Browsing by Author "Aydin, Mesut"

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Association Between Serum Cytokeratin 18 and N-Terminal Procollagen Iii Propeptide in Patients With Biopsy-Proven Nonalcoholic Fatty Liver Disease
(Taylor & Francis Ltd, 2024) Kaya, Sercan; Boydak, Murat; Aydin, Mesut; Aras, Ibrahim
Liver biopsy is still the gold standard in the staging of nonalcoholic fatty liver disease (NAFLD), which is the most common chronic liver disease worldwide. However, being an invasive method, liver biopsy has limited use in clinical practice. The aim of this study was to determine the relationship between serum levels of cytokeratin 18 (CK-M30) and N-terminal procollagen III propeptide (PIIINP) in patients with biopsy-proven NAFLD. The study was carried out on volunteers, including both healthy individuals and patients pre-diagnosed with NAFLD. The liver biopsies were re-assessed by applying the Steatosis, Activity, Fibrosis/Fatty Liver Inhibition of Progression (SAF/FLIP) algorithm. At the end of the study, frozen serum samples (-80 degrees C) were analyzed using commercial kits. CK18-M30 and PIIINP levels significantly differed in all study groups. There was no significant correlation between serum levels of CK18-M30 and PIIINP in healthy individuals but there was a significant positive correlation between CK18-M30 and PIIINP levels in NAFLD (NAFL-nonalcoholic steatohepatitis (NASH)) groups. CK18-M30 was better than PIIINP at distinguishing between NAFL and NASH. The results obtained for biopsy-proven NAFLD demonstrated that both PIIINP and CK18-M30 were partly associated with histological parameters and could aid in distinguishing between NASH and NAFL.
Can Ascites and Serum Analyses Differentiate Delta From Hbv Infection in Cirrhotic Patients With Spontaneous Bacterial Peritonitis
(Carbone Editore, 2021) Aydin, Mesut; Ozer, Serhat; Aytemiz, Enver; Dirik, Yaren; Dulger, Ahmet C.
Aim: We tried in this work to define laboratory differences in ascites and serum of cirrhotic patients with HBV or Delta infection Material and Methods: We conducted a retrospective study in a large hospital experienced in hepatology by including 46 patients with HBV and HDV between January 2018 and September 2020. Data of age and gender-matched 24 patients with HBV and 22 patients with HBV/HDV having SBP were analyzed. Results: White blood cell, neutrophil counts, serum glucose, serum albumin, serum globulin, serum ascites-albumin gradient and serum albumin-globulin gradient levels were similar. Conclusion: Cirrhotic patients with HDV infection had lower platelet and serum fibrinogen and higher INR levels than those with HBV infection.
Can We Reduce Oxidative Stress With Liver Transplantation
(Soc Medical Biochemists Serbia, 2021) Aydin, Mesut; Dirik, Yaren; Demir, Canan; Tolunay, Harun; Demir, Halit
Background: The aim of this study was to determine the levels of lipid peroxidation (MDA) and antioxidants such as reduced glutathione (GSH), catalase (CAT) and superoxide dismutase (SOD) in the blood serum of patients with cirrhosis and liver transplantation. Methods: In this study, serum malondialdehyde acid (MDA) levels, superoxide dismutase (SOD), reduced glutathione (GSH), and catalase (CAT) activities were measured spectrophotometrically and compared to the results of the healthy control group. Results: SOD, CAT and GSH activities were significantly decreased in the patient groups compared to the healthy control group (p<0.05). MDA levels were significantly higher in the patient group compared to the healthy control group (p <0.05). Conclusions: In conclusion, this study demonstrated that oxidative stress may play an important role in the development of liver cirrhosis and in liver transplantation. This study is the first one to show how MDA, SOD, CAT and GSH levels change in liver cirrhosis and liver transplantation, while further studies are essential to investigate antioxidant enzymes and oxidative stress status in patients with cirrhosis and liver transplantation.
Detection of Blastocystis Sp. in Ulcerative Colitis, Crohn?s and Chronic Diarrheal Patients by Microscopy, Culture and Real-Time Polymerase Chain Reaction
(Academic Press Ltd- Elsevier Science Ltd, 2023) Beyhan, Yunus Emre; Guven, Irem; Aydin, Mesut
Blastocystis sp. is a zoonotic parasite that is common in humans and animals and settles in the large intestine. The parasite can cause various gastrointestinal system complaints such as indigestion, diarrhea, abdominal pain, bloating, nausea and vomiting. The aim of this study is to determine the distribution of Blastocystis in patients diagnosed with ulcerative colitis, Crohn's and diarrhea from the gastroenterology outpatient clinic and to compare the diagnostic value of the most preferred methods. A total of 100 patients, 47 men and 53 women, were included in the study. Of the cases, 61 had diarrhea, 35 had ulcerative colitis (UC) and four had Crohn's disease. Stool samples of the patients were analyzed by as direct microscopic examination (DM), culture and realtime polymerase chain reaction (qPCR). A total of 42% positivity was detected, 29% positivity in DM and trichrome staining, 28% in culture and 41% in qPCR. 40.4% (20/47) of men and 37.7% (22/53) of women were found to be infected. Blastocystis sp. was found in 75% of Crohn's, 42.6% of diarrheal and 37.1% of UC patients. Diarrhea cases are more common with UC and there is a close relationship between Crohn's and Blastocystis positivity. While DM and trichrome staining showed a sensitivity of 69%, PCR test was found to be the most sensitive diagnostic method with approximately 98%. Diarrhea and UC are often seen together. A close relationship was detected between Crohn's disease and Blastocystis. High prevalence of Blastocystis in cases with clinical symptoms reveals the importance of the parasite. There is a need for studies on the pathogenicity of Blastocystis sp. in various gastrointestinal cases, and it is thought that molecular techniques should be used since PCR is seen to be a much more sensitive.
Helicobacter Pylori Infection in Amniotic Fluid May Cause Hyperemesis Gravidarum
(Yale J Biology Medicine, inc, 2020) Aydin, Mesut; Tolunay, Harun Egemen; Varli, Erol Nadi; Boza, Baris; Sahin, Ozgur; Ozer, Serhat; Dulger, Ahmet Cumhur
Objectives: Limited data are available from recent trials involving pregnant women to guide Helicobacter pylori infection diagnosis. There are no data about the presence of H. pylori in the amniotic fluid as well. Furthermore, the relation between amniotic fluid H. pylori and hyperemesis gravidarum (HG) has not been characterized yet. Materials and Methods: This is a prospective study conducted after obtaining approval from the Ethics Committee. Pregnant women undergoing amniocentesis were enrolled in the study. The stool antigen test assessed the presence of H. pylori in amniotic fluid. A perinatologist independently performed an amniocentesis. The obtained amniotic liquid was sent to the laboratory to evaluate H. pylori infection by stool H. pylori antigen assay. We determined the rate of H. pylori in amniotic fluid and assessed relations between H. pylori infection and pregnancy outcome, including HG. Results: Between May and September 2017, we enrolled 48 pregnant women who underwent amniocentesis to detect possible fetal malformations. Patients were divided into two groups regarding the HG status. There were significant differences between the groups in terms of H. pylori infection presence. Among them, 28 (58.3%) were found to have a positive H. pylori test in their amniotic fluid. The rate of HG was significantly higher (71.4%) in patients who tested positive for H. pylori in amniocentesis than the H. pylori-negative group (20%), (p<0.001). Conclusions: The study's main new finding is that presence of H. pylori in the amniotic fluid is possible. Our data suggest that H. pylori-infected amniotic fluid is associated with the experience of past HG. The current study may have important implications for HG detection and help identify patients who would benefit from future preventive strategies.
Kolon Divertiküler Hastalığı Olan Hastalarda Çölyak Hastalığı Sıklığı
(2021) Tuncel, Elif Tugba; Dulger, Ahmet Cumhur; Ozer, Serhat; Aydin, Mesut; Dirik, Yaren
Maç: Çölyak hastalığı, pozitif HLA haplotipleri DQ2 ve DQ8 olan deneklerde buğdaya aşırı duyarlılığın neden olduğu bir ince bağırsak malabsorpsiyon sendromudur. Kolonun divertiküler hastalığı, daha çok 40 yaş üstü erişkinlerde görülen kolonun sakküler dilatasyonlarıdır. Bu çalışmada, çölyak hastalığı' nın kolonun divertiküler hastalığı için koruyucu olup olmadığını araştırdık. Gereç ve Yöntem: Ocak-Ekim 2018 arasındaki 7 aylık dönemde 114 (57 kadın; ortalama yaş 58 ± 4.1 yıl) kolonun divertiküler hastalığı hastalığı tanısı olan hasta çalışmaya alındı. Yaşa uygun kontrol grubu (100 denek; 50 kadın; ortalama yaş 59 ± 3.4 yıl) kolonun divertiküler hastalığı olmayan deneklerden seçildi. Bulgular: Kolonun divertiküler hastalığı tanısı olan denekler arasında sadece bir tanesinde serolojik olarak çölyak hastalığı için pozitif tespit edildi (Doku Transglutaminaz - TTG IgA ve G). Dispepsili kontrol deneklerinde, deneklerin% 2.8'inde çölyak antikor pozitifliği tespit edildi. TTG Ig A seropozitifliği açısından gruplar arasında güçlü bir fark vardı (sırasıyla p =0.032). Sonuç: Sonuçlar, kolonun divertiküler hastalığı ve çölyak hastalığı arasında ters bir ilişki olduğunu göstermektedir. Bu veriler, çölyak antikorları varlığının kolon divertiküler hastalığı gelişimini önleyici bir role sahip olabileceğini desteklemektedir. Sunulan bulgunun mekanizması hala belirsizdir. Daha fazla araştırmaya ihtiyaç vardır.
Maternal and Fetal Outcomes of Pregnant Women With Hepatic Cirrhosis
(Hindawi Ltd, 2020) Tolunay, Harun Egemen; Aydin, Mesut; Cim, Numan; Boza, Baris; Dulger, Ahmet Cumhur; Yildizhan, Recep
Aim. The reproductive hormone levels and systemic physiology of women with hepatic cirrhosis are altered. Existing data have indicated the adverse effects of cirrhosis on both the mother and the fetus. Pregnancy is successful in most of the patients with chronic liver disease. But maternal and fetal complication rates are still high for decompensated hepatic cirrhosis. In this study, we aimed to evaluate the clinical features, etiological factors, medications, morbidity, mortality, and obstetric outcomes of pregnant women with hepatic cirrhosis. Methods. Pregnant women, who were diagnosed with maternal hepatic cirrhosis and followed up in our clinic between 2014 and 2017, were retrospectively evaluated. The pregnant women that had been followed up for hepatic cirrhosis were classified as compensated disease and decompensated disease. Eleven cases were included in this period. Results. The mean age of cases was 33.5 +/- 5.5 years. The mean gravida number was 3.2 +/- 1.1, and the mean parity number was 1.7 +/- 1. Six cases were in the compensated cirrhosis stage, and 5 cases were in the decompensated cirrhosis stage. A pregnancy with decompensated cirrhosis was terminated after the fetal heart sound was negative in the 9th week of pregnancy. Spontaneous abortus occurred in one case (<20 weeks). The mean gestational week of the 9 cases was 33.3 +/- 6.2. Two of the 9 cases delivered birth vaginally. Seven cases delivered by cesarean section. The mean first- and fifth-minute APGAR scores were 6.6 +/- 1.41 and 8.2 +/- 1.56, respectively. The mean birth weight was 2303 +/- 981 g. Among 9 cases with live birth, 6 had compensated cirrhosis and 3 had decompensated cirrhosis. In the second trimester, upper gastrointestinal endoscopy was performed to all patients in terms of esophageal varices. Endoscopic band ligation was performed in 3 cases with upper gastrointestinal bleeding. The postpartum mortality did not occur. Discussion. Pregnancy is not recommended for patients with hepatic cirrhosis due to high maternal and fetal morbidity and mortality. The pregnancy course of cases with cirrhosis changes according to the stage of liver injury and severity of disease. Although the delivery method is controversial, delivery by cesarean section is recommended for patients with esophageal varices by the reason of bleeding from varices after pushing during labor. The bleeding risk must be kept in mind as coagulopathy is common in hepatic diseases. The maternal-fetal morbidity and mortality rates have been decreased by the current developments in hepatology, prevention of bleeding from varices with drugs and/or band ligation, improvement in liver transplantation, and increasing experience in this issue.
Prognostic Significance of Hemoglobin/Prognostic Nutritional Index and Hemoglobin/Red Blood Cell Distribution in Rectal Cancer
(Aves, 2023) Tuncel, Elif Tugba; Parvizi, Murtaza; Kut, Engin; Aydin, Mesut; Kasap, Elmas
Background: We aimed to investigate the effect of hemoglobin/prognostic nutritional index and hemoglobin/red blood cell distribution, which are indicators of inflammation and nutrition, on prognosis and survival in patients with rectal cancer. Methods: The retrospective study reviewed medical records of 138 patients with rectal cancer who were followed up between 2010 and 2021. The effects of hemoglobin/red blood cell distribution, hemoglobin/prognostic nutritional index, tumor stage, and lymph node status on survival and prognosis were evaluated using univariate and multivariate analyses. Overall survival and disease-free survival were calculated for both groups. Results: Survival and prognosis were found to be significantly better in nonanemic patients with the hemoglobin/prognostic nutritional index higher than the cut-off value than in anemic patients with a normal or lower hemoglobin/prognostic nutritional index. Similarly, survival and prognosis were found to be significantly better in nonanemic patients with a hemoglobin/red blood cell distribution higher than the cut-off value than in anemic patients with a normal or lower hemoglobin/red blood cell distribution. Conclusion: The results indicated that nutrition and inflammatory markers have independent prognostic significance in rectal cancer. These markers are simple, inexpensive, and useful biomarkers commonly used in clinical practice, and they were found to predict overall survival and disease-free survival independently.
Retrospective Evaluation of Hydatid Cyst Cases During Pregnancy
(Yale J Biology Medicine, inc, 2021) Sahin, Ozgur; Tolunay, Harun Egemen; Varli, Erol Nadi; Arat, Ozgur; Aydin, Mesut
Aim: Zoonotic parasite infections affect many pregnant people around the world. Hydatid cystic disease is also a zoonotic disease caused by Echinococcus sp. This study aims to present the maternal-fetal results and clinical treatment of pregnant women diagnosed with liver hydatid cyst (CH). This zoonotic disease is discussed again in the light of current literature. Materials and Methods: Pregnant women with hydatid cyst monitored in a tertiary health center between 2018 and 2020 were evaluated. Seven cases were included in this study. We retrospectively collected and analyzed clinical data, which did not interfere with medical treatment. Results: Albendazole was started as medical therapy in six patients, and percutaneous drainage was applied to one patient. Three of our six patients who started medical treatment had to undergo surgery due to maternal complications that developed despite medical treatment. Two of our patients were delivered with a cesarean section due to the obstetric indications. Discussion: Hydatid cysts are most commonly caused by Echinococcus granulosus infection and most common in the liver. The diagnosis of liver hydatid cysts is not difficult, but pregnant women's treatment methods have some problems. Although both medical and surgical treatments are available, there is no consensus. We would also like to underscore that echinococcal disease of the liver should be kept in mind in the differential diagnosis of abdominal pain, jaundice, and/or fever, especially in endemic regions. We think that when we increase awareness about this disease, we can improve fetal and maternal outcomes by making an early diagnosis and management.
Turkish Adult Risk Factor Study Survey 2012: Overall and Coronary Mortality and Trends in the Prevalence of Metabolic Syndrome
(Turkish Soc Cardiology, 2013) Onat, Altan; Yuksel, Murat; Koroglu, Bayram; Gumrukcuoglu, H. Ali; Aydin, Mesut; Cakmak, H. Altug; Can, Gunay
Objectives: We aimed to analyze 1) overall and coronary mortality findings in the Turkish Adult Risk Factor (TARF) study survey 2012 and 2) the temporal trends in the prevalence of metabolic syndrome (MetS) and its distribution across seven geographic regions. Study design: Information on the mode of death was obtained from first-degree relatives and/ or health personnel of a local health office. Information collected in survivors was based on history, physical examination of the cardiovascular system and Minnesota coding of resting electrocardiograms. Results: Of 1527 participants to be surveyed, 796 were examined. Information was obtained on the health status in 502 subjects, and death was ascertained in 56 participants. Thirty deaths were attributed to coronary and cerebrovascular disease. Cumulative 22-year evaluation of participants in the age bracket 45-74 years revealed coronary mortality to be high, with 7.6 per 1000 person-years in men and 3.8 in women. Data used from 1754 identical subjects (median age 46 years initially), and examined in two periods 12 years apart, indicated an increase in the prevalence of MetS by 1.3% per aging of 1 year. Analysis across geographic regions showed a rise in the prevalence in the Mediterranean region, already having highest prevalence along with thr Southeast Anatolia, while the prevalence declined in the Marmara region and persisted to be thr lowest in the Aegean region. Conclusion: The prevalence of MetS in Turkish adults aged 40 years or over, currently standing at 53%, shows significant differences across geographic regions, being highest in the two southern regions and lowest in the Aegean region.
Two Approaches To Pneumoperitoneum: Surgery and Conservative
(Lippincott Williams & Wilkins, 2020) Olmez, Sehmus; Saritas, Bunyamin; Aydin, Mesut; Kara, Banu