Browsing by Author "Balkan, Fevzi"

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Do Tsh Levels in Euthyroid Patients Have an Impact on the Prevalence of Metabolic Syndrome
(Galenos Yayincilik, 2015) Balkan, Fevzi; Usluogullari, Alper; Ucler, Rifki
Purpose: Our objective in this study was to investigate the prevalence of metabolic syndrome in two different group of patients who had a thyroid-stimulating hormone (TSH) level within normal limits. Material and Method: Three hundred and fifty patients, who presented to Aksaray Public Hospital, Endocrinology and Metabolism Diseases Outpatient clinic and who had no thyroid disease, were included in the study. The patients were divided into two groups according to TSH levels. Group 1 had a TSH level of <2.5 mIU/L and group 2 had a TSH level of >2.5 mIU/L. The prevalence of metabolic syndrome, insulin resistance and lipid parameters were investigated in both groups. Results: A total of 350 patients were included in the study. Group 1 included 229 (65.5%) patients and group 2 included 121 (34.5%) patients. The prevalence of metabolic syndrome was found to be 112/229 (48%) in group 1 and 55/121 (45%) in group 2. There was no statistically significant difference between the two groups (p>0.05). FT3 level was found to be positively correlated with hip circumference (r=0.10, p=0.04), weight (r=0.12; p=0.016) and waist circumference (r=0.13; p=0.014). FT4 level was found to be positively correlated with height (r=0.12, p=0.02). Discussion: TSH level was not found to be correlated with the prevalence of metabolic syndrome (p>0.05). The prevalence of metabolic syndrome was found to be similar in both groups.
Mean Platelet Volume (Mpv): Could It Be Used as a Predictive Marker for Gestational Diabetes
(Aves Press Ltd, 2014) Balkan, Fevzi; Usluogullari, Celil Alper; Ucler, Rifki; Usluogullari, Betul; Caner, Sedat
An abnormal glucose tolerance which is first detected during pregnancy and disappears after completion of pregnancy is known as "gestational diabetes mellitus". Early detection of this condition helps preventing potential maternal and fetal complications. Some studies reported that platelets may have a role in the pathogenesis and development of gestational diabetes. In the present study, we aimed to evaluate and compare the platelet function and morphology among pregnant women with gestational diabetes and healthy pregnant women. Values of complete blood count were reviewed for pregnant women between weeks 24 and 28 of gestation while performing oral glucose tolerance tests for from January 2013 to September 2013. After screening, a total of 89 pregnant women were enrolled in the study including 38 women with gestational diabetes and 51 healthy pregnant women. The mean platelet volume (MPV) was 8.76 +/- 1.53 fl in the group with gestational diabetes and 7.80 +/- 1.34 fl in the healthy pregnant group, with a statistically significant difference between two groups (P=0.02). There was no statistically significant difference between two groups in platelet counts (P=0.25). Dissimilar results were reported by a small number of studies on this subject. MPV and other platelet parameters may be considerably helpful in detecting diabetic pregnant women who are at risk for vascular complications. In this study, significantly greater MPV was found among pregnant women with gestational diabetes compared to control group (P<0.05). Further studies are needed to elucidate the role of such changes and their potential clinical implications in women with gestational diabetes.