Browsing by Author "Aslan, SO"

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Acute Phase Effect of Trichloroethylene Ingestion on Some Biological Markers in Dogs
(Scientific Technical Research Council Turkey, 2000) Aslan, R; Tütüncü, M; Aslan, SO; Dündar, Y
Trichloroethylene (TE) is an environmental toxic solvent hazardous to human and domestic animals and well known in the industrial sector. The purpose of this study was to determine whether oral TE plays a role in lipid oxidation and tissue damage. Fourteen dogs were treated with an oral toxic dose of 0.5 ml/kg T.E. The acute changes that occurred in creatine kimase (CK), malondialdehyte (MDA), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were investigated in blood samples taken before application and 8, 24, 48, 72 and 168 hours after treatment. SOD and GSH-Px activities decreased, protein, albumin and alcalen phosphate did not change and the others increased a and 24 h after the TE treatment. Forty-eight hours after the treatment, MDA, CK, albumin and AST increased, while SOD and GSH-Px decreased. Ail markers returned to their normal levels after 72 h. It was concluded that TE plays a role in oxidative stress and tissue damage in the acute phase, Repeated intake of oral TE can reach serious toxicity in domestic animals living around industial zones polluted with chemicals.
Effects of Different Concentrations of Monensin on the Electrocardiogram and the Serum Ion Balance of the Rabbit
(Scientific Technical Research Council Turkey, 1998) Meral, I; Çinar, A; Bayiroglu, F; Aslan, SO
The present study was planned to investigate the effects of two different concentrations (10 and 40 mg/kg) of monensin, carboxylic ionophore antibiotic, on the ECG and the serum Na+ and K+ concentrations of rabbits. Fifteen male rabbits, about 2 kg and 1 year old, were used. ECGs were recorded by a direct writing electrocardiograph. Blood samples for measuring serum Na+ and the K+ concentrations were collected and the leads I, ii, II, aVR, aVL and aVF were recorded before and 6 hours after monensin was given. The durations and amplitudes of waves on the trace were measured in lead II and electrical axis also measured in leads 1 and III. We found that the effects of monensin on ECG and the serum Na+ and the K+ concentrations were dose dependent. In low doses (10 mg/kg) it produced a sinusoidal tachycardia by decreasing the time interval between two impulse production by sinoatrial node without changing the serum ion balance. However, in high doses (40 mg/kg) it produced a sinusoidal tachycardia with increasing the serum K+ and decreasing the serum Na+ concentrations.