Browsing by Author "Batur, Muhammed"

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Adherence To Drop Treatment in Glaucoma Patients and Its Relationship With Progression
(2021) Özer, Muhammet Derda; Seven, Erbil; Öcal, Halit; Tekin, Serek; Batur, Muhammed; Yaşar, Tekin
Purpose: To evaluate the adherence of glaucoma patients to eye drop therapy and determine the effects of treatment adherence on disease progression. Materials and Methods: A total of 147 patients followed at Van Yüzüncü Yıl University Department of Ophthalmology, between March 2019 and June 2019 were included in the study. Patients were examined and asked questions. Patients underwent peripapillary retinal nerve fi ber layer analysis via optical coherence tomography. Results: It was found that 66% of the patients adhered to eye drop treatment. The most common reasons for non-adherence were forgetting (40%) and running out of eye drop (38%). Correct instillation technique was demonstrated by 59% of the patients. There was signifi cantly less disease progression in adherent patients compared to non-adherent patients (p=0.002) and in patients with correct instillation technique compared to those without (p=0.001). Conclusion: This study showed adherence to eye drop therapy was 66% among glaucoma patients and 59% of patients showed correct drop instillation technique. More progression was observed in patients with poor adherence and patients who did not instill drops correctly.
Anterior Lens Capsule and Iris Thicknesses in Pseudoexfoliation Syndrome
(Taylor & Francis inc, 2017) Batur, Muhammed; Seven, Erbil; Tekin, Serek; Yasar, Tekin
Purpose: The aim of this study was to evaluate anatomic properties of the lens capsule and iris by anterior segment optical coherence tomography (AS-OCT) in patients with pseudoexfoliation (PEX).Methods: This prospective study included 62 eyes of 62 patients with PEX syndrome and 43 eyes of 43 age- and gender-matched controls. All subjects underwent full ophthalmologic examinations including AS-OCT. Pupillary diameter, midperipheral stromal iris thickness, central and temporal lens capsule thicknesses, and peripheral pseudoexfoliation material thickness on the anterior lens capsule surface were measured and recorded.Results: Mean age was 66.8 9.3 years in the PEX group and 65.5 +/- 8.9 years in the control group (p = 0.44). The PEX group consisted of 62 patients: 38 men (61.3%) and 24 women (38.7%); the control group included 43 subjects: 25 men (58.1%) and 18 women (41.9%). Pupillary diameter after pharmacologic mydriasis was 21% smaller in the PEX group than controls. Mean midperipheral iris thickness was 36 +/- 7.2 m (7.8%) thinner in the PEX group than that of control group (p = 0.047). The central anterior capsule was a mean of 3.40 +/- 0.51 m (18%) thicker in the PEX group compared to the control group (p = 0.0001). The temporal anterior lens capsule was a mean of 0.17 +/- 0.15 m thicker in the PEX group compared to the control group (p = 0.81).Conclusions: With high-resolution OCT imaging, it has become possible to evaluate the anterior lens capsule without histologic examination and demonstrate that it is thicker than normal in PEX patients.
Anti-Tumor Necrosis Factor-Alpha Treatment in Pediatric Patients With Pars Planitis: a Single-Center Experience From Turkey
(Springer, 2023) Ozer, Muhammet Derda; Batur, Muhammed
Aim To evaluate the effectiveness and safety of anti-tumor necrosis factor-alpha (anti-TNF-alpha) treatment (Adalimumab [ADA]) combined with immunomodulatory agents (IMAs) in the treatment of pars planitis (PP). Methods The patients with PP who were treated with anti-TNF-alpha agents for at least six months were qualified for the chart review. The outcome parameters were the steroid-free remission state, the best-corrected visual acuity (BCVA) and the central macular thickness (CMT) of the patients at the last visit. Results After a mean total follow-up time of 15.5 +/- 5.8 months (8-24 months), all the cases were in steroid-free remission at the last visit. The mean BCVA increased, and the mean CMT decreased significantly at the last visit (p < 0.001, p < 0.001, respectively). Conclusion ADA combined with IMAs offers effective and safe treatment modalities in the control of chronic intraocular inflammation in PP cases.
Arka Kapsülotomi Yapılmayan Okul Öncesi ve Okul Çağı Pediatrik Katarakt Cerrahi Olgularında Arka Kapsül Kesafeti
(2016) Batur, Muhammed; Yaşar, Tekin; Gül, Adem; Seven, Erbil; Can, Ertuğrul
Amaç: Arka kapsülotomi ve ön vitrektomi yapılmadan katarakt cerrahisi yapılan okul öncesi ve okul çağı pediatrik hastalarımızın arka kapsül kesafeti (AKK) gelişme durumunu değerlendirmeyi amaçladık.Gereç ve Yöntem: Pediatrik katarakt nedeniyle ameliyat olup göz içi lens (GİL) implantasyonu yapılan 21 hastanın 30 gözüne ait kayıtlar retrospektif olarak incelendi. Olguların yaşı, AKK gelişme durumu, zamanı, optik aksı kapatma durumuna göre neodymiumdoped yttrium aluminium garnet (Nd:YAG) lazer ihtiyacı ve takip süreleri kaydedildi. Bulgular: Hastaların ortalama yaşı 7,6±2,83 yıl idi. On iki (%57,14) hastanın tek gözüne, dokuz hastanın (%42,86) her iki gözüne katarakt ameliyatı ve GİL implantasyonu uygulandı. Ortalama takip süresi 17,7±22,67 ay idi. Yirmi bir (%70) gözde AKK gelişti, bunlardan 15 (%50) gözde Nd:YAG lazer ile arka kapsülotomi gerektirecek düzeyde optik aksı kapatmaktaydı. Ameliyat sonrası AKK gelişme ortalama süresi 8,91±18,7 (1 hafta-71 ay) ay idi.Sonuç: Okul öncesi ve okul çağı pediatrik kataraktlarda cerrahi tecrübe de göz önüne alınarak hastanın özelliklerine göre katarakt ekstraksiyonu ile aynı seansta arka kapsülotomi (ve ön vitrektomi) kararının verilmesinin uygun olduğunu düşünüyoruz.
Assessment of Metacognition and Retinal Optical Coherence Tomography Findings in Shift Workers
(Taylor & Francis inc, 2024) Batur, Muhammed; Ozdemir, Pinar Guzel; Tan, Rumeysa Bilmez; Tas, Zeynep Sahin
It is known that working in the shift system, especially the night shift, affects physical, mental, and social well-being. We investigated the changes in the inner retinal layers and choroidal layer of the eyes of nurses working night and day shifts using optical coherence tomography (OCT). We also explored the effect of night shift work on metacognition and the relationships between these variables. A total of 79 nurses participated in the study, of whom 40 worked night shifts. The researcher gave the participants sociodemographic information and the Metacognition Questionnaire-30 (MCQ-30) form. Retinal nerve fiber layer (RNFL) thickness, ganglion cell layer (GCL) thickness, inner nuclear layer (INL) thickness, inner plexiform layer (IPL) thickness, central macular thickness (CMT), and subfoveal choroidal thickness (SFCT) were measured with OCT. It was found that the level of metacognitive activity associated with cognitive confidence was higher (p = 0.044) for nurses who worked night shifts and that the level of metacognitive activity associated with cognitive awareness was lower (p = 0.015) for nurses who worked night shifts. RNFL-nasal superior (NS) thickness was lower in night shift workers than the day shift group (p = 0.017). Our study revealed significant relationships between metacognition and the OCT findings among night and day shift workers. Our study revealed that RNFL measurements and metacognitive activity may differ and there may be a relationship between these parameters in nurses who work shifts. Further research is needed to investigate the long-term effects of night shift work on retinal health.
The Association Between Retinal Nerve Fibre Layer Thickness and Corpus Callosum Index in Different Clinical Subtypes of Multiple Sclerosis
(Springer-verlag Italia Srl, 2017) Cilingir, Vedat; Batur, Muhammed; Bulut, Mehmet Deniz; Milanlioglu, Aysel; Yilgor, Abdullah; Batur, Abdussamet; Tombul, Temel
The objective of this paper is to evaluate the association between physical disability in multiple sclerosis (MS) patients, the thickness of the retinal nerve fibre layer (RNFL) and corpus callosum volumes, as expressed by the corpus callosum index (CCI). This study was based on a cohort of 212 MS patients and 52 healthy control subjects, who were age and gender matched. The MS patients included 144 women and 177 relapsing-remitting MS (RRMS) patients. Peripapillary and volumetric optical coherence tomography (OCT) scans of the macula were performed using spectral-domain OCT technology. All magnetic resonance imaging (MRI) scans were performed using 1.5-T systems. CCI and RNFL were lower in MS than healthy control subjects (0.341 versus 0.386, p < 0.01 and 92.1 versus 105.0, p < 0.01). In addition, CCI correlated with RNFL (r = 0.464, p < 0.01). This was also true for the subgroup of patients with no history of optic neuritis (ON). There is a correlation between the thickness of the RNFL and CCI values in MS patients with no history of ON, which suggests that OCT might be a suitable marker for neurodegeneration in MS clinical trials.
Authors' Reply To: Using Anterior Segment Optical Coherence Tomography To Compare the Smoothness of Anterior Iris Surface Between Two Eyes in Unilateral Fuchs' Uveitis Syndrome
(Springer, 2019) Ozer, Muhammet Derda; Kebapci, Fatih; Batur, Muhammed; Seven, Erbil; Tekin, Serek
Axonal Degeneration Independent of Inflammatory Activity: Is It More Intense in the Early Stages of Relapsing-Remitting Multiple Sclerosis Disease
(Karger, 2020) Cilingir, Vedat; Batur, Muhammed
Background: This study aimed to investigate whether there are differences in the axonal degeneration rate between patients in the early years of relapsing-remitting multiple sclerosis (RRMS) disease and RRMS patients in their later years. Methods: The early-stage RRMS patients (EMS) group had 65 patients whose duration of disease was within 3 years from the date of the first attack. The late-stage RRMS patients (LMS) group had 69 patients whose duration of disease was within the range of 3-10 years from the date of the first attack. In addition, a control group was composed of 32 healthy subjects. Peripapillary retinal nerve fiber layer (RNFL) thickness was monitored with spectral-domain OCT in all included patients for approximately 3 years. Results: The annual RNFL atrophy rate (aRNFLr) in the EMS group was -1.246 +/- 0.778 mu m/year, the aRNFLr in the LMS group was -0.898 +/- 0.536 mu m/year, and the aRNFLr was -0.234 +/- 0.154 mu m/year in the control group (p < 0.001). The aRNFLr in the EMS group was significantly higher than the aRNFLr in the LMS group (p = 0.01). The aRNFLr was not associated with MRI activity or the condition of having an attack. There was a correlation between Expanded Disability Status Scale (EDSS) progression and aRNFLr in both the EMS and LMS patient groups (r = -0.471, p < 0.001, and r = -0.567, p < 0.001, respectively). Conclusion: The axonal degeneration rate is faster in RRMS patients in the first years of the disease than in later years. In addition, axonal degeneration occurs independently of inflammatory activity. Axonal degeneration is correlated with disability progression, but not with inflammatory findings, such as clinical episodes and MRI activity.
Bakteriyel Keratit Tedavisinde Koenzim Q10 Göz Damlasının Korneal Yara İyileşmesi Üzerine Etkisi: Prospektif Klinik Çalışma
(2024) Batur, Muhammed; Seven, Erbil; Tekin, Serek; Ozer, Muhammet Derda
Amaç: Bu çalışmada, bakteriyel keratitte Koenzim Q10 (KoQ10) göz damlasının korneal yara iyileşmesi üzerindeki etkinliğini ve güve- nilirliğini değerlendirmeği amaçladık. Gereç ve Yöntemler: Bakteri- yel keratit tanısıyla yatırılarak tedavisi yapılan hastalar çalışmaya alındı. Hastaların yaşı, cinsiyeti ve hangi gözün tutulduğu kaydedildi. Hasta- lara tam bir göz muayenesi yapıldı ve hipopiyon olup olmadığı kayde- dildi. Korneal ülser büyüklüğü yatay ve dikey olarak ölçüldü. Hastalar rastgele 2 gruba ayr ıldı. Her iki gruba da topikal antibiyotik ve siklo- pentolat damla verildi. Birinci gruba ek olarak KoQ10 göz damlası 4×1 tedaviye eklendi. Tedavi öncesi ve tedaviye ba şlandıktan sonra ülser iyileşene kadar günlük olarak korneal ülser görüntüleri al ındı ve kay- dedildi. Bulgular: Çalışmaya alınan toplam 32 hastanın yaş ortalaması 51,16±25,31 (7-90) yıl olup, 20’si (%62,5) erkek, 12’si (%37,5) kadın idi. KoQ10 göz damlası verilen grup (n=16) ile kontrol grubunun (n=16) yaş, cinsiyet, sağ-sol göz tutulumu, hipopiyon varlığı ve korneal ülser boyutu açısından istatistiksel olarak anlamlı farkı yoktu (p>0,05). Or- talama iyileşme süresi KoQ 10 göz damlası verilen grupta 12,25±6,02 gün ve kontrol grubunda 19±12,9 gün idi (p=0,076). Sonuç: KoQ10 göz damlası, bakteriyel keratite bağlı gelişen korneal ülser tedavisindeki etkisi istatistiksel olarak anlaml ı bulunamadı. Ancak iyile şme süresi- nin kısalması açısından adjuvan ajan olarak düşünülebilir. Bu konuda daha geniş serilere sahip randomize, prospektif klinik çalışmalara ihti- yaç vardır.
Behçet Hastalığına Bağlı Üveitin Tedavisinde Oral Steroidler ve İmmünsupresan/immünmodülatörlerin Kullanımı
(2018) Batur, Muhammed; Özer, Muhammet Derda; Tekin, Serek
Behçet hastalığı sebebi bilinmeyen kronik, multisistemik enflamatuar bir hastalıktır. Hastalığın seyri sırasındaöngörülemeyen ciddi enflamatuar ataklar gözlenmektedir ve arka segmenti etkileyen ciddi ataklar hızlı ve etkilitedavilerle sakinleştirilemezse kalıcı oküler hasar kaçınılmazdır. Sadece ön segment tutulumu olan olgularda topikaltedavi yeterli olurken, ciddi arka segment tutulumu olan dirençli üveit ataklarında, yüksek doz sistemik kortikosteroidile kombine immünsüpresif ilaçlar kullanılır. Fakat konvansiyonel immünsüpresif ilaçlara rağmen dirençli üveit ataklarıgözlenebilmektedir.
A Case: Abscess Formation in the Sub-tenon's Space After Strabismus Surgery
(2017) Batur, Muhammed; Çağlar, İsmail Çağatay; Gül, Adem; Yaşar, Tekin; Seven, Erbil
A five-year-old boy was examined in follow-up in our strabismus department due to exotropia and amblyopia in the right eye. Recession to both lateral recti muscles was performed. When the patient was examined one week, postoperatively, he complained of pain in the right eye. Upon physical examination, hyperemia and minimal swelling of the surgical area were observed. The situation was diagnosed as an abscess. The abscess was drained and the eye was irrigated with cefazolin and gentamicin solutions. All signs and symptoms were determined to be resolved in subsequent postoperative visits.
Causes of Visual Impairment in the Van City Area According To the Health Committee's Reports
(Turkish Ophthalmological Soc, 2012) Ceyhan, Dogan; Yasar, Tekin; Demirok, Ahmet; Cinal, Adnan; Esmer, Oktay; Batur, Muhammed
Purpose: In this study, disability reports of the Health Committee of the Hospital of the Yiiziincii Yil University School of Medicine will be evaluated. The demographic characteristics, causes and degree of visual loss, visual system impairment rating and whole body impairment rating of the people with visual impairment will be determined. Material and Method: Health committee disability reports of our hospital, between September 2006 and August 2010, were evaluated. Relevant variables of each patient were recorded and evaluated. Results: 415 health committee reports for visual impairment were found to be prepared during the period of the study. One hundred fifty three (36,9%) of the cases were female and 262 (63.1%) were male and the mean age was 41.8 +/- 22.4 years. The most frequent causes of visual impairment were macular diseases, evisceration and phitisis, amblyopia, optic nerve diseases, degenerative myopia, acquired corneal and hereditary retinal diseases. The patients who had a disability report had a mean of 41.69 +/- 25.92% visual system impairment rating and 60,76 +/- 24,67% whole body impairment rating. Discussion: This research was planned for contributing to the epidemiologic information about visual impairment in our country. This data may serve to compute the cost of visual disability reports. The information is also expected to contribute to determine the causes and measures for the prevention of diseases and conditions leading to visual disability.
Cerebral Perfusion in Type 2 Diabetes Mellitus: a Preliminary Study With Mr Perfusion
(Elsevier, 2023) Ilik, Ibrahim; Arslan, Harun; Yokus, Adem; Batur, Muhammed; Ucler, Rifki; Akdeniz, Huseyin
Background: Type 2 diabetes mellitus (T2DM) is associated with altered cerebral vasoreactivity, cognitive impairment, and functional decline. Magnetic Resonance (MR) perfusion can be used to assess cerebral blood flow (CBF). The aim of this study is to analyze the association between diabetes mellitus and cerebral perfusion. Methods: The study included 52 patients diagnosed with T2DM and 39 healthy individuals. The diabetic patients were classified into three groups (PRP: proliferative retinopathy, NPRP: non-proliferative retinopathy, Non-RP: non-retinopathy DM). The rCBF measurements of cortical gray matter and thalami were carried out using the region of interest. Reference quantitative measurements were performed from ipsilateral white matter. Results: The comparison between the T2DM group and the control group revealed that rCBF values of bilateral frontal lobes, cingulate gyrus, medial temporal lobe, thalami and right occipital lobe were measured to be significantly lower in the T2DM group (p < 0.05). No significant difference was detected between the two groups in terms of rCBF values of the left occipital lobe and anterior aspect of the left temporal lobe (p > 0.05). The rCBF values were lower in the anterior aspect of the right temporal lobe and the difference showed borderline sta-tistical significance (p = 0.058). No significant difference was detected regarding mean rCBF values measured in the regions of cerebral hemispheres among the three patient groups with T2DM (p>0.05). Conclusion: Regional hypoperfusion was encountered in most of the lobes in the T2DM group when compared with the healthy group. However, in terms of rCBF values, there was no significant difference among the three groups with T2DM.
Choroid Vascularity Index as a Parameter for Chronicity of Fuchs' Uveitis Syndrome
(Springer, 2020) Ozer, Muhammet Derda; Batur, Muhammed; Tekin, Serek; Seven, Erbil; Kebapci, Fatih
Purpose This study aimed to compare the choroidal vascularity index (CVI) of eyes having Fuchs' uveitis syndrome (FUS) with healthy fellow eyes (N). Methods This prospective, cross-sectional study included unilateral FUS cases and an age- and gender-matched healthy control group. Thirty-nine participants were included in the FUS group, and 24 age- and gender-matched individuals were randomly selected for the control group. Endothelial cell density (ECD) was measured using Tomey specular microscopy. Spectral-domain optical coherence tomography was used to acquire the choroidal images, and binarization was applied to the images. Two blinded investigators analyzed the CVI in both eyes of the FUS cases and the right eyes of the healthy control group. Results CVI was found to be significantly decreased in FUS (p < 0.001). Additionally, ECD had a strong positive correlation with CVI (r = 0.383, p = 0.008). Conclusion CVI may provide information about the chronicity of the disease.
A Comparative Evaluation of Cataract Classifications Based on Shear-Wave Elastography and B-Mode Ultrasound Findings
(Springer international Publishing Ag, 2019) Ozgokce, Mesut; Batur, Muhammed; Alpaslan, Muhammed; Yavuz, Alpaslan; Batur, Abdussamet; Seven, Erbil; Arslan, Harun
In this study, a comparison is made of the findings of B-mode ultrasound and ultrasound elastography with the Lens Opacities Classification (LOCS) grade in patients with senile cataracts. A total of 74 patients with cataracts and 32 age-matched healthy volunteers as the control group were evaluated in the departments of ophthalmology and radiology between 2016 and 2017. In the patient group, cataracts were graded according to LOCS, and B-mode sonographic appearance and elasticity measurements were recorded, after which the cataract grade and sonoelastography/B-mode ultrasound findings were compared using statistical methods. Among the 74 patients with cataracts, 38 were females (51.4%) and 36 were males (48.6%), and the mean age was 62.05 +/- 7.95 (43-78) years. A Chi-square test revealed a significant relationship between ultrasound echogenicity of cataract and grade of cataract (p < 0.005). The ultrasound elastography revealed a mean shear-wave velocity of 2.90 m/s +/- 0.371 (2.13-3.53) among patients with grade 3 cataracts, 3.1 m/s +/- 0.45 (2.26-3.98) among patients with grade 4, 3 m/s +/- 0.58 (2.35-4.60) among patients with grade 5 and 3 m/s +/- 0.528 (2.31-4.50) among patients with grade 6 cataracts, and 3 m/s +/- 0.258 (2.36-3.58) among the normal subjects. No statistically significant difference was noted in the analysis of variance (p > 0.005). While cataract grade and B mode echogenicity were directly proportional, there was no significant difference in lens elasticity.
Comparative Results of Use and Switching of Anti-Tnf Agents in Adult Behçet's Uveitis
(Wolters Kluwer Medknow Publications, 2024) Mesen, Selma; Ozer, Muhammet D.; Batur, Muhammed
Purpose: This study was planned to compare the clinical results and optical coherence tomography (OCT) data of patients who underwent adalimumab (ADA), infliximab (IFX) and switched protocols between these two methods in cases of Behcet's associated uveitis (BAU). Methods: The patients with BAU who were treated with anti-TNF-alpha agents for at least one year were qualified for the chart review. The outcome parameters were the steroid-free remission state, the best-corrected visual acuity (BCVA), the central macular thickness (CMT), and the subfoveal choroidal thickness (SFCT) of the patients at the last visit. Results: After a mean follow-up of 16.60 months, the rate of active inflammation decreased from 63.6% to 15.1%. Mean BCVA increased, mean CMT and mean SFCT decreased significantly at the last visit (P < 0.001, P < 0.001, respectively). Conclusion: Anti-TNF-alpha treatment and switching protocols between these two agents effectively and safely control intraocular inflammation in BAU patients.
Comparison of Both Eyes Anterior Segment Structures of Patients With Unilateral Blunt Trauma
(Elsevier, 2023) Mesen, Selma; Ozer, Muhammet Derda; Kebapc, Fatih; Batur, Muhammed
Background: To evaluate anterior segment optical coherence tomography (AS-OCT) data in patients with unilateral blunt ocular trauma (BOT), to determine the relationship of results with hyphema development.Methods: 21 patients who received unilateral BOT were included in the study. Healthy eyes of patients were included in the control group. Iris stromal thickness (IST), schlemm canal area (SCA) and pupil diameter were measured by AS-OCT of the participants. In addition, eyes with ocular trauma were divided into those with and without hyphema and compared in terms of these parameters. Results: The mean nasal and temporal (n-t) IST was measured as 373 & PLUSMN; 40 & mu;m and 369 & PLUSMN; 35 & mu;m in BOT in comparison with 344 & PLUSMN; 35 & mu;m and 335 & PLUSMN; 36 & mu;m in control eyes, respectively (p = 0.000 and p = 0.001, respectively). The mean nasal and temporal (n-t) SCA was measured as 12,571 & PLUSMN; 880 & mu;m2 and 12,162 & PLUSMN; 1181 & mu;m2 in developed hyphema in comparison with 10,455 & PLUSMN; 1506 & mu;m2 and 10,188 & PLUSMN; 939 & mu;m2 in did not develop hyphema, respectively (p = 0.016 and p = 0.002 respectively).Conclusion: The ISTs of the traumatized eyes in the nasal and temporal quadrants were statistically thicker than the other healthy eyes. SCA in both nasal and temporal quadrants of eyes with hyphema was statistically significantly larger than the group without hyphema.
Comparison of Central Corneal Thickness in Corneal Edema by Ultrasound Pachymetry, Specular Microscopy, and Anterior Segment Optical Coherence Tomography
(Wolters Kluwer Medknow Publications, 2023) Artuc, Tuncay; Batur, Muhammed
PURPOSE: The purpose of this study was to compare ultrasound pachymetry Ultrasound pachymetry (UP), specular microscopy (SM), and anterior segment optical coherence tomography (ASOCT) in the measurement of central corneal thickness (CCT) in cases of corneal edema before and after uncomplicated phacoemulsification. METHODS: Preoperative pachymetric measurements were performed in all patients before cataract surgery. Sixty -seven patients who developed corneal edema after routine faoemulsification surgery were included in the study. CCT measurements were made the day before surgery and on the 1st, 7th, and 14th days after surgery. Correlation and agreement between the devices were quantified with the intraclass correlation coefficient (ICC), limits of agreement, and Bland-Altman plots. RESULTS: The mean age of the patients was 70.99 +/- 9.56 (36-92) years. While CCT could be measured in all eyes with ASOCT after surgery, the number of eyes measured with UP and SM were 24 (11.7%) and 27 (16.1%), 55 (82.1%) and 52 (77.6%), and 46 (88.8%) and 45 (86.9%) on postoperative days 1, 7, and 14, respectively. ICC values between UP and SM, UP and ASOCT, and SM and ASOCT, respectively, were: preoperative 0.91, 0.94, and 0.92; 1st postoperative day 0.93, 0.86, and 0.93; 7th postoperative day 0.94, 0.85, and 0.96; and 14th postoperative day 0.95, 0.92, and 0.96. CONCLUSION: In all eyes with corneal edema, CCT measurements can be taken with ASOCT; however, in some cases, CCT measurements with SM and UP cannot be taken. However, there is a good correlation between measurements taken with these devices.
Comparison of Heidelberg Retina Tomograph-3 Glaucoma Probability Score and Moorfields Regression Analysis of Optic Nerve Head in Glaucoma Patients and Healthy Individuals
(Springer, 2017) Caglar, Cagatay; Gul, Adem; Batur, Muhammed; Yasar, Tekin
To compare the sensitivity and specificity of Moorfields regression analysis (MRA) and glaucoma probability score (GPS) between healthy and glaucomatous eyes with Heidelberg Retinal Tomograph 3 (HRT-3). The study included 120 eyes of 75 glaucoma patients and 138 eyes of 73 normal subjects, for a total of 258 eyes of 148 individuals. All measurements were performed with the HRT-3. Diagnostic test criteria (sensitivity, specificity, etc.) were used to evaluate how efficiently GPS and MRA algorithms in the HRT-3 discriminated between the glaucoma and control groups. The GPS showed 88 % sensitivity and 66 % specificity, whereas MRA had 71.5 % sensitivity and 82.5 % specificity. There was 71 % agreement between the final results of MRA and GPS in the glaucoma group. Excluding borderline patients from both analyses resulted in 91.6 % agreement. In the control group the level of agreement between MRA and GPS was 64 % including borderline patients and 84.1 % after excluding borderline patients. The accuracy rate is 92 % for MRA and 91 % for GPS in the glaucoma group excluding borderline patients. The difference was nor statistically different. In both cases, agreement was higher between MRA and GPS in the glaucoma group. We found that both sensitivity and specificity increased with disc size for MRA, while the sensitivity increased and specificity decreased with larger disc sizes for GPS. HRT is able to quantify and clearly reveal structural changes in the ONH and RNFL in glaucoma.
Comparison of the Efficacy of Accelerated Corneal Cross-Linking Therapy in Different Pediatric Age Groups Having Progressive Keratoconus
(Springer, 2020) Ozer, Muhammet Derda; Batur, Muhammed; Mesen, Selma; Tekin, Serek; Seven, Erbil; Yasar, Tekin
Purpose To report a comparison analysis of accelerated corneal cross-linking (A-CXL) treatment for progressive keratoconus patients in different pediatric age groups. Study design Retrospective, cross-sectional. Methods Patients with progressive keratoconus aged <= 18 were retrospectively reviewed. Forty-one eyes of 41 patients were included in the study. Patients were divided into two groups according to their age (<= 14 years and 15-18 years). All patients underwent epithelium-off A-CXL protocol. Acquired data were compared between the two groups. Results The mean age was 14.3 +/- 1.8 (10-18) years. Twenty-five (61%) of the participants were male, and 16 (39%) were female. Twenty (49%) patients were separated into group 1 (<= 14 years of age), and 21 (51%) were in group 2 (15-18 years). Age at presentation was found to be the only factor in anticipating the progression of keratoconus at the second postoperative year visit (p < 0.001). Progression in keratometric values was detected in seven (35%) of the 20 eyes in group 1, and one (4%) of the 21 patients in group 2 (Z = - 2.44, p = 0.014). Conclusion Even if proper treatment is applied, the progression of keratoconus is likely in patients younger than 14 years of age. Instead of evaluating pediatric patients as a whole, closer follow-up and early treatment may be useful in younger age groups (<= 14 years).