Browsing by Author "Asker, M."

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Association of Intermittent and Continuous Hypoxaemia With Carotid and Brachial Arterial Intima-Media Thicknesses
(Univ West indies Faculty Medical Sciences, 2022) Asker, S.; Asker, M.; Ozgokce, M.; Ozbay, B.
Objective: To assess the carotid and brachial arteries' intima-media thicknesses (IMTs) in cases with intermittent (obstructive sleep apnoea syndrome (OSAS)) and continuous (chronic obstructive pulmonary disease (COPD)) hypoxaemia together with other confounding demographic and biochemical factors. Methods: The study was prospectively performed on 197 patients allocated in three groups: 80 with severe OSAS, 80 with severe COPD patients and 37 healthy controls. These groups were compared in terms of demographics, biochemical markers and IMTs of the right and left carotid and brachial arteries. Results: Carotid and brachial arterial IMTs were found to be higher in both patient groups than the control group (p < 0.001). Similarly, levels of haemoglobin, haematocrit, cholesterol, triglycerides, low-density lipoproteins (LDL), C-reactive protein and D (domain)-dimer were significantly increased in patient groups. Oxygen saturations (p < 0.001) and ejection fractions (p = 0.001) were found to be worse and D-dimer levels (p = 0.010) were elevated more prominently in COPD patients, whereas, cholesterol (p < 0.001), hemoglobin (p = 0.004) and LDL (p = 0.001) levels were higher in the OSAS group. Except the right carotid IMT, which was increased significantly in OSAS patients, IMT measurements were similar in the OSAS and COPD groups (p < 0.001). Conclusion: We have shown that both intermittent and continuous hypoxia result in remarkable alterations in carotid BIT and brachial IMT. Further prospective trials are warranted to confirm and extend these findings, including the biochemical markers, which may aid in the diagnosis and follow-up of patients suffering from hypoxaemia.
Clinical, Echocardiographic and Haemodynamic Predictors of Morbidity and Mortality in Pulmonary Hypertension: a Nation-Wide Registry
(Oxford Univ Press, 2024) Akbulut, M.; Kaymaz, C.; Basarici, I; Yildirimturk, O.; Asker, M.; Yaylali, T.; Tokgozoglu, L.
The Effect of Low Sodium Dialysate on Ambulatory Blood Pressure Measurement Parameters in Patients Undergoing Hemodialysis
(Oxford Univ Press, 2015) Akdag, S.; Akyol, A.; Cakmak, H. A.; Tosu, A. R.; Asker, M.; Yaman, M.; Gumrukcuoglu, H. A.
Effects of Lowered Dialysate Sodium on Left Ventricle Function and Brain Natriuretic Peptide in Maintenance of Hemodialysis Patients
(Sage Publications Ltd, 2017) Akyol, A.; Akdag, S.; Asker, M.; Gumrukcuoglu, H. A.; Duz, R.; Demirel, K. C.; Begenik, H.
Introduction: Impaired diastolic flow is characterized by decreased left ventricular (LV) filling diastole, abnormal LV distensibility, or delayed relaxation. B-Type natriuretic peptide (BNP) is an indicator of various cardiovascular diseases and body volume status. The aim of this study was to determine whether the lowering of dialysate sodium (Na) levels is effective on LV systolic and diastolic parameters and BNP in the maintenance of hemodialysis patients. Materials and Methods: The study included 49 chronic hemodialysis patients. Left atrium (LA) diameter and LV ejection fraction, LV systolic and diastolic diameter, deceleration time (DT), pulmonary artery pressure (PAP), inferior vena cava diameter (IVCD), early diastolic transmitral flow (E) and late diastolic transmitral flow (A) velocities, E/A ratio, isovolumic relaxation time, peak early diastolic velocity (E), late diastolic velocity (A) of tissue Doppler mitral annulus, and flow propagation velocity of mitral inflow (V-p) were measured before and 6 months after hemodialysis with low Na dialysate. Results: Six months after low Na hemodialysis, a decrease was observed in echocardiographic parameters such as PAP and IVCD (p < 0.05, p < 0.001, and p < 0.001, respectively). However, a significant difference was not observed in LA diameter. In LV diastolic measurement of E and A waves, E/A ratio, DT, V-p, septal E and A, and lateral E and A exhibited significant improvement by low Na HD. BNP level was significantly reduced (p < 0.001). Conclusions: Lowered dialysate Na concentration improves PAP, IVCD, and LV diastolic properties assessed by mitral inflow filling, tissue Doppler velocity, and mitral inflow velocity propagation.
Improving Morbidity and Mortality in Patients With Pulmonary Hypertension: Insights From a Nation-Wide Registry
(Oxford Univ Press, 2024) Kaymaz, C.; Akbulut, M.; Basarici, I.; Yildirimturk, O.; Asker, M.; Kaya, E. B.; Tokgozoglu, L.
Multiparametric Risk Predictions for Morbidity and Mortality in Patients With Pulmonary Arterial Hypertension: Insights From a Nation-Wide Registry
(Oxford Univ Press, 2024) Basarici, I; Kaymaz, C.; Akbulut, M.; Yildirimturk, O.; Asker, M.; Yaylali, T.; Tokgozoglu, L.
A Novel Echocardiographic Method for Assessing Arterial Stiffness in Obstructive Sleep Apnea Syndrome
(Oxford Univ Press, 2015) Akdag, S.; Akyol, A.; Cakmak, H. A.; Gunbatar, H.; Asker, M.; Babat, N.; Gumrukcuoglu, H. A.
An Overlooked Cause of Resistant Hypertension; Upper Airway Resistance Syndrome
(Excerpta Medica inc-elsevier Science inc, 2014) Asker, M.; Asker, S.; Kucuk, U.; Kucuk, H. O.
Platelet-To Ratio May Predict the Severity of Calcific Aortic Stenosis
(International Scientific Literature Inc., 2015) Akdag, S.; Akyol, A.; Asker, M.; Duz, R.; Gumrukcuoglu, H.A.
Background: Platelet-to-lymphocyte ratio (PLR) is an emerging inflammatory indicator which is closely associated with adverse cardiovascular events. Therefore, we aimed to investigate the relationship between PLR and the severity of calcific aortic stenosis (AS). Material/Methods: The study was designed as a retrospective study. A total of 86 consecutive patients with calcific AS were divided into two groups as mild-to-moderate AS and severe AS according to the transaortic mean pressure gradient. PLR levels were calculated from the complete blood count (CBC). Results: Platelet to lymphocyte ratio was significantly higher in severe and mild-to-moderate AS groups when compared to the control subjects (151±31.2, p<0.001, 138±28.8 vs. 126±26.5, p=0.008, respectively). In the subgroup analysis of AS patients, PLR was found to be higher in the severe AS group compared to mild-to-moderate group (p<0.001). A significant correlation was found between PLR and transaortic mean pressure gradient in patients with AS (r=0.421, p<0.001). Conclusions: Our study results demonstrated that increased PLR correlates with the severity of calcific AS. © Med Sci Monit, 2015.