ.
This study determined the enzyme inhibition potential of three species (Calendula officinalis, Matricaria chamomilla, and Anthemis pseudocotula) from the Asteraceae family through in silico, followed by in vitro studies. Quinic acid, fumaric acid, gallic acid, chlorogenic acid, vanillic acid, quercetin, apigenin, and isorhamnetin were determined by LC-MS/MS in all of the species. Metabolic enzymes are essential catalysts regulating biochemical reactions within living organisms, facilitating energy production, detoxification, and biosynthesis. These enzymes play a crucial role in maintaining cellular homeostasis and are tightly regulated to ensure optimal metabolic function. High docking scores were also obtained for butyrylcholinesterase (BChE), α-glycosidase, α-amylase, and human carbonic anhydrase I and II enzymes (hCA I and hCA II). Among the extracts, Anthemis pseudocotula was concluded to be the best inhibitor for the enzymes, which was further determined by in vitro enzyme inhibition tests. Besides, it was concluded that all extracts showed anti-cholinergic, anti-diabetic, and anti-glaucoma properties. This is the first study determining the enzyme inhibition property of Anthemis pseudocotula and the three species' hCA I and hCA II inhibition activities. © 2025 ACG Publications. All rights reserved.
The Incidence of Asymptomatic Hypertension in School Children
(2010) Akgun, C.; Dogan, M.; Akbayram, S.; Tuncer, O.; Peker, E.; Taşkin, G.; Arslan, D.
Background: Although hypertension is a well-documented risk factor for cardiovascular diseases, including myocardial infarction and stroke, in adults, only recently has knowledge about childhood hypertension increased significantly. Aim: To determine the incidence of asymptomatic hypertension in school-age children. Subjects and Methods: Children in primary school were chosen with a randomized sampling method. During measurement of blood pressure, a calm, comfortable setting was provided. Blood pressure measurements were performed by only 1 researcher. For accurate measurement of blood pressure, recommended standards were followed. Results: A total of 1,963 children were included in the study. The incidence of systolic hypertension and diastolic hypertension were 7% and 2%, respectively. Obesity was present in 10.5% girls with hypertension and 13.9% of boys with hypertension. Conclusion: Our findings indicate that hypertension is an important health problem in children, and its prevalence is quite high. Blood pressure measurements must be a part of routine clinical examinations. Further studies should be performed in high-risk populations to prevent hypertension and to establish methods of early diagnosis and treatment in children.
A Novel Numerical Approach for Solving Convection-Diffusion Problem With Boundary Layer Behavior
(Gazi Universitesi, 2020) Cakir, M.; Masiha, R.Y.; Arslan, D.
This study deals with a new approach method for solving singularly perturbed boundary value problem of convection-diffusion type. Firstly, bounds on the solution and its derivative of solution to be used later in the article are obtained. This robust method is constructed with fitted difference scheme on a uniform mesh. It is proved that the presented method is first-order convergent with respect to the perturbation parameter ε in the discrete maximum norm. Two examples are given to illustrate the efficiency of the method. The numerical results are presented in tables and figures. © 2020, Gazi University Eti Mahallesi. All rights reserved.
Numerical Simulation for Singularly Perturbed Problem With Two Nonlocal Boundary Conditions
(Association of Mathematicians (MATDER), 2022) Arslan, D.; Cakir, M.
In this paper, numerical solution for singularly perturbed problem with nonlocal boundary conditions is obtained. Finite difference method is used to discretize this problem on the Bakhvalov-Shishkin mesh. The some properties of exact solution are analyzed. The error is obtained first-order in the discrete maximum norm. Finally, an example is solved to show the advantages of the finite difference method. © MatDer.