Browsing by Author "Baydar, Caner"

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Evaluation of Toxoplasma Gondii in the Etiology of Cryptogenic Epilepsy: a Case-Control Study
(Galenos Publ House, 2024) Aydemir, Selahattin; Afshar, Milad Torkamanian; Afshar, Ozlem Sari Torkamanian; Cengiz, Zeynep Tas; Kiraz, Mustafa; Baydar, Caner; Yilmaz, Hasan
Objectives: This study was conducted to evaluate the relationship between toxoplasmosis and cryptogenic epilepsy (CE) by comparing the rate of Toxoplasma gondii seropositivity identified in CE patients with those without any neurological disorder. Methods: The study included 200 cryptogenic patients and 164 individuals without neurological disorders. T. gondii seropositivity was studied in individuals Results: The study found T. gondii IgG in 15.50% of CE patients and 28.66% of individuals without any neurological disorder. The difference between the two Conclusion: Toxoplasmosis did not increase the risk of epilepsy in the region where this study was conducted. However, for a better understanding of the CE-T. gondii relationship, we believe that seroprevalence studies should be conducted in larger populations.
İzole Optik Nörit ile Prezente Olan Nörosifiliz Olgusu
(2024) Genç, Hamit; Tan, Rıza; Baydar, Caner
Sadece oküler tutulum ile prezente olan ve dermatolojik ya da nörolojik ve başka bir sistemik bulgusu olmayan, bir sifiliz olgusunu sunmayı amaçladık. Sol gözde 3 ay önce başlayan bulanık görme ve renkli görmede azalma şikayeti bulunan hastada, optik nörit etiyolojisine yönelik yapılan laboratuvar ve radyolojik incelemelerde sifilizin varlığını venereal hastalık araştırma laboratuvarı ve treponema pallidum hemaglutinasyon testi gibi serolojik testlerle tespit ettik. Hastanın solda göz dibi bakısı normaldi, görsel uyarılmış potansiyeli latansı sağa göre sınırda uzun bulundu. İndirekt oftalmoskopik incelemede majör patoloji saptanmadı. Hasta kronik retrobulber nörit olarak kabul edildi. Sifilizin optik tutulumu genellikle tek taraflı ya da bilateral perinörit, anterior veya retrobulber nörit ya da papil ödem şeklinde olabilir. Sifilizde gözlenen optik nörit tablosunda sıklıkla beklenen asemptomatik gidiş olmakla birlikte bazen hızlı progresyon gösteren vizyon kaybı olabilir. Bu olguda semptomatik, sifilizin primer tedavisine klinik yanıtı iyi olan ve tama yakın iyileşme gösteren izole optik nöritle prezente olan nörosifiliz olgusu sunulmuştur.
Serum 25-Hydroxy Vitamin D, Vitamin B12 and Folic Acid Levels in Myasthenic Crisis
(2022) Yevgi, Recep; Baydar, Caner
Aim: Myasthenia gravis (MG) is an autoimmune disease often caused by autoantibodies against postsynaptic acetylcholine receptors (AChR). It is known that vitamin D (VD), vitamin B12 and folic acid have some effects on the immune system. The aim of this study is to evaluate whether there is a difference in serum VD, vitamin B12 and folic acid levels in MG patients during the myasthenic crisis period compared to the non-crisis period. Material and Method: 32 patients followed up with the diagnosis of MG in Atatürk University Faculty of Medicine, Department of Neurology were included in the study. Serum 25(OH)D, vitamin B12 and folic acid levels were measured by taking blood from the antecubital vein in two different time periods, during the myasthenic crisis and during the non-crisis period, and periods were compared among themselves. Results: During the myasthenic crisis period, 25(OH)D level was 11.54 (1.08-50.33) ng/mL, vitamin B12 level was 299.5 (104-964) pg/mL, and folic acid level was 9.54±5.08 ng/mL. In the non-crisis period, 25(OH)D level was 18.74 (6.63-30.19) ng/mL, vitamin B12 level was 266 (119-678) pg/mL and folic acid level is 10.26±3.5 ng/mL. During the myasthenic crisis period, 25(OH)D vitamin levels of the patients were statistically significantly lower than the non-crisis period (p0.05). Conclusion: Low VD levels can be a facilitating factor in worsening myasthenic symptoms and entering myasthenic crisis. The use of VD supplements in MG patients with low VD levels may be beneficial in terms of protection from myasthenic crisis. Despite the limitations of our study, such as the small number of patients and the fact that 25(OH)D levels were not adjusted for seasonal effects, this study is the first study showing that VD levels are lower in the myasthenic crisis period than in the non-crisis period.