Browsing by Author "Atalay, C."

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Evaluation of a Mixture of Thiopental-Guafinesine and Sevoflurane Anesthesia in Horses
(Academic Journals inc, 2009) Atasoy, N.; Mercan, N.; Atalay, C.; Bayram, E.; Tas, A.
The anesthetic and cardiopulmonary effects of a combination of continuous intravenous infusion using a mixture of 6 g L-1 thiopental-75 g L-1 guafinesine-3 mg L-1 metedomidine (0.30 mL/kg/h) and Oxygen-Sevoflurane (OS) anesthesia (TGM-OS anesthesia) in horses were evaluated. The concentration of sevoflurane (Sevo) required maintaining surgical anesthesia was around 1.5% in TGM-OS and 3.3% in OS anesthesia. Mean Arterial Blood Pressure (MABP) was maintained at around 77 mm Hg under TGMOS anesthesia, while dobutamine (0.43 +/- 0.13 mu g kg(-1)) infusion was necessary to maintain MABP at 60 mmHg under OS anesthesia. No apparent complication was observed during and after anesthesia in all cases. Recovery from anesthesia tinder TGM-OS anesthesia was very calm and smooth. The times required for the horse to return both sternal and standing position in group under TGM-OS anesthesia tended to be shorter than group under OS anesthesia which statistical differences were p<0.05 and p<0.01, respectively. Thiopental Guafinesine-Metedomidine and Oxygen-Sevoflurane anesthesia (TGM-OS anesthesia) may be useful for prolonged equine anesthesia because of its minimal cardiopulmonary effects and good recovery from anesthesia.
Thoracic Sympathetic Nuclei Ischemia: Effects on Lower Heart Rates Following Experimentally Induced Spinal Subarachnoid Hemorrhage
(Masson Editeur, 2020) Koza, Y.; Bayram, E.; Koza, E. Armagan; Aydin, M. Dumlu; Soyalp, C.; Atalay, C.; Sipal, S.
Background. - The neuropathological mechanism of heart rhythm disorders, following spinal cord pathologies, to our knowledge, has not yet been adequately investigated. In this study, the effect of the ischemic neurodegeneration of the thoracic sympathetic nuclei (TSN) on the heart rate (HR) was examined following a spinal subarachnoid hemorrhage (SSAH). Methods. - This study was conducted on 22 rabbits. Five rabbits were used as a control group, five as SHAM, and twelve as a study group. The animals' HRs were recorded via monitoring devices on the first day, and those results were accepted as baseline values. The HRs were remeasured after injecting 0.5 cc of isotonic saline for SHAM and 0.5 cc of autolog arterial blood into the thoracic spinal subarachnoid space at T4-T5 for the study group. After a three-week follow-up with continuous monitoring of their HRs, the rabbit's thoracic spinal cords and stellate ganglia were extracted. The specimens were evaluated by histopathological methods. The densities of degenerated neurons in the TSN and stellate ganglia were compared with the HRs. Results. - The mean HRs and mean degenerated neuron density of the TSN and stellate ganglia in control group were 251 + 18/min, 5 + 2/mm(3), and 3 + 1/mm(3), respectively. The mean HRs and the mean degenerated neuron density of the TSN and stellate ganglia were detected as 242 + 13/min, 6 + 2/mm(3), and 4 + 2/mm(3) in SHAM (P > 0.05 vs. control); 176 + 19/min, 94 + 12/mm(3), and 28 + 6/mm(3) in the study group (P< 0.0001 vs. control and P < 0.005 vs. SHAM), respectively. Conclusions. - SAH induced TSN neurodegeneration may have been responsible for low HRs following SSAH. To date this has not been mentioned in the literature. (C) 2020 Elsevier Masson SAS. All rights reserved.