Browsing by Author "Bayiroglu, F"

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Anti-Oxidant Activity in Measles
(Maney Publishing, 2005) Cemek, M; Bayiroglu, F; Çaksen, H; Cemek, F; Dede, S
Background: Measles leads to serious complications, especially in developing countries. Aim: Our aim was to evaluate the effect of oxidative stress on the enzymatic and non-enzymatic anti-oxidant status in children with measles. Methods: Levels of superoxide dismutase, glutathione peroxidase, catalase, ceruloplasmin, albumin, total bilirubin and uric acid were studied in 17 children with measles and 29 healthy controls. Results and conclusions: There was a statistically significant difference between the groups for all parameters. All of the anti-oxidant activities except for albumin level were increased in the study group. Both enzymatic and nonenzymatic anti-oxidant defence systems were affected in measles.
Blood Lipoperoxidation and Antioxidant Enzymes in Healthy Individuals: Relation To Age, Sex, Habits, Life Style and Environment
(Marcel dekker inc, 1997) Aslan, R; Sekeroglu, MR; Gultekin, F; Bayiroglu, F
We report the concentrations of superoxide dismutase (SOD), glutathione peroxidase (GSN-Px) and malonaldialdehyde (MDA) an end product of lipoperoxidation in human whole blood. Method for measuring was the based on spectrophotometer. Blood MDA level was higher in elderly than in children, adults. Smoking, alcohol taking, acute exercise and air pollution group's MDA levels were increased than their control groups. GSH-Px activity was significantly lower in acute exercise group, and higher in trained group than those of controls. SOD was decreased in elderly, smoking and acute exercise groups and increase in trained individuals. As a result the mean values we obtained were slightly significant in age groups. The life style, environment has polluted air and habits are thought to be responsible for these significance also.
Effect of Estrogen on Fibrinogen Clotting Time in Rabbits
(Scientific Technical Research Council Turkey, 1998) Ercan, M; Yegin, E; Akdeniz, H; Irmak, H; Bayiroglu, F; Tuncer, I
The aim of this study was to examine the effect of estrogen on fibrinogen clotting time in rabbit model experimentally, The study was performed on 14 white New Zealand race female prepubertary rabbits at two months old weighing meanly 1.4+/-0.3 kg. Blood samples was taken from ear veins of the rabbits and first fibrinogen clotting time levels were measured to obtain control values. Next day, female sex hormone preparate estradiol valerinate at a dose of 0.3 mg/kg were injected to the rabbits IM. In their examinations made on 10(th) day of injection, they were evaluated as in oestrus and under the maximal effects of estrogen, acid their blood samples were taken again to measure their fibrinogen clotting time levels. Fibrinogen clotting time levels were determined from blood samples taken before and after female sex hormone administration. Samples taken from ear veins of the rabbits were used for measurement of fibrinogen clotting time. In the study, fibrinogen clotting time values were found meanly 18.13+/-1.00 sec. from blood samples taken before estrogen injection versus 18.87+/-0.61 sec. from blood samples after 10 days of estrogen injection, in statistical assessment performed, there were not statistically significant differences (t=0.94, p>0.05) between fibrinogen clotting time values before and after estrogen administration. Our data revealed that estrogen administration caused a silghtly but insignificantly increase in fibrinogen clotting time values in the rabbits.
Effects of Different Concentrations of Monensin on the Electrocardiogram and the Serum Ion Balance of the Rabbit
(Scientific Technical Research Council Turkey, 1998) Meral, I; Çinar, A; Bayiroglu, F; Aslan, SO
The present study was planned to investigate the effects of two different concentrations (10 and 40 mg/kg) of monensin, carboxylic ionophore antibiotic, on the ECG and the serum Na+ and K+ concentrations of rabbits. Fifteen male rabbits, about 2 kg and 1 year old, were used. ECGs were recorded by a direct writing electrocardiograph. Blood samples for measuring serum Na+ and the K+ concentrations were collected and the leads I, ii, II, aVR, aVL and aVF were recorded before and 6 hours after monensin was given. The durations and amplitudes of waves on the trace were measured in lead II and electrical axis also measured in leads 1 and III. We found that the effects of monensin on ECG and the serum Na+ and the K+ concentrations were dose dependent. In low doses (10 mg/kg) it produced a sinusoidal tachycardia by decreasing the time interval between two impulse production by sinoatrial node without changing the serum ion balance. However, in high doses (40 mg/kg) it produced a sinusoidal tachycardia with increasing the serum K+ and decreasing the serum Na+ concentrations.
Investigation of Antioxidant Status in Children With Acute Otitis Media and Tonsillitis
(Elsevier Ireland Ltd, 2004) Cemek, M; Çaksen, H; Cemek, F; Bayiroglu, F; Dede, S; Dülger, H; Ustün, R
Objective: Antioxidant enzymes status was investigated in children with acute otitis media (AOM) and acute tonsillitis. The aim was to determine the effect of oxidative damage due to free radicals on the antioxidant enzymes status in children with AOM and acute tonsillitis. Methods: We measured erythrocyte levels of superoxide dismutase and glutathione peroxidase (GPx) and activity of serum catalase, ceruloplasmin, albumin and total bilirubin in 23 children with AOM, 27 with acute tonsillitis and 17 control subjects. Results: There was statistically significant difference between the groups for all parameters. ALL antioxidant activities except for albumin Level were increased in the studies groups. When the values of AOM and acute tonsillitis were compared, there was statistically significant difference between the groups for erythrocyte GPx. Conclusion: Our findings indicate that not only a few antioxidant enzymes but almost all antioxidant activities showed a significant enhancement in children with AOM and acute tonsillitis. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
Oxidant and Antioxidant Levels in Children With Acute Otitis Media and Tonsillitis
(Elsevier Ireland Ltd, 2005) Cemek, M; Dede, S; Bayiroglu, F; Çaksen, H; Cemek, F; Yuca, K
Objective: Recurrent episodes of acute otitis media (AOM) and acute tonsillitis (AT) are a common problem in infectious disorders during childhood and are major cause of morbidity in children. The organism maintains defense systems including nonenzymatic antioxidants such as Vitamins A, E and C and reduced glutathione (GSH) against reactive oxygen species (ROS). In the present study, Lipid peroxidation status and nonenzymatic antioxidant capacity were investigated in children with AOM and AT. Our aim was to compare the lipid peroxidation and responses of the body's antioxidant status in the closely associated infections such as AOM and acute tonsillitis. Methods: The study included 23 (14 mates, 9 females) children with AOM, 27 (14 mates, 13 females) with AT and 29 (16 mates, 13 females) healthy control subjects. The ages of the study and control subjects were between 2 and 7 years. Serum beta-carotene, retinol, Vitamin E, Vitamin C, and whole blood malondialdehyde (MDA) (as an indicator of lipid peroxidation) and GSH Levels were studied in all subjects. Results: There was a statistically significant difference between the groups for all parameters (P < 0.05). All of the antioxidant vitamins such as beta-carotene, retinol, Vitamin E, and Vitamin C levels were observed to be significantly decreased in the both patient groups. Nevertheless, GSH levels were also decreased in the patient groups. MDA levels were found to be higher in children with AOM and AT than in the healthy control subjects. When compared the AOM and AT groups, there was statistically significant difference between the groups for whole blood MDA (P < 0.05). Conclusion: Even though they seem to react in a similar way against ROS, in the cases of AOM and AT, it is possible to see the different approaches in these tissues for the oxidative stress. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
Role of Vitamin E in Decreasing the Toxic Effect of Digoxin
(Scientific Technical Research Council Turkey, 1999) Meral, I; Baydas, B; Bayiroglu, F; Uysal, H
This experiment was carried out to evaluate the role of Vitamin E in decreasing the toxic effect of digoxin. Electrocardiographic recordings of New Zealand rabbits which were treated with digoxin-only or digoxin+vitamin E were used. Recordings were obtained before and 24 hours after treatments. It was found that digoxin-only treatment caused a sinusoidal tachicardia without changing the durations or amplitudes of any wave on the trace. However, digoxin+vitamin E treatment did not produce any increase in heart rate. It was concluded that Vitamin E injection along with digoxin injection might lower the toxic effect of digoxin. More studies are needed to convince these findings.