Browsing by Author "Baran, Ali Irfan"

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Akut Lenfoblastik Lösemi Tanılı Hastada Gelişen Mukormikozis: Olgu Sunumu
(2019) Ekinci, Ömer; Demir, Cengiz; Dogan, Ali; Düzenli, Ufuk; Demircioğlu, Sinan; Baran, Ali Irfan; Bayram, İrfan
Mukormikoz, yüksek morbidite ve mortaliteye sahip, nadirgörülen bir mantar enfeksiyonudur. Rino-orbito-serebralformu sık görülmektedir. Bu formun tedavisinde amfoterisinB ve cerrahinin birlikte uygulanması önerilmektedir. Ancak butedavilere rağmen mortalitesi oldukça yüksektir. Bizde akutlenfoblastik lösemi tanılı hastamızda gelişen 3 kez cerrahiuyguladığımız eş zamanlı hem intravenöz hemde burun içilipozomal amfoterisin B uygulayarak başarılı bir şekilde tedaviettiğimiz mukormikozis olgusunu sunduk.
Asymmetric Dimethylarginine Levels in Patients With Cutaneous Anthrax: a Laboratory Analysis
(Bmc, 2014) Sunnetcioglu, Mahmut; Mengeloglu, Zafer; Baran, Ali Irfan; Karahocagil, Mustafa; Tosun, Mehmet; Kucukbayrak, Abdulkadir; Aypak, Cenk
Background: Asymmetric dimethylarginine (ADMA), the main endogenous inhibitor of nitric oxide synthase, is considered to be associated with endothelial dysfunction. High ADMA levels have been shown to be related with disorders causing vascular inflammation such as hypertension, hypercholesterolemia, atherosclerosis, chronic heart failure, stroke and sepsis. Cutaneous anthrax (CA) is a serious infectious disease which may cause vasculitis. The aim of the study was to investigate the serum ADMA levels in patients with CA. Methods: A total of 35 serum samples of the patients with CA and 18 control sera were tested for ADMA levels using ADMA ELISA kit (Immunodiagnostik AG, Bensheim, Germany). Results: ADMA levels were found to be significantly higher in the patients group than the controls (p < 0.001). In addition, ADMA levels were found to be positively associated with sedimentation rates (R = 0.413; p = 0.026), and inversely associated with international normalized ratio (INR) levels (R = -0.46; p = 0.011). A cut-off value of 0.475 of ADMA had a sensitivity of 74.3%, specificity of 77.8%, and accuracy of 75.5% in the diagnosis of CA. Conclusion: Although the exact mechanism still remains unclear, ADMA levels could be related to immune activation in CA. In addition, these data might suggest the higher ADMA levels in patients could be due to the perivascular inflammation and vasculitis in CA.
Blood Prestin Levels in Covid-19 Patients
(Lippincott Williams & Wilkins, 2023) Turan, Mahfuz; Alp, Hamit Hakan; Yildiz, Hanifi; Baran, Ali Irfan; Ekin, Selami; Akin, Ramazan; Bozan, Nazim
Background: Many studies have found that viral infections affect different tissues, including the inner ear. Coronavirus disease 2019 (COVID-19), a viral infection, is a significant health problem worldwide. Prestin is a motor protein with important functions both in the outer hair cells of the inner ear and in cardiac tissue. In addition, prestin is promising as an early biomarker in the detection of ototoxicity. To determine the severity of infection in COVID-19 patients and to determine whether other tissues are affected by the infection, lactate dehydrogenase (LDH), C-reactive protein (CRP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatine kinase MB (CK-MB), biochemical markers such as ferritin and D-dimer are used. This study aimed to compare prestin levels in patients with COVID-19 and healthy volunteers.Methods: In blood samples taken from 45 patients diagnosed with COVID-19 and 40 healthy volunteers, prestin levels were determined with the kit that used an enzyme-linked immunosorbent assay method and was commercially available. At the same time, LDH, CRP, ALT, AST, CK-MB, ferritin, and D-dimer levels were also detected in both patients and healthy control groups and correlations with prestin levels were examined.Results: The main result of our study is that serum prestin levels in COVID-19 patients are significantly higher than in healthy controls (p < 0.001). In addition, a statistically significant strong positive correlation was found between prestin-LDL (r = 0.537, p = 0.001), prestin-CRP (r = 0.654, p = 0.001), and prestin-D-dimer (r = 0.659, p = 0.001).Conclusion: The levels of prestin, a motor protein in inner ear outer hair cells and cardiac myocytes, were found to be higher in COVID-19 patients than in healthy volunteers. It also showed a positive correlation with CRP and D-dimer. This may be associated with systemic dysfunction.
Botulism Presenting With Unilateral Paralysis: First Case Report
(Aves, 2011) Karsen, Hasan; Baran, Ali Irfan; Ekin, Selami; Odabas, Faruk Omer; Duygu, Fazilet
Food-borne botulism is an acute form of food poisoning that results from ingestion of the toxin produced by Clostridium botulinum. Intoxication classically presents as an acute, symmetrical paralysis. In this study, we report a case of botulism with unilateral paralysis that was confirmed by the mouse inoculation and neutralization method.
Brucellosis-Associated Hepatitis
(Springer London Ltd, 2024) Arslan, Yusuf; Baran, Ali Irfan; Celik, Mehmet
AimBrucellosis is a zoonotic infection that can affect almost every organ. A mild elevation of aminotransferase levels is usually observed in liver involvement. However, the development of clinical hepatitis is rare. In this study, we aimed to present the hospitalized cases with brucellosis hepatitis in our clinic in a 13-year period.MethodsA hundred and three patients with significant hepatobiliary involvement, diagnosed by microbiological analysis, were included in the study. For the presence of hepatitis, it was required that the aminotransferases must be >= 5 times more than the upper limit and/or the total bilirubin level must be >= 2 mg/dl and/or the local hepatic lesion must be demonstrated.ResultsOf the cases, 35.9%, 17.5%, and 46.6% had clinical hepatitis, cholestatic hepatitis, and both clinical and cholestatic hepatitis, respectively. The most frequent symptom was fever (85.4%) while the most preferred treatment options were combinations containing aminoglycosides. It was observed that the mean time-interval to decrease to normal values of ALT, AST, and bilirubin values was 15.2 +/- 7.8 days while the patients having their treatment regimens. In our study, which focused on liver involvement, it was found that a chronic liver disease did not develop in any of the cases.ConclusionOur study showed that, even in the presence of hepatitis, clinical response and laboratory improvement were high with appropriate treatment. It was observed that the improvement in aminotransferases and total bilirubin values delayed in the cases with blood culture positivity, secondary organ involvement, and alanine aminotransferase/aspartate aminotransferase > 1.
Can Hematological Inflammatory Indices Be Used To Differentiate Modic Type 1 Changes From Brucella Spondylodiscitis
(Mdpi, 2024) Sah, Volkan; Baran, Ali Irfan
Background and Objectives: Differentiation between brucella spondylodiscitis and Modic type I changes (MC1) includes difficulties. Hematological inflammatory indices (HII) such as neutrophil to lymphocyte ratio (NLR) and aggregate index of systemic inflammation (AISI) are suggested as indicators of inflammation and infection and have diagnostic, prognostic, and predictive roles in various diseases. This study aimed to evaluate differences between brucella spondylodiscitis and MC1 in terms of HII. Materials and Methods: Thirty-five patients with brucella spondylodiscitis and thirty-seven with MC1 were enrolled in the study. Brucella spondylodiscitis and MC1 were diagnosed by microbiological, serological, and radiological diagnostic tools. HII (NLR, MLR, PLR, NLPR, SII, SIRI, AISI) were derived from baseline complete blood count. Results: The two groups were similar for age (p = 0.579) and gender (p = 0.092), leukocyte (p = 0.127), neutrophil (p = 0.366), lymphocyte (p = 0.090), and monocyte (p = 0.756) scores. The Brucella spondylodiscitis group had significantly lower pain duration (p < 0.001), higher CRP and ESR levels (p < 0.001), and lower platelet count (p = 0.047) than the MC1 group. The two groups had similarity in terms of HII: NLR (p = 0.553), MLR (p = 0.294), PLR (p = 0.772), NLPR (p = 0.115), SII (p = 0.798), SIRI (p = 0.447), and AISI (p = 0.248). Conclusions: Increased HII can be used to differentiate infectious and non-infectious conditions, but this may be invalid in brucellosis. However, pain duration, CRP and ESR levels, and platelet count may be useful to distinguish brucella spondylodiscitis from MC1.
Candida Globosa’nın Etken Olduğu Bir Piyojenikkaraciğer Apsesi Olgusu
(2019) Sunnetcioglu, Mahmut; Baran, Ali Irfan; Karahocagil, Mustafa Kasim; Çelik, Mehmet; Arslan, Yusuf
Piyojenik karaciğer apsesi bakteriyel veya fungal etkenlere bağlı gelişebilen, nadiren görülen bir hastalıktır. Uygun antibiyotik ve drenaj ile mortalitesi önemli ölçüde azaltılabilir. Bu yazıda ateş, sağ yan ağrısı, iştahsızlık, bulantı şikayetleriyle başvuran, radyolojik görüntülemelerde subhepatik karaciğer apsesi saptanıp perkütan apse drenajı uygulanan ve apse kültüründe Candida globosa üreyen, kaspofungin tedavisi sonrası kliniği düzelen bir olgu sunuldu. Karaciğer apselerinde bakteriyel ajanlar sıklıkla izole edilmekle beraber fungal ajanlar da enfeksiyon etkeni olarak karşımıza çıkabilmektedir. ( Sakarya Tıp Dergisi 2019, 9(3):550-553
Clinical and Laboratory Features of Adult Measles Cases Detected in Van, Turkey
(Pakistan Medical Assoc, 2015) Sunnetcioglu, Mahmut; Sunnetcioglu, Aysel; Mentes, Osman; Baran, Ali Irfan; Karadas, Sevdegul; Aypak, Adalet
Objective: To evaluate adult measles patients with respect to their clinical and laboratory findings as well as complications. Methods: The retrospective study was conducted at YuzuncuYil University, Van, Turkey, between December 2012 and June 2013, and comprised cases diagnosed with measles. The diagnosis was based on clinical findings and all were serologically confirmed with the presence of Anti-measles Immunoglobulin M antibodies. Results: Of the 50 records studied, 41(84%) related to women. Overall mean age was 25.52+/-4.07 years. The most common symptoms were fever and rash 50(100%), malaise 49(98%), cough 48(96%), headache 44(88%) and sore throat 36(72%). The presence of Koplik spots, lymphadenopathy and hepatomegaly were observed in 3(6%), 6(12%) and 2(4%) patients respectively. Thrombocytopenia and elevated liver enzymes were detected in 26(52%) and 22(44%)patients. Pneumonia was the most common complication in 9(18%) patients. Other respiratory complications were bronchitis 5(10%) and laryngotracheitis 6(12%). Of the cases, 9(18%) exhibited otitis media. Premature delivery and spontaneous abortus occurred in 2(4%) and 3(6%) patients of the 15(30%) pregnant women. Conclusion: Measles continues to be an important health problem in Turkey and needs an effective elimination programme.
Clinical Manifestations and Complications in 1028 Cases of Brucellosis: a Retrospective Evaluation and Review of the Literature
(Elsevier Sci Ltd, 2010) Buzgan, Turan; Karahocagil, Mustafa Kasim; Irmak, Hasan; Baran, Ali Irfan; Karsen, Hasan; Evirgen, Omer; Akdeniz, Hayrettin
Introduction: Brucellosis is the most prevalent bacterial zoonosis worldwide. In this study, we aimed to compare our 1028 brucellosis cases with other big series in the literature in view of epidemiological, clinical, and laboratory findings and therapeutic features. Methods: A total of 1028 brucellosis cases admitted to the Department of Infectious Diseases and Clinical Microbiology over a 10-year period were included in the study. A retrospective analysis was undertaken and patient files were reviewed for history, clinical and laboratory findings, and therapeutic features, as well as complications. Results: Of the 1028 patients, 539 (52.4%) were female and 489 (47.6%) were male. The mean age of patients was 33.7 +/- 16.34 years and 69.6% of cases were aged 13-44 years. Four hundred and thirty-five cases (42.3%) had a history of raising livestock and 55.2% of the cases were found to have no occupational risk for brucellosis. Six hundred and fifty-four of the cases (63.6%) had a history of raw milk and dairy products consumption. The most frequently seen symptoms were arthralgia (73.7%) and fever (72.2%), while the most common clinical findings were fever (28.8%) and hepatomegaly (20.6%). The most frequent laboratory finding was a high C-reactive protein level (58.4%). The standard tube agglutination (STA) test + Coombs STA test was positive in 1016 cases (98.8%). Focal involvement was present in 371 (36.1%) cases. The most frequent involvement was osteoarticular involvement with 260 cases (25.3%). The overall relapse rate for patients with brucellosis was 4.7%. The highest relapse rate, 8.5%, was observed in the group of patients with osteoarticular involvement. Regimens including doxycycline and streptomycin with or without rifampin appeared more effective than other regimens in osteoarticular involvement. Conclusions: In humans, brucellosis may lead to serious morbidity, and it continues to be a major health problem in Turkey. There is no recommended treatment protocol for complicated brucellosis. Large multicenter studies are needed to determine the most appropriate treatment choices and durations in complicated brucellosis. (C) 2009 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
Comparative Analysis of Pulmonary and Extrapulmonary Tuberculosis of 411 Cases
(Biomed Central Ltd, 2015) Sunnetcioglu, Aysel; Sunnetcioglu, Mahmut; Binici, Irfan; Baran, Ali Irfan; Karahocagil, Mustafa Kasim; Saydan, Muhammed Ridvan
Background: Tuberculosis is a disease that can involve every organ system. While pulmonary tuberculosis is the most common presentation, extrapulmonary tuberculosis (EPT) is also an important clinical problem. The current study aimed to outline and compare the demographic and clinical features of pulmonary and extrapulmonary tuberculosis cases in adults. Methods: Medical records of 411 patients (190 women, 221 men) treated between January 2010 and July 2014 in provincial tuberculosis control dispensary was retrospectively reviewed. Demographic and clinical characteristics were compared for pulmonary and extrapulmonary tuberculosis cases. Results: Of these 411 cases, 208 (50.6%) had pulmonary tuberculosis (PTB) and 203 were diagnosed with extrapulmonary tuberculosis (EPTB) (49.4%). The average ages for PTB and EPTB groups were 33.00-27.00 and 31.00-29.75, respectively (p = 0.513). Men were more frequently affected by PTB (59.6%), while EPTB was more commonly detected in women (52.2%) (p = 0.016). Main diagnostic modalities for PTB were sputum/smear analyses (72.7%), clinical-radiological data (21.7%) and biopsy (6.1%); while biopsy (71.5%), sputum/fluid analysis (18.8%) and clinical-radiological data (4.9%) were used for confirming EPTB (p < 0.0019). The most common sites of EPTB involvement were lymph nodes (39.4%), followed by pleura (23.6%), peritoneum (9.9%) and bone (7.4%). Conclusions: Extrapulmonary involvement of tuberculosis is common and females are more likely to be affected. Increased clinical awareness is important since atypical presentations of the disease may constitute diagnostic and therapeutic challenges.
Comparison of Carbapenem Resistance Detected by the Bd Phoenix Automated System in Enterobacteriaceae Isolates E-Test Method
(Modestum Ltd, 2022) Celik, Mehmet; Sunnetcioglu, Mahmut; Guducuoglu, Huseyin; Arslan, Yusuf; Akyuz, Sumeyye; Baran, Ali Irfan
Objective: Automatic identification and antimicrobial susceptibility systems are frequently used to identify clinical isolates in hospitalized patients, but mistakes in these systems can lead to potentially devastating treatment failures for patients. Therefore, the "Centers for Disease Control and Prevention (CDC)" recommends confirming all Carbapenem-resistant and low-susceptibility isolates with a different method. The aim of this study is to compare the Carbapenem susceptibility results of isolates reported as Carbapenem-resistant Enterobacteriaceae according to the BD Phoenix 100 automated system with the E-test method. Materials and Methods: The study included 70 strains of Carbapenem-resistant Enterobacteriaceae members which were isolated and grown from several types of clinical samples in the Medical Microbiology Laboratory. Conventional methods (Gram stain, negative oxidase test) and the BD Phoenix 100 automated system were used to identify the isolates. The susceptibility of all strains to imipenem, ertapenem and meropenem was investigated by E-test method. Automated system results and E-test results were compared. Results: The frequency distribution of all isolated bacterial strains comprised K. pneumoniae in 56 (80%) of the samples included in the study. The automated system test results were correlated with the results of the E-test at a rate of 96.1 % for the imipenem-resistant strains, 84.3% for the meropenem-resistant strains, 84.1% for the ertapenem-resistant strains Conclusions: Automated systems are frequently used in microbiology laboratories to identify isolates. However, automated systems can show a high error rate against some antimicrobials. For this reason, comparing the results of automated system test results with tests such as E-test is very important to prevent both treatment failures and inappropriate antibiotic use that may occur on a patient basis.
Comparison of the Automated Cell Counter and Manual Method for the Assessment of Dialysis Fluids in Peritoneal Dialysis Patients
(Drunpp-sarajevo, 2011) Soyoral, Yasemin Usul; Begenik, Huseyin; Aldemir, Mehmet Naci; Baran, Ali Irfan; Emre, Habib; Karahocagil, Mustafa Kasum; Erkoc, Reha
Objective: To compare the accuracy of automated cell counter and the manual methods for the peritoneal fluid assessments in peritoneal dialysis patients. Material and Method: We analyzed 72 peritoneal fluid samples collected under sterile conditions from 27 patients with peritonitis (15 female; 12 male) following by the peritoneal dialysis unit of Yuzuncu Yil University Medical Faculty. The white blood cell counts of these peritoneal fluid samples were assessed by the both manual method and the automated cell counter. Results: The white blood cells were usually higher in the automated cell count method than the manual method (p<0,01). In 5 subjects, white cell counts were less than 100 cell/mu L in the manual method, but were more than 100 cell/mu L in the automated counter. There was a significant correlation between the manual and automated methods in terms of cell counts (p<0.01, r = 0.79). We also found good correlation between the two methods when WBC counts were greater than 300 cell/mu L (r = 0.87). Conclusions: There is a good correlation between the automated method and the manual methods for the assessment of peritoneal fluid samples in CAPD patients. However, in the assessment of fluids with less than 300 cell/mu L, the manual method should be preferred for critical clinical decisions.
Ensefalomyelit İle Seyreden Bir Kızamık Olgusu
(2020) Baran, Ali Irfan; Sunnetcioglu, Mahmut; Karahocagil, Mustafa Kasim; Çelik, Mehmet; Mentes, Osman
Kızamık, bulaştırıcılığı yüksek olan enfeksiyonlardan biridir ve dünyadaki önemli morbidite ve mortalite nedenleri arasındadır. Erişkin dönemde komplikasyon hızı ve mortalitesi yüksek olan ciddi bir hastalıktır. Ensefalomiyelit, kızamık enfeksiyonun en fatal komplikasyonudur. Bu yazıda, bölgemizdeki kızamık salgını döneminde bilinç bozukluğu ve kismi motor defisit ile seyreden nadir görülen kızamık ensefalomyelit olgusunun sunulması amaçlandı.
Erişkin Kist Hidatik Vakalarının Retrospektif Değerlendirilmesi
(2024) Çelik, Mehmet; Baran, Ali Irfan; Altındağ, Deniz; Arslan, Yusuf; Tarcan, Tayyar; Sunnetcioglu, Mahmut; Alkan, Sevil
Amaç: Bu çalışmanın amacı kist hidatik nedeniyle takip edilen erişkin hastaların özelliklerini değerlendirmekti. Yöntem: Çalışmaya Ocak 2015-Eylül 2021 tarihleri arasında kist hidatik tanısı konan 18 yaş üstünde hastalar dahil edildi. Hastalara ait klinik, laboratuvar, radyolojik özellikler retrospektif olarak değerlendirildi. Bulgular: Çalışmaya 66 hasta dahil edildi. Hastaların %59,1’i kadın cinsiyette olup, yaş ortalaması 40.9±15.60 yıldı. Hastaların en sık tarifledikleri başvuru semptomu karın ağrısıydı (%42,4). En sık tutulum yeri sırasıyla karaciğer (%78,8) ve akciğerdi (%18,2). Hastaların büyük çoğunluğunda soliter kist (%84,8) vardı. Laboratuvar tetkiklerinde en sık saptanan bulgu total IgE yüksekliğiydi (%74,1). İndirekt hemaglütinasyon (IHA) testi, test edilen hastaların % 77,4’ünde pozitif olarak saptandı. Sonuç: Çalışmamızda kist hidatiğin en sık karaciğerde görüldüğü, sıklıkla tek organ tutulumu şeklinde olduğu, laboratuvar tanısında total IgE yüksekliğinin kist hidatik hastalığınını kesin tanısını koydurmasa da tanıya yardımcı olabileceği sonucuna varıldı.
Evaluation of 257 Extra Pulmonary Tuberculosis Cases at the Tuberculosis Control Dispensary, Van, Turkey
(Pakistan Medical Assoc, 2018) Sunnetcioglu, Mahmut; Baran, Ali Irfan; Binici, Irfan; Esmer, Fatih; Gultepe, Bilge
Objective: To determine whether there were any changes in demographic and clinical features of extrapulmonary tuberculosis cases. Methods: This retrospective study was conducted at Yuzuncu Yil University, Van, Turkey, and comprised records of extrapulmonary tuberculosis patients treated between January 2009 and July 2014 at the tuberculosis control dispensary. Descriptive and clinical data, including age, gender, site of involvement, diagnostic method and coexisting systemic diseases, were noted. Any changes in terms of these parameters were investigated on a yearon- year basis. SPSS 20 was used for data analysis. Results: There were 257 cases detected. Of them, 50(19.45%) related to 2009, 61(23.75%) to 2010, 24(9.33%) to 2011, 50(19.45%) to 2012, 47(18.28%) to 2013 and 25(9.72%) to 2014. Although lymph nodes were by far most frequently affected in 2009, 2010, 2011 and 2013; pleura was most commonly involved in 2012 and 2014. Age and gender distribution displayed no changes between 2009 and 2014 (p>0.05). However, diagnostic method of choice and frequency of co-existent systemic disorders displayed remarkable alterations in this period (p<0.05). Conclusion: Improved insight of clinicians for atypical demographic and clinical features at presentation may provide reduction of rates of morbidity and mortality due to extrapulmonary tuberculosis.
Evaluation of Cerebrospinal Fluid Levels for Alox5, S100b, Defa1, and Gfap in Infectious Meningitis
(Lippincott Williams & Wilkins, 2023) Baran, Ali Irfan; Huyut, Zubeyir; Oncu, Mehmet Resit; Akbay, Halil Ibrahim; Akmese, Sukru; Karsen, Hasan; Tarcan, Tayyar
Background: The aim of this study was to determine how the levels of peptide and protein-based biomarkers in cerebrospinal fluid change in bacterial, tuberculous, and aseptic meningitis, and to determine the success of these agents in distinguishing between different types of infectious meningitis.Methods: The levels of arachidonate-5-lipoxygenase, S100 calcium-binding protein B, defensin-alpha 1, and glial fibrillary acidic protein in cerebrospinal fluid samples from 20 tuberculosis, 40 bacterial, 25 aseptic meningitis patients, and 55 control groups were measured and compared using an enzyme-linked immunosorbent assay.Results: The mean age of the patients was 37.9 +/- 14.4 years. The parameter that contributed the most to the differential diagnosis of the infectious meningitis groups was S100 calcium-binding protein B. The S100 calcium-binding protein B levels were significantly higher in the tuberculous meningitis group than in the other groups, and arachidonate-5-lipoxygenase levels were significantly higher in the tuberculous meningitis and bacterial meningitis groups (P < .05).Conclusion: This study showed that cerebrospinal fluid arachidonate-5-lipoxygenase, and S100 calcium-binding protein B levels may differ in bacterial, aseptic, and tuberculous meningitis, and the results obtained may be quite effective as important potential biomarkers in the differential diagnosis of different types of meningitis.
Evaluation of Oculocutaneous Anthrax. a Series of 20 Cases
(Carbone Editore, 2015) Gonullu, Hayriye; Karads, Sevdegul; Batur, Muhammed; Baran, Ali Irfan; Sunnetcioglu, Mahmut
Introduction: Cutaneous anthrax is the most common clinical presentation of human anthrax. This study presents an evaluation of cases of ocular lesions from cutaneous anthrax. Methods: A total of 20 patients who attended the emergency department of Yuzuncu Yil University, School of Medicine between 2007 and 2013 were enrolled in the study. Results: 65% of the cases were female and 35% were male. The mean age was 29.16+/-14.80. In 60% there were periorbital lesions in the right eye. 90% of the patients had a history of contact with animals or had eaten animal meat. The mean starting time of lesion was 3.2+/-1.2 days before admittance. In 75% of the cases the diagnosis was based on the characteristic appearance of the lesion and the patient's history. All the patients spent 9.9+/-4.3 days in hospital. Upper eyelid scar tissue and ectropion were found respectively in 20 % and 10 % of the cases. Conclusions: Early diagnosis and appropriate antibiotic treatment can facilitate recovery and prevent the development of eyelid complications.
Evaluation of Risk Factors in Patients With Ventilator-Associated Pneumonia Caused by Acinetobacter Baumannii
(Univ Udayana, 2020) Baran, Ali Irfan; Celik, Mehmet; Arslan, Yusuf; Demirkiran, Hilmi; Sunnetcioglu, Mahmut; Sunnetcioglu, Aysel
Purpose: Ventilator-associated pneumonia is a significant disease with high mortality rates. Acinetobacter baumannii is one of the most critical pathogens leading to ventilator-associated pneumonia. This study aims to evaluate the underlying risk factors in patients diagnosed with ventilator-associated pneumonia caused by Acinetobacter baumannii, who were followed in intensive care units of our hospital. Patients and Methods: The data of 112 patients diagnosed with ventilator-associated pneumonia caused by Acinetobacter baumannii, who were followed in Intensive Care Units other than Pediatric Intensive Care Unit of our hospital from 2013 to 2017, were evaluated retrospectively. Results: Of the cases included in our study, 70.5% were male, and 29.5% were female patients. Of the cases, 875% were followed in Anaesthesiology and Reanimation Intensive Care Unit. The most common modifiable risk factors are mechanical ventilation, antacid use, and the most common non-modifiable risk factors were the presence of trauma and a history of cardiovascular disease. Conclusion: Ventilator-associated pneumonia is a clinical condition with high mortality and morbidity in intensive care units. Incidence and mortality of ventilator-associated pneumonia can be reduced through the implementation of some necessary policies for the prevention of ventilator-associated pneumonia and the practices for the reduction or elimination of modifiable risk factors.
Hastanemize Başvuran Gebe Hastalarda Rubella, Cytomegalovırus, Toxoplasma Gondii Seroprevalansı, Ölü Doğum ve Erken Doğum Oranları, Igg Pozitif Hastalarda Igg Avidite Karşılaştırılması
(2021) Gürbüz, Esra; Baran, Ali Irfan
Bu çalışmanın amacı, gebelerde Rubella, Cytomegalovırus ve T. gondii seroprevalansını belirlemek, ölü doğum ve erken doğum oranlarının saptanması ayrıca IgG antikorları pozitif olan gebe hastalarda avidite bakılarak IgG avidite değerlerinin karşılaştırılmasıdır. Çalışma, Kadın Hastalıkları ve Doğum Polikliniği’ne başvuran 18-48 yaş aralığındaki gebe hastalardan alınan 300 kan örneğinde Cytomegalovirus, Rubella ve T.gondii IgG ve IgM antikorlarının araştırılması amacıyla ELISA yöntemi ile yapıldı. Gebelerden alınan kan örneklerinde Rubella IgG %96 ve Rubella IgM %4, CMV IgG %99 ve CMV IgM %1,3, T.gondii IgG %56,3 ve IgM %7,6 oranında seropozitiflik tespit edildi. Ölü doğum/erken doğum olan gebelerde alınan kan örneklerinde oranlar sırasıyla Rubella IgM 2 (%18,1) / 4 (%17,3), Rubella IgG 11 (%100) / 22 (%95,6), CMV IgM 1 (%9) / 2 (%8,6), CMV IgG 11 (%100) / 23 (%100), T.gondii IgM 1 (%9) / 3 (%13), T.gondiiIgG 4 (%36,3) / 8 (%34,7) olarak saptandı. Avidite değerlerinin sırayla düşük/gri zon/yüksek değerlerin Rubella’da 3/0/2, Cytomegalovırus’te 0/0/3 ve T.gondii’de 8/1/12 şeklinde olduğu saptandı. Sonuç olarak, düşük veya ölü doğumlara sebep olabilen T. gondii, Cytomegalovırus ve Rubella etkenleri, bölgemizdeki gebe hastalarda halen önemini koruyan sağlık sorunları arasındadır. Serolojik yöntemlerin, bu enfeksiyonların teşhisinde ve IgG avidite testi yapılarak şüpheli durumların netleştirilmesinde, hekime yol gösterici bir yöntem olabileceği kanaatine varıldı.
Hematologic Inflammation Indices for Differentiating Between Brucella, Pyogenic, and Tuberculous Spondylodiscitis
(Mdpi, 2024) Baran, Ali Irfan; Binici, Irfan; Arslan, Yusuf; Karaduman, Zekiye Hakseven; Ilter, Server; Tarcan, Tayyar; Unal, Murat
Infectious spondylodiscitis is a life-threatening disease and has some challenges in terms of diagnostic, differentiative, and therapeutic processes. Therefore, rapid and effective management of infectious spondylodiscitis is necessary. Hematological inflammation indices (HIIs) such as the neutrophil/lymphocyte ratio and aggregate index of systemic inflammation are derived from blood cells and used as diagnostic, prognostic, predictive, and treatment monitoring indicators. This study aimed to evaluate HIIs for discriminating between infectious spondylodiscitis pathogens. This retrospective comparative study included 116 patients with infectious spondylodiscitis. According to the responsible infectious pathogens, three types of infectious spondylodiscitis were defined: Brucella (n = 51), pyogenic (n = 43), and tuberculous (n = 22). The HIIs were derived from baseline complete blood counts. The three types of infectious spondylodiscitis were statistically compared for the HII scores. We found that the Brucella group had significantly lower HII scores than the pyogenic group (p < 0.05). Also, the Brucella group had significantly lower HII scores than the tuberculous group (p < 0.05). However, no significant differences were found between the pyogenic and tuberculous groups regarding HIIs (p > 0.05). In conclusion, the HIIs may be considered in the differentiation between Brucella spondylodiscitis and other types of infectious spondylodiscitis.