Browsing by Author "Askar, Muntecep"

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Can B-Type Natriuretic Peptide (Bnp) Levels Serve as an Early Predictor of Clinical Severity in Patients With Covid-19 Pneumonia
(Clin Lab Publ, 2022) Cilingir, Buket Mermit; Askar, Selvi; Meral, Ayfer; Askar, Muntecep
Background: COVID-19 has continued to aggressively spread and kill. The incidence of complications and associated mortality rates are high. Cardiac damage, which is related to survival, is one of these. The purpose of this study is to assess the role of BNP, a cardiac biomarker, in predicting mortality in COVID-19. Materials and Methods: This single-center, prospective observational study was performed from July to September 2020 in a tertiary university hospital designated for the treatment of COVID-19 patients. Patients whose diagnoses were confirmed with real-time polymerase chain reaction (RT-PCR) tested nasopharyngeal swabs and with thoracic computed tomography (CT) findings compatible with COVID-19 pneumonia were included in the study. All clinical and laboratory data were obtained within the first 24 hours of hospital admission. To determine the risk of in-hospital death, patients were followed from admission until their discharge (1 to 15 days). The primary outcome was in-hospital death, defined as the case-fatality ratio. Results: Among all biomarkers that were included in the multivariate analysis only high BNP levels was independently associated with mortality [Mean 1.012, 95% CI (1.005 -1.02 pg/mL) (p = 0.002)]. Mortality was found to be significantly associated with older age and higher BNP, LDH, AST, HGB, PLT, ferritin, D-dimer, and CRP levels. In addition, mortality was found to be higher with longer duration of hospitalization (p = 0.041). Conclusions: Our fundamental goal for COVID-19 is to determine whether the hospitalized patients are in the mortality risk group at an early stage of disease. Adding measurement of BNP levels to routine laboratory tests for COVID-19 may be a practical approach to determine the patients with a high risk of mortality. (Clin. Lab. 2022;68:xx-xx. DOI: 10.7754/Clin.Lab.2021.210602)
Hospital and 1-Year Mortality Outcomes in Covid-19 Pneumonia
(Bayrakol Medical Publisher, 2024) Askar, Selvi; Askar, Muntecep; Bilgin, Mehmet Hakan; Yildiz, Hanifi; Beyzaei, Rasa; Keskin, Siddik
Aim: COVID-19 caused many deaths, and its socioeconomic impact continues. Hospital mortality is generally known, but information on 1 -year mortality is limited. This study aimed to measure all -cause mortality rates in hospitalized and 1 -year follow-up COVID-19 patients and to evaluate the factors affecting these rates. Material and Methods: PCR-positive patients' demographic, clinical, and laboratory characteristics were retrospectively analyzed. Hospitalization duration and mortality data were recorded. Discharged patients' polyclinic, follow-up, and mortality status within one-year were evaluated. Results: The study included 201 patients, with a mean age of 63.12 +/- 14.5 years, and 59.2% were male. Logistic regression analysis identified several factors affecting hospital mortality, including male gender, smoking, lactate-dehydrogenase, and ferritin. Further analyses indicated that advanced age, low -oxygen saturation, high -sodium levels, low -potassium levels, low -hemoglobin), elevated -white -blood cell count, reduced -platelet count, increased INR and D-Dimer count, and elevated -CRP (C -reactive protein) levels were significant factors influencing hospital mortality. Mortality within 1 -year was associated with factors including male gender, diabetes, low -oxygen saturation, elevated -AST levels, elevated -ALT levels, elevated-ferritin levels, and hospitalization length. Those who died within one year were more likely to have been hospitalized in intensive -care unit, required oxygen support, and were smokers. Discussion: Hospital mortality was associated with impaired laboratory parameters and smoking, whereas 1 -year mortality was associated with intensivecare, oxygen requirements, and diabetes.
Relationship of Right Ventricular Functions With In-Hospital and 1 Year Later Mortality in Patients Hospitalized for Covid-19 Pneumonia
(Wolters Kluwer Medknow Publications, 2024) Askar, Muntecep; Karaduman, Medeni; Coldur, Rabia; Askar, Selvi
BACKGROUND:The aim of this study was to determine the association of right ventricular function with in-hospital mortality and mortality 1 year after discharge in patients hospitalized for COVID-19 pneumonia. METHODS:The study was conducted in Van Yuzuncu Yil University Faculty of Medicine hospital between February 10, 2021 and August 10, 2022. A total of 156 patients hospitalized in intensive care and wards due to COVID-19 pneumonia were included in this study. Echocardiography was performed in all patients. RESULTS:Among the demographic findings of the patients included in the study, male gender, patients hospitalized in the intensive care unit (ICU), patients receiving O-2 support, and smokers were found to have higher mortality rates during hospitalization. At the end of 1 year, the mortality rate was higher in patients who were hospitalized in the ICU received O-2 support and had diabetes mellitus. Among echocardiographic findings, those with a low left ventricular ejection fraction had higher early and 1-year mortality rates. Of the right ventricular functions, low fractional area change, high systolic pulmonary artery pressure (SPAP), shortened pulmonary acceleration time, low right ventricle systolic wave S' velocity, increased right atrium area, and inferior vena cava diameter were found to be associated with high mortality. Increased right atrial area and inferior vena cava diameter, increased SPAP, and shortened pulmonary acceleration time were found to be significant in 1-year mortality. The presence of pericardial effusion was associated with mortality during hospitalization but not with 1-year mortality. B-type natriuretic peptide, D-dimer, and hemoglobin levels were significantly correlated with both hospital mortality and 1-year mortality. CONCLUSIONS:In the follow-up of COVID-19 pneumonia, right ventricular function is considered to be an important factor in early and late mortality. It could be helpful to establish a follow-up program for discharged patients from the parameters involved in mortality.