Browsing by Author "Barzani, Hemn A. H."

Now showing 1 - 13 of 13

An Anodically Pretreated Boron-Doped Diamond Electrode Surface for Square-Wave Adsorptive Stripping Voltammetric Quantification of the Non-Absorbable Antibiotic Rifaximin in the Pharmaceutical Formulation
(Elsevier Science Sa, 2023) Barzani, Hemn A. H.; Ali, Hoshyar Saadi; Yardim, Yavuz
This study presents an electroanalytical examination with the voltammetric technique for quantitatively evaluating rifaximin (RFX) using the non-modified boron-doped diamond (BDD) electrode. By utilizing cyclic voltammetry (CV) method, RFX illustrated only one well-defined, irreversible, adsorption-controlled by oxidation and reduction peak at about +0.64 V and +0.21 V, respectively, (vs Ag/AgCl) in 0.1 M HNO3 solution. The square-wave (SW) voltammetric technique examined the dependence of potentials and current intensities on the BDD electrode pretreatment, the nature of a supporting electrolyte, pH, and another characteristic. When the SW mode was used, a satisfactory linear response was achieved in 0.1 M HNO3 solution at +0.56 V (vs Ag/AgCl). The dynamic range is observed from 0.5 to 20.0 mu g mL-1 (6.36 x 10-7-2.54 x 10- 5 M) via a low limit of detection of 0.14 mu g mL-1 (1.7810-7 M). The applicability of the developed method for detecting RFX was exhibited in pharmaceutical formulation samples.
Developing an Electroanalytical Procedure for the Determination of Caffeic Acid Phenethyl Ester at a Boron-Doped Diamond Electrode by the Use of Cationic Surfactant Media
(Elsevier Science Sa, 2022) Barzani, Hemn A. H.; Ali, Hoshyar Saadi; Ozok, Hande Izem; Yardim, Yavuz
The aim of the present work is to describe voltammetric analysis of caffeic acid phenethyl ester (CAPE) by using a boron-doped diamond (BDD) electrode in the presence of the cationic surfactant. Using cyclic voltammetry, CAPE demonstrated a single well-defined, quasi-reversible, adsorption-controlled by oxidation and reduction peak at approximately +0.44 V & +0.22 V respectively, (vs. Ag/AgCl) in the Britton-Robinson buffer (BR, 0.04 mol L-1, pH 5.0). The obtained results showed that the oxidation peaks of CAPE are pH dependent (ranging from 2.0 to 6.0). The oxidation peak currents of CAPE were significantly increased by using cetyltrimethylammonium bromide (CTAB, cationic surfactant) in the selected supporting electrolyte. Under the optimum parameters of experiment, the linear relationship was found for CAPE determination in 0.04 mol L-1 BR buffer solution (pH 5.0) including 1 x 10(-4) mol L-1 CTAB at +0.41 V (vs. Ag/AgCl) (after 30 s accumulation at the open-circuit condition). The linear range was found with 0.01 to 1.0 mu g mL(-1) (3.5 x 10(-8)-3.5 x 10(-6) mol L-1) via the detection limit 0.0028 mu g mL(-1) (9.8 x 10(-9) mol L-1). The developed approach was used successfully to detect CAPE concentration in the model urine samples. To our knowledge, this is the first approach for electrochemically analyzing of CAPE.
The Effect of Ctab, a Cationic Surfactant, on the Adsorption Ability of the Boron-Doped Diamond Electrode: Application for Voltammetric Sensing of Bisphenol a and Hydroquinone in Water Samples
(Elsevier, 2021) Hoshyar, Saadi Ali; Barzani, Hemn A. H.; Yardim, Yavuz; Senturk, Zuhre
The present study introduces for the first time the effect of the cationic surfactant, cetyltrimethylammonium bromide (CTAB) on the adsorption capability of the boron-doped diamond (BDD) electrode for the sensing of environmental pollutants bisphenol A (BPA) and hydroquinone (HQ). Cathodic pretreatment of the electrode surface after an anodic pretreatment exhibited a best electrochemical response for these two phenolic compounds. The electrochemical characteristics of BPA and HQ were first sufficiently documented by cyclic voltammetry in aqueous solutions without the addition of surfactant over a shorter and longer potential range. Square-wave voltammetry was employed for a detailed study depending on the operational conditions (e.g., pH and nature of supporting electrolyte, concentration of CTAB, accumulation variables, instrumental parameters, etc.). The sensitivity of the voltammetric measurements for BPA and HQ was increased when CTAB was present in strong acidic media (more effective for BPA) due to its interaction with the neutral forms of the selected compounds on the hydrophobic surface of BDD electrode. Besides, a significant increase in the detecting sensitivity of BPA in CTAB-containing solutions could be obtained after applying an accumulation process. Using square-wave stripping mode (after 30 s accumulation at open-circuit condition) in 0.1 M H2SO4 containing 1 x 10(-4) M CTAB, the limits of detection were found to be 0.05 mu g/mL (2.19 x 10 M), and 0.23 tig/mL (2.09 x 10(-6) M) for the simultaneous determination of BPA and HQ, respectively. In this way, modification-free BDD electrode could introduce an alternative to chemically modified electrodes for the analysis of environmental samples.
Electroanalytical Sensing of Antidiabetic Drug Linagliptin by Using Square-Wave Voltammetry on the Boron-Doped Diamond Electrode
(Springer Wien, 2024) Barzani, Hemn A. H.; Ali, Hoshyar Saadi; Yardim, Yavuz
This research paper presents an electroanalytical investigation utilizing voltammetry to quantify the antidiabetic drug linagliptin with an unmodified boron-doped diamond electrode. Using cyclic voltammetry, linagliptin exhibited a single, distinct, irreversible oxidation peak at around + 1.03 V (vs. Ag/AgCl) in a 0.1 mol dm-3 phosphate buffer solution at pH 7.4. The square-wave voltammetry technique achieved acceptable linearity at approximately + 0.94 V in PBS (pH 7.4). The methodology demonstrated linearity within the concentration range of 1.0 and 50.0 mu g cm-3 (equivalent to 2.1 x 10-6-1.1 x 10-4 mol dm-3) and yielded a limit of detection of 0.28 mu g cm-3 (equivalent to 5.9 x 10-7 mol dm-3). The investigation of the proposed method's applicability was ultimately conducted through the sensing of linagliptin in drug formulations. The established methodologies can serve as viable alternatives to other analytical techniques due to their cost-effectiveness, user-friendliness, efficiency, and ability to yield reliable and repeatable results.
Fast and Simple Voltammetric Sensing of Avanafil in the Pharmaceutical Formulation by Using Unmodified Boron-Doped Diamond Electrode
(Iapc Publishing, 2024) Ali, Hoshyar Saadi; Barzani, Hemn A. H.; Yardim, Yavuz
Background and purpose: Erectile dysfunction is a common issue among adult males involving difficulty in maintaining an erection, and it is often treated with fast -acting, low -side -effect drugs like avanafil (AVN), among other phosphodiesterase-5 inhibitors. Hence, developing fast, simple, and sensitive methods to detect AVN is crucial. Experimental approach: This study conducts an electroanalytical inquiry and provides a new voltammetric method for accurately analyzing AVN utilizing a boron -doped diamond (BDD) electrode without any modifications. Key results: In the Britton -Robinson buffer (BR, 0.04 mol L-1, -1 , pH 4.0), cyclic voltammetry showed a clearly defined and irreversible anodic peak at around +1.44 V relative to Ag/AgCl. The pH of the solution was shown to have an impact on the voltammetric signals of the oxidation peaks. A good linear response for AVN quantification was achieved using square -wave voltammetry. This was done in a 0.04 mol L-1 BR (pH 4.0) solution at a potential of +1.33 V ( vs. Ag/AgCl). The method exhibited a wide dynamic range of 0.5 to 30.0 p.g mL-1 -1 (1.0 to 62 p.mol L-1) -1 ) and a low limit of detection of 0.14 p.g mL-1 -1 (0.29 p.mol L-1). -1 ). The method proposed demonstrated suitability for determining AVN content in pharmaceutical formulations. The accuracy of the approach was demonstrated by comparing the results obtained using the developed method with those achieved using the UV-Vis spectrometry method. Conclusion: Our method simplifies the analytical process by eliminating the need for electrode modification, reducing both time and resource requirements while enhancing overall feasibility. (c) 2024 by the authors. This article is an open -access article distributed under the terms and conditions of the Creative Commons Attribution license ( http://creativecommons.org/licenses/by/4.0/ ).
First Approach for the Voltammetric Sensing of Rifabutin by the Use of Cationic Surfactant Media on the Boron-Doped Diamond Electrode
(Elsevier Science Sa, 2023) Barzani, Hemn A. H.; Yardim, Yavuz
An excellent electrochemical sensor for determining rifabutin (RFB) by square-wave voltammetry was developed utilizing a non-modified boron-doped diamond electrode. Measurements of RFB using cyclic voltammetry with Britton-Robinson buffer (BR, 0.04 M, pH 7.0) solution revealed irreversible behaviour, diffusion-controlled as well as well-defined two oxidation peaks at around +0.67 (PA1) and + 1.23 (PA2) V vs Ag/AgCl. RFB oxidations depend critically on pH and supporting electrolytes. The anodic peak currents of the RFB were enormously enhanced by adding cetyltrimethylammonium bromide (CTAB, cationic surfactant) in the chosen supporting electrolyte, mainly when accumulating conditions were utilized. RFB was quantified using its two anodic peaks. By using optimized procedures also instrumental variables, the current response via RFB is proportionally linear throughout the concentration range of 0.1 to 10.0 mu g mL-1 (1.18 x 10-7-1.18 x 10-5 M) via a detection limit of 0.030 mu g mL-1 (3.54 x 10-8 M) for PA1 and 0.026 mu g mL-1 (3.07 x 10-8 M) for PA2 in BR buffer (PH 7.0) solution. Ultimately, the proposed approach was accurately utilized to evaluate RFB in pharmaceutical formu-lation. To the greatest of our knowledge, this is the first approach for electroanalytical determination of RFB.
First Electrochemical Investigation of the Potent Antibiotic Rifapentine: Enhanced Voltammetric Detection Using a Boron-Doped Diamond Electrode in Tween-Mediated Measurements
(Elsevier Science Sa, 2025) Barzani, Hemn A. H.; Ali, Hoshyar Saadi; Yardim, Yavuz
A non-modified boron-doped diamond electrode provided excellent electrochemical sensing capabilities for detecting rifapentine (RPT) using square-wave voltammetry. RPT was measured by cyclic voltammetry with phosphate buffer solutions (PBS, 0.1 M, pH 2.5), which exhibited irreversible behavior with distinct oxidation peaks at approximately +0.53 V (PA1) and + 1.08 V (PA2). The oxidation of RPT is strongly influenced by both pH and the choice of supporting electrolytes. The addition of the non-ionic surfactant Tween 20 to the supporting electrolyte notably enhanced the anodic peak currents of RPT. RPT was measured using two anodic peaks. Under optimal experimental conditions and instrumental factors, the current response for RPT exhibited a linear relationship within the range of 1 to 25.0 mu g mL-1 (1.1 x 10-6-2.9 x 10-5 M), with detection limits of 0.29 mu g mL-1 (3.3 x 10- 7 M) for PA1 (+0.48 V) as well as 0.19 mu g mL-1 (2.2 x 10- 7 M) for PA2 (+1.04 V) in PBS (pH 2.5). Finally, RPT in a pharmaceutical formulation was accurately quantified using the proposed methodology. This represents, to the best of our knowledge, the first electroanalytical method for determining RPT.
First Electrochemical Study of a Potent Antifungal Drug Caspofungin: Application To Its Enhanced Voltammetric Sensing Based on the Performance of Boron-Doped Diamond Electrode in Ctab-Mediated Measurements
(Elsevier Science Sa, 2022) Ali, Hoshyar Saadi; Barzani, Hemn A. H.; Yardim, Yavuz; Senturk, Zuhre
This present study describes the first electrochemical investigation of caspofungin, which is a semisynthetic echinocandin class of antifungal drug. For this purpose, an electrochemically pretreated (anodically and subsequently cathodically) boron-doped diamond (BDD) electrode was used. The cyclic voltammetric scans showed a single oxidation step that is irreversible and controlled by a dual mechanism of adsorption and diffusion. For the optimization of experimental conditions, the influence of the electrode pretreatment, pH of the supporting electrolyte, concentration of cationic surfactant cetyltrimethylammonium bromide (CTAB), accumulation variables, and instrumental parameters was examined on the current response of caspofungin. The improved sensitivity of the voltammetric measurements was observed due to the synergistic effect of CTAB on the adsorption capacity of BDD electrode in alkaline pH conditions. Employing square-wave adsorptive stripping voltammetry (using open-circuit accumulation for 60 s), the oxidation signal at around +0.45 V allowed to the determination of caspofungin in Britton-Robinson buffer at pH 11.0 containing 1 x 10-4 M CTAB. The process could be used in the concentration range from 2.06 x 10-7 to 1.03 x 10-5 M (from 0.25 to 12.5 mu g mL-1 as acetate salt) with a detection limit of 5.27 x 10-8 M (0.064 mu g mL-1 as acetate salt). A technique developed here was used successfully to determine caspofungin concentration in commercial parenteral dosage formulations.
A New Approach for the Voltammetric Sensing of the Phytoestrogen Genistein at a Non-Modified Boron-Doped Diamond Electrode
(Wiley-v C H verlag Gmbh, 2022) Barzani, Hemn A. H.; Ali, Hoshyar Saadi; Sahin, Cihat; Kiran, Musa; Yardim, Yavuz
An effective electrochemical sensor was constructed using an unmodified boron-doped diamond electrode for determination of genistein by square-wave voltammetry. Cyclic voltammetric investigations of genistein with HClO4 solution indicated that irreversible behavior, adsorption-controlled and well-defined two oxidation peaks at about +0.92 (P-A1) & +1.27 V (P-A2). pH, as well as supporting electrolytes, are important in genistein oxidations. Quantification analyses of genistein were conducted using its two oxidation peaks. Using optimized experiments as well as instrumental conditions, the current response with genistein was proportionately linear in the concentrations range of 0.1 to 50.0 mu g mL(-1) (3.7x10(-7)-1.9x10(-4) mol L-1), by the detection limit of 0.023 mu g mL(-1) (8.5x10(-8) mol L-1) for P-A1 and 0.028 mu g mL(-1) (1.1x10(-7) mol L-1) for P-A2 in 0.1 mol L-1 HClO4 solution (in the open circuit condition at 30 s accumulation time). Ultimately, the developed method was effectively applied to detect genistein in model human urine samples by using its second oxidation peak (P-A2).
Quantification of Ferulic Acid Using Square-Wave Voltammetric Method at an Unmodified Boron-Doped Diamond Electrode
(Springer Wien, 2023) Pinar, Pinar Talay; Barzani, Hemn A. H.; Ali, Hoshyar Saadi; Yardim, Yavuz
For the first time, a boron-doped diamond electrode was employed in square-wave voltammetry for the sensitive and selective measurement of ferulic acid (FA). The impact of the electrode's pretreatment procedure on the current response was investigated, leading to the discovery that the consecutive pretreatment approach yielded the most optimal signal results. This determination was made upon observing that the highest quality signal could be obtained through this method. The electrochemical oxidation of FA was studied in aqueous media on a cathodically pretreated boron-doped diamond electrode. FA was shown to have two sets of oxidation/reduction peaks when tested in aqueous solutions using cyclic voltammetry. Diffusion governs the electrode process, which is pH-dependent. In 0.1 mol dm-3 H2SO4, the calibration curves were linear for FA peak over dynamic ranges of 5.1 x 10-7-4.1 x 10-5 mol dm-3, via a detection limit of 1.5 x 10-7 mol dm-3. The practical applicability of the developed methodology was tested in the commercial ampoule formulation of FA. The method can be used instead of other analytical methods because it is fast, easy to use, and cheap, has a wide calibration range, and gives consistent results.
Sensing Ivacaftor Accomplished Using the Square-Wave Voltammetric Technique With the Assistance of a Cationic Surfactant on a Boron-Doped Diamond Electrode
(Elsevier Science Sa, 2024) Barzani, Hemn A. H.; Ali, Hoshyar Saadi; Yunusoglu, Oruc; Yardim, Yavuz
This investigation aims to describe the voltammetric analysis of ivacaftor (IVA) by utilizing the boron -doped diamond (BDD) electrode to add a cationic surfactant. Cyclic voltammetry via Britton-Robinson (BR, 0.04 mol L-1, pH 2.0) buffer was used to perform determinations of the IVA demonstrating irreversible behaviors, adsorption-controlled and well-defined (+1.04 V, PA1) and an ill-defined (+1.42 V, PA2) oxidation peaks (vs. Ag/ AgCl). The findings revealed that the oxidation peaks of IVA are pH-dependent (ranging from 2.0 to 5.0). The use of cetyltrimethylammonium bromide (CTAB, cationic surfactant) in the chosen supporting electrolyte enormously raised the oxidation peak currents of IVA. For the measurement of IVA in a 0.04 mol L-1 BR buffer solution with a pH of 2.0, the linear relationship was discovered to exist under the conditions of the experimental optimal parameters involving 2 x 10-4 mol L-1 CTAB at +1.11 V (vs. Ag/AgCl) (after an accumulation of 60 s at the open-circuit condition). The linear concentration was discovered using 0.25 to 10.0 mu g mL-1 (6.4 x 10-7-2.5 x 10-5 mol L-1) and the limit of detection 0.073 mu g mL-1 (1.9 x 10-7 mol L-1). The devised methodology was effectively employed to determine IVA in pharmaceutical formulation. To the best of our understanding, it represents the first electroanalytical method for detecting IVA by voltammetry.
An Unmodified Boron-Doped Diamond Electrode for Electroanalytical Investigation and Sensitive Voltammetric Quantification of Antiviral Drug Famciclovir in the Pharmaceutical Formulation and Serum Samples
(Elsevier Science Sa, 2022) Yardim, Yavuz; Ali, Hoshyar Saadi; Barzani, Hemn A. H.
The current study offers an electroanalytical investigation and a novel voltammetric approach for the quanti-tative analysis of famciclovir (FCV) utilizing an unmodified boron-doped diamond (BDD) electrode. An irre-versible, well-defined, diffusion-controlled anodic peak was observed at approximately +1.27 V (vs. Ag/AgCl) in acetate buffer solution (ABS, 0.1 mol L-1, pH 4.7) when the agent was tested using cyclic voltammetry. The voltammetric signals of the oxidation peaks are pH dependent (ranging from 2.0 to 7.0). Using square-wave mode, a good linear response was obtained for FCV quantification in 0.1 mol L-1 ABS (pH 4.7) solution at +1.26 V (vs. Ag/AgCl). Wide dynamic range was found for 0.1 to 50.0 mu g mL-1 (3.11 x 10-( 7)-1.56 x 10(-4) mol L-1), with a low detection limit of 0.029 mu g mL-1 (9.02 x 10(-8) mol L-1). Applicability of the proposed method for the determination of FCV was demonstrated in the pharmaceutical formulation and model serum samples.
Utilizing Epicatechin Voltammetric Oxidation Signal for the Estimation of Total Phenolic Content in the Tea Samples Via the Unmodified Boron-Doped Diamond Electrode Surface
(Elsevier, 2023) Ali, Hoshyar Saadi; Barzani, Hemn A. H.; Yardim, Yavuz
In this work, the boron-doped diamond (BDD) electrode surface was employed for the first time in conjunction with the epicatechin (EC) oxidation signal to estimate the total phenolic content of tea samples by voltammetry. During cyclic voltammetry analysis of the EC, an easily identifiable, irreversible, and adsorption-controlled oxidation peak was observed at around +1.05 V (vs. Ag/AgCl) in HNO3 solution. Our experimental setup was fine-tuned by investigating the effect of electrode pretreatment, pH of the supporting electrolyte, accumulation factors, and instrumental parameters on the oxidation peak response of EC. When measuring EC in a 0.1 mol L-1 HNO3 solution at +1.0 V, square-wave adsorptive stripping voltammetry provided a highly linear response (at open-circuit accumulation for 30 s). The dynamic range was determined to be between 1.0 and 50.0 mu g mL-1 (3.4510-6-1.7210-4 mol L-1), while the detection limit was found to be 0.28 mu g mL-1 (9.6510-7 mol L-1). Selectivity studies were performed with other phenolic compounds found in tea such as epigallocatechin gallate, catechin, tannic acid, and gallic acid. Finally, by assessing the total phenolic content in the black and green tea samples, the suggested approach's applicability was shown by providing an estimate of the EC equivalents present in the samples.