Browsing by Author "Arslan, Mustafa"

Now showing 1 - 4 of 4

Effects of Blood Hemoglobin Levels on Vertebral Discal Degeneration
(2023) Cetin, Eyup; Şah, Volkan; Arslan, Mustafa; Arabacı, Ozkan; Akyol, Mehmet Edıp; Ünlü, İlker
Introduction: Vertebral discopathies are one of the most important causes of low back pain, which is very common in the community. Although there are many biochemical and mechanical causes of discogenic low back pain, the most important is discal degeneration. Many studies have been conducted suggesting that disc degeneration could be associated with various factors. In our study, we aimed to reveal a possible relationship between disc degeneration and levels of hemoglobin (HGB). Methods: We investigated the connection between discal degeneration and certain parameters, especially HGB levels, in a total of 174 patients in two separate groups; those with and without disc degeneration. Age, weight, height, body mass index, chronic diseases, mean HGB, hematocrit (HTC) level, white blood cell (WBC), high-density lipoprotein, low-density lipoprotein (LDL), and triglyceride (TG) values of the patients were recorded. Results: No significant difference was detected (p>0.05) between the groups with and without degeneration in terms of HGB, HTC, WBC, and LDL values. The TG level in the group with disc degeneration was significantly (p<0.05) higher than the group without disc degeneration. Discussion and Conclusion: Lumbar disc degeneration is a public health problem that continues to be discussed in the literature. There was no significant difference in terms of HGB levels between the groups, with and without degenerated disc.
Evaluation of Cholinergic Enzymes and Selected Biochemical Parameters in the Serum of Patients With a Diagnosis of Acute Subarachnoid Hemorrhage
(de Gruyter Poland Sp Z O O, 2023) Aycan, Abdurrahman; Tas, Abdurrahim; Yeltekin, Asli Cilingir; El-Tekreti, Sama Amer Abbas; Arslan, Ayse; Arslan, Mustafa; Aycan, Nur
Background: Spontaneous subarachnoid hemorrhage (SAH) is the most severe form of hemorrhagic stroke and accounts for 5-7% of all strokes. Several chemical enzymes and cytokines are thought to cause reactions that may affect the mortality and morbidity of SAH patients. This study aimed to examine the possible relationships between these parameters and the occurrence of SAH and the clinical-radiological parameters in patients with acute SAH. Methods: This study evaluated 44 patients, including 20 with SAH and 24 controls. We obtained blood from the patients and control groups, which was stored in heparinized tubes and used in determining tumor necrosis factor alpha (TNF-alpha), brain-derived neurotrophic factor (BDNF), acetylcholinesterase (AChE), caspase-3, and butyrylcholinesterase (BChE) enzymes. Results: TNF-alpha, BDNF, AChE, and BChE enzyme levels were not related to the Glasgow Coma scale (GCS) score in the patient group (p > 0.05), whereas higher enzyme levels of caspase-3 were associated with lower GCS scores (p < 0.05). The difference between the control and patient groups in terms of mean TNF-alpha levels was statistically significant (p < 0.01). The BDNF levels were statistically insignificant in the patient groups (p > 0.05). Caspase-3, AChE, and BChE levels were significantly different between the control and patient groups (p < 0.01). Conclusions: Our results may be valuable for predicting the prognosis, diagnosis, and follow-up of patients with SAH. However, further studies are required to elucidate the relationship between the clinical and radiological results in patients with SAH and certain enzymes, cytokines, and growth factors.
Nvestigation of Total Sulphydryl and Protein Carbonyl Levels in Spina Bifida Aperta Patients
(2023) Arslan, Mustafa; Arabacı, Özkan
Bu çalışmada, spina bifida aperta bulunan çocuklarda ve kontrol grubunda serum protein karbonil ve serum total sülfihidril düzeylerinin araştırılması ve bu parametrelerin spina bifida aperta patogenezindeki rolünün araştırılması amaçlandı. Yöntem: Çalışmaya, spina bifida aperta tanısı ile takip edilen 45 hasta ve bu hastalığa sahip olmayan 47 kontrol dâhil edildi. Seçilen hastalardan, ailenin onamı alındıktan sonra kan örneği alınarak serum protein karbonil ve serum total sülfihidril düzeyleri çalışıldı. Ayrıca hastalarda, NTD tipi, lezyonun bulunduğu seviye, klinik bulgular ve hidrosefali cerrahisi ihtiyacıyla birlikte, serum B12 vitamini, folat ve kalsiyum düzeylerine ilişkin bilgiler toplandı. Bulgular: Serum total sülfihidril düzeyi spina bifida aperta hastalarında 0.528±0.195 nmol/mg protein olarak saptanırken kontrol grubunda 1,105±0.102 nmol/mg protein olarak belirlendi. Ayrıca, hasta grubunda serum protein karbonil düzeyi 0,428±0,009 µmol/ml iken kontrol grubunda 0,216±0,009 µmol/ml idi. Her iki parametre açısından hasta ve kontrol grupları arasında anlamlı fark bulunduğu belirlendi (p<0,001). Meningomyelosel, meningosel, myeloşizis hastaları arasında her iki parametre açısından istatistiksel olarak anlamlı fark bulunmuyordu. Sonuç: Oksidatif stresin iyi birer belirteci oldukları bilinen protein karbonil ve serum total sülfihidril düzeyleri ile yapılan bu çalışmada, spina bifida aperta hastalarında oksidatif stresin kontrol grubuna göre anlamlı olarak yüksek olduğu belirlendi.
Serum Prolidase and Ischemia-Modified Albumin Levels in Neural Tube Defects: a Comparative Study of Myelomeningocele, Meningocele, and Myeloschisis
(int Scientific information, inc, 2025) Zengin, Irfan; Akyol, Mehmet Edip; Arslan, Mustafa; Arabaci, Ozkan; Yurekturk, Eyyup; Cetin, Eyup; Demir, Halit
Background: Neural tube defects (NTDs) are congenital malformations resulting from incomplete neural tube closure, leading to severe neurological impairments. Despite advances in prenatal screening and surgical interventions, the biochemical mechanisms underlying NTDs remain unclear. Prolidase, an enzyme involved in collagen metabolism, and ischemia-modified albumin (IMA), a marker of oxidative stress, may play roles in NTD pathogenesis. This study aimed to compare serum prolidase and IMA levels in infants with NTDs and healthy controls to assess their potential contribution to NTD development. Material/Methods: A case-control study was conducted, including 45 infants diagnosed with NTDs (myelomeningocele, meningocele, and myeloschisis) and 45 age-and sex-matched healthy controls. Serum prolidase and IMA levels were measured using validated spectrophotometric methods. Statistical analyses were performed to compare biomarker levels between groups and among NTD subtypes. Results: Serum prolidase levels were significantly elevated in NTD patients (2.21 +/- 0.06 IU/L) compared to controls (1.07 +/- 0.04 IU/L, p<0.001). Similarly, serum IMA levels were higher in NTD patients (0.40 +/- 0.01 ABSU) than in controls (0.22 +/- 0.01 ABSU, p<0.001). No significant differences were observed in biomarker levels among the different NTD subtypes (p>0.05). Conclusions: Elevated prolidase and IMA levels in NTD patients suggest a potential role in NTD pathogenesis, possibly through impaired collagen metabolism and oxidative stress. Further research is needed to explore their diagnostic and therapeutic implications in neural tube defect management.