Browsing by Author "Arslan, M."

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Abc, Ved, and Abc-Ved Matrix Analyses for Inventory Management in Community Pharmacies: a Case Study
(Society of Pharmaceutical Sciences of Ankara (FABAD), 2022) Dursa, E.; Arslan, M.
Inventory control methods should be used effectively in community pharmacies to determine and obtain the needs for pharmaceuticals and non-pharmaceutical products at appropriate times and with proper procedures. An effective stock control provides positive outputs in the community pharmacy’s economy, the quality of the service to be provided, and the pharmacy’s image. In this context, within the scope of this study, it aims to evaluate ABC, VED, and ABC-VED matrix analyses in terms of community pharmacies. In the study, ABC, VED, and ABC-VED matrix analyzes were applied using the inventory data of a community pharmacy serving in the city center of Van for the 2019-2020 financial year. For this purpose, firstly, annual consumption and expenditure data for each pharmacy item specified for the 2019-2020 financial year were collected. The data were then transferred to an MS Excel spreadsheet, and statistical analysis was performed using MS Excel statistical functions. As a result of ABC-VED analysis, it was determined that the drugs in the first category were of great importance for effective stock control, the drugs in the second category were of medium importance, and the drugs in the third category were of low importance. They are because the pharmacy from which the research data is taken is close to the family health center and the socioeconomic structure of the pharmacy’s environment. This categorization is thought to be appropriate. © 2022 Society of Pharmaceutical Sciences of Ankara (FABAD). All rights reserved.
Application of Ahp Method for the Selection of Pharmaceutical Warehouse Location
(University of Ankara, 2020) Arslan, M.
Objective: The primary purpose of this study is to find a solution to the warehouse location selection problem of a pharmaceutical warehouse serving in the pharmaceutical industry by using the Analytical Hierarchy Process (AHP) method. Material and Method: Within the scope of this study, a possible new warehouse location problem that can be established in the Eastern and Southeastern Anatolia Region of Turkey for a pharmaceutical warehouse, which has a significant market share among the drug distribution channels in Turkey, will be solved with the AHP method. Firstly, the algorithm for the AHP is determined. Then, pair-wise comparison matrices for determined criteria and alternatives were prepared by decision-makers, and matrices were transferred to the Super Decision package program for the solution. Result and Discussion: As a result, the most important criterion in the selection of the pharmaceutical warehouse location was determined as the infrastructure and physical conditions (35%) and transportation conditions (29%) followed by it. According to these criteria, the first alternative was found as the optimum. © 2020 University of Ankara. All rights reserved.
Bilateral Abducens Paralysis Following Head Injury: a Case Report
(2003) Yilmaz, N.; Arslan, M.; Kiymaz, N.; Demir, Ö.; Yilmaz, C.
Cranial nerve lesions often accompany head trauma. Olfactory, facial and vestibular nerves are the most commonly injured nerves. Optic and oculomotor nerve injuries are less frequently involved, and trigeminal, abducens and lower cranial nerves are rarely involved. The injury may occur in central nervous system or in the lower motor unit. Traumatic bilateral abducens paralysis is a very rare occurrence. It may follows cervical spine trauma and sixth nerve avulsion has been reported to complicate lumbar puncture. In this study, we describe an 11-year-old boy with bilateral abducens paralysis following hematoma in the left ponto-cerebellar angle and hemorrhage in the prepontine cisterns due to head trauma. Such hemorrhages might result in lesions in the supranuclear regions by traction on the nerve due to displacement of the pons and its nucleus as a result of direct pressure. © 2003, IOS Press. All rights reserved.
Callosal Branches of the Anterior Cerebral Artery: an Anatomical Report
(Wiley-liss, 2008) Kahilogullari, G.; Comert, A.; Arslan, M.; Esmer, A. F.; Tuccar, E.; Elhan, A.; Ugur, H. C.
Although the morphology of the corpus callosum is well defined, the arterial supply of this structure has not been comprehensively studied. To elucidate this further, 40 cerebral hemispheres from. 30 adult cadaveric brains were obtained. The anterior cerebral arteries were cannulated and injected with red latex. The following were observed and documented: (1) the number, diameter, and course of the arteries supplying the corpus callosum; (2) the territories vascularized by these arteries; (3) any variations of the callosal arteries. Short callosal arteries were present in 58 hemispheres (96.6%) and supplied the superficial surface of the corpus callosum along its midline and were a primary arterial source to this structure. Long callosal arteries were found in 28 hemispheres (46.6%) and contributed to the pial plexus. The cingulocal-losal arteries were present in all hemispheres and supplied the corpus callosum, cingulate gyrus, and also contributed to the pericallosal pial plexus. The recurrent cingulocal-losal arteries were present in 17 hemispheres (28.3%) and also contributed to the pericallosal pial plexus. The median callosal artery, an anatomical variation, was present in 10 brains (33.3%). This vessel supplied the corpus callosum and the cingulate gyrus. The aim of the present study was to provide a detailed description of the arteries supplying the corpus callosum for those who encounter these vessels radiologically or surgically.
Colloid Cyst Presenting With Acute Hydrocephalus in an Adult Patient: Case Report and Review of Literature
(Yuzuncu Yil Universitesi Tip Fakultesi, 2018) Aycan, A.; Gülşen, İ.; Arslan, M.; Kuyumcu, F.; Akyol, M.E.; Arslan, H.
Colloid cysts (CC) are rare cystic lesions with a wide clinical spectrum including the asymptomatic cysts that are coincidentally diagnosed and the cysts leading to sudden death. The symptoms in CC are usually caused by obstructive hydrocephalus. The most common symptom for CC is headache. CC rarely cause intracranial herniation and death. In this study, we aimed to present our experience in the diagnostic and treatment process of a 57-year-old male patient with CC who presented to the emergency service with sudden severe headache, vomiting and confusion. © 2018, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Detecting Drug-Drug Interactions Induced by Antacids Encountered in a Community Pharmacy: an Observational Study
(University of Ankara, 2024) Gökeş, D.; Arslan, M.
Objective: This study aimed to reveal drug-drug interactions (DDIs) due to antacids through programs used to detect DDIs. Material and Method: Within the scope of this study, 207 prescriptions containing at least one antacid and a drug from a different pharmacological group were evaluated in terms of DDIs. Evaluations were made on the prescriptions received in a community pharmacy serving in Van, Türkiye. Three different DDI checking programs were used for this evaluation. Result and Discussion: Antacid-induced DDIs were detected in 64 of the prescriptions. Interactions occurred between 52 active ingredient pairs, and it was revealed that DDIs were most common between calcium carbonate and famotidine. This interaction is minor and has been detected by only one database. Another common interaction was found between the calcium carbonate and cholecalciferol (Vitamin D) pair, and this interaction was reported as Level 2 and should be closely monitored in two different databases. As a result, DDIs induced by antiacids generally were found to be at moderate levels. However, it is seen that three DDI checking programs used in the study provide different results in detecting DDIs. © 2024 University of Ankara. All rights reserved.
Evaluation of Knowledge, Attitudes, and Practices of Community Pharmacists Toward Celiac Disease
(University of Ankara, 2023) Orunç, E.A.; Arslan, M.
Objective: The knowledge and attitude of pharmacists play an essential role in the patient counseling services of pharmacists. Celiac disease is one of the diseases in which patient follow-up and counseling are essential, and the number of studies dealing with the roles of pharmacists in this disease is very limited. This study aims to fill this gap and contribute to public health by evaluating community pharmacists' knowledge, attitudes, and practices for celiac disease. Material and Method: Based on the literature, a measurement tool including the knowledge, attitudes, and practices of community pharmacists for celiac disease has been developed. The measurement tool was applied online to community pharmacists in Törkiye in 2021. The obtained data were subjected to explanatory factor analysis (EFA). Result and Discussion: The number of pharmacists participating in this study is 408. A four-factor structure was obtained: knowledge of celiac disease, attitude towards celiac disease, counseling practices for celiac patients, and professional development practices. The Cronbach's alpha values of the factors were calculated between 0.794 and 0.935, which shows high reliability. These factors explained 70.343% of the total variance. The community pharmacists had positive attitudes toward counseling for celiac disease. Still, there were some deficiencies in terms of knowledge and practice. It is thought that the knowledge and awareness of pharmacists on celiac diseases can be increased by including issues related to celiac disease in both undergraduate education and vocational training programs. © 2023 University of Ankara. All rights reserved.
Evaluation of Patients Operatively Treated With a Diagnosis of Lumbar Disc Hernia: an Epidemiological Investigation
(Yuzuncu Yil Universitesi Tip Fakultesi, 2017) Aycan, A.; Gülşen, İ.; Arslan, M.; Kuyumcu, F.; Akyol, M.E.
Lower back and leg pain is a common condition in the community which leads to loss of work and restricts daily life activities. About 2-3% of all painful lower back syndromes are caused by lumbar disc herniation (LDH). Surgery is performed in patients with sensory and motor deficits and the patients which are not responding to physical and medical treatment. In this study, we retrospectively evaluated the LDH patients that were operatively treated in our clinic through the review of the literature and the study was aimed to provide contribution to epidemiological studies. The retrospective study included 190 patients who were operatively treated between January 2013 and December 2015. Age, gender, level of herniation, neurological examination findings, presence of trauma, length of hospital stay, profession, recurrence, and surgical outcome were evaluated in all patients. The 190 patients included 108 (56.8%) males and 82 (43.2%) females with a mean age of 45 years. Mean length of hospital stay was 1.8 days. The level of herniation was L4-5 (51.6%), L5-S1 (32.1%) with a rate of 83.7%. Preoperative foot drop was found in 2.1% of the patients. Of these, 50% of them were improved and 50% of them sustained foot drop following the surgery. Lumbar disc herniation is one of the most common spine surgeries performed. Appropriate surgical procedure with an accurate diagnosis leads to good success rates and high patient satisfaction. Following the surgery, 122 patients were graded as “perfect”, 50 patients as “good”, 15 patients as “moderate”, and 3 patients as “poor”. These findings were consistent with the findings of the literature. © 2017, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Evaluation of Patients' Willingness To Use and Pay for Pharmaceutical Care Services in Törkiye
(Society of Pharmaceutical Sciences of Ankara (FABAD), 2024) Alabdullah, Z.; Arslan, M.
Pharmacists' consultancy roles, covering many essential tasks such as preventing diseases, monitoring medication, and increasing patient compliance, significantly improve healthcare. Patients' views on pharmaceutical care services should be evaluated to improve these services. Thus, the main objective of this study is to assess patients' willingness to use and pay for pharmacy services provided in community pharmacies. A measurement tool was developed according to relevant literature, including 24 statements, and applied to the patients in Van, Törkiye. Obtained data (n=445) were first subjected to descriptive statistical analysis, and then the exploratory factor analysis (EFA) was applied. Lastly, independent samples t-Test and ANOVA tests were conducted using factor scores to test the hypotheses. As a result of the EFA, a three-factor solution was obtained. The factors were labeled as advanced pharmacy services, core pharmacy services, and providing information for usage. Cronbach's Alpha values of the factors are 0.859, 0.883, and 0.691, respectively. It was determined that the participants were more willing to benefit from the services discussed under the core pharmacy services factor. These services were followed by the services in the factors of providing information for usage and advanced pharmacy services. Contrary to this situation, it is seen that the participants are more willing to pay for the services included in the advanced pharmacy services. This paper has put forth that patients were generally willing to use pharmaceutical services but not willing to pay for them. © 2024 Society of Pharmaceutical Sciences of Ankara (FABAD). All rights reserved.
Evolutionary Engineering and Molecular Characterization of a Caffeine-Resistant Saccharomyces Cerevisiae Strain
(Springer Netherlands, 2019) Sürmeli, Y.; Holyavkin, C.; Topaloğlu, A.; Arslan, M.; Kısakesen, H.İ.; Çakar, Z.P.
Abstract: Caffeine is a naturally occurring alkaloid, where its major consumption occurs with beverages such as coffee, soft drinks and tea. Despite a variety of reports on the effects of caffeine on diverse organisms including yeast, the complex molecular basis of caffeine resistance and response has yet to be understood. In this study, a caffeine-hyperresistant and genetically stable Saccharomyces cerevisiae mutant was obtained for the first time by evolutionary engineering, using batch selection in the presence of gradually increased caffeine stress levels and without any mutagenesis of the initial population prior to selection. The selected mutant could resist up to 50 mM caffeine, a level, to our knowledge, that has not been reported for S. cerevisiae so far. The mutant was also resistant to the cell wall-damaging agent lyticase, and it showed cross-resistance against various compounds such as rapamycin, antimycin, coniferyl aldehyde and cycloheximide. Comparative transcriptomic analysis results revealed that the genes involved in the energy conservation and production pathways, and pleiotropic drug resistance were overexpressed. Whole genome re-sequencing identified single nucleotide polymorphisms in only three genes of the caffeine-hyperresistant mutant; PDR1, PDR5 and RIM8, which may play a potential role in caffeine-hyperresistance. Graphic abstract: [Figure not available: see fulltext.]. © 2019, Springer Nature B.V.
Evolutionary Engineering and Molecular Characterization of Cobalt-Resistant Rhodobacter Sphaeroides
(Frontiers Media SA, 2024) Atay, G.; Holyavkin, C.; Can, H.; Arslan, M.; Topaloğlu, A.; Trotta, M.; Çakar, Z.P.
With its versatile metabolism including aerobic and anaerobic respiration, photosynthesis, photo-fermentation and nitrogen fixation, Rhodobacter sphaeroides can adapt to diverse environmental and nutritional conditions, including the presence of various stressors such as heavy metals. Thus, it is an important microorganism to study the molecular mechanisms of bacterial stress response and resistance, and to be used as a microbial cell factory for biotechnological applications or bioremediation. In this study, a highly cobalt-resistant and genetically stable R. sphaeroides strain was obtained by evolutionary engineering, also known as adaptive laboratory evolution (ALE), a powerful strategy to improve and characterize genetically complex, desired microbial phenotypes, such as stress resistance. For this purpose, successive batch selection was performed in the presence of gradually increased cobalt stress levels between 0.1–15 mM CoCl2 for 64 passages and without any mutagenesis of the initial population prior to selection. The mutant individuals were randomly chosen from the last population and analyzed in detail. Among these, a highly cobalt-resistant and genetically stable evolved strain called G7 showed significant cross-resistance against various stressors such as iron, magnesium, nickel, aluminum, and NaCl. Growth profiles and flame atomic absorption spectrometry analysis results revealed that in the presence of 4 mM CoCl2 that significantly inhibited growth of the reference strain, the growth of the evolved strain was unaffected, and higher levels of cobalt ions were associated with G7 cells than the reference strain. This may imply that cobalt ions accumulated in or on G7 cells, indicating the potential of G7 for cobalt bioremediation. Whole genome sequencing of the evolved strain identified 23 single nucleotide polymorphisms in various genes that are associated with transcriptional regulators, NifB family-FeMo cofactor biosynthesis, putative virulence factors, TRAP-T family transporter, sodium/proton antiporter, and also in genes with unknown functions, which may have a potential role in the cobalt resistance of R. sphaeroides. Copyright © 2024 Atay, Holyavkin, Can, Arslan, Topaloğlu, Trotta and Çakar.
From Saccharomyces Cerevisiae To Ethanol: Unlocking the Power of Evolutionary Engineering in Metabolic Engineering Applications
(Multidisciplinary Digital Publishing Institute (MDPI), 2023) Topaloğlu, A.; Esen, Ö.; Turanlı-Yıldız, B.; Arslan, M.; Çakar, Z.P.
Increased human population and the rapid decline of fossil fuels resulted in a global tendency to look for alternative fuel sources. Environmental concerns about fossil fuel combustion led to a sharp move towards renewable and environmentally friendly biofuels. Ethanol has been the primary fossil fuel alternative due to its low carbon emission rates, high octane content and comparatively facile microbial production processes. In parallel to the increased use of bioethanol in various fields such as transportation, heating and power generation, improvements in ethanol production processes turned out to be a global hot topic. Ethanol is by far the leading yeast output amongst a broad spectrum of bio-based industries. Thus, as a well-known platform microorganism and native ethanol producer, baker’s yeast Saccharomyces cerevisiae has been the primary subject of interest for both academic and industrial perspectives in terms of enhanced ethanol production processes. Metabolic engineering strategies have been primarily adopted for direct manipulation of genes of interest responsible in mainstreams of ethanol metabolism. To overcome limitations of rational metabolic engineering, an alternative bottom-up strategy called inverse metabolic engineering has been widely used. In this context, evolutionary engineering, also known as adaptive laboratory evolution (ALE), which is based on random mutagenesis and systematic selection, is a powerful strategy to improve bioethanol production of S. cerevisiae. In this review, we focus on key examples of metabolic and evolutionary engineering for improved first- and second-generation S. cerevisiae bioethanol production processes. We delve into the current state of the field and show that metabolic and evolutionary engineering strategies are intertwined and many metabolically engineered strains for bioethanol production can be further improved by powerful evolutionary engineering strategies. We also discuss potential future directions that involve recent advancements in directed genome evolution, including CRISPR-Cas9 technology. © 2023 by the authors.
Hydrocephalus
(2008) Arslan, M.; Yazici, T.
Hydrocephaly is called increased intracranial pressure associated with enlarged ventricle as a result of imbalance between produce and absorption of Cerebral Spinal Fluid (CSF) which functions as a natural pillow in the brain. Prevalence is 1-1.5 percent. Hydrocephaly may depend on many cause including subnormal CSF reabsorbtion, increased CSF production, increased venous pressure, and obstruction in circulation of CSF. There is an increased CSF volume. Increased CSF volume results from imbalance between absorption and production of CSF. CSF produces in the choroid plexus and absorbs in the arachnoid villuses. The brain which is closely pressed in the cranium is damaged. Therefore, pressed brain tissue cannot function completely. Hydrocephalus may be obstructive type, which there is a obstruction in CSF pathways, and non obstructive type which there is not a obstruction in CSF pathways. The patient with hydrocephalus complains of nause, vomiting and headache. There may be also lethargy, unconscious, irritability, enlarged head circumference, growth and mental retardation findings. Dilated ventricle can be seen in CT and MRI. If it is not treated immediately, it may end with the death of the patient. Aim of the treatment of hydrocephalus is to reduce to intracranial volume to normal limits in order to provide normal brain development.
Myxoid Solitary Fibrous Tumour of the Meninges
(Blackwell Publishing, 2006) Kosem, M.; Arslan, M.; Kontas, O.; Unal, O.
Pharmacy Profession From the Perspective of Female Pharmacists
(University of Ankara, 2020) Arslan, M.; Çoban, E.S.; Şar, S.
Objective: The aim of this study is evaluating the pharmacy profession from the perspective of the female pharmacists working in different areas of the pharmaceutical sector, also addressing the job satisfaction of the female pharmacists. Material and Method: The population of the study consists of female pharmacists working in different fields of the pharmacy profession in Ankara. The qualitative interview method was used in the study and semi-structured questions were asked to the participants. After the interviews were completed, the data obtained from the short notes and voice recordings held during the qualitative interview were analyzed by the researchers and thematic analysis was conducted. Result and Discussion: In the study, three main themes were determined: Vocational Preference, Difficulties Encountered and Job Satisfaction. When the identified themes and sub-themes were evaluated, it was seen that gender difference did not cause any negativity in the practice of the pharmacy profession. It has been observed that the job satisfaction of female pharmacists depending on the field in which they work, and the job satisfaction of the academic female pharmacists, in particular, is very high. When job satisfaction is taken into consideration financially, it is determined that the group with the highest level of satisfaction is women working as a community pharmacist. It is thought that the results obtained in this study will guide both the individuals who will make a career choice and the members of the pharmacy professionals who are indecisive in the selection of the working area. © 2020 University of Ankara. All rights reserved.
The Role of Matrix Metalloproteinase as Biomarkers for Neural Tube Defect
(Yuzuncu Yil Universitesi Tip Fakultesi, 2023) Akyol, M.E.; Ebiri, F.N.D.; Taspinar, F.; Yüksek, V.; Tuncer, O.; Arslan, M.; Taspinar, M.
Neural Tube Defect (NTD) is one of the most common congenital malformations. It is crucial to determine the prognostic, predictive, or therapeutic genetic factors for preventing NTD. The formation of the extracellular matrix (ECM) plays an essential role in migrating neural crest cells. Matrix metalloproteinases (MMPs) play a significant role in cell migration in ECM organization. The role of expressions and activation of MMP in NTD is unknown. This study aimed to investigate the roles of MMP-1,-2, and 9 gene expressions as biomarkers for NTD. Peripheral blood samples and NTD tissues were collected from 40 newborn babies diagnosed with NTD, which were also divided into subgroups based on pathology, and peripheral blood samples from only 20 healthy babies were taken for control. After total RNA isolation from blood and tissues, MMP-1,-2,-9 gene expressions were analyzed by Quantitative Real-Time PCR (RT-PCR). There was no difference between the control group and the NTD group in terms of MMP expressions in blood samples (p>0.05). A statistically significantly higher MMP-1 expression was found in Meningocele and Myeloschisis than in Encephalocele (p=0.014). A significant difference was found between the tissue and blood samples of the Meningomyelocele patient group regarding MMP-9 expression (p=0.019). There was no significant relationship between Ca2+, B12, and Folate levels, NTD, and MMP genes expressions (p>0.05). Even though MMP genes were not different between control and NTD groups, they were found to vary between different subgroups and can serve as biomarkers. © 2023, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Short-Term Outcomes of Aneurysmatic/Non-aneurysmatic Patients Operated for Spontaneous Subarachnoid Hemorrhage: a Tertiary Referral Center
(Yuzuncu Yil Universitesi Tip Fakultesi, 2023) Aycan, A.; Taş, A.; Arslan, M.; Tufan, A.
We aimed to retrospectively analyze patients with aneurysmal dilatation and vascular malformation who presented with spontaneous SAH. Clinical data in patients files, Preoperative and postoperative neurological and radiological findings, age, gender, and treatment results were evaluated retrospectively. The same team performed surgery on 38 (47.5%) patients. Twenty (52.6%) of the patients included in the study were female, and 18 (47.3%) were male. There were 33 patients with detected bleeding aneurysms, three with bleeding AVMs, and two patients with non-bleeding aneurysms. It was determined that 5% of the patients had a Fisher score of 1, 34% had a Fis her score of 2, 24% had a Fisher score of 3, and 37% had a Fisher score of 4. Ten patients died. There were signs of vasospasm in 18 patients. Nine (50%) of 18 patients with vasospasm survived, and 9(50%) died. Eleven patients had hydrocephalus. EVD was in serted in 10 patients. Lamina terminalis was opened in 29 patients. The vessel with the most common aneurysm was the isolated AcomA aneurysm, with a rate of 31.5% (n=12). MCA aneurysm was found with the second frequency with a rate of 23.6% (n=9) Spontaneous subarachnoid hemorrhage is a disease with high mortality and morbidity in neurosurgery. Rebleeding, vasospasm, onset GCS, Fisher score, and experienced surgical equipment are among the factors affecting the treatment outcome. Multidisciplinary treatment in centers where diagnosis, treatment, and follow-up can be made by the same team will reduce mortality and morbidity rates. © 2023, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Sildenafil (Viagra) and a Rare Complication: Intracerebral Hemorrhage
(2007) Arslan, M.; Yazici, T.
Sildenafil is fist efective oral agent in treatment of erectil dysfunction. It relaxes the smooth muscles of the corpus cavernosum selectively by inhibiting phosphodiesterase type 5 and causes potential erection during sexual stimulation. Although its low dose is efective, the most effective dose is 50-100 mg. The use of sildenafil is associated with various complications. Using high-dose sildenafil in especially groups with risk may cause mortal complications. It reduces transiently the blood pressure. If it is used associated with nitrates, it may cause severe hipotension. The most frequent reported complications are headache, flushing, nasal kongestion, dispepsi and vision disorder. With painful and long-term erections are frequent seen. The side effects are transient. A 45 - year - old man was admitted to our hospital because of intraventricle hemorrhage after sildenafil use. To our knowledge, this rare complication related to sildenafil has never been reporded until now. Chronic sildenafil use causes disorder in the endotel layer of the vessel, also high dose sildenafil lead to vasodiladation extensively. Therefore, we believe that extensive vasodilatation due to high dose sildenafil in the defeated vessels causes rupture of cerebral arteries. Also undiagnosed cerebrovascular disease such as aneurysm, arteriovenous malformation, cavernous angioma may cause brain bleeding extensive excersize during sexual performance.