Browsing by Author "Bayiroglu, Fahri"

Now showing 1 - 9 of 9

Altered Antioxidant Status and Increased Lipid Peroxidation in Children With Acute Gastroenteritis Admitted To a Pediatric Emergency Service
(Elsevier Science inc, 2009) Bayiroglu, Fahri; Cemek, Mustafa; Caksen, Hueseyin; Cemek, Fatma; Dede, Semiha
Acute gastroenteritis is a common illness worldwide and has a great impact on children. Our aim was to examine possible alterations in the antioxidant defense in pediatric gastroenteritis. To comprehensively examine the reaction of the antioxidant system, all possible components of the system were measured. The whole blood malondialdehyde and reduced glutathione, serum beta-carotene, retinol, vitamin C, vitamin E, catalase, ceruloplasmin, albumin, total bilirubin, uric acid, erythrocyte superoxide dismutase, and glutathione peroxidase levels were studied. Superoxide dismutase and glutathione peroxidase antioxidant enzyme activities and malondialdehyde levels were found to be increased, however, beta-carotene, retinol, vitamin C, vitamin E, reduced glutathione, and albumin levels were observed to be significantly decreased. Catalase activity remained unchanged, whereas some of the other non-enzymatic antioxidants such as ceruloplasmin, total billirubin, and uric acid levels were increased compared to the control group. We have shown an association between antioxidant levels and gastroenteritis in children. Further study is needed to assess whether antioxidant supplementation will be beneficial as an adjunct to conventional relevant therapy of the disease. (C) 2009 Elsevier Inc.
The Effect of a Highly Saturated Fat Diet and Intermittent Fasting Diet on Adiponectin and Lipid Metabolism
(Wiley-blackwell, 2015) Gunbatar, Nizamettin; Bayiroglu, Fahri; Bulduk, Bahttin; Karaaslan, Selver
The Effect of Moderate-Intensity Physical Exercise on Some Serum Inflammation Markers and the Immune System in Rats Fed Intermittent Fasting With a High-Fat Diet
(Mdpi, 2023) Gunbatar, Nizamettin; Bulduk, Bahattin; Bezgin, Selver; Oto, Gokhan; Bayiroglu, Fahri; Bulduk, Mehmet
Background and Objectives: This study aimed to investigate the impact of moderate-intensity physical exercise on serum inflammation markers and the immune system in rats that were fed a high-fat diet (HFD) with intermittent fasting. Materials and Methods: A total of 48 Wistar albino male rats were included in the study and divided into eight groups, each consisting of six rats. Group 1 served as the control group (CG), receiving a standard diet. Group 2 followed the standard nutrition program with intermittent fasting (CG + IF). Group 3 underwent exercise with a standard diet (CG + E). Group 4 underwent both a standard diet with intermittent fasting and exercise (CG + IF + E). Group 5 was fed a high-fat diet (HFD). Group 6 received a high-fat diet with intermittent fasting (HFD + IF). Group 7 followed a high-fat diet with exercise (HFD + E). Group 8 underwent both a high-fat diet with intermittent fasting and exercise (HFD + IF + E). The study lasted for 8 weeks. Results: The results of the analysis show that lymphocyte cell levels in groups HFD + IF, HFD + IF, and HFD + IF + E were higher compared to groups CG-HFD (p < 0.05). Additionally, B lymphocyte and monocyte cell levels were higher in group HFD + IF + E compared to groups CG, CG + IF, and CG + IF + E, as well as CG, CG + IF, and CG + E, respectively. TNF-alpha levels were significantly higher in group HFD compared to the other groups. Furthermore, IL 10 levels were higher in group HFD + IF + E compared to the other groups. Conclusions: These findings indicate that moderate exercise and intermittent fasting, particularly in groups fed a high-fat diet, increased anti-inflammatory cytokine levels, and certain immune system cell counts, while decreasing pro-inflammatory cytokine levels.
The Effects of Nutritional Differentiation and Duration on Levels of Inflammation Markers in the Experimental Acute Colitis Model
(Wiley, 2017) Emlik, Huseyin; Bayiroglu, Fahri; Mis, Leyla
High Fat Diet Induces Anti-Inflammatory Effect in Experimental Colitis
(Natl inst Science Communication-niscair, 2023) Emlik, Huseyin; Bayiroglu, Fahri; Mis, Leyla; Kaya, Mehmet Salih; Gunbatar, Nizamettin
The prevalence of ulcerative colitis, one of the inflammatory bowel diseases, has been increasing worldwide. Though fatty diet leads to development of colitis, only little is known about the separate and combined effects of different fat compositions and intermittent fasting, and the effects of preventative dietary changes on experimental colitis. In this study, we investigated the effect of feeding type and frequency on the inflammation ulcerative colitis. Five groups, each comprising 7 male Wistar albino rats, were formed viz. Colitis (as a control), High sucrose diet + Colitis, High sucrose diet + Intermittent fasting + Colitis, High fat diet + Colitis, High fat diet + Intermittent fasting + Colitis. The intermittent fasting group (experimental group) was not fed for 2 days (non-consecutive) in a week (except water), otherwise fed with ad libitum. Following the 7-wk feeding application, the rats were treated with intrarectal administration of 4% acetic acid (pH 2.4). After the rats were sacrificed, the levels of interleukin-10, insulin, C-reactive protein, leptin, tumor necrosis factor-alpha, interleukin-6, insulin-like growth factor-1 and adiponectin were analyzed from the blood samples. Analyzes of results revealed a statistically significant decrease in interleukin-10, C-reactive protein, tumor necrosis factor-alpha, interleukin-6 and adiponectin levels in High sucrose diet + Intermittent fasting + Colitis and High fat diet + Intermittent fasting + Colitis groups (P<0.05). According to these findings, the amount of fat and fatty acid composition in the fatty diet may have a protective effect against the development of colitis. Intermittent fasting further enhances this protective effect by lowering proinflammatory cytokine levels and reducing systemic inflammation in the body.
In Case of Obesity, Longevity-Related Mechanisms Lead To Anti-Inflammation
(Springer, 2014) Kaya, Mehmet Salih; Bayiroglu, Fahri; Mis, Leyla; Kilinc, Dide; Comba, Bahat
The exact mechanisms which contribute to longevity have not been figured out yet. Our aim was to find out a common way for prompting longevity by bringing together the well-known applications such as food restriction, exercise, and probiotic supplementing in an experimental obesity model. Experimental obesity was promoted in a total of 32 young (2 months old) and 32 aged (16 months old) male Wistar albino rats through 8-week cafeteria diet (salami, chocolate, chips, and biscuits). Old and young animals were divided into groups each consisting of eight animals and also divided into four subgroups as obese control, obese food restriction, obese probiotic-fed and obese exercise groups. Probiotic group diet contained 0.05 %w/total diet inactive and lyophilized Lactobacillus casei str. Shirota. The exercise group was subjected to treadmill running 1 h/day, at 21 m/min and at an uphill incline of 15 % for 5 days a week. Food restriction group was formed by giving 40 % less food than the others. The control group was fed regular pellet feed ad libitum. This program was continued for 16 weeks. Blood samples from all the groups were analyzed for fasting glucose, insulin, IGF-1, insulin-like growth factor binding protein 3 (IGFBP-3), interleukin (IL)-6, IL-12, malondialdehyde (MDA), fT3, TT3, fT4, TT4, and liver tissue MDA levels were measured. All applications showed anti-inflammatory effects through the observed changes in the levels of IGFBP-3, IL-6, and IL-12 in the young and old obese rats. While the interventions normally contribute to longevity by recruiting different action mechanisms, anti-inflammatory effect is the only mode of action for all the applications in the obesity model.
Oxidant and Non-Enzymatic Antioxidant Status in Measles
(Oxford Univ Press, 2007) Cemek, Mustafa; Dede, Semiha; Bayiroglu, Fahri; Caksen, Hueseyin; Cemek, Fatma; Mert, Nihat
Measles is a highly contagious viral disease of childhood associated with serious complications and significant morbidity and mortality. In the present study, antioxidant and oxidant status was investigated in children with measles. Our aim was to evaluate the possible changes in non-enzymatic antioxidant levels and their relationship to the oxidative stress in measles. According to our knowledge, there are no data about the blood levels of malondialdehyde (MDA), reduced glutathione (GSH) and vitamin C in measles. We measured the whole blood MDA (as a marker of lipid peroxidation) and GSH, and serum beta-carotene, retinol, alpha-tocopherol and ascorbic acid levels in all subjects. There was a statistically significant difference between the groups for all parameters (p < 0.05). Non-enzymatic antioxidant status was found to be decreased but, lipid peroxidation was increased in the study group. As a conclusion, these findings suggested that oxidant and antioxidant defence system were altered in children with measles.
Oxidative Stress and Enzymic-Non Antioxidant Responses in Children With Acute Pneumonia
(Wiley, 2006) Cemek, Mustafa; Caksen, Huseyin; Bayiroglu, Fahri; Cemek, Fatma; Dede, Semiha
In this article, oxidative stress and enzymic-non-enzymic antioxidants status were investigated in children with acute pneumonia. Our study included 28 children with acute pneumonia and 29 control subjects. The age ranged from 2 to I I years (4.57 +/- 2.13 years) and 2 to 12 years (4.89 +/- 2.22 years) in the study and control groups, respectively. Whole blood malondialdehyde (MDA) and reduced glutathione (GSH), serum beta-carotene, retinol, vitamin C, vitamin E, catalase (CAT), ceruloplasmin (CLP), total bilirubin, erythrocyte superoxide dismutase (SOD) and glutathione peroxidase (GPx) levels were studied in all subjects. There was a statistically significant difference between the groups for all parameters except for serum CAT. Whole blood MDA, serum CLP and total bilirubin levels were higher in the study group than those of the control group. However, SOD, GPx, beta-carotene, retinol, vitamin C, vitamin E and GSH levels were lower in the study group compared with the control group. All antioxidant vitamin activities were decreased in children with acute pneumonia. Our study demonstrated that oxidative stress was increased whereas enzymic and non-enzymic antioxidant activities were significantly decreased in children with acute pneumonia. Copyright (c) 2005 John Wiley & Sons, Ltd.
Relationship Between Antioxidant Capacity and Oxidative Stress in Children With Acute Hepatitis a
(Baishideng Publishing Group inc, 2006) Cemek, Mustafa; Dede, Semiha; Bayiroglu, Fahri; Caksen, Hueseyin; Cemek, Fatma; Mert, Nihat
AIM: To investigate in children with acute hepatitis A. According to our knowledge, there are no data about the blood levels of malondialdehyde (MDA, an indicator of oxidative stress) and nonenzymic antioxidants in children with acute hepatitis A. METHODS: Whole blood MDA and reduced glutathione (GSH), serum beta-carotene, retinol, vitamin E and vitamin C levels were studied in 19 (10 females, 9 males) children with acute hepatitis A and in 29 (13 females, 16 males) healthy control subjects. RESULTS: There was a statistically significant difference between patients and controls for all parameters (P < 0.05). Lipid peroxidation marker MDA was significantly elevated (P < 0.001), while antioxidants beta-carotene, retinol and GSH were significantly decreased (all P < 0.001) in patients compared to healthy subjects. In addition, a-tocopherol and ascorbic acid levels were significantly lower in patients when compared to age and sex matched controls (P < 0.05, P < 0.01, respectively). CONCLUSION: Our study shows that hepatitis A virus induces oxidative stress in childern with hepatitis A. This finding could be taken into consideration to improve the therapeutic approach in acute hepatitis A. (C) 2006 The WJG Press. All rights reserved.