Browsing by Author "Atli, Abdullah"

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Aile İçi Cinsel İstismar Sonrası Zedelenmiş Cinsellik: Kompulsif Cinsel Davranışları Olan Bir Olgu Sunumu
(2011) Atli, Abdullah; Selvi, Yavuz; Özdemir, Pınar Güzel; Kıran, Gündoğdu Songül
Aile içi cinsel istismar, sebep olduğu utanç ve suçluluk duygularının yanı sıra, aileden ve yakın çevreden gizlenmesi nedeniyle tespit edilenden daha sık olarak yaşanan, istismara uğrayan bireyin şimdiki ve gelecekteki yaşantısını olumsuz etkileyen, bu konuda çalışanları oldukça zorlayan bir durumdur. Çocukluk çağı cinsel istismarı, Finkelhor ve Browne’nin travma modelinde ifade edildiği gibi, 4 ana başlık altında incelenen ciddi sorunlara neden olur. Bunlar, zedelenmiş cinsellik, ihanet duygusu, acizlik ve damgalanma şeklinde sıralanabilir. Zedelenmiş cinsellik, cinsel duygu ve davranışların normal gelişiminden sapması olarak tanımlanabilir. Cinsel istismar ve sebep olduğu zedelenmiş cinsellik bireyin cinsel kimlik gelişiminde, çocukluk ve ergenlik dönemi boyunca belirgin bozulmalar şeklinde ortaya çıkar. Cinsel istismar, psikopatolojik anlamda duygudurum bozuklukları ve travma sonrası stres bozukluğuna sebep olabileceği gibi, tekrarlayıcı, rastgele kompulsif davranışlar da ortaya çıkabilir. Bu olgu sunumunda, çocukluk döneminde maruz kaldığı cinsel istismarın uzun dönemdeki etkileri arasında sayılabilecek cinsel obsesyonlar ve kompulsif cinsel davranışlar sergileyen bir olgu sunulmuştur.
Altered Lipid Peroxidation Markers Are Related To Post-Traumatic Stress Disorder (Ptsd) and Not Trauma Itself in Earthquake Survivors
(Springer Heidelberg, 2016) Atli, Abdullah; Bulut, Mahmut; Bez, Yasin; Kaplan, Ibrahim; Ozdemir, Pinar Guzel; Uysal, Cem; Sir, Aytekin
The traumatic life events, including earthquakes, war, and interpersonal conflicts, cause a cascade of psychological and biological changes known as post-traumatic stress disorder (PTSD). Malondialdehyde (MDA) is a reliable marker of lipid peroxidation, and paraoxonase is a known antioxidant enzyme. The aims of this study were to investigate the relationship between earthquake trauma, PTSD effects on oxidative stress and the levels of serum paraoxonase 1 (PON1) enzyme activity, and levels of serum MDA. The study was carried out on three groups called: the PTSD group, the traumatized with earthquake exercise group, and healthy control group, which contained 32, 31, and 38 individuals, respectively. Serum MDA levels and PON1 enzyme activities from all participants were measured, and the results were compared across all groups. There were no significant differences between the PTSD patients and non-PTSD earthquake survivors in terms of the study variables. The mean PON1 enzyme activity from PTSD patients was significantly lower, while the mean MDA level was significantly higher than that of the healthy control group (p < 0.01 for both measurements). Similarly, earthquake survivors who did not develop PTSD showed higher MDA levels and lower PON1 activity when compared to healthy controls. However, the differences between these groups did not reach a statistically significant level. Increased MDA level and decreased PON1 activity measured in PTSD patients after earthquake and may suggest increased oxidative stress in these patients. The nonsignificant trends that are observed in lipid peroxidation markers of earthquake survivors may indicate higher impact of PTSD development on these markers than trauma itself. For example, PTSD diagnosis seems to add to the effect of trauma on serum MDA levels and PON1 enzyme activity. Thus, serum MDA levels and PON1 enzyme activity may serve as biochemical markers of PTSD diagnosis.
Aripiprazole-Related Acute Transient Myopia and Diplopia a Case Report
(Lippincott Williams & Wilkins, 2011) Selvi, Yavuz; Atli, Abdullah; Aydin, Adem; Yener, Halil Ibrahim
Assessment of Covid-19 Trauma Responses. Who Has Been More Traumatized During the Pandemic
(Masson Editeur, 2022) Cim, Emine Fusun Akyuz; Kurhan, Faruk; Dinc, Dilem; Atli, Abdullah
Background and Objective. - To evaluate the effect of cognitive and sociodemographic characteristics of healthcare and non-healthcare workers on their traumatic responses to the COVID-19 pandemic. Methods. - Data were collected using an online survey between August-September 2020. The survey included the following scales: Beck Anxiety Inventory (BAI), Anxiety Sensitivity Index (ASI), and Impact of Event Scale-Revised (IES-R). Traumatic responses were categorized into three types: avoidance (IESR_A), intrusion (IES-R_I), and hyperarousal (IES-R_H). Results. - The study included a total of 672 participants, comprised of 399 (59.4%) men, and 273 (40.6%) women with a mean age of 39.25 +/- 933 years. The results indicated that women had higher IES-R_I (r=.5.78, p < 0.001), IES-R_A (r = 4.47, p < 0.001), and IES-R_H (r =.5.20, p < 0.001) scores compared to men. Patients with a history of psychiatric diseases had significantly higher IES-R_I (r = -3.82, p < 0.001), IES-R_A (r = -2.00, p < 0.05), and IES-R_H (r = -4.06, p < 0.001) scores compared to patients with no history of psychiatric diseases. Non-healthcare workers had significantly higher IES-R_A (r = -2.69, p < 0.01) scores compared to healthcare workers. Conclusion. - Female gender and a positive history of psychiatric diseases were found to lead to an increase in the frequency of all three traumatic responses to COVID-19. Contrary to expectation, being a healthcare worker was not found as a factor facilitating trauma response formation in our study. (C) 2022 Elsevier Masson SAS. All rights reserved.
Associations Between Chronotype, Sleep Quality, Suicidality, and Depressive Symptoms in Patients With Major Depression and Healthy Controls
(Taylor & Francis inc, 2010) Selvi, Yavuz; Aydin, Adem; Boysan, Murat; Atli, Abdullah; Agargun, Mehmed Yucel; Besiroglu, Lutfullah
Research interest concerning associations between sleep characteristics and suicidality in psychopathology has been growing. However, possible linkages of suicidality to sleep characteristics in terms of sleep quality and chronotypes among depressive patients have not been well documented. In the current study, the authors investigated the possible effects of sleep quality and chronotype on the severity of depressive symptoms and suicide risk in patients with depressive disorder and healthy controls. The study was conducted on 80 patients clinically diagnosed with major depression and 80 healthy subjects who were demographically matched with the patient group. All participants completed a questionnaire package containing self-report measures, including the Beck Depression Inventory (BDI), Pittsburgh Sleep Quality Index (PSQI), Morningness-Eveningness Questionnaire (MEQ), and Suicide Ideation Scale (SIS), and subjects were interviewed with the suicidality section of the Mini-International Neuropsychiatric Interview (MINI). Results are as follows: (a) logistic regression analyses revealed that poor sleep quality and depression symptom severity significantly predicted onset of major depression; (b) morningness-type circadian rhythm may play as a significant relief factor after onset of major depression; (c) sleep variables of chronotype and sleep quality did not significantly predict suicide ideation after controlling for depressive symptoms in the major depression group; and (d) suicide ideation and poor sleep quality were antecedents of depression symptom severity in patients with major depression, and in healthy controls. Findings are discussed under the theoretical assumptions concerning possible relations between chronotype, sleep quality, depression, and suicidality. (Author correspondence: dryavuzselvi@yahoo.com).
Bipolar Bozukluğu Olan Hastalarda Aile Öyküsü
(2016) Coşkun, Salih; Keskin, Sıddık; Özdemir, Osman; Atli, Abdullah; Yılmaz, Ekrem; Ozdemir, Pinar Guzel; Mutlu, Elif Aktan
Amaç: Bu çalışmada bipolar bozukluğu (BB) olan hastalarda aile öyküsünün incelenerek hastalığın genetik geçişinin daha iyi anlaşılması amaçlanmıştır. Yöntem: Çalışmaya 63 BB 1 hastası olan aile alındı. Örneklemi toplam 156 hasta oluşturdu. Çalışmaya alınma ölçütü hastanın ailesinde BB 1 öyküsünün olmasıydı. Hasta olan diğer aile bireylerinin tanıları dosyaları, hastane kayıtları incelenerek ve muayene edilerek doğrulandı. Bulgular: Tüm hastaların (156 hasta) 65'i kadın (%41,6), 91'i (%58,3) erkekti (erkek/kadın oranı: 1,40). Bozukluğun anne tarafından veya baba tarafından geçişi açısından değerlendirildiğinde benzer sonuçlar ortaya çıkıyordu. Toplamda anne tarafından 25, baba tarafından da 25 hasta vardı. Sonuç: Çalışmamızın bulguları akrabalık derecesi ile BB'un kalıtımı arasında önemli bir ilişki bulunduğunu, anne ve baba tarafından hastalığın geçişinin benzer olduğunu desteklemiştir.
Catatonic Symptoms Associated With Tuberculous Lymphadenitis: a Case of Catatonia
(Turkish Neuropsychiatry Assoc-turk Noropsikiyatri dernegi, 2011) Selvi, Yavuz; Ozdemir, Pinar Guzel; Atli, Abdullah; Besiroglu, Lutfullah
Catatonia is a neuropsychiatric syndrome that can occur due to medical or psychiatric disorder. Catatonia with a medical co-morbidity accounts for 30-80% of all catatonias. These conditions are various and include infections, metabolic disturbances, neurological disorders, drug intoxication and withdrawal. Identifying causes for catatonia is important not only to guide proper management but to determine prognostic outcomes. Tuberculous lymphadenitis is part of the extrapulmonary tuberculosis and is the most common form of the mycobacterial lymphadenitis group. Tuberculous lymphadenitis-induced catatonia has not been reported yet in the literature. We report the case of a patient who presented with catatonia and showed partial improvement with electroconvulsive therapy and complete recovery after treatment with anti-infective drugs. (Archives of Neuropsychiatry 2011; 48: 265-7)
Chronotype Differences in Suicidal Behavior and Impulsivity Among Suicide Attempters
(Taylor & Francis inc, 2011) Selvi, Yavuz; Aydin, Adem; Atli, Abdullah; Boysan, Murat; Selvi, Fatih; Besiroglu, Lutfullah
Morning- and evening-type individuals differ on a number of psychological and biological variables. There has been increasing interest in the relationship between chronotype and personality traits. The aim of this study was to investigate the relationship between impulsivity and chronotype in suicide attempters. Eighty-nine suicide attempters were included in the study, and systematic information on suicide attempts was recorded. The Morningness-Eveningness Questionnaire was applied to determine chronotype, and attempter impulsivity was measured by the total score of the Barratt Impulsiveness Scale. Significant differences between chronotype and impulsivity scores were found. Evening-type subjects reported significantly higher impulsivity scores than both neither- and morning-types. A significant association between chronotype and type of suicide attempt was detected. The largest proportion of violent suicide attempters were evening-type subjects. Violent suicide attempters also reported significantly higher impulsivity scores than nonviolent attempters. Previous studies have pointed out possible relations between eveningness and impulsivity. Current findings suggest that eveningness may be a risk factor for violent suicide attempts by increasing impulsivity. (Author correspondence: dryavuzselvi@yahoo.com).
Çocukluk Çağı Cinsel İstismar ve Ensest Olgularına Çok Yönlü Bakış
(2018) Atli, Abdullah; Ibiloglu, Aslihan Okan; Özkan, Mustafa Hulusi; Oto, Remzi
Aile içi şiddet deneyimi, çocuğun doğrudan bir mağdur ya da tanık olmasına bakılmaksızın fiziksel,zihinsel ve psikolojik olarak kalıcı zararlara yol açabilir. Standart bir tanımı olmamakla birlikte, genelolarak çocuklukta cinsel istismar ve ensestin eksik bildirildiği kabul edilmektedir. Cinsel istismarınçoğunluğu çocukluk çağında görülür, bununla beraber ensest en yaygın görülen biçimidir. Ensest,aile üyeleri ya da yakın akrabalar arasında cinsel bir faaliyet ya da saldırıdır ve çocuğun cinselistismarı olarak da tanımlanabilir. Diğer yandan, pedofilik bozukluk, ergenlik öncesi bir çocuğa, enaz 6 aylık bir süre boyunca, tekrarlayan, şiddetli cinsel dürtüler veya davranışlar içeren cinsel aktiviteolarak tanımlanmaktadır. Bu makalede, cinsel istismarın klinik, sosyal ve adli sonuçları araştırılmışve sosyal politikayı bilgilendirme ve zihinsel sağlık uygulamalarına rehberlik etme konusundaoldukça yardımcı olması amaçlanmıştır.
The Comparison of Aripiprazole and Risperidone Augmentation in Selective Serotonin Reuptake Inhibitor-Refractory Obsessive-Compulsive Disorder: a Single-Blind, Randomised Study
(Wiley, 2011) Selvi, Yavuz; Atli, Abdullah; Aydin, Adem; Besiroglu, Lutfullah; Ozdemir, Pinar; Ozdemir, Osman
Objective To investigate the comparative efficacy of aripiprazole and risperidone as augmenting agents in the treatment of obsessive-compulsive disorder (OCD) patients who did not show a >= 35% decrease in the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) after 12-week monotherapy with selective serotonin reuptake inhibitors (SSRIs). Methods The study consists of two different periods of treatment: a 12-week prospective period to determine resistance to SSRI treatment and an 8-week single-blind addition period for refractory patients only. Ninety patients were randomly assigned to receive one of the SSRI treatments. Sixty-nine patients (76.6%) completed the 12-week SSRI monotherapy period. Forty-one patients (59.4%) were considered refractory and were randomised to receive either risperidone (20 patients, 3 mgr daily) or aripiprazole (21 patients, 15 mgr daily) as augmentation to SSRI treatment. Sixteen patients (76.2%) in the aripiprazole group and 18 patients (84%) in the risperidone group completed the 8-week treatment period. Results Eight patients (50%) in aripiprazole and 13 patients (72.2%) in risperidone group met response criteria of Y-BOCS decrease >= 35% at the end of the study. The risperidone group showed a significant improvement in Y-BOCS obsession scores compared with aripiprazole. Conclusions The present findings suggest that risperidone may be more effective than aripiprazole. Copyright (C) 2011 John Wiley & Sons, Ltd.
A Cross-Sectional Measurement of Endogenous Oxidative Stress Marker Levels in Obsessive Compulsive Disorder
(Aves, 2022) Kurhan, Faruk; Kamis, Gulsum Zuhal; Alp, Hamit Hakan; Cim, Emine Fusun Akyuz; Atli, Abdullah
Background: There is a correlation between the increase in reactive oxygen radicals and the presence of specific mental illnesses. In this context, the objective of this study is to investigate the relationship between obsessive-compulsive disorder and the variations in the levels of several endogenous oxidative stress markers. Methods: Thirty obsessive-compulsive disorder patients were included in the study as the patient group, and 30 healthy volunteers of matching demographic characteristics were included in the study as the control group. Accordingly, the patient group consisted of 10 females and 20 males with a mean age of 29.5 +/- 6.1 years, and the control group consisted of 15 females and 15 males with a mean age of 31.9 +/- 5.6 years. The serum nicotinamide adenine dinucleotide phosphate oxidase-2, nicotinamide adenine dinucleotide phosphate oxidase-4, and malondialdehyde levels of the 2 groups were compared using the independent samples t-test. The relationships between the serum nicotinamide adenine dinucleotide phosphate oxidase-2, nicotinamide adenine dinucleotide phosphate oxidase-4, and malondialdehyde levels of the 2 groups were analyzed using the Pearson's correlation coefficient. Results: The serum nicotinamide adenine dinucleotide phosphate oxidase-2, nicotinamide adenine dinucleotide phosphate oxidase-4, and malondialdehyde levels of the patient group were statistically significantly higher than those of the control group (P < .001). Statistically significant positive correlations were detected between the serum nicotinamide adenine dinucleotide phosphate oxidase-2 and nicotinamide adenine dinucleotide phosphate oxidase-4 levels (r=0.692, P= .001) and between the serum nicotinamide adenine dinucleotide phosphate oxidase-2 and malondialdehyde levels (r=0.563, P. .001). Conclusion: The results of this study indicated that oxidative stress and lipid peroxidation levels were higher in obsessive-compulsive disorder patients. Based on this finding, NOX-2 and NOX-4 levels can be used as indicators of endogenous oxidative stress in obsessive-compulsive disorder patients.
Decreased Prolidase Activity in Patients With Posttraumatic Stress Disorder
(Korean Neuropsychiatric Assoc, 2016) Demir, Suleyman; Bulut, Mahmut; Atli, Abdullah; Kaplan, Ibrahim; Kaya, Mehmet Cemal; Bez, Yasin; Sir, Aytekin
Objective Many neurochemical systems have been implicated in the development of Posttraumatic Stress Disorder (PTSD). The prolidase enzyme is a cytosolic exopeptidase that detaches proline or hydroxyproline from the carboxyl terminal position of dipeptides. Prolidase has important biological effects, and to date, its role in the etiology of PTSD has not been studied. In the present study, we aimed to evaluate prolidase activity in patients with PTSD. Methods The study group consisted of patients who were diagnosed with PTSD after the earthquake that occurred in the province of Van in Turkey in 2011 (n=25); the first control group consisted of patients who experienced the earthquake but did not show PTSD symptoms (n=26) and the second control group consisted of patients who have never been exposed to a traumatic event (n=25). Prolidase activities in the patients and the control groups were determined by the ELISA method using commercial kits. Results Prolidase activity in the patient group was significantly lower when compared to the control groups. Prolidase activity was also significantly lower in the traumatized healthy subjects compared to the other healthy group (p<0.01). Conclusion The findings of the present study suggest that the decrease in prolidase activity may have neuroprotective effects in patients with PTSD.
Effectiveness of Aripiprazole in Ocd Patients With Sri Treatment-Refractory; Comperative Study With Risperidone
(2010) Atli, Abdullah; Beşiroğlu, Lütfullah
SGİ'ler obsesif-kompulsif bozukluk (OKB) tedavisinde en sık kullanılan ve en etkili olan ilaçlardır. Fakat OKB hastalarının %40-60'ı SGİ tedavisine yeterli yanıt vermemektedir. OKB tedavisinde SGİ'lerin antipsikotiklerle güçlendirilmesi ile ilgili kanıtlar giderek artmaktadır. Olanzapin, ketiapin, risperidonla ile yapılan çalışmalarda OKB hastalarının obsesif-kompulsif semptomlarının atipik antipsikotiklerle azaldığı gösterilmiştir. Bu çalışmada SGİ tedavisine yetersiz yanıt veren OKB hastalarında yeni bir antipsikotik olan aripiprazolün etkinliğinin risperidon ile karşılaştırılması amaçlandı. Yüzüncü Yıl Üniversitesi Tıp Fakültesi Hastanesi Psikiyatri Polikliniğine ardışık başvuran 69 erişkin OKB hastası çalışmanın örneklemini oluşturdu. Bu hastalardan SGİ'ye az yanıt veren 34 hasta, iki gruba ayrılarak tedavilerine atipik antipsikotikler eklendi. Bu şekilde aripiprazolün OKB'nin güçlendirme tedavisindeki etkinliği risperidonla karşılaştırarak değerlendirildi.Başvuru sırasında farmakoterapi almamış OKB'li hastalardan seçilen bireylere birer SGİ olan flouksetin, sertralin ya da paroksetin'den herhangi biri rastgele bir biçimde başlandı ve tedricen en OKB için etkili olduğu bilinen en yüksek doza çıkıldı. Hastalar 12 haftalık takiplerinin ardından klinik olarak tekrar değerlendirilip, tedaviye yetersiz yanıt veren 41 hasta aripiprazol ve risperidon alan hastalar olmak üzere iki gruba ayrıldı. Aripipirazol grubunda 16, risperidon grubunda 18 hasta çalışmayı tamamladı. DSM IV-TR Eksen-I Bozuklukları İçin Yapılandırılmış Klinik Görüşme Aracı (SCID-I) ile tanıları konan olgular tedavi öncesi, antipsikotik tedavinin başlandığı 12. haftada ve 20. haftada olmak üzere üç ayrı zamanda Yale-Brown Obsesyon Kompulsiyon Derecelendirme Ölçeği (Y-BOKÖ), Hamilton Depresyon Ölçeği (HDÖ) ve Klinik Global İzlenim (KGİ) ölçekleri ile değerlendirildi.Yaptığımız çalışmada her iki grupta da Y-BOKÖ obsesyon, Y-BOKÖ kompulsiyon, Y-BOKÖ toplam ve içgörü puanlarında istatiksel olarak belirgin azalma tespit edilmiştir. Hem aripiprazol hem de risperidon OKB'nin güçlendirme tedavisinde etkin bulunmuştur. Aripiprazol ve risperidon uygulanan gruplar arasındaki fark Yale Brown Obsesyon alt ölçeği puanları ve Yale Brown toplam puanlarında anlamlı bulunmuştur (p<.01). Risperidon grubundaki hastaların obsesyon puanlarında [F(1, 32) = 6.782; p<.05] ve toplam puanlarındaki [F(1,32) = 6.311; p<.05] azalma aripiprazol uygulamasına göre anlamlı düzeyde daha fazla bulunmuştur. İçgörü ve depresyon puanlarında iki antipsikotik uygulaması arasında önemli bir farka rastlanmamıştır.Sonuç olarak OKB'nin güçlendirme tedavisinde hem aripiprazol hem de risperidone etkin bir tedavi seçeneği olarak görülmüştür. SGİ monoterapisine yetersiz cevap veren hastalarda aripiprazol eklenmesinin tedaviye cevabı artırması ile birlikte risperidonun daha etkin bulunmuş olması; OKB'nin etyopatogenezinde artmış dopamin nörotransmisyonu yönündeki literatür bilgilerini desteklemektedir.Anahtar sözcükler: Obsesif-kompulsif bozukluk, atipik antipsikotikler, aripiprazol, tedaviye direnç, risperidon, seçici serotonin geri alım inhibitörleri
Effects of Selective Serotonin Reuptake Inhibitors on Thought-Action Fusion, Metacognitions, and Thought Suppression in Obsessive-Compulsive Disorder
(W B Saunders Co-elsevier inc, 2011) Besiroglu, Lutfullah; Cetinkaya, Nuralay; Selvi, Yavuz; Atli, Abdullah
Objective: We aimed to assess whether cognitive processes change over time in patients with obsessive-compulsive disorder (OCD) receiving selective serotonin reuptake inhibitors without cognitive behavioral therapy and to investigate the factors associated with probable cognitive changes. Methods: During the 16 weeks of the study, 55 patients who met the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, criteria for OCD received open-label treatment with sertraline (100-200 mg/d) or fluoxetine (40-80 mg/d) and were assessed using the Yale-Brown Obsessive-Compulsive Scale, Beck Depression Inventory (BDI), Thought-Action Fusion Scale (TAFS), Metacognitions Questionnaire (MCQ-30), and White Bear Suppression Inventory (WBSI). Results: The Yale-Brown Obsessive-Compulsive Scale (P < .001), BDI (P < .001), TAFS morality (P < .005), MCQ-30 (P < .01), and WBSI (P < .005) scores at follow-up were significantly lower than baseline scores. When we excluded OCD patients with depressive disorder (n = 12), statistical significance in paired comparisons for MCQ and WBSI disappeared. Similarly, when OCD patients with religious obsessions (n = 16) were excluded, paired comparisons for MCQ and TAF morality were not statistically significant. Changes in BDI, TAFS morality, MCQ-30, and WBSI (P < .005) were significantly correlated with changes in severity of obsessions, but not that of compulsions. After controlling for the change in depression severity, significant correlations between changes in obsessive and cognitive scales did not continue to have statistical significance. The BDI changes (P < .05) significantly explained the changes in symptom severity in a linear regression model. Conclusions: Our findings suggest that selective serotonin reuptake inhibitors can change appraisals of obsessive intrusions via their effects on negative emotions. (C) 2011 Elsevier Inc. All rights reserved.
Family History in Patients With Bipolar Disorder
(Aves, 2016) Ozdemir, Osman; Coskun, Salih; Aktan Mutlu, Elif; Ozdemir, Pinar Guzel; Atli, Abdullah; Yilmaz, Ekrem; Keskin, Siddik
Introduction: In this study, we aimed to better understand the genetic transmission of bipolar disorder by examining the family history of patients. Methods: Sixty-three patients with bipolar disorder and their families were included. The final sample comprised 156 bipolar patients and their family members. An inclusion criterion was the presence of bipolar disorder history in the family. The diagnosis of other family members was confirmed by analyzing their files, hospital records, and by calling them to the hospital. Results: Sixty-five patients were women (41.6%) and 91 were men (58.3%) (ratio of men/women: 1.40). When analyzing the results in terms of the transition of disease from the mother's or father's side, similar results were obtained: 25 patients were from the mother's side and 25 patients were from the father's side in 63 cases. Conclusion: The results of our study support the fact that a significant relationship exists between the degree of kinship and the heritability of bipolar disorder and, furthermore, that the effect of the maternal and paternal sides is similar on the transmission of genetic susceptibility.
The Impact of Obsessive Beliefs on Pharmacological Treatment Response in Patients With Obsessive-Compulsive Disorder
(Taylor & Francis Ltd, 2011) Selvi, Yavuz; Atli, Abdullah; Besiroglu, Lutfullah; Aydin, Adem; Gulec, Mustafa
Objective. The present study examined whether obsessive beliefs change over time in the OCD patients receiving selective serotonin reuptake inhibitors (SSRIs) and the impact of obsessive beliefs in treatment response. Methods. In the first part of a two-stage study comparing the efficacy of antipsychotics as augmenting agent in SSRI-resistant OCD patients, 57 patients were interviewed with the Yale-Brown Obsessive Compulsive Scale (Y-BOCS), Hamilton Depression Rating Scale (HDRS) and Obsessive Beliefs Questionnaire-44 (OBQ-44) before and after 12-week of SSRI treatment period. Results. All OBQ-44 subscale scores significantly decreased with SSRI treatment. The mean changes in OBQ-44 Importance and Control of Intrusive Thoughts (I/CT) subscale and HDRS total scores of responders were significantly higher than those of SSRI-resistant patients. The baseline OBQ-44 P/C and Y-BOCS obsession subscale scores significantly predicted the treatment resistance in a logistic regression model. Conclusions. The alleviation of negative mood by SSRIs may help the sufferer to disengage from dysfunctional appraisals. Since individuals with highly obsessive beliefs about P/C are more likely to be resistant to SSRI treatment, the treatment of OCD can be made more effective when focusing on altering appraisals about P/C.
Latent Class Analysis of Obsessive-Compulsive Symptoms in a Clinical Sample
(W B Saunders Co-elsevier inc, 2014) Atli, Abdullah; Boysan, Murat; Cetinkaya, Nuralay; Bulut, Mahmut; Bez, Yasin
Objective: Obsessive compulsive disorder (OCD) is probably a heterogeneous condition. To date, research investigating the symptom structure of OCD has generally focused on variable-classification approaches, primarily factor analysis. Our aim was to use the latent class analysis, an advanced individual-classification method, in order to define homogeneous sub-groups based on the Yale Brown Obsessive Compulsive Scale Check List (Y-BOCS CL) assessments within 193 outpatients with OCD. Method: Latent class analysis of 13 obsessive compulsive symptom-clusters measured by the Yale Brown Obsessive Compulsive Scale Check List was performed. Associations of demographic and clinical features with latent class membership were tested by using logistic regression models. Differences in severity of obsessive compulsive symptoms, obsessive beliefs; and depressive symptomotology between latent classes were evaluated with the chi-square likelihood test. Results: Latent class analysis models of best fit yielded 3 latent classes: "autogenous obsessions", "reactive obsessive compulsive", and "reactive obsessions". Outpatients in reactive obsessive compulsive group reported significantly higher scores on the Y-BOCS global, obsessions, and compulsions scales than outpatients in other two sub-groups. Participants in reactive obsessive compulsive group were predominantly female, single, and had a history of family psychopathology; whereas autogenous and reactive obsessions groups were predominantly male. There were no differences in severity of depression and obsessive belief domains. Conclusions: The results provide support for the validity of autogenous/reactive distinction for OCD. These three classes may have important implications for research and clinical purposes. (C) 2014 Elsevier Inc. All rights reserved.
Mood and Metabolic Consequences of Sleep Deprivation as a Potential Endophenotype' in Bipolar Disorder
(Elsevier, 2013) Aydin, Adem; Selvi, Yavuz; Besiroglu, Lutfullah; Boysan, Murat; Atli, Abdullah; Ozdemir, Osman; Balaharoglu, Ragip
It has been commonly recognized that circadian rhythm and sleep/wake cycle are causally involved in bipolar disorder. There has been a paucity of systematic research considering the relations between sleep and mood states in bipolar disorder. The current study examines the possible influences of sleep deprivation on mood states and endocrine functions among first-degree relatives of patients with bipolar disorder and healthy controls. Blood samples were taken at two time points in the consecutive mornings at predeprivation and postdeprivation periods. Participants simultaneously completed the Profiles of Mood States at two time points after giving blood samples. Plasma T3 and TSH levels increased after total sleep deprivation in both groups. Sleep deprivation induced TSH levels were reversely associated with depression-dejection among healthy controls. A paradoxical effect was defected for only the first-degree relatives of the patients that changes in plasma cortisol levels negatively linked to depression-dejection and anger-hostility scores after total sleep deprivation. Plasma DHEA levels became correlated with vigor-activity scores after sleep deprivation among first-degree relatives of bipolar patients. On the contrary, significant associations of depression-dejection, anger-hostility, and confusion-bewilderment with the baseline plasma DHEA levels became statistically trivial in the postdeprivation period. Findings suggested that first-degree relatives of patients with bipolar disorder had completely distinct characteristics with respect to sleep deprivation induced responses in terms of associations between endocrine Functions and mood states as compared to individuals whose relatives had no psychiatric problems. Considering the relationships between endocrine functions and mood states among relatives of the patients, it appears like sleep deprivation changes the receptor sensitivity which probably plays a pivotal role on mood outcomes among the first-degree relatives of patients with bipolar disorder. (C) 2013 Elsevier B.V. All rights reserved.
Obsesif İnanışlar Ölçeği-44'ün (Oi̇ö-44) Türkçe Formunun Geçerlik ve Güvenirliği
(2010) Atli, Abdullah; Beşiroğlu, Lütfullah; Çetinkaya, Nuralay; Aydın, Adem; Boysan, Murat
Amaç: Obsesif kompulsif bozukluğun (OKB) etiyolojisinde ve süreğenliğinde bilişsel faktörler merkezde yer almaktadır. Bu çalışmada OİÖ-44’un Türkçe formunun psikometrik özelliklerinin araştırılması amaçlanmıştır. Türk örnekleminde OİÖ-44’ün orijinal faktör yapısı ve ölçme aracının OKB hastaları ve klinik olmayan bireyleri ayırt edebilme özelliğinin ayrıntılı bir değerlendirmesi yapılmıştır.Yöntem: Çalışmanın verileri 175 sağlıklı birey ve Y.Y.Ü. Tıp Fakültesi psikiyatri kliniğine başvuran 62 OKB hastasından elde edildi. Çalışmaya katılan kişilere SCID-I, Obsesif İnançlar Ölçeği-44 (OİÖ-44), Padua Envanteri (PE-41), Yale-Brown Obsesyon Kompülsiyon Ölçeği (YBOKÖ), Üst Biliş Ölçeği – 30 (ÜBÖ-30), Düşünce Eylem Kaynaşması Ölçeği (DEKÖ), Beyaz Ayı Supresyon Envanteri (BASE), Dini Kaygılar Ölçeği (DKÖ), Penn State Endişe Ölçeği (PSEÖ) ve Beck Depresyon Envanteri (BDE) uygulanmıştır. OBQ-44 toplam ve alt ölçekleri için geçerlik ve güvenirlik düzeylerini gösteren istatistikler hesaplanmıştır.Bulgular: Doğrulayıcı faktör analizi kullanılarak test edilen üç faktörlü orijinal yapının çalışmanın verilerle (VERILERIYLE?)uyumu yüksek bulunmuştur. OKB hastaları sağlıklı kontrollere göre önemli düzeyde daha yüksek ÖİÖ-44 puanları bildirmiştir. OİÖ-44 puanları ve diğer ölçekler arasında genel olarak önemli bağıntı düzeyleri elde edilmiştir. OİÖ-44 için iç turtalılık katsayısı a0,95 ve 30 günlük test tekrar test korelasyonu r=0.79’dur. Sonuç: OİÖ-44’ün Türkçe formu klinik ve klinik olmayan Türk örnekleminde yeterli geçerlilik ve güvenilirliğe sahip bir ölçme aracıdır.
Obsesif Kompulsif Bozukluğun Kelime Kökü Tamamlama Testi (Kktt) ve Bilişsel Süreçlere Etkisi
(2020) Aydın, Adem; Atli, Abdullah; Kurhan, Faruk; Cim, Emine Fusun Akyuz
Amaç: Bu çalışmada, Obsesif Kompülsif Bozukluğu (OKB) olanbireylerde örtük bellek performansı ile bilişsel süreçlerin ilişkisinindeğerlendirilmesi amaçlandı. Materyal ve Metot: Bu çalışma; Yüzüncü Yıl Üniversitesi TıpFakültesi Hastanesi Psikiyatri Polikliniğine başvuran; 30 Obsesif Kompülsif Bozukluk (OKB) tanılı hasta ve rastgele seçilen 40 kişiliksağlıklı kontrol grubunda örtük bellek performansı ile bilişsel süreçlerdeğerlendirildi. Her iki grup için; örtük bellek performansını değerlen diren Kelime Kökü Tamamlama Testi (KKTT) ve Sosyo-demografikbilgi formu uygulandı. Hasta grubuna ise bu teste ilave olarak, Yale– Brown Obsesyon Kompulsiyon Ölçeği (Y-BOCS), Boyutsal Yale Brown Obsesyon Kompulsiyon Ölçeği (DY-BOCS), Obsesyonelİnanışlar Ölçeği (OİÖ), Düşünce Eylem Kaynaşması Ölçeği (TAF) veÜst Biliş Ölçeği (ÜBÖ) uygulandı. Bulgular: Yapılan değerlendirme neticesinde; Y-BOCS ve bilişselparametrelerin (TAF-OİÖ-ÜBÖ) puanlarındaki artışın KKTT perfor mansını ters yönde etkilediği saptandı. Ortalama KKTT skoru hastagrubunda 7,63±3,05, kontrol grubunda 6,30±2,09 idi (p=0,034).Örtük bellek performansını en fazla etkileyen bilişsel parametre iseTAF parametresi idi. Sonuç: OKB’da, hastalığın şiddeti arttıkça örtük bellek performansıolumsuz etkilediği saptandı.