Browsing by Author "Aydinlioglu, Atif"

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Aperture in Coronoid-Olecranon Septum: a Radiological Evaluation
(Wolters Kluwer Medknow Publications, 2011) Koyun, Necat; Aydinlioglu, Atif; Gumrukcuoglu, Fatma Nur
Background: The humerus bone with coronoid-olecranon septal aperture have very narrow medullary canal and extreme anterolateral bowing proximally and/or extreme anterolateral compressed surface at distal part. Septal perforation might make nailing through a retrograde technique more difficult or possibly with an increased risk of iatrogenic fracture at the site of insertion. Coronoid-olecranon perforation might be very important in preoperative planning for successful nailing. Since the data available has been obtained from the ancient studies using the skeletal material, the present study is aimed at investigating originally the presence of the coronoid-olecranon septum perforation in the living subjects, using a radiographic method. Materials and Methods: The study was performed on direct radiograms and computed tomography of the elbow obtained from the 709 volunteers (367 males, 342 females). Results: The incidence of the perforation was found to be 8.6%. Bilateral occurrence was found to be more common significantly. The highest incidence occurred in second decade. Conclusion: The present study suggests female prepronounced and left asymmetry in case of septal perforation. Bilateral occurrence from our study might be peculiar to the clinician.
The Effect of Mobile Phone on the Number of Purkinje Cells: a Stereological Study
(Taylor & Francis Ltd, 2010) Ragbetli, Murat C.; Aydinlioglu, Atif; Koyun, Necat; Ragbetli, Cennet; Bektas, Seyman; Ozdemir, Serdar
Purpose: The World Health Organisation proposed an investigation concerning the exposure of animals to radiofrequency fields because of the possible risk factor for health. At power frequencies there is evidence to associate both childhood leukaemia and brain tumours with magnetic field exposures. There is also evidence of the effect of mobile phone exposure on both cognitive functions and the cerebellum. Purkinje cells of the cerebellum are also sensitive to high dose microwave exposure in rats. The present study investigated the effect of exposure to mobile phone on the number of Purkinje and granule neurons in the developing cerebellum. Material and methods: Male and female Swiss albino mice were housed as control and mobile phone-exposed groups. Pregnant animals in the experimental group were exposed to Global System for Mobile Communication (GSM) mobile phone radiation at 890-915 MHz at 0.95 W/Kg specific absorption rate (SAR). The cerebella were processed by frozen microtome. The sections obtained were stained with Haematoxylin-eosin and cresyl violet. For cell counting by the optical fractionator method, a pilot study was firstly performed. Cerebellar areas were analysed by using Axiovision software running on a personal computer. The optical dissectors were systematically spaced at random, and focused to the widest profile of the neuron cell nucleus. Results: A significant decrease in the number of Purkinje cells and a tendency for granule cells to increase in cerebellum was found. Conclusion: Further studies in this area are needed due to the popular use of mobile telephones and relatively high exposure on developing brain.
Effect of Prenatal Exposure To Mobile Phone on Pyramidal Cell Numbers in the Mouse Hippocampus: a Stereological Study
(Taylor & Francis Ltd, 2009) Ragbetli, Murat Cetin; Aydinlioglu, Atif; Koyun, Necat; Ragbetli, Cennet; Karayel, Metin
Because of the possible risk factor for the health, World Health Organization (WHO) recommended the study with animals on the developing nervous system concerning the exposure to radiofrequency (RF) field. A few studies related to hippocampal exposure are available, which indicate the impact of RF field in some parameters. The present study investigated the effect of exposure to mobile phone on developing hippocampus. Male and female Swiss albino mice were housed as control and mobile phone exposed groups. The pregnant animals in tested group were exposed to the effects of mobile phone in a room possessing the exposure system. The left hemispheres of the brains were processed by frozen microtome. The sections obtained were stained with Hematoxylin Eosin. For cell counting by the optical fractionator method, a pilot study was first performed. Hippocampal areas were analyzed using Axiovision software running on a personal computer. The optical dissector, systematically and randomly spaced, was focused to the widest profile of the pyramidal cell nucleus. No significant difference in pyramidal cell number of total Cornu Ammonis (CA) sectors of hippocampus was found between the control and the mobile phone exposed groups (p .05). It was concluded that further study is needed in this field due to popular use of mobile telephones and relatively high exposure to the developing brain.
Effects of Diclofenac Sodium on the Rat Liver in Postnatal Period
(Medwell online, 2009) Ragbetli, Cennet; Aydinlioglu, Atif; Kara, Mikail; Ragbetli, Murat Cetin; Ilhan, Fatma
Diclofenac Sodium (DS) is a nonsteroidal anti-inflammatory drug used in painful conditions, trauma, dysmenorrhoea, rheumatoid arthritis, degenerative joint disease and ankylosing spondylitis. There is the paucity of the research investigating DS effect on the rat liver in the fetal period. The present study aimed to investigate the possible postnatal effects of DS on the liver tissues of the offspring of rats. DS was administered to pregnant rats for 15 days from the 5th-20th day of pregnancy. After mating day, pregnant female rats were separated into the control and DS treated groups. DS (1 mg kg(-1) daily) was injected intraperitoneally to the drug-treated group and physiological saline (1 mL kg(-1)) to the control group. Liver tissues were collected from pups at the 20th week and paraffin sections were dyed with hematoxylen-eosin. DS caused proliferation of bile ducts, enlargement of periportal area, dilatation of sinusoids and the central vein, parenchymal degeneration and mononuclear cell infiltration. Significant changes between the control and the treated groups were found (p<0.05). However, no significant difference was observed between the sexes in both groups. This study using DS with low dose did not show parenchymal cell death, as a different finding from the previous studies. However, these observations need to be confirmed by further studies using different doses of DS during pregnancy.
A Histological Investigation Concerning the Effects of Diclofenac Sodium To the Lung in 4-And 20-Week Rats Treated Prenatally
(informa Healthcare, 2011) Ragbetli, Cennet; Ilhan, Fatma; Aydinlioglu, Atif; Kara, Mikail; Ragbetli, Murat C.
Objective. We aimed to investigate the possible postnatal effects on the lung tissues of the rat offspring treated with diclofenac sodium (DS) during pregnancy. Methods. After mating, pregnant female rats were separated into the control (n = 10) and DS (n = 10) groups. DS (1 mg/kg) was injected intraperitoneally (i.p) to the drug-treated group for the period of gestational days 5-19. Physiological saline (1 ml, i.p.) was given to the control groups. After birth, pups were separated into DS treatment groups (n=24) and control group (n=24). The DS and control group animals were anaesthetised with i.p. injection of urethane and their lungs were removed to prepare for histopathological evaluation. Results. Histological examination of the lung tissues of the 4- and 20-week-old rats revealed no significant differences between males and females in both the control and DS treated rats. Conclusion. Because of the use of DS in the pregnant women further studies are needed in this field.
Morphometric Study of the Human Metatarsals and Phalanges
(Wiley-liss, 2007) Dogan, Ali; Uslu, Mustafa; Aydinlioglu, Atif; Harman, Mustafa; Akpinar, Fuat
Mathematical relation between metatarsals and between phalanges in terms of their lengths and widths in themselves is considered to be significant with respect to its functional and aesthetic roles. The objective of this study is to conduct measurements for determining lengths and widths of metatarsals and phalanges on the foot radiographs and to determine possible mathematical correlations between metatarsals themselves and between phalanges themselves in terms of their lengths and widths. Anteroposterior right and left foot radiographs were taken from 100 volunteers (50 men and 50 women). Lengths and widths of the metatarsals and phalanges were measured in millimeter on radiographs. The mean, minimum and maximum values, and standard deviations of each bone's length and width were studied and data were put into formulation. The results were evaluated by Regression statistical test, and the relation between metatarsals and between phalanges in terms of their lengths and widths was studied. As a result of the measurements, we found fixed proportions between metatarsals in themselves and between phalanges in themselves in terms of their lengths and widths. Knowing these morphometric relations may be useful for performing any surgical procedures designed to manage any defects or imperfections of the foot, chief among them is shortness.
A Morphometric Study on Dog Cerebellum
(Taylor & Francis Ltd, 2011) Koyun, Necat; Aydinlioglu, Atif; Aslan, Kadir
In healthy humans and patient with schizophrenia, studies investigating cerebellar asymmetries have been performed by using magnetic resonance images (MRIs), which have failed to demonstrate the presence of the left-right asymmetry. Due to the paucity of animal studies in this field, the present study was undertaken to investigate whether the dog cerebellum shows any pattern of volumetric asymmetry. A total of 16 adult mongrel dogs, 8 male and 8 female, were assessed with respect to pawedness. After the animals were anesthetized and killed by exsanguinations, the cerebellum was removed and divided into the anterior and the posterior lobes by a dissection passing into the fissure prima. The volumes of the right and left hemispheres were separately calculated by a volumetric device. The present study demonstrated significant volume asymmetries as to right-left, sex and pawedness in dog cerebellum. Morphological asymmetries in dog cerebellum might relate to cerebral specialization of function. Further studies need to be performed to demonstrate the relationship between cerebellar asymmetries and functional lateralization.
Total Neuron Numbers in Ca1-4 Sectors of the Dog Hippocampus
(indian Council Medical Res, 2010) Ragbetli, Murat Cetin; Aydinlioglu, Atif; Koyun, Necat; Yayici, Recep; Arslan, Kadir
Background & objectives: Early reports addressed morphological asymmetry in the cross-sectional width of the rat hippocampus. The present study was aimed at counting total number of neurons in CA1-4 sectors and the subiculum of the dog hippocampus as well as investigating possible left/right and male/female asymmetry. Methods: Adult mongrel dogs (8 female and 5 male) were assessed by the right and left pawedness and sacrificed by exsanguinations. In each hippocampus dissected, the total neuron numbers of CAs and subiculum were estimated by the physical fractioning method. Results: Significant hemispheric asymmetries were found in the number of pyramidal cells of CA1, CA3/2, CA4 and the subiculum. Sex difference was also found in the subiculum, in favour of the males. Interpretation & conclusion: Our study indicated a left dominant asymmetry in males and right dominancy in females as well as no functional asymmetry in specific regions of the dog hippocampus. Further investigations are necessary to verify the hypothesis that hippocampal morphological asymmetries in normal subjects are functionally related in memory or in cognitive skills.