Browsing by Author "Bayram, I"

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Anti-Fibrogenic Effects of Captopril and Candesartan Cilexetil on the Hepatic Fibrosis Development in Rat - the Effect of At1-R Blocker on the Hepatic Fibrosis
(Elsevier Gmbh, 2003) Tuncer, I; Ozbek, H; Ugras, S; Bayram, I
Background/Aim: Angiotensin converting enzyme (ACE) and angiotensin II (AT-II) have been suggested to play an important role in liver fibrogenesis. There is a significant relationship between inheritance of hightened expression of transforming growth factor beta1 (TGF-beta1) and AT-II and the development of progressive hepatic fibrosis. The purpose of this study was to investigate the effects of captopril. an ACE inhibitor and candesartan cilexetil, an AT-II type I receptor (AT1-R) blocker, on liver fibrosis induced in rats by carbon tetrachloride (CCl4) administration. Methods: rats were divided into 4 experimental groups: The first group was given CCl4 alone; the second was given both CCl4 and captopril (100 mg(.)kg(-1.)day(-1)); the third was given both CCl4 and candesartan cilexetil (8 mg(.)kg(-1.)day(-1)); fourth group was given 0.9% NaCl only. Seven weeks after initiating the treatment. indices of fibrosis were assessed. Results: Candesartan cilexetil treatment significantly reduced the fibrosis development. These inhibitory effects were not observed in the captopril-treated group. The mean fibrosis score was significantly lower in the CCl4/candesartan group compared with the group applied to CCl4 alone and the group applied to CCl4/captopril. Similarly, the number of alpha-smooth muscle actin positive cells was markedly suppressed by candesartan treatment. Conclusions: The results suggest that AT-II plays a pivotal role in hepatic fibrogenesis and candesartan significantly attenuates the progression of liver fibrosis. This drug may provide an effective new strategy for prevention of liver fibrosis. Its effectiveness should be investigated in chronic liver disease associated with progressive fibrosis.
Asymmetrical Nonscalp Aplasia Cutis Congenita: a Case Report
(Wiley, 2004) Atik, B; Tan, O; Bayram, I; Tuncer, O; Kirimi, E
Aplasia cutis congenita or congenital absence of the skin is a rare and serious congenital disease; its etiopathogenesis remains unclear. In this condition, localized or widespread areas of skin are absent at birth. A newborn suffering from an unusual aplasia cutis congenita located asymmetrically on the nonscalp, without blistering, was presented. This patient was completely healed with conservative treatment.
Cavernous Haemangioma of the Mitral Valve in a Child: Report of a Case and Review of the Literature
(Taylor & Francis Ltd, 2005) Ugras, S; Bayram, I
Desmoplastic Medulloblastoma in a 48-Year Male
(Tohoku Univ Medical Press, 2004) Bayram, I; Ibiloglu, I; Ugras, S; Yilmaz, N; Harman, M
Medulloblastoma is a malignant invasive embryonal tumor of the cerebellum with preferential manifestation in children. The peak of occurrence is seven years of age Seventy percent of medulloblastomas occur in individuals Younger than 16. In adulthood, 80% of medulloblastomas arise in the 21-40 years age group. A 48-year-old male patient was admitted to the hospital with complains of headache, ataxia, morning vomitting and difficulty in speech was operated with the diagnosis of presence of mass of 4 x 7 cm size retaining a diffuse homogenous contrast in the posterior fossa. The diagnosis of desmoplastic medulloblastoma was given after histopathological examination. Immunohistochemical examination revealed that neoplastic cells showed staining with neuron-specific enolase and synaptophysin but not with glial fibrillary acidic protein. This lesion showed nodular, reticulin free-zones (pale islands) surrounded by densely packed, highly, proliferative cells. The pale regions within the tumor did not contain retictifin fibers. Desmoplastic medulloblastoma is encountered especially in adulthood. This type of tumor rarely occurs beyond the fifth decade of life. We present a case of desmoplastic medulloblastoma in a 48-year-old male. - desmoplastic medulloblastoma; adulthood; posterior fossa (C) 2004 Tohoku University Medical Press.
The Effect of Colchicine on the Peritoneal Membrane
(Taylor & Francis inc, 2006) Sayarlioglu, H; Dogan, E; Erkoc, R; Ozbek, H; Bayram, I; Sayarlioglu, M; Bozkurt, H
Peritoneal dialysis (PD) is a treatment modality for patients with renal failure. Peritoneal fibrosis is one of the most serious complications after long-term continuous ambulatory peritoneal dialysis (CAPD). Histological studies in both humans and animals show that chronic peritoneal dialysis results in fibrosis of the peritoneal membrane. In our study, we investigated the effect of colchicine on peritoneal alterations induced by hypertonic PD solution in rats. Sprague-Dawley rats intraperitoneally received saline (control group) once daily, for 28 days, or 3.86% glucose (PDF group), or 3.86% glucose plus colchicine (colchicine group). Animals from each group were sacrificed after 28 days with anesthetized ketamine (60 mg/kg BW). For the PD fluid assessment, 1 h before the sacrifice of animals, 10 mL PD fluid of 2.27% glucose was given, and this fluid was obtained after the sacrifice. The levels of transforming endothelial growth factor ss (TGF-ss), tumor necrosis factor alpha (TNF-alpha) and albumin were investigated both in the peritoneal dialysate and blood, and the levels of malondialdehyde (MDA) were investigated only in peritoneal dialysate. The peritoneal membrane was evaluated histologically by light microscopy. When groups were compared in terms of body weight change, the colchicine group significantly lost weight compared to controls and PDF group (-4.7% 4.5, 3.5% 7.2, 3.0% 1.3, respectively, p = 0.018). Also, the blood albumin level was significantly lower for these in the colchicine group compared to those in the PDF group (2.7 0.35 versus 3.2 0.3 g/dL, respectively, p = 0.048). The blood TGF-ss level was significantly lower in the control group, and no difference was observed between the PDF and colchicine groups (294.4 67.5 versus 787.4 237.4 versus 615.3 235.1 pg/mL, respectively, p = 0.004). The mesothelial thickness found in groups was as follows: control group 102 18.9 mu m, PDF group 128.33 33.1 mu m, colchicine group 117 35.6 mu m ( p = 0.34). In conclusion, a rat model for peritoneal dialysis associated peritoneal derangement without fibrosis could be induced. Colchicine could not prevent peritoneal derangement in this model.
Effects of Erythropoietin and Pentoxifylline on the Oxidant and Antioxidant Systems in the Experimental Short Bowel Syndrome
(Wiley, 2003) Noyan, T; Onem, O; Sekerglu, MR; Köseoglu, B; Dülger, H; Bayram, I; Bakan, V
In this study, we investigated the effects of erythropoietin (Epo), and pentoxifylline (Ptx) on the oxidant and antioxidant systems in the experimental short bowel syndrome. Spraque-Dawley rats were divided into four groups and all animals underwent 75% small bowel resection. Group E was treated with 500 IU kg(-1) Epo subcutaneously (s.c.), group P with 50 mg kg(-1) day(-1) s.c. Ptx and group E + P with 500 IU kg(-1) s.c. Epo plus 50 mg kg(-1) day(-1) s.c. Ptx for a period of 28 days. In group C, which is the control group, no drug treatment was given. At the end of 28 days the experimented rats were killed and ileum samples excised for biochemical and histopathological testing. Malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) levels were determined in ileum homogenates. When compared to group C, the MDA and GSH-Px levels were significantly decreased (p < 0.05), but SOD activitiy was not changed (p > 0.05) in groups P and E + P, whereas both MDA and SOD and also GSH-Px activities were not changed significantly in group E (p > 0.05). The average villous length, crypt depth, muscular thickness and mucosal length were measured in all groups. The average crypt depth and mucosal length were statistically higher in the group P than group C (p < 0.001, p < 0.01, respectively). In addition, the crypt depth was statistically higher in both E and E + P groups as compared to group C (p < 0.001, p < 0.01, respectively). Therefore, our study indicates that Ptx may be more effective than Epo in reducing lipid peroxidation. Moreover, we considered that Ptx may give this protective effect by inhibiting the free oxygen radicals to a greater extent than developing the antioxidant capacity. Copyright (C) 2002 John Wiley Sons, Ltd.
Hepatoprotective Effect of Foeniculum Vulgare Essential Oil
(Elsevier Science Bv, 2003) Özbek, H; Ugras, S; Dülger, H; Bayram, I; Tuncer, I; Öztürk, G; Öztürk, A
Hepatoprotective activity of Foeniculum vulgare (fennel) essential oil (FEO) was studied using carbon tetrachloride (CCl4) induced liver injury model in rats. The hepatotoxicity produced by acute CCl4 administration was found to be inhibited by FEO with evidence of decreased levels of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and bilirubin. The results of this study indicate that FEO has a potent hepatoprotective action against CCl4-induced hepatic damage in rats. (C) 2003 Elsevier Science B.V. All rights reserved.
Hepatoprotective Effect of Pentoxifylline
(indian veterinary Journal, 2005) Bayram, I; Ozbek, H; Ugras, S; Tuncer, Y
Hepatorprotective Effect of Foeniculum Vulgare Essential Oil
(Scandinavian Federation Laboratory Animal Science, 2004) Özbek, H; Ugras, S; Bayram, I; Uygan, I; Edrogan, E; Öztürk, A; Huyut, Z
Hepatoprotective activity of Foeniculum vulgare (fennel) essential oil was studied using a carbon tetrachloride-induced liver fibrosis model in rats. The hepatotoxicity produced by chronic carbon tetrachloride administration was found to be inhibited by Foeniculum vulgare essential oil with evidence of decreased levels of serum aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and bilirubin. Histopathological findings also suggest that Foeniculum vulgare essential oil prevents the development of chronic liver damage. The changes in body weights in the rats assigned to the study groups supported these biochemical and histopathological findings. The results of this study clearly indicate that Foeniculum vulgare essential oil has a potent hepatoprotective action against carbon tetrachloride-induced liver fibrosis in rats.
The Importance of Rigid Nasal Endoscopy in the Diagnosis and Treatment of Rhinolithiasis
(Elsevier Sci Ltd, 2006) Yuca, K; Çaksen, H; Etlik, Ö; Bayram, I; Sakin, YF; Dülger, H; Kiris, M
Objectives: Rhinolithiasis is the presence of mineralized and calcareous formations located in the nasal cavity. They have rare occurrence and can be easily confused with infection or obstruction of tipper airways. If they are undetected for a long time, they may grow large enough to cause of nasal obstruction, mimicking sinusitis. Seven cases of rhinolithiasis were presented, and their diagnosis was made by rigid endoscopic nasal examination. Also computerized tomography scan was used to describe the size and site of the rhinoliths accurately. Our purpose was to determine the role of rigid nasal endoscopy in the diagnosis and the treatment of rhinolithiasis. Methods: In this study, seven cases of rhinolithiasis, who were diagnosed and treated by rigid nasal endoscopy were presented. Results: Between January 2000 and November 2004, seven cases (Four males and three females: age ranged front 8 to 45 years) with rhinolithiasis were diagnosed. The most frequent symptoms were nasal obstruction With purulent rhinorhea. nasal and oral malodor. As complementary examinations, computerized tomography and simple X-ray of paranasal sinuses were used to locate and measure the dimension of calcareous mass, and to reveal possible invasion of the adjacent structures. The removal of rhinolithiasis was done with rigid nasal endoscopy under topical anesthesia in six cases and general anesthesia in one case. Conclusion: Rhinolithiasis is a rare condition but must always be suspected in patients with long standing nasal obstruction, nasal and oral malodor, purulent rhinorrhea and chronic headache. (C) 2005 Elsevier Ireland Ltd. All rights reserved.
Malignant Meningioma in a 3-Year Girl
(Lippincott Williams & Wilkins, 2006) Bayram, I; Kiymaz, N; Harman, M; Ugrath, S
A New Agent for Treatment of Acute Respiratory Distress Syndrome: Thymoquinone. an Experimental Study in a Rat Model
(Oxford Univ Press inc, 2005) Isik, AF; Kati, I; Bayram, I; Ozbek, H
Objective: Acute respiratory distress syndrome (ARDS) and acute lung injury (ALI) are important clinical problems in thoracic surgery and critical care medicine. Most of the treatment methods are still supportive. Thymoquinone has anti-inflammatory, spasmolytic, bronchoditator and antibacterial effects. We studied its effects on ALI/ARDS in a rat model. Methods: ALI/ARDS was developed in 40 Sprague-Dawley mate rats (200-250 g in weight) by intratracheal instillation of human gastric juice (pH 1.2). Rats were treated with mechanic ventilator for 3 h. There were five groups: Control group (n = 11); Steroid group (n = 10); Ethanol group (n = 5); Thymoquinone group (n = 9) and Thymoquinone+Steroid group (n = 5). No instillation except gastric juice was applied in the first group. Thymoquinone was given in dosage of 6mg/kg, metilprednisolone in dosage of 10 mg/kg, ethanol 0.75 ml/kgintraperitoneatly (IP). Blood gas analysis and compliance measurement were done. At the end of the third hour, rats were sacrificed and their lungs were excised for histopathotogical examination. Results: In the thymoquinone group, the ratio of arterial oxygen to the fraction of inspired oxygen (PO2/FiO(2),) was significantly better compared to the other groups (P = 0.0000.043). Static compliance measurements revealed higher values in thymoquinone and thymoquinone+steroid groups. Histopathotogical examinations showed that affected lung tissue is tower in groups 2 and 4 (P = 0.000-0.027). Conclusions: This study revealed that thymoquinone improved oxygenation white both thymoquinone and steroids protect lung tissue from hazardous effects of human gastric juice (pH 1.2) histopathologically. (c) 2005 Elsevier B.V. All rights reserved.
Papillary Thyroid Carcinoma Presenting as a Giant Cervical Mass
(Royal Belgian Society Ear, Nose, Throat, Head & Neck Surgery, 2005) Yuca, K; Ünal, Ö; Bayram, I; Çankaya, H; Kiris, M
Papillary thyroid carcinoma presenting as a giant cervical mass; a case report. Papillary thyroid carcinoma (PTC) is a relatively uncommon malignancy. The prognosis is generally good and the mortality rate is low. PTC is more common in younger patients; incidence is two to three times higher in women and in individuals with radiation exposure to the neck. We report on a 75-year-old woman with PTC admitted to our clinic for a giant mass in the neck dating back ten years. A hyperintense huge cystic lesion and hypo-intense central solid component were seen on T1- and T2-weighted magnetic resonance imaging. No distant metastasis was present. The PTC was treated surgically and radioiodine (I-131) treatment was applied postoperatively. No recurrence was observed one year later.
Pediatric Intraoral Ranulas
(Tohoku Univ Medical Press, 2005) Yuca, K; Bayram, I; Çankaya, H; Çaksen, H; Kiroglu, AF; Kiris, M
An intraoral ranula is a retention cyst arises from the sublingual gland on the floor of the mouth as a result of ductal obstruction and fluid retention. Many techniques for management of ranulas have been described in the literature. The purpose of this study was to analyze our surgically treated pediatric patients with Intraoral ranulas and to discuss the results in the light of the literature. Nine pediatric patients (six females and three males) with intraoral ranulas surgically treated were analyzed retrospectively regarding their treatment methods and results. The surgical specimens were also re-examined histologically. Seven cases of superficial, protruded and smaller than 2 cm ranulas were treated with marsupialization (unroofing). Two cases who were previously operated and then recurred had bigger than 2 cm ranulas. In these two cases. marsupialization of the ranula plus removal of the sublingual gland was performed. The most common complication was intraoperative cyst rupture of the ranula, which was noted in four cases. A recurrence was observed in only one case in the 16th months of follow up period. Our findings show that marsupialization is a suitable and effective method for pediatric intraoral ranulas, whereas in recurrent cases marsupialization of the ranula combined with total excision of sublingual gland may be preferred - ranula: intraoral cyst; sublingual mass, inarsupialization (C) 2005 Tohoku University Medical Press
Remitting Seronegative Symmetrical Synovitis With Pitting Edema Syndrome Associated With Non-hodgkin's Lymphoma: a Case Report
(Springer-verlag, 2004) Sayarlioglu, M; Bayram, I; Sayarlioglu, H; Erkoc, R
Rocky Form Giant Synovial Chondromatosis: a Case Report
(Springer, 2006) Dogan, A; Harman, M; Uslu, M; Bayram, I; Akpinar, F
We report a case of painless synovial chondromatosis with an extremely large mass at the popliteal area related to the right knee joint. A hard mass at the posterior aspect of the knee was the only complaint reported by the patient. Plain X-ray studies revealed punctuated calcifications both intra-articularly and around the knee joint. With the surgical procedure performed subsequently, multiple rocky-hard giant chondroid nodules were excised from the posterior aspect of the knee. After 9 months following the surgery, the patient had full range of motion, and no complaints. We emphasize on the importance this case because these lesions may simulate tumors, and lead to misdiagnosis.
Skin Tag
(Karger, 2005) Tan, O; Atik, B; Bayram, I
Treatment of Recurrent Perforating Intestinal Ulcers With Thalidomide in Behcet's Disease
(Harvey Whitney Books Co, 2004) Sayarlioglu, M; Kotan, MC; Topcu, N; Bayram, I; Arslanturk, H; Gul, A
OBJECTIVE: To report the beneficial effects of thalidomide on recurrent perforating intestinal ulcers in a patient with Behcet's disease (BD). CASE SUMMARY: A 24-year-old Turkish woman with BD was admitted to our hospital because of severe abdominal pain and vomiting. She had been receiving colchicine 1.5 mg/day and azathioprine 150 mg/day for treatment of BD for 2 years. During emergency laparatomy, 2 perforating ulcers were detected in the anterior cecum, which were treated with debridement and primary repair. She experienced 2 more episodes of intestinal perforations during the second and fifth weeks despite intense immunosuppressive treatment with methylprednisolone and cyclophosphamide. New intestinal perforations were found in the posterolateral cecum and transverse colon during the second operation and in the terminal ileum during the third one. Thalidomide 100 mg/day was then started, and the symptoms disappeared within 2 weeks. The woman experienced no other intestinal perforation during the follow-up period of 4 months. DISCUSSION: The mode of action of thalidomide in BID is still unclear. In BID, various cytokines have been shown to be abnormally expressed and neutrophils are overactive. This is a possible mechanism of action with thalidomide reducing both tumor necrosis factor and the neutrophil migration. CONCLUSIONS: Thalidomide may be an effective alternative treatment for BID patients with recurrent and perforating intestinal ulcers despite intense immunosuppressive therapy.