Browsing by Author "Aydemir, Ozan"

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Factors Affecting Recurrence in Operated Breast Cancer Patients Receiving Adjuvant Chemotherapy
(2021) Aydemir, Ozan; Aldemir, Mehmet Naci
Meme kanseri kadınlarda cilt kanserleri hariç tutulduğunda en sık görülen kanserdir. Kadınlarda kanserden ölümlerin ikinci en sık nedenidir. Bu çalışmada adjuvan kemoterapi alan opere meme kanserli hastalarda nüksü etkileyen faktörlerin incelenmesi amaçlandı. Materyal ve Metod: Çalışmaya 2007-2020 yılları arasında Van Yüzüncü Yıl Üniversitesi Tıp Fakültesi Dursun Odabaş Tıp Merkezine takip ve tedavi amacıyla başvuran meme kanserli hastalar alındı. Çalışamaya meme kanseri nedeniyle opere olan ve adjuvan tedavi alan 18 yaşın üzerindeki hastalar alındı. Bulgular: Çalışmaya tümü kadın olan 285 hasta alındı. Hastaların ortanca yaşı 52 (24-92) idi. Hastalardan 50 (%17.54) tanesinde nüks gözlendi. Hastalarda 10 yıllık genel sağkalım %89 iken, 10 yıllık hastalıksız sağkalım oranı %70.3 idi. Hastalardan tümör evresi arttıkça hastalıksız sağkalım istatistiksel olarak anlamlı kısaydı (log rank p=0.013). Hastalıksız sağkalım için yapılan tek değişkenli analizde tümörün invaziv duktal karsinom (İDC) ve invaziv lobüler karsinom (İLC) dışında kalan diğer histolojik alt tipte olması (p=0.025), çıkarılan lenf nodu sayısı (p<0.001), pozitif lenf nodu sayısı (p<0.001), tümör evresinin artması (p=0.006) sağkalımı olumsuz etkiliyordu. Çok değişkenli analizde yine tümörün İDC ve İLC dışında kalan diğer histolojik alt tipte olması (p=0.006) ve tümörün ileri evrede olması (p=0.004) sağkalımı olumsuz etkiliyordu. Tartışma: Çalışmamızda adjuvan tedavi alan opere meme kanserli hastalarda tümörün İDC ve İLC dışında kalan diğer histolojik alt tiplerden biri olması ve tümörün ileri evrede olması sağkalımı anlamlı olarak kısaltıyordu. Sonuç: Bu bulgular eşliğinde meme kanserinde erken evrede tanı konulmasının ve bu doğrultuda 40 yaş üstü kadınlarda meme kanseri tarama programlarının son derece önemli olduğu kanaatindeyiz. Bu çalışmamızın prospektif klinik çalışmalar ile desteklenmesi gerekmektedir.
The Prognostic Effect of Pretreatment 18f-Fdg Pet/Ct Metabolic Parameters in Locally Advanced Esophageal Squamous Cell Carcinoma Treated With Definitive Chemoradiotherapy
(Elsevier Sci Ltd, 2022) Sakin, Abdullah; Ozcelik, Mahsun; Sahin, Suleyman; Aydemir, Ozan; Aldemir, Mehmet Naci; Iliklerden, Umit Haluk; Kotan, Mehmet Cetin
Introduction: In this study, we aimed to examine the relation between pre-treatment 18F-FDG PET/CT metabolic parameters [(including the maximum standard uptake value (SUVmax), metabolic tumor volume (MTV), and tumor lesion glycolysis (TLG)] and treatment response and survival in locally-advanced Esophageal Squamous Cell Cancer (ESCC) treated with definitive chemoradiotherapy (dCRT). Methods: A total 76 patients with locally-advanced ESCC who received dCRT between June 2015 and December 2019 were included in this retrospective study. Patients were divided into two groups as complete response (CR) or non-complete response (Non-CR) according to response to treatment. AUC was obtained as 0.749 (p < 0.001) in the ROC curve drawn by MTV for the CR. The MTV value was <= 12 cm(3), with 72.1% sensitivity and 73.0% specificity. Results: Of the 76 patients, 38 (50%) were male and 38 (50%) were female. The median age was 62 (39-84) years. The treatment response in 35 (46%) patients was CR. MTV value was > 12cm3 in 41(54%) patients. Median follow-up time was 14.5 months. In patients with MTV > 12cm3, median progression-free survival(mPFS) and median overall survival(mOS) were 9 months and 11 months, respectively, whereas mPFS and OS could not be reached in those with MTV & LE;12 cm3 (p < 0.001 and p < 0.001, respectively). In patients with non-CR, mPFS and mOS were 8 months and 9 months, respectively, whereas mPFS and OS could not be reached in patients with CR (p < 0.001 and p < 0.001, respectively). In multivariate analysis, age (odds ratio [OR], 1.07), ECOG PS (OR, 11.1), and MTV (OR, 4.73) were found to be the factors affecting treatment response. Conclusion: In our study, treatment response and MTV were found to be the factors associated with survival in patients treated with dCRT, showing the pre-treatment MTV value as a predictor of treatment response.
Prognostic Significance of Neutrophil-To Ratio in Esophageal Squamous Cell Carcinoma
(Kare Publ, 2021) Sakin, Aysegul; Alay, Murat; Sahin, Suleyman; Aydemir, Ozan; Aldemir, Mehmet Naci; Sakin, Abdullah; Kotan, Cetin
OBJECTIVE: The purpose of the study was to assess the effect of neutrophil-to-lymphocyte ratio (NLR) on recurrence and survival in patients with Esophageal Squamous Cell Carcinoma (ESCC) undergoing surgery. METHODS: This was a retrospective analysis of the 80 resectable ESCC patients who underwent surgery at Yuzuncu Yil University Faculty of Medicine between 2008 and 2018. Receiver operator characteristics curve of NLR was plotted for disease-free survival (DFS). The area under the curve of NLR was 0.692 (p=0.008) with 65.2% sensitivity and 2.8 with 69.5% specificity. Patients were divided into two groups based on the NLR as follows: NLR <2.8 and NLR >= 2.8. RESULTS: Among 80 ESCC patients, 54 (65.5%) were female. The median age was 55 years (range, 26-77). The NLR was <2.8 in 47 (58.7%) patients. Median DFS was 55 months in patients with NLR >= 2.8, whereas it was not reached in those with NLR <2.8 (p=0.008), with corresponding overall survival (OS) durations of 71 months and not reached (p=0.027). Eastern Cooperative Oncology Group performance score 2, presence of obstruction at diagnosis, lower 1/3 esophageal localization, neoadjuvant treatment, and NLR >= 2.8 were found to be the factors related to survival. CONCLUSION: The present study demonstrated that high pre-treatment NLR was associated with worse DFS and OS in patients with resectable esophageal cancer. We believe that pre-treatment NLR may help guide predicting treatment outcomes in non-metastatic resectable ESCC patients.