Browsing by Author "Aytekin, I."

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Effects of Acute and Subacute Digoxin Intoxication on Haematological Parameters and Serum Ck and Ldh Activities in Dogs
(Ecole Nationale veterinaire Toulouse, 2008) Karadeniz, A.; Aytekin, I.; Akgul, Y.
For determining the variations of haematological parameters and of serum CK and LDH activities induced by digoxin intoxication in dogs, 24 healthy dogs were used in this study and were randomly divided into 2 equal group: in the group 1 (acute intoxication) dogs received an unique i.v. injection of 0.15 mg/kg digoxin, haematological parameters were determined one day before the treatment and during the 4 consecutive days after the injection while serum enzyme activities were measured at 12, 24, 48 and 72 hours after. In the group 2 (sub acute intoxication), animals received 3 intravenous digoxin injections on day 1 (50 mu g/kg 2 times then 25 mu g/kg), then they were treated by 25 mu g/kg digoxin i.v. once a day for 6 consecutive days. Haematological and biochemical parameters were assessed one day before and on Days 1, 3, 5, 7, 9, 11 and 15 after the first injection. Whereas haematological parameters remained relatively constant according to time and to the digoxin administration schedule, both digoxin treatments have induced significant increases of serum CK and LDH activities. During acute intoxication, CK variations were particularly intense whereas LDH activities were transiently altered (between 12 and 24 hours). By contrast, LDH activities gradually and significantly increased from the Day 5 to the Day 11 in the group 2 and CK activities were only significantly elevated on Day 11: LDH may be a more sensitive marker than CK in the situation of sub acute poisoning.
Effects of Onion Juice Administration on Electrocardiogram in Dogs
(2009) Ceylan, E.; Aytekin, I.; Keles, I.; Altug, N.
The purpose of this study, was to investigate the effects of Onion Juice Administration (OJA) on Electrocardiogram (ECG) in dogs. Five clinically healthy street dogs were used in this study. Onion juice was given through oro-gastric tube of 400 g onion kg-1 body weight dose in 500 mL water. Blood samples were collected at just before and after (6, 12 and 24th h) Onion Juice Application (OJA). PCV, heart beats counts and electrocardiograms of the animals in the same time were determined. PCV values gradually, decreased and these decreases were significant at 6th (p<0.01), 12th (p<0.01) and 24th (p<0.001) h after OJA. Bradicardia was observed at 6th (p<0.05) and 12th (p<0.001) h after OJA whereas tachycardia was observed at 24th h (p<0.001). Before and 6th h after OJA heart rates were within normal limits in this study. First degree heart block occurred 12th h after OJA and aritmia was obvious at this time. P-Q interval also increased. Bradicardia developed in some derivations. The mean heart rate was approximately 60 beats min-1. Twenty-four hours after OJA tachycardia developed and the mean heart rate was 130 beats mm-1. In summary, OJA caused the anemia (reduction in the PCV values,) 1st degree heart block, tachycardia in dogs. Further studies on this issue, might be helpful for determining the effects of OJA on ECG in different species. © Medwell Journals, 2009.