Browsing by Author "Aslan, Mehmet"

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Abnormal Liver Function Test in Hydatidiform Moles: a Retrospective Study Comparing the Hyperthyroid State and the Euthyroid State
(informa Healthcare, 2014) Kucukoglu, Mehmet Emin; Dulger, Ahmet Cumhur; Aslan, Mehmet; Olmez, Sehmus; Guler, Ayse; Aldemir, Mehmet Naci; Demirkiran, Davut
Introduction: The effect of a hyperthyroid or euthyroid state on liver function tests in patients with hydatidiform moles (HM) is not known. The aim of this study was to determine the effect of hyperthyroidism on liver transaminases in HM. Patients and methods: We retrospectively reviewed aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels in 80 patients with HM (23 complete moles and 57 partial moles). Results: Of the 80 HM patients, 52 (65%) were euthyroid and 28 (35%) were hyperthyroid. The number of gravida and the levels of serum beta-human chorionic gonadotropin (beta-HCG), AST, and ALT were significantly higher in the hyperthyroid state than in the euthyroid state (p = 0.033, p = 0.001, p = 0.001 and p = 0.001; respectively). Number of gravida, serum TSH and total T4 were significantly higher in complete HM than partial HM (p < 0.05, p < 0.001, p < 0.05; respectively). Conclusions: Our results demonstrated that HM-related beta-HCG may activate thyroid cells via TSH-related signalling, resulting in the release of high levels of FT4, FT3, TT3 and TT4, and a subsequent decrease in TSH.
Alveolar Echinococcosis of the Liver: a Single Center Experience
(Medycyna Praktyczna Sp K Sp Zoo, 2012) Dulger, Ahmet C.; Esen, Ramazan; Begenik, Huseyin; Aytemiz, Enver; Demirtas, Levent; Aslan, Mehmet
INTRODUCTION In humans, alveolar echinococcosis (AE) of the liver is caused by canine tapeworm called Echinococcus multilocularis. The disease is most prevalent in the northern hemisphere and in the eastern part of Turkey. OBJECTIVES The aim of the study was to review the natural history of AE and its clinical and radiological features. PATIENTS AND METHODS The retrospective study involved 23 patients (10 men, 13 women), aged 34-75 years with AE who had been referred to our liver disease clinic in the past 4 years. Only patients with pathologically proven AE were included in the study. The sociodemographic, clinical, and radiological features of AE were also evaluated. RESULTS The main laboratory characteristics of AE included mild eosinophilic leukocytosis with hyper-gammaglobulinemia, elevated C-reactive protein levels, near-normal liver transaminases, and increased levels of cholestatic enzymes and immunoglobulin E. Eight patients (35%) had hepatitis B e antigen-negative hepatitis B infection. Budd-Chiari syndrome was identified in 3 of 23 patients (13%). Eighty-three percent of the patients had a seropositive test result for AE, and approximately one-third of the patients had distant metastasis. Surgical treatment was administered in 4 patients. Four patients died due to complications during follow-up. CONCLUSIONS Patients with AE have numerous complications and advanced disease at the time of diagnosis. The clinical picture of AE comprises a number of hepatic and extrahepatic disturbances related both to destructive and mass effects of the tapeworm.
Assessment of the Serum Paraoxonase Activity and Oxidant/Antioxidant Status in Patients With Recurrent Aphthous Stomatitis
(Wiley, 2013) Bilgili, Serap Gunes; Ozkol, Halil; Takci, Zennure; Ozkol, Hatice Uce; Karadag, Ayse Serap; Aslan, Mehmet
ObjectivesSeveral studies have indicated that recurrent aphthous stomatitis (RAS) is associated with oxidative stress. The aim of this study was to investigate serum paraoxonase (PON) activity and oxidant/antioxidant status in patients with RAS. Design and methodsThirty-one patients with RAS and 31 healthy controls were enrolled. Serum PON1 and arylesterase activities, total antioxidant capacity, total oxidant status, and oxidative stress index were determined. ResultsSerum total antioxidant capacity levels, PON1, and arylesterase activities were significantly lower in RAS than controls (P<0.001), while total oxidant status levels andoxidative stress index were significantly higher (P<0.001). PON1 activity had a significant correlation with high-density lipoprotein cholesterol only (r=0.482, P<0.05),while there were no correlations with other lipids (P>0.05) in patients with RAS. ConclusionsOur results indicate that RAS is associated with decreased PON1 activity and increased oxidative stress that plays a crucial role in the pathogenesis of RAS. Further studies on a larger number of patients are needed to verify these results.
Benign Glycogenic Acanthosis Lesions of the Esophagus
(Turkish Soc Gastroenterology, 2012) Nazligul, Yasar; Aslan, Mehmet; Esen, Ramazan; Yeniova, Abdullah Ozgur; Kefeli, Ayse; Kucukazman, Metin; Celik, Yilmaz
Background/aims: Glycogenic acanthosis is described as benign thickening of the esophageal squamous epithelium of unknown etiology. Although its etiology is unknown, it has been reported that glycogenic acanthosis may be related to gastroesophageal reflux and hiatal hernia. The aim of the present study was to review the patients who were diagnosed with glycogenic acanthosis on upper gastrointestinal endoscopy and to determine whether there is any association between glycogenic acanthosis and gastroesophageal reflux and hiatal hernia. Material and Methods: A total of 504 patients who underwent upper gastrointestinal endoscopy for evaluation of non-ulcer dyspepsia were reviewed retrospectively. Results: Glycogenic acanthosis was detected in 143 (28.3%) of those 504 patients. Of the 143 patients, 82 (57.3%) were male and 61 (42.7%) were female. Patients with glycogenic acanthosis were aged 20-83 years. Gastroesophageal reflux was detected in 50 (34.9%) cases with glycogenic acanthosis, while hiatal hernia was detected in 30 (20.9%) cases. Gastroesophageal reflux was detected in 102 (28.2%) control subjects, while hiatal hernia was detected in 50 (13.8%). Hiatal hernia was significantly higher in glycogenic acanthosis patients than in controls subjects (p<0.05). Glycogenic acanthosis patients had higher gastroesophageal reflux than seen in controls subjects, but the difference between groups was not statistically significant (p>0.05). Conclusions: Our results suggest that glycogenic acanthosis is primarily an age-related disease. We demonstrated that glycogenic acanthosis may be associated with gastroesophageal reflux and hiatal hernia. Further studies are necessary to confirm these findings.
Co-Occurrence of Hepatocellular Cancer and Non-Hodgkin Lymphoma
(Medycyna Praktyczna Sp K Sp Zoo, 2013) Dulger, Ahmet C.; Aslan, Mehmet; Olmez, Sehmus; Esen, Ramazan; Tasdemir, Mehmet; Aytemiz, Enver; Kalkan, Nurhan O.
Coexistence of Gastric Diverticulum and Gastric Cancer
(Lippincott Williams & Wilkins, 2018) Olmez, Sehmus; Aslan, Mehmet; Yavuz, Alpaslan; Saritas, Bunyamin
Coexistence of the Poems Syndrome With Hepatitis B: a Rare Case Report
(Springer Wien, 2016) Celik, Yilmaz; Aslan, Mehmet; Sayin, Refah; Cifci, Adem; Canbaz, Esra Turan; Kucukoglu, Mehmet Emin; Dulger, Ahmet Cumhur
POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) is a rare multisystemic disease of unknown pathogenesis. Proinflammatory and proangiogenic cytokines play important roles in its pathogenesis. POEMS syndrome is a rare cause of ascites. Until now, the coexistence of POEMS syndrome and hepatitis B has not been reported. In this case report, we present a 48-year-old male patient who presented with malaise, fatigue, diarrhea, and abdominal swelling. Organomegaly, endocrinopathy, ascites, skin changes, and polyneuropathy were identified, and we arrived at a diagnosis of POEMS syndrome. The patient was administered methylprednisolone 64 mg/day, lamivudine 100 mg/day, calcium 1.5 g/day, and calcitriol 0.5 A mu g/day. The patient's clinical manifestations had moderately resolved at the follow-up visits. At the end of 6 months of follow-up, his ascites was minimally reduced, and his neurologic manifestations had not lessened. The present case shows that accurate diagnosis is required for the management of patients with coexisting POEMS syndrome and hepatitis B.
Determining Oxidant and Antioxidant Status in Patients With Genital Warts
(Taylor & Francis Ltd, 2015) Cokluk, Erdem; Sekeroglu, Mehmet Ramazan; Aslan, Mehmet; Balahoroglu, Ragip; Bilgili, Serap Gunes; Huyut, Zubeyir
Objectives: Warts are abnormal skin growths caused by human papilloma virus (HPV) infections within the skin of patients. Genital warts usually appear in the perianal and perigenital regions. Asymptomatic warts may be activated after years and may damage natural immunity. The inflammation that occurs during this process may lead to an imbalance between the prooxidant and the antioxidant systems. The aim of this study was to investigate erythrocyte glutathione peroxidase (GSH-Px) activity, serum paraoxonase enzyme levels, and oxidative stress levels in patients with genital warts. Patients and Methods: In total, 32 patients with genital warts and 35 healthy subjects were included in this study. Erythrocyte GSH-Px activity, serum catalase activity, and paraoxonase enzyme, and malondialdehyde (MDA) levels were determined. Results: Erythrocyte GSH-Px activity, serum MDA levels, and catalase activity were significantly higher in patients with genital warts than in controls (P < 0.01, P < 0.05, and P < 0.05, respectively). However, serum paraoxonase enzyme levels were not significantly different between groups (P > 0.05). Serum triglyceride levels were significantly lower in patients with genital warts than in controls (P < 0.01). However, there were no statistically significant differences between groups with respect to total cholesterol, high-density lipoprotein cholesterol, or low-density lipoprotein cholesterol levels (all P > 0.05). Conclusions: Our data suggest that oxidative stress is increased in genital warts. Increased oxidative stress levels may contribute to the pathogenesis of genital warts, and prolonged HPV infection due to chronic inflammation could also affect oxidative stress.
Diffuse Nodular Lymphoid Hyperplasia of the Small Bowel Associated With Common Variable Immunodeficiency and Giardiasis: a Rare Case Report
(Springer Wien, 2014) Olmez, Sehmus; Aslan, Mehmet; Yavuz, Alpaslan; Bulut, Gulay; Dulger, Ahmet Cumhur
Diffuse nodular lymphoid hyperplasia (DNLH) of the intestine is an extremely rare lymphoproliferative disorder of uncertain etiology. Typically, numerous polypoid nodules composed of hyperplastic benign lymphoid tissue are present in the small and/or large intestinal mucosa. DNLH has been observed in association with common variable immunodeficiency (CVID). A 38-years-old man was admitted to our clinic due to dyspeptic complaints. An upper gastrointestinal system endoscopic examination revealed DNLH in the duodenum. A biopsy specimen showed the presence of nodular lymphoid hyperplasia and a Giardia lamblia infection in the duodenum. CVID was suspected, and the diagnosis was established by demonstrating a significant reduction in the serum gamma-globulin levels. DNLH is a rare benign condition with regards to diagnosis and treatment of unknown etiology. In patients with DNLH, screening for the immune deficiencies is being important in addition to histopathological examinations.
The Effect of Disease Control on Mean Platelet Volume and Red Blood Cell Distribution in Patients With Acromegaly
(E-century Publishing Corp, 2015) Ucler, Rifki; Aslan, Mehmet; Atmaca, Murat; Alay, Murat; Ademoglu, Esra Nur; Candan, Zehra; Gulsen, Ismail
Objectives: Several studies have shown increased atherogenic risk factors and biomarkers of inflammation and atherosclerosis in association with growth hormone excess. Mean platelet volume (MPV) and red blood cell distribution (RDW) are currently gaining interest as new independent cardiovascular risk factors. The aim of this study was to evaluate the effect of disease control on MPV and RDW in acromegaly patients. Materials and methods: We retrospectively enrolled 36 acromegaly patients (23 males, 13 females; mean age 41.94 +/- 11.55). Patients were divided into two groups: disease controlled by surgical treatment alone (group A) or by somatostatin analog (SSA) therapy (group B). MPV and RDW measurements were evaluated during active and inactive disease periods in the two groups. Results: There were statistically significant increases in MPV and RDW in patients receiving SSA therapy (P = 0.012 and P = 0.020, respectively). The differences in MPV and RDW changes in patients receiving surgical treatment alone were not statistically significant (P=0.364 and P=0.339, respectively). Conclusions: This is the first report on the evaluated the effect of disease control on MPV and RDW in acromegaly patients. Our study results showed that MPV and RDW measurements are significantly increased in acromegaly patients with disease controlled by SSA therapy. Therefore, acromegalic patients treated with SSAs may have increased cardiovascular risk based on an increase in MPV and RDW.
The Effect of Helicobacter Pylori Infection on Autoimmune Thyroid Antibodies in Patients Who Have Had Gastroscopy
(2023) Şakı, Hüseyin; Aslan, Mehmet
Amaç: Helikobakter Pilori enfeksiyonu neredeyse dünyada insanların yaklaşık %50‟sini çeşitli klinikler oluşturarak etkilemektedir. Bu yüzden tanısını koymak ve uygun tedaviyi başlamak çok önemlidir. Bu çalışmada daha önce gastroskopi yapılmış hastalarda Helikobakter Pilori enfeksiyonun otoimmun tiroid antikorları üzerine etkisi araştırılacaktır. Aynı zamanda bu çalışmada Helikobakter Pilori‟nin pozitiflik derecesine göre tiroid otoantikorlarındaki değişiklik araştırılacaktır. Böylece Helikobakter Pilori enfeksiyonu olan hastalarda hem otoimmün tiroidit açısından taranmasının hem de tiroidit için kullanılan ilaç dozunun ayarlanmasının gerekip gerekmediği planlanması yapılacaktır. Yöntem: Çalışmamız retrospektif olarak Van YYÜ Tıp Fakültesi Dursun Odabaş Tıp Merkezi‟nde İç Hastalıkları polikliniğine ayaktan başvuran ve endoskopi yapılmış hastalar üzerinde yapıldı. Çalışmaya 18 yaş ve üzerinde olan Helikobakter Pilori enfeksiyonu tanısı alan 138 hasta dâhil edildi. Hasta gruplarıyla karşılaştırmak üzere aynı yaş ve benzer cinsiyet dağılımına sahip Helikobakter Pilori enfeksiyonu tanısı almayan bireylerden oluşan 104 kontrol grubu oluşturuldu. Her iki grupta yaş, cinsiyet, TSH ve ST4 gibi tiroid fonksiyon testleri, Anti-TPO ve Anti-TG gibi tiroid otoantikorları, tiroid ultrasonu, lökosit sayısı, sedimantasyon hızı, vitamin D ve vitamin B12 parametreleri çalışıldı. Bulgular: Helikobakter Pilori ile enfekte olan 138 hastanın 58‟i erkek ve 80‟i kadın ve 104 kontrol hastanın 40‟i erkek ve 64 ise kadın idi. Helikobakter Pilori pozitif hastalar ile negatif hastalar arasında Anti-TPO ve Anti-TG düzeyleri arasında anlamlı bir fark yoktu (hepsi; p>0.05). Ayrıca Helikobakter Pilori enfeksiyon şiddeti arttıkça Anti-TPO ve Anti-TG düzeylerinde önemli bir değişim görülmedi (p>0.05). Tiroid ultrasonunda tiroidit varlığı Helikobakter Pilori pozitif olan hastalarda negatif olanlara göre anlamlı fark saptandı (p<0.05). Hastaların yaşları arttıkça Helikobakter Pilori enfeksiyon şiddetinin de azaldığı saptandı (p<0.05). iii Sonuçlar: Bu çalışmamızda Helikobakter Pilori enfeksiyonunun yaş arttıkça şiddetinin azalmış olduğu gösterildi. Hastalarımızda tiroidit bulguları ile Helikobakteri Pilori enfeksiyonu şiddeti arasında negatif bir korelasyon vardı. Ancak bu çalışmamızda her iki grupta tiroid otoantikorları açısından istatistiksel olarak anlamlı bir fark saptanmadı. Sonuç olarak otoimmün tirodit açısından kritik etkisi olan Helikobakter Pilori enfeksiyonunun bu rolünün netleşmesi için daha kapsamlı çalışmalara ihtiyaç olduğunu düşünüyoruz.
The Effect on Serum Myeloperoxidase Activity and Oxidative Status of Eradication Treatment in Patients Helicobacter Pylori Infected
(Pergamon-elsevier Science Ltd, 2011) Nazligul, Yasar; Aslan, Mehmet; Horoz, Mehmet; Celik, Yilmaz; Dulger, Ahmet Cumhur; Celik, Hakim; Erel, Ozcan
Objectives: Myeloperoxidase activity has been investigated after eradication of Helicobacter pylon (H. pylori) in infected patients in previous studies but the results are controversial. The aim of this study was to investigate effect on serum myeloperoxidase activity and oxidative status of eradication treatment in H. pylon-infected patients. Design and methods: Gastric biopsy specimens were obtained from 30 H. pylori infected patients. Serum Myeloperoxidase activity was measured by enzyme-linked immunoassay. Oxidative status was determined using total antioxidant capacity (TAC) and total oxidant status (TOS) measurement and calculation of oxidative stress index (OSI). Results: After 2 weeks of the eradication treatment, serum myeloperoxidase activity, TOS and OSI values were significantly lower (all: p<0.001), while TAC was significantly higher (p<0.001). Conclusions: Our results indicate that eradication treatment in H. pylori-infected patients may affect both oxidative stress and myeloperoxidase activity which is an important biomarker in pathogenesis of atherosclerosis. (C) 2011 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
Esophageal Squamous Papillomatosis
(Springer Wien, 2016) Olmez, Sehmus; Aslan, Mehmet; Guducuoglu, Huseyin; Erten, Remzi; Tas, Adnan; Saritas, Bunyamin
Esophagitis Due To Dexketoprofen Trometamol: a Rare Case Report
(Springer Wien, 2015) Olmez, Sehmus; Donmez, Salim; Aslan, Mehmet; Karadas, Sevdegul; Yavuz, Alpaslan
Various drugs are known to cause pill esophagitis. Antimicrobial drugs and nonsteroidal anti-inflammatory drugs are the most common causes of pill-induced esophagitis. Most patients suffer only self-limiting pain, but serious complications can occur. A 21-year-old man was admitted to our outpatient clinic with retrosternal chest pain, dysphagia, and odynophagia complaints, which occurred within 2 weeks after starting dexketoprofen trometamol. An upper endoscopy system examination revealed three well-demarcated ulcers in the esophagus at 35 cm from the incisors. Dexketoprofen trometamol may cause esophageal lesions. This rare disorder should be considered in patients presenting with sudden-onset retrosternal pain in addition to dysphagia and odynophagia.
Evaluation of Oxidative Status in Patients With Hyperthyroidism
(Humana Press inc, 2011) Aslan, Mehmet; Cosar, Niyet; Celik, Hakim; Aksoy, Nurten; Dulger, Ahmet Cumhur; Begenik, Huseyin; Selek, Sahbettin
Data on the antioxidant levels enzyme in patients with hyperthyroidism are limited and conflicting. Therefore, the objective of this study was to evaluate the oxidative status using an automated method in patients with hyperthyroidism. Thirty-six subjects with hyperthyroidism and 30 healthy controls were enrolled in this study. Serum oxidative status was determined via measurement of total antioxidant capacity (TAC) and total oxidant status (TOS) and calculation of oxidative stress index (OSI). Serum TAC levels were significantly lower in patients with hyperthyroidism than controls (P = 0.002), while serum TOS levels and OSI values were significantly higher (P = 0.008, 0.004; respectively). Serum TAC levels were correlated with TSH levels (rho = 0.223, P = 0.032), FT3 levels (rho = -0.434, P = 0.002) and FT4 levels (rho = -0.363, P = 0.003) in patients. Further, TOS levels and OSI values were correlated with TSH levels (rho = -0.245, P = 0.037; rho = -0.312, P = 0.011, respectively), FT3 levels (rho = 0.293, P = 0.017, rho = 0.505, P = 0.002, respectively), and FT4 levels (rho = 0.302, P = 0.006, rho = 0.321, P = 0.008, respectively) in patients. Duration of disease was significantly correlated with OSI values in patients (rho = 0.420, P = 0.011), while no correlation with serum TAC levels and TOS levels (P > 0.05). Oxidants are increased and antioxidants are decreased in patients with hyperthyroidism; as a result, the oxidative-antioxidative balance is shifted to the oxidative side. Increased oxidative stress may play a role in the pathogenesis of hyperthyroidism. It is believed that supplementation of antioxidant vitamins such as vitamins C and E may be helpful for these patients.
Frequency of Cholelithiasis in Cirrhotic Patients
(2014) Gönültaş, Engin; Aslan, Mehmet
Amaç: Karaciğer sirozunda safra taşı görülme oranı artmaktadır. Bu artışın mekanizması tam olarak bilinmemektedir. Sirozlu hastalarda safra kesesi taşı (SKT) ile ilgili çelişkili çalışmalar mevcuttur. Bu retrospektif çalışmada karaciğer sirozu tanısı konulan hastalarda safra kesesi taşı sıklığı ve bunun yaş, cinsiyet, hastalık etyolojisi ve evresi ile ilişkisinin araştırılması planlandı. Gereç ve yöntem: Çalışmamızda 01.01.2009-31.12.2013 tarihleri arasında Yüzüncü Yıl Üniversitesi Tıp Fakültesi Dursun Odabaş Eğitim ve Araştırma Hastanesi İç Hastalıkları ve Gastroenteroloji Polikliniği'ne başvuran, siroz tanısı ile tedavi gören 123 olgu ve 145 sağlıklı kontrol grubunun dosyaları retrospektif olarak incelendi. Karaciğer hastalığının etyolojisi ve evresi kaydedildi. Olgulara üst abdominal ultrasonografik inceleme yapılarak safra kesesi taşı varlığı araştırıldı. Bulgular: Sirozlu hastaların yaş ortalaması 53±14 yıl, kontrol grubunun yaş ortalaması ise 52±12 yıl idi. Karaciğer sirozlu 123 olgunun 34'ünde (%27.64) SKT saptandı. 145 sağlıklı kontrol grubunun 13'ünde (%8.9) SKT saptandı. SKT sirotik grupta kontrol grubuna göre anlamlı olarak yüksek bulundu (p<0.001). Çalışmamızda Hepatit B ve Delta hepatitine bağlı karaciğer sirozunda SKT sıklığı daha yüksek saptandı. Sonuç: Çalışmamızda sirozlu olgularda safra kesesi taşı görülme sıklığı %27.64 olarak saptandı. Bölgemizde HBV ve Delta'ya bağlı sirozda SKT sıklığı yüksek saptandı. Sirotik erkeklerde taş sıklığı kadınlardan daha yüksek saptandı.
Haptoglobin Levels in Turkish Patients With Bladder Cancer and Its Association With Clinicopathological Features
(Asian Pacific Organization Cancer Prevention, 2012) Pirinicci, Necip; Gecit, Ilhan; Gunes, Mustafa; Kemik, Ahu Sarbay; Yuksel, Mehmet Bilgehan; Kaba, Mehmet; Aslan, Mehmet
Although alteration in the haptoglobin phenotype has been reported in patients with bladder cancer, serum haptoglobin levels have not been evaluated. We hypothesized that serum haptoglobin can be used as a biomarker. The aim of this study was to evaluate the expression of haptoglobin in bladder cancer and to determine the relationship with clinicopathological features. A total of 68 serum specimens obtained before surgery were used to investigate haptoglobin expression using the sandwich ELISA technique. Serum haptoglobin levels were higher in the patients with bladder cancer compared to healthy controls (p<0.0001). Additionally, the levels of haptoglobin protein increased with increasing tumor grades (p<0.001) and were significantly higher in patients with metastatic disease and the presence of lymphovascular involvement, lymph node metastases and increasing tumor burden (p<0.0001). This study suggests that elevated haptoglobin levels are associated with a higher stage, grade, and extent of distant metastasis and larger tumor size. Haptoglobin may therefore provide a useful diagnostic and treatment biomarker for patients with bladder cancer.
Harmanlanmış Mobil Öğrenmenin Efl Öğrencilerinin Kelime Gelişimi Üzerindeki Etkisi
(2024) Aslan, Mehmet; Tutunıs, Bırsen
Çalışmanın amacı Harmanlanmış Mobil Öğrenmenin (BML) İngilizceyi yabancı dil olarak öğrenen hazırlık öğrencilerinin kelime gelişimi üzerindeki etkilerini ve BML'ye ilişkin görüşlerini incelemektir. Bir karma yöntem çalışması olarak, Türkiye'deki bir devlet üniversitesindeki 40 hazırlık öğrencisi ile gerçekleştirilmiştir. Kontrol grubuna kelimeler sadece sınıf içinde ders kitabına bağlı kalınarak okuma metinleri ile öğretilirken, deney grubuna aynı eğitime ek olarak sınıf dışında Google Classroom uygulamasında oluşturulan bir sanal sınıf üzerinden kelimeler öğretildi. BML'nin kelime dağarcığı gelişimine etkisini belirlemek için öğrencilere bir ön test ve bir son test uygulandı. Testlerin sonuçları SPSS programı ile analiz edildi ve grupların kelime gelişimi bağımsız bir T-testi ile karşılaştırıldı. Ayrıca deney grubu öğrencilerinin BML'ye ilişkin görüşlerini belirlemek amacıyla yapılandırılmış bir görüşme yapılmıştır. Öğrencilerin yanıtları MAXQDA 2020 programı kullanılarak içerik analizi yöntemiyle analiz edilmiştir. Bu araştırma ile bir öğretim yöntemi olarak BML'nin hazırlık öğrencilerinin kelime gelişimini güçlendirdiği ve kelime öğrenmek için onları motive ettiği sonucuna varılmıştır.
Hashimoto's Thyroiditis Associated With Idiopathic Portal Hypertension
(Medycyna Praktyczna, 2013) Dulger, Ahmet C.; Aslan, Mehmet; Olmez, Sehmus; Yavuz, Alpaslan; Cifci, Adem; Kalkan, Nurhan O.; Demirkiran, Davut
Investigation of Magnesium, Calcium and Vitamin D Levels in Patients With Polycystic Over Syndrome
(2022) Kılıç, Resul; Aslan, Mehmet
Amaç: Polikistik over sendromu (PKOS), tipik olarak kronik anovulasyon ve androjen yüksekliği ile giden endokrinolojik bozukluklar içinde sık görülen bir sendromdur. Klasik vitaminlerden farklı olarak D vitamini, vücutta sentezlenmekte ve hormonal işlevi bulunmaktadır. D vitaminin klasiyum dengesi ve kemik metabolizması üzerindeki etkileri dışında birçok hastalıkta D vitaminin rolü olduğu bilinmektedir. Bu çalışmamızda PKOS'u olan bayanlarda kalsiyum, magnezyum ve D vitamini düzeyi ile ilişki olup olmadığının belirlenmesi amaçlandı. Materyal ve Metod: Çalışmaya Rotterdam kriterlerine göre PKOS tanısı almış olan 40 olgu ve PKOS'u olmayan 40 olgu olmak üzere toplam 80 olgu alındı. Bu hastaların dosyaları retrospektif olarak incelendi. Tüm olguların magnezyum, kalsiyum ve D vitamini düzeyleri karşılaştırıldı. İlave olarak bu çalışmada PKOS'u olan ve olmayan olguların beyaz kan hücreleri (WBC), ortalama trombosit hacmi (MPV), eritrosit dağılım hacmi (RDV), nötrofil sayısı, lenfosit sayısı, trombosit sayısı, trombosit/lenfosit oranı, nötrofil/lenfosit oranı (NLR) gibi inflamatuar markırlar ile birlikte insülin, glukoz, insülin direnci, HbA1c, yüksek dansiteli lipoprotein (HDL), düşük dansiteli lipoprotein (LDL), trigliserit (TG), total kolesterol (TK), parathormon (PTH) ve fosfor düzeyleri karşılaştırıldı. Bulgular: Çalışmamızda PKOS'u olan ve olmayan olgular arasında magnezyum, kalsiyum, D vitamini değerleri açısından anlamlı fark saptanmadı (hepsi için p>0.05). PKOS'u olan ve olmayan olgular arasında lenfosit, nötrofil, trombosit, NLR, trombosit/lenfosit oranı, RDV, MPV, WBC, HbA1c, glukoz, insülin, PTH ve fosfor düzeyleri açısından fark saptanmadı (hepsi için p>0.05). PKOS'u olan ve olmayan olgular arasında lipit düzeyleri kıyaslandığında ise PKOS olmayanlarda TK ve LDL düzeyleri anlamlı derecede yüksek saptandı ancak HDL ve TG düzeyleri açısından fark görülmedi (TK için p=0.05, LDL için p=0.042). PKOS'lu olgularda yaş ortalaması PKOS olmayan grup ile kıyaslandığında anlamlı derecede düşük saptandı (p<0.001). Sonuç: Bu çalışmada iki grup arasında magnezyum, kalsiyum ve D vitamini düzeyleri açısından anlamlı bir fark görülmedi. Ancak daha fazla hasta sayısı ve aynı yaş grubu ile yapıldığında anlamlı bir fark olabileceğini düşünüyoruz.