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Browsing by Author "Aymelek, Fatih"

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    Article
    Bio-Element Status in Children With Acute Rheumatic Fever: Before Treatment and After Clinical Improvement
    (Springer, 2010) Cemek, Mustafa; Buyukokuroglu, Mehmet Emin; Buyukben, Ahmet; Aymelek, Fatih; Yilmaz, Fatma; Dogan, Murat; Yildirim, Derya
    Acute rheumatic fever (ARF) is an autoimmune multisystem disease. Bio-elements are required in different quantities by an organism to maintain its physiologic function. Monitoring the status of bio-elements is critical in human health. This study aimed to determine possible changes in levels of bio-elements in children with ARF before and after treatment. Levels of trace and major elements in children with ARF were investigated. The study included 33 children with ARF (17 boys and 16 girls) and 20 healthy control children (11 boys and 9 girls). The ages ranged from 5 to 16 years (mean 11.4 +/- A 3.82 years) in the study group and from 6 to 15 years (mean, 10.7 +/- A 3.22 years) in the control group. Trace and major element concentrations (total of 14 elements) in the serum were measured by inductively coupled plasma-optical emission spectroscopy. Before treatment, the levels of the major elements potassium (K) and magnesium (Mg) in children with ARF were higher than in the control group, whereas the calcium (Ca) level was lower. Before treatment, the levels of trace elements iron (Fe), selenium (Se), zinc (Zn), aluminum (Al), and barium (Ba) were lower, whereas the copper (Cu), beryllium (Be), cadmium (Cd), chromium (Cr), gallium (Ga), and strontium (Sr) levels were higher in the serum of the patients with ARF than in the control patients. The major findings show that the homeostasis of some trace and major elements were altered in the children with ARF and that these alterations may be a contributing factor in the pathogenesis of this disease.
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    Article
    Protective Potential of Royal Jelly Against Carbon Tetrachloride Induced-Toxicity and Changes in the Serum Sialic Acid Levels
    (Pergamon-elsevier Science Ltd, 2010) Cemek, Mustafa; Aymelek, Fatih; Buyukokuroglu, Mehmet Emin; Karaca, Turan; Buyukben, Ahmet; Yilmaz, Fatma
    Royal Jelly (RJ) is used in the Turkish folk medicine for the treatment of number of disorders. The present study describes the hepatoprotective and antioxidant activities of the RJ against carbon tetrachloride (CCl4)-induced acute liver damage. Sprague-Dawley rats were used for the experiment. CCl4 (0.8 ml/kg; s.c.) and RJ (50, 100, 200 mg/kg: orally) were given every other day, for 20 days. Malondialdehyde, reduced glutathione in whole blood and tissues: ceruloplasmin, sialic acid, ascorbic acid, retinol, beta-carotene and liver enzymes levels in serum were measured. Additionally, histopathological alterations in the liver were examined. RJ exerted the significant protective effect on liver damage as well as on oxidative stress induced by CCl4, resulting in reduced lipid peroxidation and improved endogenous antioxidant defence systems. It also reduced the elevated levels of liver enzymes. Histopathological study further confirmed the hepatoprotective effect of RJ, when compared with the CCl4 treated control groups. In conclusion, present study reveals biological evidence that supports the use of RJ in the treatment of chemical-induced hepatotoxicity. (C) 2010 Elsevier Ltd. All rights reserved.