Browsing by Author "Beşiroǧlu, L."

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A Case With Late-Onset Obsessions and Compulsions Following Chronic Cerebral Ischemia
(2004) Beşiroǧlu, L.; Özer, Ö.A.; Bal, A.C.; Saǧlam, M.
Obsessive-compulsive disorder (OCD) is an illness that usually manifests itself in the second or third decade of the life. Onset of OCD after age 70 has been rarely reported in the literature. Late-onset OCD is generally associated with an underlying cerebrovascular disease. The current consensus regarding choice of treatment(s) for idiopathic OCD includes cognitive behavioral therapy and serotonin reuptake inhibitors. However, the effectiveness of cognitive behavioral therapy or medications in cases with obsessive-compulsive symptoms due to general medical conditions has remained unclear. In this paper, an elderly patient who had late-onset obsessions and compulsions following chronic cerebral ischemia is presented with special emphasize made on specific issues about late-onset OCD cases and the application of standard therapeutic methods to these patients.
Factors Associated With Quality of Life in Obsessive Compulsive Disorder
(Cukurova University, Faculty of Medicine, 2007) Beşiroǧlu, L.; Uǧuz, F.; Saǧlam, M.; Yilmaz, E.; Aǧargün, M.Y.; Aşkin, R.
Objective: Since obsessive compulsive disorder (OCD) is an illness that considerably influences the family, academic, occupational and social functioning of patients, the relationship between OCD and QOL has been acquiring more importance. The present study was designed to investigate which aspects of quality of life (QOL) are most affected in OCD and to explore the predictors of decreased QOL in OCD. Methods: Seventy three patients with OCD and 69 healthy control subjects were compared in terms of their quality of life scores by means of WHOQOL-BRIEF. The relationship between QOL and probable clinical variables were explored by means of multivariate regression analyses. Results: Psychological health and social relationship scores of OCD patients were significantly lower than healthy subjects. Multivariate regression analyses revealed that the severity of depressive symptoms was the best predictor of both psychical health, and psychological health. The presence of comorbid personality disorder was the second significant factor to predict psychological health. While the severity of compulsions was the sole associated factor with psychological health, in second model, severity of depression as an associated variable was added to equation. Only the duration of illness was associated with environment scores. In the bivariate correlational analyses, while the severity of obsessions and depressive symptoms were significantly associated with psychological health, there is no association between psychological health and compulsion severity. Discussion: Since the subjective perception of QOL is considerably affected by depression severity, a quality of life assessment instrument that is specific for OCD should be developed.
The Psychometric Properties of the Clark-Beck Obsessive-Compulsive Inventory in a Turkish Population
(2007) Beşiroǧlu, L.; Aǧargün, M.Y.; Boysan, M.; Güleç, M.; Eryonucu, B.
Objective: We examined the psychometric properties of the Clark-Beck Obsessions and Compulsions Inventory eveloped to assess the frequency and severity of obsessive compulsive symptoms. Methods: The sample consisted of 52 OCD patients, 32 non-OCD patients with other anxiety disorders, 36 nonobsessional depressed patients, 75 healthy adults, and 278 undergraduate students. We investigated internal consistency, test-retest reliability, concurrent and discriminant validity of the instrument. Results: Cronbach's α coefficients for the CBOCI Obsessions, Compulsions and Total scale were found as 0.86, 0.83 and 0.91 in all samples respectively. The CBOCI obsessions (r=0.81, p<0.001), compulsions (r=0.85, p<0.001) and total score (r=0.85, p<0.001) showed a significant level of temporal stability. OCD patients scored significantly higher on CBOCI obsessions, compulsions and total scale than non-obsessional anxious, depressed patients, healthy control subjects. Obsession, compulsion and total scores of both OCD and nonclinical sample were significantly correlated with other scales assessing obsessive compulsive symptoms. Discussion: The Turkish version of the CBOCI has appropriate reliability and validity for assessing the frequency and severity of obsessive-compulsive symptoms.
Psychopharmacological Treatment Response in Obsessive Compulsive Patients With Autogenous and Reactive Obsessions
(2007) Beşiroǧlu, L.; Uǧuz, F.; Saǧlam, M.; Aǧargün, M.Y.; Aşkin, R.; Çilli, A.S.
Objective: It has been suggested that obsessions related with different cognitive process can be discriminated as autogenous and reactive obsessions. This study aimed to compare treatment response to psychopharmacological interventions of the OCD patients with autogenous and reactive obsessions. Methods: Using the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), Hamilton Depression Rating Scale (HDRS) and White Bear Suppression Inventory we assessed 20 patients with auotogenous obsessions (Autogenous group, AG) and 22 patients with reactive obsessions (Reactive group, RG) who met the DSM-IV criteria for OCD. The patients were consecutively assigned to receive either sertraline (100-200 mg/day), fluvoxamine (200-300 mg/day) or paroxetine (40-80 mg/day). We reassessed 80% of the initial AG (n=16) and 68% of initial RG (n=15) after 12 weeks. Results: The YBOCS obsession, compulsion, total scores, HDRS and WBSI scores at follow-up in both AG and RG were significantly lower than at baseline scores. The mean differences from baseline to follow up for obsession severity and suppression tendency in the AG were significantly higher than RG. The relationships between mean differences from baseline to follow up assessments on severity of obsessions, depressive symptoms and suppression tendency were found to be significant in the AG. Mean difference from baseline to follow up assessments on severity of obsessions were significantly associated with mean difference for compulsion severity in the RG. Conclusions: Discrimination for obsessions based on autogenous versus reactive may have implications for identifying psychopathological mechanisms implicated in the OCD, and for understanding variability in treatment response.
Sleep Quality, Depression and Anxiety in Carpal Tunnel Syndrome
(2008) Tekeoǧlu, I.; Gülcü, E.; Sayin, R.; Beşiroǧlu, L.; Yazmalar, L.
Objective: The purpose of this study was to examine the sleep disorders, anxiety and depression caused by CTS in patients, and whether electrodiagnostic study findings were associated with the severity of symptoms of sleep quality, anxiety and depression in patients. Materials and Methods: Using a case-control methodology, 87 electrophysiologically confirmed CTS patients with a mean age of 45±13 (27-62) years (86.9% women, n=73) and 50 controls with a mean age of 40±9.2 (21-56) years (54% women, n=27) were examined. Clinical neurological examinations of CTS patients and validated Turkish version of self-reported Sleep Quality Index, Beck Depression Scale and Beck Anxiety Scale were employed. Results: The majority of patients in the CTS group had worse symptoms of depression and anxiety, compared with the control group (p<0.05). The severity of CTS was not significantly associated with right and left hand utilization and the severity of symptoms of self-reported sleep quality, anxiety and depression scales. There were no statistically significant relationships between the electrodiagnostic findings and the patient functional status and symptom severity. Conclusion: Electrodiagnostic findings and patient CTS-related symptoms and sleep, anxiety and depression appear to be independent measures. Clinicians and researchers interested in CTS outcomes need to assess both. While depression and anxiety levels are found to be high in CTS, sleep-quality is relatively low. However, knowing that there is no correlation between the intensity of the illness and the number of symptoms with those variables, leads us to consider that the severity of the illness is evaluated on the self reports of patients. For this reason, physical impacts of the illness should also be evaluated as subjective.
Sociodemographic and Clinical Characteristics in Patients With Obsessive-Compulsive Disorder With and Without Comorbid Obsessive-Compulsive Personality Disorder
(2009) Uǧuz, F.; Beşiroǧlu, L.; Aşkin, R.
Objective: In this study, we aimed to investigate sociodemographic and clinical characteristics in patients with obsessive-compulsive disorder (OCD) with and without comorbid obsessive-compulsive personality disorder (OCPD). Methods: This study was conducted among patients who were admitted to outpatients clinics of department of psychiatry of 2 different university hospitals. The study sample consisted of 30 OCD outpatients with only OCPD among the Axis II disorders and 38 OCD patients without any Axis II disorders. Axis I and Axis II psychiatric disorders were determined by means of the Structured Clinical Interview for DSM-IV/ Clinical Version (SCID-I/CV) and the Structured Clinical Interview for DSM-III-R Personality Disorders (SCID-II), respectively. The Yale-Brown. Obsessive-Compulsive Scale (Y-BOCS) was used to determine types and severity of obsessive-compulsive symptoms. The patients' insight degree on obsessive-compulsive symptoms was assessed by means of the item 11 on the Y-BOCS. Results: The study groups had similar characteristics with respect to age, sex, educational level, marital status, and employment status. Compared to OCD patients without OCPD, symmetry/exactness obsessions, ordering/arranging compulsions, and diagnoses of comorbid major depression, dysthymic disorder, generalized anxiety disorder and social phobia were found to be significantly more frequent in OCD patients with OCPD. There was no significant difference between study groups in terms of other types and severity of obsessive-compulsive symptoms, other comorbid axis I disorders, age at onset and duration of OCD, and the patients' insight degree. Conclusion: The study results suggest that OCD patients with and without comorbid OCPD have generally similar sociodemographic and clinical characteristics.
Study of Validity and Reliability of the Turkish Version of the Core Bereavement Items
(2011) Selvi, Y.; Öztürk, R.I.; Aǧargün, M.Y.; Beşiroǧlu, L.; Cilli, A.S.
Objective: The aim of this study was to examine the reliability and validity of the Turkish version of the Core Bereavement Items (CBI) that assess the intensities of the bereavement reaction of bereaved individuals. Methods: The study involved 50 bereaved subjects who had lost a loved one through death within the past two months and 50 unbereaved subjects who had not experience such a loss within the past 5 years or more prior to the test. Internal consistency and homogeneity were tested by the Cronbach's and Pearson's correlation coefficients. The student's t-test and Pearson's correlation coefficient were used for rest-retest reliability. Validity was assessed with the student's t-test in independent groups. Results: Psychometric analyses showed that the Turkish version of the CBI had a high internal consistency (α=0.94). As for internal consistency, the · ranged between 0.46 and 0.87 for each item. The items of the CBI discriminated the bereaved group from the unbereaved group, except for items 4, 8, 9, 10. Conclusion: The Turkish version of the CBI has appropriate reliability and validity for assessing the intensity of bereavement. © Archives of Neuropsychiatry.