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Browsing by Author "Basaran, M"

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    Article
    Aggressive Non-hodgkin's Lymphoma Treated at the Institute of Oncology, Istanbul - Treatment, Outcome, and Prognostic Factors
    (Lippincott Williams & Wilkins, 2002) Alici, S; Bavbek, SE; Kaytan, E; Basaran, M; Eralp, Y; Onat, H
    In an unselected group of patients with aggressive non-Hodgkin's lymphoma (A-NHL) treated at our institution during a 10-year period (1989-1998), we studied the treatment outcome and influence of possible prognostic factors. Two hundred one patients with A-NHL were analyzed retrospectively with regard to personal, treatment, and disease-specific characteristics. Median age was 55 years (range: 16-87 years) and the male:female ratio was 1.5. During a median follow-up of 26 months, the overall response rate was 74% (complete response 63%, partial response 11%). The 2- and 5-year disease-free survival rates were 49 +/- 3% (mean +/- SEM) and 41 +/- 4%, respectively. In a univariate analysis, the following variables were associated with prognosis in terms of survival: patient age, clinical stage, performance status, B symptoms, erythrocyte sedimentation rate, treatment response, and histologic grade of tumor. In multivariate analyses, patient age, performance status, and treatment response emerged as independent prognostic factors for survival.
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    Article
    Clinical Characteristics of Gestational Trophoblastic Disease at a Single Institute
    (Tohoku Univ Medical Press, 2002) Alici, S; Eralp, Y; Saip, P; Argon, A; Basaran, M; Topuz, E; Aydiner, A
    ALICI, S., ERALP, Y., SAIP, P., ARGON, A., BASARAN, M., Topuz, E. and AYDINER, A. Clinical Characteristics of Gestational Trophoblastic Disease at A Single Institute. Tohoku J. Exp. Med., 2002, 197 (2), 95-100-Gestational trophoblastic diseases (GTD) represent a group of malignancies classified as invasive mole, chorlocarcinoma, and placental-site trophoblastic tumors. The overall cure rate in the treatment of this malignant disorder now exceeds 90%. The aim of this study is retrospectively to evaluate the clinical characteristics and effectiveness of single-agent chemotherapy (CT) and combination chemotherapy according to the World Health Organization (WHO) risk groups of gestational trophoblastic diseases. Thirty one patients with GTD were treated in our institute between 1990-1998. Median age at presentation was 29 years (range 19-70 years). All patients were classified with respect to the WHO scoring system. According to this system, patients were divided into three clinical groups: low-risk nonmetastatic (low-risk group with good prognosis), low-risk metastatic, and high-risk metastatic (high risk group with poor prognosis). Eighteen patients in the nonmetastatic low-risk group with favorable prognostic factors received single agent CT (methotrexate and folinic acid), while 3 patients with metastatic low-risk and 10 patients in the metastatic high-risk group with poor prognosis received combination CT (EMA-CO). Complete response (CR) was obtained in all patients in the low risk group with good prognosis, whereas 9/13 (69%) patients in the poor prognosis group achieved CR and 4 (31%) had partial responses. This clinical classification system may be currently prefer for determining initial therapy in women with malignant gestational trophoblastic tumors. And, our report confirms that the alternating EMA/CO regimen is a well-tolerated and effective combination for the treatment of women with high-risk GTD. gestational trophoblastic diseases; EMA/CO; choriocarcinoma (C) 2002 Tohoku University Medical Press.
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