Browsing by Author "Atabey, Rukiye Derin"

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Aggregate Index of Systemic Inflammation: the Strongest Predictor of In-Hospital Venous Thromboembolism Events Among Patients Hospitalized for Trauma or Surgery
(Elsevier Science inc, 2025) Atabey, Rukiye Derin; Kocaoglu, Alper Selim
Background: To investigate the power of inflammation/immune indices in-hospital deep vein thrombosis (DVT) and any venous thromboembolism (VTE) event (VTE: DVT + pulmonary embolism [PE]) that may occur after trauma or surgery and to identify the strongest predictors. Methods: This was a retrospective study conducted between January 2020 and December 2022. A total of 216 patients with suspicion of DVT or PE during their hospital stay for trauma or surgery were included in the study. Monocyte-lymphocyte ratio, neutrophil-lymphocyte ratio, and aggregate index of systemic inflammation (AISI) were calculated. Participants were divided into the following 3 groups: those without DVT or PE (control group, n = 70), only DVT (DVT group, n = 71), and both DVT and PE (VTE group, n = 75). Results:The median D-dimer, neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, monocyte-lymphocyte ratio, systemic inflammatory index, systemic inflammation response index, and AISI values of VTE group were significantly higher than both the control and DVT groups (P < 0.001 for all). The DVT group also had significantly higher values for these parameters compared to controls (P < 0.001 for all). All of these indices had significantly high performance to detect DVT or PE (P < 0.001 for all). Despite very high performance (some exceeding D-dimer measurement) detected for all examined parameters, AISI was the best predictor in both DVT and VTE (DVT + PE) prediction (area under receiver operating characteristic curve = 0.995 and 0.959, respectively). Conclusions: These indices, especially AISI, can play a role in the initial screening and risk stratification of patients at high risk of DVT or VTE after surgery or trauma.
Cardiovascular Drugs and Analysis of Potential Risk Factors Associated With Mortality in Severe Coronavirus Disease 2019 Patients
(Assoc Medica Brasileira, 2022) Atabey, Rukiye Derin; Aladag, Nesim; Sipal, Abdulcebbar; Akbulut, Tayyar; Dogan, Zeki; Ozdemir, Mahmut
OBJECTIVES: Cardiovascular diseases are also considered to increase the risk of death in COVID-19 patients. However, real-world data concerning the risk factors for death in patients with severe COVID-19 still remain vague. This study aimed to identify the potential risk factors associated with mortality in severe COVID-19 patients. METHODS: All consecutive patients admitted to the intensive care unit (ICU) of our institute for COVID-19 for severe COVID-19 pneumonia from April 1, 2020 to July 20, 2020 were included in the analysis. Patient characteristics, including complete medical history and comorbid diseases, blood test results during admission and on day 7, and clinical characteristics were compared between survivors and nonsurvivors. RESULTS: There was no significant difference between survivors and nonsurvivors regarding age, gender, and preexisting cardiovascular diseases. Moreover, the rate of the medications including angiotensin-converting enzyme (ACE) inhibitor and angiotensin receptor blockers did not differ between survivors and nonsurvivors. The peak C-reactive protein (CRP), procalcitonin, fibrinogen, and D-dimer levels and the rate for chronic renal failure were significantly higher in nonsurvivors compared with survivors. Intubated patients had a higher risk of death than the others had. CONCLUSIONS: This study failed to demonstrate a significant difference in preexisting cardiovascular diseases and cardiovascular medications between survivors and nonsurvivors who were admitted to ICU for severe COVID-19. Our findings indicate that the presence of chronic renal failure, a high peak ferritin concentration, and the need for invasive mechanical ventilation appear predictive for mortality. We propose that these risk factors should be taken into account in defining the risk status of severe COVID-19 patients admitted to the ICU.
Küçük Çaplı Venler ile Oluşturulan Arteriyovenöz Fistüllerin Uzun Dönem Açıklığında Hangi Teknik Daha Üstündür? Prospektif Randomize Kontrollü Bir Çalışma
(2023) Atabey, Rukiye Derin
Amaç: Arteriyovenöz fistül (AVF) oluştururken hastanın uygun çapta veni önemlidir..Hastalarımızda ven dilatasyonu için hidrostatik dilatasyon (HD) ve primer balon anjiyoplasti (PBA) yöntemlerini kullandık. Çalışmamızda farklı yöntemlerle yapılan venöz dilatasyonların sonuçlarını, fistül açıklığına etkisini ve işlemlerin birbirlerine üstünlüğünü belirlemeyi amaçladık. Gereç ve Yöntem: Prospektif yapılan randomize kontrollü çalışma, AVF oluşturulacak hastalarla gerçekleştirildi. Ven dilatasyon işlemi yapılacak 100 hasta 2 gruba ayrıldı. Birinci gruba HD, ikinci gruba PBA işlemi uygulandı. Bulgular: Grup 1’de 51 (%51) hasta, grup 2’de ise 49 (%49) hasta vardı. 1. hafta, 1.ay ve 6.ay sonunda fistül açıklığı, trill varlığı kaydedildi. İşlem sonrası 1.ayda trill alınanların 44 (%66.7)’üne PBA, 22 (%33.3)’sine HD işlemi uygulandı. 1.ayda trillin varlığı uygulanan işlemle ilişkili bulundu. Sonuç: Çapı <2,5 cm’den küçük venlerin PBA'sı, etkili bir dilatasyon yöntemidir. Fistül açıklığı, olgunlaşma sonuçları iyi olduğu gibi HD tekniğinden de üstün bulunmuştur.
Oxidants and Antioxidants in Myocardial Infarction (Mi); Investigation of Ischemia Modified Albumin, Malondialdehyde, Superoxide Dismutase and Catalase in Individuals Diagnosed With St Elevated Myocardial Infarction (Stemi) and Non-Stemi (Nstemi)
(Soc Medical Biochemists Serbia, 2021) Aladag, Nesim; Asoglu, Ramazan; Ozdemir, Mahmut; Asoglu, Emin; Atabey, Rukiye Derin; Demir, Canan; Demir, Halit
Background: Coronary ischemia can lead to myocardial damage and necrosis. The pathogenesis of cardiovascular diseases often includes increased oxidative stress and decreased antioxidant defense. The study aimed to assess levels of ischemia modified albumin (IMA), malondialdehyde acid (MDA), superoxide dismutase (SOD), and catalase in individuals diagnosed with ST elevated myocardial infarction (STEMI) and non-STEMI. Methods: The present study prospectively included 50 STEMI patients, 55 NSTEMI patients, and 55 healthy subjects. Only patients who were recently diagnosed with STEMI or NSTEMI were included in this study. IMA, MDA, SOD, and catalase activities were measured spectrophotometrically. Significant coronary artery lesions were determined by angiography. Results: Patients with ACS had significantly greater IMA and MDA values than the healthy controls (p<0.001). Besides, patients with STEMI had IMA levels that were significantly greater than those of the patients with NSTEMI (p<0.001), while the reverse was true for MDA levels (p<0.001). The healthy controls had the highest levels of SOD and catalase levels, followed by patients with STEMI and patients with NSTEMI, respectively (p<0.001). There was a significant negative correlation among MDA and SOD with catalase levels (r = -0.771 p<0.001 MDA vs catalase; r = -0.821 p<0.001 SOD vs catalase). Conclusions: Data obtained in this study reveals that compared to healthy controls, STEMI and NSTEMI patients had increased levels of MDA and IMA and decreased levels of SOD and catalase.
The Role of Concomitant Cardiovascular Diseases and Cardiac Biomarkers for Predicting Mortality in Critical Covid-19 Patients
(Taylor & Francis Ltd, 2021) Aladag, Nesim; Atabey, Rukiye Derin
Background to identify the potential cardiovascular risk factors associated with mortality in hospitalised COVID-19 patients. Methods All consecutive patients admitted to intensive care unit (ICU) of our institute for COVID-19 from 1 April 2020 to 20 May 2020 were included. Patient characteristics including complete medical history and comorbid diseases, admission and 7th day blood test results and clinical characteristics were compared between survivors and non-survivors. Results There were no significant difference between survivors and non-survivors regarding age, gender, and pre-existing coronary artery disease, hypertension, diabetes, heart failure, coronary artery bypass grafting surgery, percutaneous coronary intervention and coronary stenting. Admission D-dimer and NT-proBNP levels of non-survivors were significantly higher than survivors. CRP, procalcitonin, creatine kinase (CK) and troponin I levels on 7th day of admission were significantly higher in non-survivors compared to survivors. In addition, both admission and 7th day lymphocyte count were lower in non-survivors compared to that of the survivors. CRP declined from admission to 7th day of hospitalisation in survivors, whereas a median 6.75 mg/L increase was observed in non survivors. The peak and minimum CRP, procalcitonin and levels were significantly higher in non-survivors than survivors. The peak NT-proBNP level of non-survivors was also significantly higher than that of the survivors. Intubation, lower GFR values and higher NT-proBNP values were predictive for death. Conclusion The prothrombotic coagulopathy mediated by the endothelial interaction with SARS-CoV-2 may also have role in unfavourable prognosis in COVID-19. These readily available biomarkers might be useful in risk stratification of COVID-19 cases.