Browsing by Author "Atalay, Tugay"

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The Association of the Epidermoid Cyst of the Filum Terminale, Intradural Spinal Lipoma, Tethered Cord, Dermal Sinus Tract, and Type I Diastematomyelia in a Child
(Elsevier Science inc, 2014) Ak, Hakan; Atalay, Tugay; Gulsen, Ismail
Comparison of Dorsal Intercostal Perforator Artery Flap and Primary Closure in Myelomeningocele Repair
(Springer, 2021) Atalay, Tugay; Oktay, Kadir; Guzel, Ebru; Tekes, Lutfi; Solakhan, Mehmet; Ozkiraz, Servet; Guzel, Aslan
Purpose Of the many suggested techniques, we used dorsal intercostal perforator artery flap (DIPAF) for the closure of myelomeningocele defects. This study compared the outcomes of primary closure and DIPAF in the closure of myelomeningoceles. Methods Data of 24 patients that underwent myelomeningocele surgery at a single institution between November 2015 and September 2019 were retrospectively reviewed. Results The primary closure group had 13 patients (54.17%) and the DIPAF group had 11 (45.83%). The mean age was 7.91 +/- 13.27 days (1-60 days). Twelve patients were female and 12 were male. In 22 patients, the myelomeningocele sacs were in the lumbosacral region, while in 2, they were in the thoracolumbar region. The mean defect sizes were 14.20 +/- 4.62 cm(2)and 18.44 +/- 3.49 cm(2)in the primary closure and DIPAF groups, respectively. In each group, four patients had a kyphotic deformity. In the primary closure group, three patients had wound necrosis, two had wound dehiscence, and four had cerebrospinal fluid (CSF) leakage. In the DIPAF group, one patient had wound necrosis and one had CSF leakage. Significantly fewer complications related to the operation area were observed in the DIPAF group (p < 0.05). Increased defect size, kyphotic deformity, and presence of hydrocephalus were found to be risk factors for complications related to the operation area. Conclusion This surgical treatment protects neural tissue, prevent CSF leakage, and reduce central nervous system infection rates in myelomeningocele patients. Closure technique with the fasciocutaneous skin flap has more satisfying results than primary closure.
The Effects of Membranous Abnormalities on Mortality and Morbidity in Chronic Subdural Hematomas
(Journal Neurological Sciences, 2015) Ak, Hakan; Gulsen, Ismail; Yaycioglu, Soner; Atalay, Tugay; Demir, Ismail; Sosuncu, Enver; Arslan, Mehmet
Objective: Our aim was to evaluate the effects of membranous abnormalities on morbidity and mortality in chronic subdural hematomas (CSDH). Methodology: This retrospective study included 116 patients operated in three different hospitals during last three years. Patients were analyzed for the presence of trauma, operation type, recurrence, complication/s, presence of membranous abnormalities like thick outer membrane and septa formation, and mortality. Results: The mean age of the patients 62,06 +/- 11.4 ranging between 42 and 87. 78 (67.2%) of them were male and 38 (32.8%) were female The most common predisposing factor was the trauma especially in male gender. The presence of membranous abnormalities played significant effects on recurrence and complication rates. However, it didn't have significant effect on mortality. Conclusion: Trauma is still the most common etiological factor in chronic subdural hematomas. The presence of membranous abnormality in CSDH increases the recurrence and complication rates.
Effects of Resveratrol on Acute Sciatic Nerve Injury in a Rat Model
(Journal Neurological Sciences, 2015) Ak, Hakan; Gulsen, Ismail; Kara, Mikail; Atalay, Tugay; Akyol, Veysel; Ragbetli, Murat Cetin
Aim: This study evaluated the therapeutic efficacy of resveratrol (RVT), a naturally occurring polyphenol, during the management of acute nerve injury in a rat model. Materials and Methods: A total of 28 rats were divided into trauma, control and low-and high-dose RVT groups (all n = 7). In all three non-control groups, trauma was induced by a medium-pressure aneurysm clip, applied to the sciatic nerve for 30 s. After trauma, the animals were treated with RVT for 7 days, after which nerve tissue samples were obtained from the site of injury for use in histological and stereological analyses. Results: There was a significant group difference in myelin thickness. At 50 mg/kg, RVT treatment was associated with increased myelin thickness, but a decrease was observed at 100 mg/kg. Conclusion: RVT has a beneficial effect on acute crush injury of the sciatic nerve at a dose of 50 mg/kg.
Lumbar Suturing With Pack Needle in the Management of Low Back Pain: a False Non-Medical Manipulation
(Journal Neurological Sciences, 2013) Ak, Hakan; Gulsen, Ismail; Atalay, Tugay; Balbaloglu, Ozlem; Evcili, Gokhan
Low back pain is a common pathology in all societies and it has an important effect on health costs. Although low back pain is too often, problems are being still experienced in the management of it and these problems sometimes lead to seeking of non-medical methods. Herein, we present method of lumbar suturing with pack needle performed by a health merchant and results of this application.
Resveratrol Treatment Prevents Hippocampal Neurodegeneration in a Rodent Model of Traumatic Brain Injury
(Turkish Neurosurgical Soc, 2017) Atalay, Tugay; Gulsen, Ismail; Colcimen, Nese; Alp, Hamit Hakan; Sosuncu, Enver; Alaca, Ilker; Ragbetli, Murat Cetin
AIM: Traumatic brain injury (TBI) is a complex process. Increasing evidence has demonstrated that reactive oxygen species contribute to brain injury. Resveratrol (RVT) which exhibits significant antioxidant properties, is neuroprotective against excitotoxicity, ischemia, and hypoxia. The aim of this study was to evaluate the neuroprotective effects of RVT on the hippocampus of a rat model of TBI. MATERIAL AND METHODS: Twenty eight rats were divided into four groups. A moderate degree of head trauma was induced using Feeney"s falling weight technique. Group 1 (control) underwent no intervention or treatment. Head trauma was induced in Group 2 (trauma) and no drug was administered. Head trauma was induced in Group 3 and low-dose RVT (50 mg/kg per day) was injected. In Group 4, high-dose RVT (100 mg/kg per day) was used after head trauma. Brain tissues were extracted immediately after perfusion without damaging the tissues. Histopathological and biochemistry parameters were studied. RESULTS: Brain tissue malondialdehyde (MDA) levels in the trauma group were significantly higher than those in the control, lowdose RVT-treated, and high-dose-RVT-treated groups. The superoxide dismutase (SOD) levels in the control group were significantly higher than those in the trauma, low-dose RVT-treated, and high-dose RVT-treated groups. Glutathione peroxidase (GSH-Px) levels in the control group were significantly higher than those in the trauma and low-dose RVT-treated groups. The level of oxidative deoxyribonucleic acid (DNA) damage (8-OHdG/106 dG) in the trauma group was higher than that in the control group, low-dose RVT-treated, and high-dose RVT-treated groups. CONCLUSION: Resveratrol has a healing effect on neurons after TBI.
Risk Factors Associated With Mortality and Survival of Acute Subdural Hematoma: a Retrospective Study
(Wolters Kluwer Medknow Publications, 2019) Atalay, Tugay; Ak, Hakan; Gulsen, Ismail; Karacabey, Sinan
Background: Acute subdural hematoma (ASDH) is mostly seen after head injury and is a major cause of morbidity and mortality. We studied the risk factors for ASDH and the effects of these factors on mortality as well as on survival with 100 cases from the rural area of Anatolia region. Materials and Methods: One-hundred cases of the ASDH that had been treated surgically between 2011 and 2014, at three different health-care centers from the rural area of Anatolia region, were retrospectively reviewed. Demographic data of patients, etiology, Glasgow Coma Scale (GCS) on admission, survival, presence of comorbid disease, unilaterality or bilaterality of the hematoma, and length of stay in the Intensive Care Unit (ICU) and/or neurosurgery clinic were recorded from the patients' files. Results: The total mortality rate was 34%. Age, etiology, GCS on admission, and laterality of the hematoma (unilateral or bilateral) affected the mortality rates (P = 0.005, P = 0.001, P = 0.001, and P = 0.001, respectively). Advanced age, low GCS on admission, and bilaterality of the hematoma were related with high mortality rates (P = 0.005, P = 0.001, and P = 0.001, respectively). The presence of comorbid disease and gender had no effect on patient survival (P = 0.299 and P = 0.861). Conclusion: The most important factors affecting the mortality rate were GCS on admission, etiology, age, and laterality of the hematoma in this study. Advanced age, low GCS on admission, and bilaterality of the hematoma were related with high mortality rates. Etiology had an important role in mortality rates, especially in the pedestrian injury group.