Browsing by Author "Aslan, Nezir"

Now showing 1 - 4 of 4

Azotça Zengin ve Çevre Dostu (Yeşil) Piroteknikler, Daat, Dht, Dıat ve Cuat In Dekompozisyon Mekanizmalarının Teorik Olarak İncelenmesi
(2017) Uygur, Rıdvan; Aslan, Nezir; Gümüş, Selçuk
Chemoenzymatic Synthesis of Novel 1,4-Disubstituted 1,2,3-Triazole Derivatives From 2-Heteroaryl Substituted Homopropargyl Alcohols
(Pergamon-elsevier Science Ltd, 2015) Buyukadali, Nalan Nuriye; Seven, Semih; Aslan, Nezir; Yenidede, Duygu; Gumus, Aysegal
The one-pot synthesis of novel 1,4-disubstituted 1,2,3-triazoles from homopropargyl alcohol backbones is described. The key intermediates 2-benzothiophenyl la and 2-benzofuranyl lb substituted homopropargyl alcohols were synthesized starting from their corresponding carboxyaldehyde derivatives. The racemic heteroaryl-substituted homopropargyl alcohol derivatives are successfully resolved to give the corresponding enantiopure acetates and the alcohols with 84-99% ee by applying chemoenzymatic methods using various lipases. Enantiomerically enriched homopropargyl alcohol derivatives were reacted with various aromatic and aliphatic halides and sodium azide via a one-pot synthesis method and novel chiral benzothiophenyltriazoles 3a-9a and benzofuranyltriazoles 3b-9b were constructed without the isolation of potentially unstable organic azide intermediates. (C) 2015 Elsevier Ltd. All rights reserved.
Design, Stereoselective Synthesis and Computational Calculations of Novel Hybrid Compounds Via Pauson-Khand Reactions
(Pergamon-elsevier Science Ltd, 2017) Gumus, Selcuk; Aslan, Nezir; Buyukadali, Nalan Nuriye; Gumus, Aysegul
A series of novel chiral hybrid compounds between benzofuran and bicyclic cyclopentenone and also benzothiophene and bicyclic cyclopentenone have been designed and synthesized. Chiral enynes derived from enantiomerically enriched homoallyl and homopropargyl alcohols were converted into bicyclic cyclopentenone structures by intramolecular Pauson-Khand reactions. This strategy provides a facile access to various bicyclic cyclopentenones substituted with benzofuran or benzothiophene ring systems in good yields. In addition to the experimental work, the ground state geometries of the hybrid compounds were optimized using Density Functional Theory applications at the B3LYP/6-31G(d,p) level in order to obtain information about the 3D geometries and electronic structure. (C) 2017 Elsevier Ltd. All rights reserved.
Stereoselective Synthesis of Benzofuran and Benzothiophene Substituted Dihydropyran Derivatives Via Ring Closing Metathesis
(Pergamon-elsevier Science Ltd, 2016) Buyukadali, Nalan Nuriye; Aslan, Nezir; Gumus, Selcuk; Gumus, Aysegul
Ring closing metathesis reactions have been applied to diene and enyne systems derived from homoallylic alcohol backbones are described. The key intermediates 2-benzofuranyl la and 2-benzothiophenyl lb substituted homoallylic alcohols were synthesized from their corresponding carboxaldehyde derivatives. Racemic 2-heteroaryl-substituted homoallylic alcohols are successfully resolved to give the corresponding enantiopure acetates and alcohols with 80-99% ee through enzymatic resolution by various lipases. Enantiomerically enriched diene and enyne skeletons derived from homoallylic alcohols were subjected to the ring closing metathesis via first and second generation Grubbs' catalysts and the corresponding chiral heteroaryl-substituted dihydropyran derivatives were obtained with good yields (41-96%). (C) 2016 Elsevier Ltd. All rights reserved.