Browsing by Author "Aygun, Nafi"

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Imaging Findings of Bisphosphonate-Related Osteonecrosis of the Jaw With Emphasis on Early Magnetic Resonance Imaging Findings
(Lippincott Williams & Wilkins, 2009) Krishnan, Anant; Arslanoglu, Atilla; Yildirm, Nadir; Silbergleit, Richard; Aygun, Nafi
Purpose: To describe the imaging findings of bispbosphonate-related osteonecrosis of the jaw (BRONJ) with emphasis on early magnetic resonance imaging (MRI) findings. Materials and Methods: The medical records and computed tomography. MRI, and bone scintigraphy images of 5 female and 1 male patients (n = 6) between the ages of 49 and 79 years (mean age, 70 years) who had a diagnosis of BRONJ were retrospectively reviewed, and temporal changes in imaging features were noted. Results: The earliest MRI finding was tire loss of the normal TI hyperintensity of fatty marrow in the mandible and maxilla. The MRI findings of more advanced BRONJ included bone destruction, Soft tissue edema and enhancement. interior alveolar nerve thickening. and pterygoid muscle swelling and enhancement. On computed tomography, sclerosis and subtle lucencies (widening) of the periodontal ligament and cortex and around the apices of the teeth in the early stage, and osteolytic bone lesions, cortical disruption, and frank bone fragmentation in the later stages were observed. Bone scintigraphy showed increased uptake early in the disease. Conclusions: Osteonecrosis of the mandible and maxilla occurs as a complication of bisphosphonate treatment of bone metastasis and ostcoporosis and typically manifest after a dental procedure. Magnetic resonance imaging, and bone scintigraphy findings may precede clinical symptoms and mimic metastatic disease.
Otologic and Leptomeningeal Involvements as Presenting Features in Seronegative Wegener Granulomatosis
(W B Saunders Co-elsevier inc, 2008) Yidirim, Nadir; Arslanoglu, Atilla; Aygun, Nafi
Wegener granulomatosis is an immune-mediated, systemic vasculitis with unknown etiology that can be seen in almost any anatomical site. Positivity for antineutrophil cytoplasmic antigene, which is a serological marker, and presence of granulomatous vasculitis in histopathologic specimens from the lesions are accepted as diagnostic. A case of Wegener granulomatosis whose presenting symptoms and signs are related to otologic and meningeal involvement of the disease is reported. Apart from atypical presentation, histopathological and serological findings from this patient remained negative throughout the course of the disease, and the diagnosis was made on the basis of clinical and secondary laboratory findings. We herewith discuss this unusual case in the light of relevant literature. (c) 2008 Published by Elsevier Inc.