Browsing by Author "Basaranoglu, Murat"

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A Case of Chediak-Higashi Syndrome Presented With Hemophagocytic Lymphohistiocytosis
(Akad Doktorlar Yayinevi, 2011) Akbayram, Sinan; Akgun, Cihangir; Basaranoglu, Murat; Kaya, Avni; Balta, Gunay; Ustyol, Lokman; Oner, Ahmet F.
Chediak Higashi syndrome, is a rare autosomal recessive disorder characterised by oculocutaneus albinism, recurrent respiratory system infections and other pyogenic infections. Hemophagocytic lymphohistiocytosis can develop in any time of the life in patients with Chediak Higashi syndrome. A 14-month-old girl patient was diagnosed as hemophagocytic lymphohistiocytosis with the laboratory findings of pancytopenia, high levels of triglyceride and ferritin, hypofibrinogenemia, low ratio of natural killers in lymphocyte subtypes, and with determined macrophages that made hemophagocytosis in recurrent bone marrow aspirates. The treatment protocol of hemophagocytic lymphohistiocytosis 2004 was administered. During the maintenance treatment, recurrence was developed. In the second bone marrow examination, the diagnosis of Chediak Higashi syndrome was made with determined intracytoplasmic giant granules. Hair analysis result was meaningful for Chediak Higashi syndrome. In this report, we would like to emphasize the condition that especially in early infants, Chediak Higashi syndrome presenting with hemophagocytic lymphohistiocytosis may be misdiagnosed because of the uncertain clinical findings and this can be the result of resistance to treatment.
A Case With Theophylline Intoxication
(Aves, 2013) Sal, Ertan; Kaya, Avni; Temel, Hayrettin; Basaranoglu, Murat; Caksen, Huseyin
Theophylline is an agent used in the treatment of obstructive airway diseases. It has a risk of intoxication with serum concentrations higher than 15 mu g/mL. A seven-year-old female patient presented with complaints of vomiting and headache. She had tachycardia and other physical examination findings were found to be normal. We were informed that she ingested 10 tablets named Bronkolin (R) each containing 300 mg theophylline. Her serum theophylline levels were found to be > 40 mu g/ml (normal range: 10-20 mu g/ml). She was monitorized and received charcoal, potassium supplementation and intravenous fluid. Her serum theophylline declined to 3.1 mu g/ml and she was discharged. With this case presentation we wanted to emphasize that the possibility of drug intoxication should be considered in presence of hyperglycemia, hypopotassemia and tachycardia with accompanying symptoms including acute and unexplained vomiting and headache.
Cerebral Venous Sinus Thrombosis in 2 Children With Celiac Disease
(Sage Publications inc, 2011) Dogan, Murat; Peker, Erdal; Akbayram, Sinan; Bektas, Mehmet S.; Basaranoglu, Murat; Cesur, Yasar; Caksen, Huseyin
Cerebral venous sinus thrombosis (CVST) is an uncommon disease in childhood. In the largest study carried out so far, the incidence was 0.67 case per 100 000 children per year. A number of etiologies and risk factors have been so far identified for CVST in childhood, including head trauma, local and systemic infectious diseases, malignancies, and autoimmune diseases. Celiac disease (CD) is a disease of the small intestine caused by an immune response to ingested gluten. Epilepsy, bilateral occipital calcification, cerebellar ataxia, degenerative central nervous system disease, peripheric neuropathy, myopathy, and rarely stroke were defined as neurologic disorders. In this presentation, we report 2 cases (16-year-old boy and 2-year-old boy) with CD and CVST. We emphasized that CD can be investigated in patients with CVST even with the absence of gastrointestinal symptoms. Finally, we suggest that algorithm of CVST can be involved in the investigation of CD.
Clinical and Laboratory Findings of Paediatric Patients With Brucellosis
(Galenos Yayincilik, 2021) Karaman, Serap; Bitkin, Eda Celebi; Sonmez, Bulent; Basaranoglu, Murat; Karaman, Kamuran; Tuncer, Oguz
Objective: Brucellosis is the most common bacterial zoonotic disease transmitted via unpasteurised milk and dairy products from infected animals. This study aimed to evaluate paediatric patients treated for brucellosis and followed for 2 years. Materials and Methods: The records of 73 patients with childhood brucellosis who had undergone treatment and follow-up for 2 years were retrospectively evaluated. Results: The patient age ranged from 1 to 14 years, with 39 boys (53%) and 34 girls (47%). Fever (94%) was the first common symptom. Other symptoms, in the order of frequency, were myalgia (80%), arthralgia (75%), fatigue (38%) and anorexia (33%). Complications included sacroiliitis (12%), hemophagocytic lymphohistiocytosis (4%), epididymo-orchitis (1.3%), focal abscess (1.3 %) and meningitis (1.3%). Splenomegaly, hepatomegaly and lymphadenopathy (24%, 33% and 5%, respectively) were also reported. Moreover, 18% of the patients had hepatosplenomegaly at initial admission. Dermatological involvement revealed maculopapular rash in 4.1% and petechial rash in 9.6% of patients. Body weight loss was observed in 14% of the cases. In addition, 76.3% and 23.7% of the patients had acute and sub-acute forms, respectively. Conclusion: Brucellosis can display several different clinical presentations. This diversity can lead to diagnostic delay. In settlements where the disease is common, patients with fever and joint pain should be treated early and the disease should be ruled out.
Clinical Outcome and Magnetic Resonance Imaging Findings in Infants With Hypoglycemia
(Sage Publications inc, 2011) Caksen, Huseyin; Guven, Ahmet Sami; Yilmaz, Cahide; Unal, Ozkan; Basaranoglu, Murat; Sal, Ertan; Kaya, Avni
The authors examined clinical outcome and cranial magnetic resonance imaging (MRI) findings in infants with hypoglycemia to determine the effects of hypoglycemia on the developing brain. A total of 110 infants with hypoglycemia were included in the study. Of the patients, 36 were females and 74 were males. The age of the infants was between 1 day and 22 months. Of the 110 infants, 47 were preterm neonates, 40 were term neonates, and 23 were older than 28 days. No difference in serum glucose level was noted between symptomatic and asymptomatic infants. The most common observed abnormal findings were hyperintense lesions, encephalomalacia, and cerebral atrophy. Abnormal MRI findings were found in 4% of preterm infants, in 32.5% of term infants, and in 43.5% of older infants. Abnormal MRI findings were statistically significantly more common in symptomatic infants than in asymptomatic infants. Of the infants, 45.5% of hypoglycemic infants had cerebral palsy and/or cerebral palsy plus epilepsy.
Efficiency of Topical Rifampin on Infection in Open Neural Tube Defects: a Randomized Controlled Trial
(Taylor & Francis Ltd, 2021) Deger, Ibrahim; Basaranoglu, Murat; Demir, Nihat; Aycan, Abdurrahman; Tuncer, Oguz
Objectives Neural tube defects are the second most common congenital malformation in humans. Despite significant decreases in neural tube defects and related mortality and morbidity with recent developments, infections remain an important problem. Research on the role of topical therapy for managing neural tube defects and associated infections in the neonatal period has been limited. This randomized controlled trial aimed to investigate the efficiency of topical Rifampin on infection control in paraplegic newborns with open neural tube defects. Methods Thirty-seven patients who underwent an operation for neural tube defects were included. Topical Rifampin and cefotaxime were administered to 19 patients constituting the case group and local saline and cefotaxime were administered to a control group. Patients were examined for ventriculoperitoneal shunt infection/dysfunction, surgical site infection, urinary tract infection, and sepsis. Results None of the patients using topical rifampin had ventriculoperitoneal shunt infection/dysfunction, surgical site infection, urinary tract infection, or sepsis. In the control group, ventriculoperitoneal shunt infection/dysfunction was found in 4 (22.2%) cases, surgical site infection in 3 (27.7%), urinary tract infection in 3 (27.7%), and sepsis in 5 (27.7%), with statistically significant differences between the groups (p = 0.01, p = 0.032, p = 0.032, and p = 0.002, respectively). No local or systemic side effect was observed regarding rifampin use. Conclusion Topical Rifampin is effective in minimizing complications like sepsis, surgical site infection, urinary tract infection, and ventriculoperitoneal shunt infection due to neural tube defect operations. Further research with larger numbers of cases is needed to implement this practice routinely.
Evaluation of Children With Nutritional Rickets
(Walter de Gruyter Gmbh, 2011) Cesur, Yasar; Dogan, Murat; Ariyuca, Sevil; Basaranoglu, Murat; Bektas, Mehmet Selcuk; Peker, Erdal; Caksen, Huseyin
Aim: To evaluate the clinical findings, risk factors, therapy and outcome in 946 children with nutritional rickets. Patients and methods: This retrospective study included a review of medical records of patients with nutritional rickets between March 2004 and 2009. Patients who displayed both the biochemical inclusion criteria and the clinical signs/symptoms or radiological signs of rickets were included in the study. Results: The present study included 946 patients aged between 4 months and 15 years. Distribution of the cases showed a density between December and May. The age at diagnosis, showed two peaks and most of the patients were in the age range 0-23 months and 12.0-15 years. In infants and young children, most of the patients had been admitted to the hospital due to infectious diseases. In older children, short stature and obesity were the most common complaints. Conclusion: Children aged between 0-23 months and 12.0-15 years were under most risk for nutritional rickets, especially in winter and spring and vitamin D should be given to them as supplementation dose.
Evaluation of the Incidence, Characteristics, and Outcomes of Pediatric Chronic Critical Illness
(Public Library Science, 2021) Demirkiran, Hilmi; Kilic, Mehmet; Tomak, Yakup; Dalkiran, Tahir; Yurttutan, Sadik; Basaranoglu, Murat; Oksuz, Hafize
Our aim was to determine characteristics of children with chronic critical illness (CCI) admitted to the pediatric intensive care unit (PICU) of a tertiary care children's hospital in Turkey. The current study was a multicenter retrospective cohort study that was done from 2014 to 2017. It involved three university hospitals PICUs in which multiple criteria were set to identify pediatric CCIs. Pediatric patients staying in the ICU for at least 14 days and having at least one additional criterion, including prolonged mechanical ventilation, tracheostomy, sepsis, severe wound (burn) or trauma, encephalopathy, traumatic brain injury, status epilepticus, being postoperative, and neuromuscular disease, was accepted as CCI. In order to identify the newborn as a chronic critical patient, a stay in the intensive care unit for at least 30 days in addition to prematurity was required. Eight hundred eighty seven (11.14%) of the patients who were admitted to the PICU met the definition of CCI and 775 of them (87.3%) were discharged to their home. Of CCI patients, 289 (32.6%) were premature and 678 (76.4%) had prolonged mechanical ventilation. The total cost values for 2017 were statistically higher than the other years. As the length of ICU stay increased, the costs also increased. Interestingly, high incidence rates were observed for PCCI in our hospitals and these patients occupied 38.01% of the intensive care bed capacity. In conclusion, we observed that prematurity and prolonged mechanical ventilation increase the length of ICU stay, which also increased the costs. More work is needed to better understand PCCI.
Hemiplegic Migraine: a Case Report
(Galenos Yayincilik, 2010) Yilmaz, Cahide; Sonmez, Bulent; Basaranoglu, Murat; Kaya, Avni; Acikgoz, Mehmet; Caksen, Hueseyin
The girl patient aged twelve had been brought to the hospital having weakness at her left side. After having fallen from a balcony, her paroxysmal headeche accompanying nause and vomiting had began. This case was cured by valproic acid. Electroencephalography showed focal slowing and deep wave discharge. This case was presented to remind that hemiplegic migraine can seldomly begin, after minor head trauma. (Turk Arch Ped 2010; 45: 153-4)
Indicator of Early Kidney Injury in Adolescents With Polycystic Ovary Syndrome: Can Urine Ngal Level Be
(Taylor & Francis Ltd, 2021) Karaman, Serap; Sabanciogullari, Enis; Karaman, Erbil; Basaranoglu, Murat; Cetin, Mecnun; Karaman, Kamuran
Introduction and Purpose:The Urinary Neutrophil-gelatinase associated lipocalin (NGAL) levels which are a biomarker for early diagnosis of kidney damage that may develop in patients with Polycystic Ovary Syndrome (PCOS) were investigated in the study. Material and Methods:The 30 patients diagnosed with Polycystic Ovarian Syndrome between the ages of 13 and 18 who applied to the Yuzuncu Yil University General Children's Outpatient Clinic were included in the PCOS group and 30 healthy adolescents without any known acute or chronic illness and drug use were included in the control group. Findings:Urine NGAL value was 842.204 +/- 21.561 in PCOS group and 775.379 +/- 23.98 in control group. NGAL level in PCOS group was statistically significantly higher than control group (p: .045). When we examine the relationship between dyslipidemia and PCOS; While dyslipidemia was positive in 10 (33.7%) patients in the PCOS group, it was negative in 20 (66.7%) patients. While 1 patient had dyslipidemia, 29 patients did not have dyslipidemia in the control group. A significant relationship was found between dyslipidemia and PCOS (p: .005). Conclusion:We found that subclinical kidney dysfunction started in early stage patients in PCOS in our study. The urine NGAL level was thought to increase in response to increased oxidative stress in PCOS. We found no relationship between, insulin resistance and urea, BUN, creatinine and NGAL levels. However, we found a negative correlation between NGAL level and LDL. In addition, dyslipidemia, insulin resistance and ALT elevation were detected in the PCOS group.
İndirekt Hiperbilirubinemili Term Yenidoğanların Etiyolojik Değerlendirmesi
(2024) Basaranoglu, Murat; Batu, Utku; Aycan, Nur; Yurekturk, Eyyup; Karaman, Serap; Tuncer, Oguz
Amaç: İndirekt hiperbilirubinemi, yenidoğanlarda sık görülen birçok risk faktörü olan bir hastalıktır. Çalışmamızda, yenidoğan yoğun bakım ünitemize indirekt hiperbilirubinemi tanısı ile yatırılan hastaların öykü, fizik muayene ve tetkiklerinin, hastaların tedavi ve takipleri üzerine olan etkileri incelenmesi amaçlandı. Yöntemler: Kesitsel ve retrospektif olarak yapılan çalışmamıza, miadında doğan, indirekt hiperbilirunemi tanısıyla yatırılan 226 hasta alındı. Hasta dosyalarından öyküleri, fizik muayene ve tetkik verileri değerlendirildi. Bulgular: Çalışmaya alınan 226 hastanın 126’sı (%55,8) erkek, 100’ü (%44,2) kızdı. Gestasyon haftaları ortalama 38,3±0,4 hafta, ortalama doğum ağırlıkları 3146±32 gramdı. Hastaların yatış anındaki ortalama postnatal günleri 4,1±0,1 gün, yatış bilirubinleri 17,1±0,2 mg/dl, fototerapi alma süreleri ise 38,2±1 saat, yatış sırasında tartı kaybı ise %3,7±0,3 olarak görüldü. Hastalardaki en sık tanının ABO uygunsuzluğu (%27,9) olduğu görüldü. Tartı kaybı olan hastaların bilirubin düzeyleri istatiksel açıdan anlamlı yüksekti. Kan uyuşmazlığı ve diğer tanılar karşılaştırıldığında; kan uyuşmazlığı olan hastalarda bilirübin ve hemoglobin düzeyi ve yatış anındaki postnatal yaş istatistiksel açıdan anlamlı daha düşük, yatış süresi ise istatistiksel açıdan anlamlı daha yüksekti. Sonuç: Cinsiyet ve doğum şekli ile yatış total bilirübin ve fototerapi alma süresi arasında anlamlı ilişki görülmedi. Tartı kaybı olan hastaların olmayanlara göre yatış total bilirübin istatistiksel olarak daha yüksekti. Ek olarak ABO uygunsuzluğu olan hastaların yatış sürelerinin de diğer tanılarla yatan hastalara göre istatistiksel açıdan anlamlı daha uzun olduğu görüldü.
Mirtazapine Intoxication in a Child
(Elsevier Science inc, 2012) Akbayram, Sinan; Dogan, Murat; Basaranoglu, Murat; Cagan, Eren; Aktar, Fesih; Kaya, Avni; Peker, Erdal
Oxidative and Antioxidative Biomarker Profiles in Neonatal Hypoxic-Ischemic Encephalopathy: Insights for Pathophysiology and Treatment Strategies
(int Scientific information, inc, 2024) Aycan, Nur; Demir, Derya Cay; Yurekturk, Eyyup; Basaranoglu, Murat; Karaman, Serap; Tuncer, Oguz
Background: Neonatal hypoxic-ischemic encephalopathy (HIE) is a significant cause of perinatal and postnatal morbidity and mortality worldwide. Catalase (CAT) activity detection is used to determine levels of inflammation and oxidative stress. Glutathione (GSH) is the most critical non-enzymatic endogenous antioxidant. Lipid peroxidation levels marked after hypoxia can be detected based on the level of malondialdehyde (MDA). Ischemia-modified albumin (IMA) is considered a biomarker for cardiac ischemia and is known to increase in the liver, brain, and kidney in states of insufficient oxygenation. We aimed to explain the results and relations between the oxidant and antioxidants to detail oxidant-antioxidant balance and cellular mechanisms. Material/Methods: Serum levels of IMA and MDA, as an oxidative stress marker, and CAT and GSH, as antioxidant enzymes, were measured in first blood samples of 59 neonates diagnosed with HIE, with pH <7, base excess >12, and APGAR scores. Results: Neonates who were >= 37 weeks of gestation and had hypoxia were included. Compared with healthy newborns (n=32), CAT was statistically significantly lower in the hypoxia group (P=0.0001), P =0.0001), while MDA serum levels were significantly higher in neonates with hypoxia (P=0.01). P =0.01). There was no difference between hypoxic and healthy neonates in GSH and IMA measurements (P=0.054, P =0.054, P =0.19 respectively). Conclusions: HIE pathophysiology involves oxidative stress and mitochondrial energy production failure. Explaining the pathways between oxidant-antioxidant balance and cell death, which explains the pathophysiology of HIE, is essential to develop treatment strategies that will minimize the effects of oxygen deprivation on other body organs, especially the brain.
Pseudo-bartter's Syndrome Associated With Cystic Fibrosis
(Nobel Ilac, 2009) Akgun, Cihangir; Basaranoglu, Murat; Yuca, Sevil Ari; Akbayram, Sinan; Arslan, Suekrue; Kirimi, Ercan
Cystic fibrosis is an autosomal recessive inherited generalized disorder of exocrine gland function that results in abnormal mucus production. There is a tendency in infants with cystic fibrosis to develop episodes of hyponatremic, hypochloremic dehydration with metabolic alkalosis and elevated plasma renin and aldosterone levels which are the biochemical picture of the pseudo-Bartter's syndrome, Here in, we report a 48 day old boy with Pseudo-Bartter's syndrome associated with cystic fibrosis and we emphasized the importance of the salt supplementation in these patients.
The Relationship Between Mother and Infant Plasma Trace Element and Heavy Metal Levels and the Risk of Neural Tube Defect in Infants
(Taylor & Francis Ltd, 2019) Demir, Nihat; Basaranoglu, Murat; Huyut, Zubeyir; Deger, Ibrahim; Karaman, Kamuran; Sekeroglu, M. Ramazan; Tuncer, Oguz
Objective: To determine levels of trace elements [copper (Cu), zinc (Zn), selenium (Se), and cobalt (Co)] and heavy metals [arsenic (As), mercury (Hg), lead (Pb), and cadmium (Cd)] in the plasma of mothers and infants and investigate the relationship between those levels and neural tube defects (NTD). Methods: A total of 100 neonates diagnosed with NTD and placed in the Neonatal Intensive Care Unit of Yuzuncu Yil University, Turkey between May 2013 and December 2016 comprised the study group. The control group consisted of 70 healthy neonates not diagnosed with NTD or any other congenital anomalies. For both the groups, mother and infant plasma levels of Cu, Zn, Co, Cd, Se, Hg, As, and Pb were measured and compared. Plasma levels of Cu, Zn, Co, Cd, Se, Hg, As, and Pb were measured and compared between two groups of mothers and infants. Findings: Mother and infant plasma levels of trace elements Zn and Se were determined to be significantly lower in the study group compared with the control group, while Cu levels were significant elevated in the study group (all p values < .05). Plasma levels of heavy metals As, Pb, and Cd were found to be significantly higher in the NTD control group (p < .05 for all). There was no association between maternal infection, maternal smoking status, history of miscarriage, or history of NTD with the development of NTD (p > .05). Differences in maternal age, birth weight, length of gestation, and infant gender for the two groups were also determined not to be statistically significant. Results: High plasma levels of heavy metals As, Pb, and Cd and trace element Cu were identified as risk factors for the development of NTD. At the same time, low plasma levels of trace elements Zn and Se were also found to be risk factors for NTD. However, no association between Hg and Co plasma levels and increased risk for the development of NTD was observed. This study, while being the most comprehensive case study to date investigating the relationship between heavy metals and trace element levels and increased risk of NTD, nonetheless highlights the need for further research in order to make definite statements regarding this relationship.
Role of Netrin-1 in Staging Hypoxic Ischemic Encephalopathy
(Assoc Medica Brasileira, 2025) Aycan, Nur; Demir, Derya Cay; Yurekturk, Eyyup; Basaranoglu, Murat; Karaman, Serap; Tuncer, Oguz
OBJECTIVE: The diagnosis and prognosis of neonatal hypoxic-ischemic encephalopathy are established through clinical evidence and laboratory, imaging, and electrophysiological assessments of the nervous system. Netrin-1 was the first axon guidance molecule identified as a critical component of embryonic development in vertebrates and has a solid chemotropic function for angiogenesis, morphogenesis, cell migration, and axonal guidance. It was hypothesized that Netrin-1 will differ at different hypoxic-ischemic encephalopathy stages. METHODS: This study included 75 hospitalized hypoxic-ischemic encephalopathy newborns and 48 healthy newborns born at the same hospital and followed up only by their mothers. Demographic, laboratory, and Netrin-1 data were evaluated for all hypoxic-ischemic encephalopathy stages. RESULTS: Serum Netrin-1 concentrations were significantly greater in patients with moderate and severe hypoxic-ischemic encephalopathy who underwent therapeutic hypothermia than in controls and patients with severe hypoxic-ischemic encephalopathy. However, serum Netrin-1 concentrations were not significantly greater in patients with mild hypoxic-ischemic encephalopathy than in controls. In 75 hypoxic-ischemic encephalopathy patients, correlations of Netrin-1 with lactate, uric acid, and lactate dehydrogenase were statistically significant (p=0.0001, 0.008, and 0.043, respectively). CONCLUSION: Netrin-1 significantly increased in moderate and severe patients. Therefore, this marker could be a biomarker for staging hypoxicischemic encephalopathy and therapeutic hypothermia and predicting the prognosis of neonatal hypoxic-ischemic encephalopathy patients.
Tarka® Overdose in a Young Child
(Sage Publications Ltd, 2011) Dogan, Murat; Basaranoglu, Murat; Peker, Erdal; Akbayram, Sinan; Sahin, Musa; Uner, Abdurrahman; Caksen, Huseyin
Tarka (R) is a combination antihypertensive medication composed of verapamil hydrochloride and trandolapril. A 3.5-year-old female was brought to our hospital due to a sleepy condition 7 hours after an accidental ingestion of six tablets of Tarka (R) containing 240 mg verapamil hydrochloride and 4 mg trandolapril in each tablet. Five hours after hospitalization, her condition deteriorated and arterial pressure progressively decreased despite the treatment. Finally, a temporary pacemaker was implanted, after which the vital findings began to return to normal values. The pacemaker was removed 13 hours after implantation as normal heart rhythm was observed. There are no reports of intoxication with fixed-dose combination products, especially Tarka (R), in young children in the literature. Therefore, we believe that our report can provide an insight on the toxic dose of this drug in younger children. Clinicians should keep in mind that lethargy can be the first symptom of a possible clinical deterioration, even in normotensive and normorhythmic individuals.