Browsing by Author "Begenik, Huseyin"

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Alveolar Echinococcosis of the Liver: a Single Center Experience
(Medycyna Praktyczna Sp K Sp Zoo, 2012) Dulger, Ahmet C.; Esen, Ramazan; Begenik, Huseyin; Aytemiz, Enver; Demirtas, Levent; Aslan, Mehmet
INTRODUCTION In humans, alveolar echinococcosis (AE) of the liver is caused by canine tapeworm called Echinococcus multilocularis. The disease is most prevalent in the northern hemisphere and in the eastern part of Turkey. OBJECTIVES The aim of the study was to review the natural history of AE and its clinical and radiological features. PATIENTS AND METHODS The retrospective study involved 23 patients (10 men, 13 women), aged 34-75 years with AE who had been referred to our liver disease clinic in the past 4 years. Only patients with pathologically proven AE were included in the study. The sociodemographic, clinical, and radiological features of AE were also evaluated. RESULTS The main laboratory characteristics of AE included mild eosinophilic leukocytosis with hyper-gammaglobulinemia, elevated C-reactive protein levels, near-normal liver transaminases, and increased levels of cholestatic enzymes and immunoglobulin E. Eight patients (35%) had hepatitis B e antigen-negative hepatitis B infection. Budd-Chiari syndrome was identified in 3 of 23 patients (13%). Eighty-three percent of the patients had a seropositive test result for AE, and approximately one-third of the patients had distant metastasis. Surgical treatment was administered in 4 patients. Four patients died due to complications during follow-up. CONCLUSIONS Patients with AE have numerous complications and advanced disease at the time of diagnosis. The clinical picture of AE comprises a number of hepatic and extrahepatic disturbances related both to destructive and mass effects of the tapeworm.
Assessment of Internal Jugular Vein Thrombosis Due To Central Venous Catheter in Hemodialysis Patients: a Retrospective and Prospective Serial Evaluation With Ultrasonography
(Sage Publications inc, 2012) Yardim, Hasan; Erkoc, Reha; Soyoral, Yasemin Usul; Begenik, Huseyin; Avcu, Serhat
Aim: We aimed to evaluate the frequency of catheter-related internal jugular vein (IJV) thrombosis, associated factors, and the anatomical variations of IJV in hemodialysis patients. Material and methods: Hemodialysis patients were evaluated with B-mode ultrasonography (USG). Participants in the prospective group were evaluated using USG prior to catheter insertion, 10 days after catheter insertion, at the time of catheter removal, and 15 days after removal. Results: The rate of thrombosis was increased correlated with the number of catheter insertions. These rates were 14%, 15%, and 47% in those undergoing catheter insertion once, twice, and three times, respectively (P < .05). The anatomical variations of IJV were 21% in the retrospective cases. No significant relationship was found between anatomical variations and thrombosis and between some biochemical parameters and thrombosis. Conclusion: Catheter-related IJV thrombosis is frequent in hemodialysis patients. Long catheter remaining time and repeated catheterization increase the thrombosis rate.
The Assessment of the Diet Knowledge Level and Daily Dietary Practice of the Relatives of Hemodialysis Patients
(Drunpp-sarajevo, 2012) Emre, Habib; Soyoral, Yasemin Usul; Begenik, Huseyin; Erdur, Mehmet Fatih; Kucukoglu, Mehmet Emin; Erkoc, Reha
Objectives: In this study, we aimed to investigate the level of nutrition and diet knowledge and the daily dietary practices of the relatives of hemodialysis patients. Material and Methods: We recruited 39 relatives whose patients receiving hemodialysis, and who provided the patient's dietary needs. The questionnaire containing questions regarding daily salt, water, potassium and phosphate intakes was conducted to the patient's relatives. The questionnaire results were reflected to the graphics with numbers and percentages. Results: The patient's relatives had sufficient information about the salt and water intakes, but they were not very sensitive to use their dietary knowledge during their daily practice. The relatives did not have enough information about the foods which containing phosphate and potassium and the clinical situations/complications related to the phosphor and potassium. Conclusions: The nutrition and diet education should be also provided to the patients' relatives. Besides the education, the patients and the relatives should be followed up periodically to see if they apply their knowledge. The relatives especially should be instructed about foods containing salt, phosphate and potassium.
Azigos Vein: Is It a Malposition or an Alternative
(Turk Nefroloji Diyaliz Transplantasyon dergisi, 2011) Emre, Habib; Soyoral, Yasemin Usul; Begenik, Huseyin; Demirkiran, Davut; Erdur, Fatih Mehmet; Gumrukcuoglu, Hasan Ali; Erkoc, Reha
Use of a temporary central venous catheter is common practice in hemodialysis therapy. One of the most common complications of central venous catheterization is catheter malposition. Cannulation of the azygos vein (particularly the azygos arch) is a rare but hazardous catheter malposition that carries a substantial risk of perforation, thrombosis and vascular stenosis. On the other hand, the azygos vein can be used for vascular access in patients whose superior vena cava and inferior vena cava are thrombosed. We present a case where the required blood flow for hemodialysis was provided by a dilated azygos vein due to superior vena cava obstruction.
Burkitt Lymphoma in Renal Transplant Recipient
(Taylor & Francis inc, 2007) Soyoral, Yasemin; Dogan, Ekrem; Sayarfloglu, Hayriye; Erkoc, Reha; Begenik, Huseyin
Clinical and Laboratory Aspects of Our Patients Have Pericardial Effusion
(Elsevier Ireland Ltd, 2010) Gumrukcuoglu, Hasan Ali; Akyol, Aytac; Tuncer, Mustafa; Gunes, Yilmaz; Akdag, Serkan; Begenik, Huseyin; Simsek, Hakki
Comparison of the Automated Cell Counter and Manual Method for the Assessment of Dialysis Fluids in Peritoneal Dialysis Patients
(Drunpp-sarajevo, 2011) Soyoral, Yasemin Usul; Begenik, Huseyin; Aldemir, Mehmet Naci; Baran, Ali Irfan; Emre, Habib; Karahocagil, Mustafa Kasum; Erkoc, Reha
Objective: To compare the accuracy of automated cell counter and the manual methods for the peritoneal fluid assessments in peritoneal dialysis patients. Material and Method: We analyzed 72 peritoneal fluid samples collected under sterile conditions from 27 patients with peritonitis (15 female; 12 male) following by the peritoneal dialysis unit of Yuzuncu Yil University Medical Faculty. The white blood cell counts of these peritoneal fluid samples were assessed by the both manual method and the automated cell counter. Results: The white blood cells were usually higher in the automated cell count method than the manual method (p<0,01). In 5 subjects, white cell counts were less than 100 cell/mu L in the manual method, but were more than 100 cell/mu L in the automated counter. There was a significant correlation between the manual and automated methods in terms of cell counts (p<0.01, r = 0.79). We also found good correlation between the two methods when WBC counts were greater than 300 cell/mu L (r = 0.87). Conclusions: There is a good correlation between the automated method and the manual methods for the assessment of peritoneal fluid samples in CAPD patients. However, in the assessment of fluids with less than 300 cell/mu L, the manual method should be preferred for critical clinical decisions.
Correlation of 24-Hour Urine Sodium, Potassium and Calcium Measurements With Spot Urine
(Modestum Ltd, 2013) Kara, Pinar Sonat; Erkoc, Reha; Soyoral, Yasemin Usul; Begenik, Huseyin; Aldemir, Mehmet Naci
In this study, we analyzed the correlation of sodium(Na), potassium(K) and calcium(Ca) amounts with spot urine(SU) and 24-hour urine(24-HU) collected as 8-hour portions. 21 hypertensive patients and 21 normotensive individuals were enrolled in the study. Na, K and Ca were studied in three sequential 8-hour urine samples and with the sum of three, 24-HU samples of the cases. Sodium/creatinine, potassium/creatinine, and calcium/creatinine were studied in fasting SU and serum Na, K and creatinine were studied. A significant correlation was found between the SU sodium/creatinine ratio and the Na amount in each 8-hour urine collections, and the Na amount in the 24-hour urine in hypertensive patients, the control group, and when all patients were evaluated together. When all group were evaluated together for Ca, a significant correlation was determined between the SU calcium/creatinine ratio and the Ca amount in all three 8-hour urine collections. The Na amount in the 24-HU may be estimated both with the SU Na/creatinine ratio and the 8-hour urine collection; SU does not have clinical significance for potassium. However, it may be estimated with 8-hour urine collections; SU may help roughly for calcium, and the collected urine gives higher correlation coefficients.
The Course of Hypercalciuria and Related Markers of Bone Metabolism Parameters Associated With Corticosteroid Treatment
(Taylor & Francis Ltd, 2012) Duzen, Omer; Erkoc, Reha; Begenik, Huseyin; Soyoral, Yasemin Usul; Aldemir, Mehmet Naci
Background and objective: Prolonged corticosteroid (CS) use induces osteoporosis; the pathogenesis of this condition is multifactorial and includes CS-induced hypercalciuria. We investigated the course of hypercalciuria and related markers of bone metabolism parameters during and after the CS treatment. Materials and Methods: We recruited 42 patients who were taking at least 10 mg/day of methylprednisolone or an equivalent dose of CSs for at least 30 days. The 24-h urinary calcium and sodium, a spot urinary calcium/creatinine ratio, and urinary deoxypyridinoline were measured prior to the treatment, at day 7, at days 30-60, and after the cessation of the treatment. Additionally, the serum levels of phosphorus, calcium, alkaline phosphatase (ALP), albumin, creatinine, osteocalcin, and parathyroid hormone (PTH) were analyzed. Results: The 24-h urinary calcium excretion was significantly increased at day 7 (182.2 +/- 158.6 mg/day; p < 0.001) and at days 30-60 (196.9 +/- 167.8 mg/day; p < 0.001) compared with baseline (98.7 +/- 88.1 mg/day) and returned to basal level after the cessation of the CSs (118.9 +/- 90.2 mg/day; p = 0.725). The urinary deoxypyridinoline level was significantly higher at days 30-60 compared with basal level. The serum osteocalcin level was decreased at days 30-60 when compared with day 7. No significant changes were detected in the PTH, phosphorus, creatinine, and ALP levels. Conclusions: CS treatment induces hypercalciuria just after starting the treatment until the end of it. CS-induced hypercalciuria promptly improved after cessation of the treatment. By days 30-60, the excretion of urinary deoxypyridinoline was accompanied by hypercalciuria. The serum osteocalcin level was decreased at days 30-60 when compared with day 7.
Dialysis Therapy for Lactic Acidosis Caused by Metformin Intoxication: Presentation of Two Cases
(Sage Publications Ltd, 2011) Soyoral, Yasemin Usul; Begenik, Huseyin; Emre, Habib; Aytemiz, Enver; Ozturk, Mustafa; Erkoc, Reha
Metformin is an oral antidiabetic, which is frequently used in the treatment of type II diabetes mellitus. Serious side effects may be seen during the administration of high doses of metformin. Two cases of lactic acidosis due to ingestion of high dose metformin for suicidal purposes have been presented here; in both cases, clinical improvement was seen with bicarbonate hemodialysis.
Effects of Low Sodium Dialysate in Chronic Hemodialysis Patients With Hypertension
(Oxford Univ Press, 2007) Esen, Ramazan; Erkoc, Reha; Sayarlioglu, Hayriye; Soyoral, Yasemin; Dogan, Ekrem; Sekeroglu, Ramazan; Begenik, Huseyin
Endodermal Sinus Tumor Presented With Ascites: a Case Report
(Elmer Press inc, 2012) Dulger, Ahmet Cumhur; Begenik, Huseyin; Esen, Ramazan; Rafet, Mete
We report a case of primary endodermal sinus tumor of the omenturn which may be the fourth reported case in the English literature. A 19-year-old boy presented with ascites. Analysis of ascites revealed high levels of AFP and CA 125. Laparoscopic biopsy showed endodermal sinus tumour. He was treated with four courses of the BEP regimen (bleomycin, etoposide, cisplatin). The patient was died 2 months after the first appearance of the ascites. Endodermal sinus tumor (EST) is a rare neoplasm which usually arises in the testis or ovary. But extragonadal EST especially located in the abdomen is very rare condition. Clinicians should remain vigilant particularly, when there is a low gradient ascites and are high levels of tumor markers in ascites in young patients.
Evaluation of Oxidative Status in Patients With Hyperthyroidism
(Humana Press inc, 2011) Aslan, Mehmet; Cosar, Niyet; Celik, Hakim; Aksoy, Nurten; Dulger, Ahmet Cumhur; Begenik, Huseyin; Selek, Sahbettin
Data on the antioxidant levels enzyme in patients with hyperthyroidism are limited and conflicting. Therefore, the objective of this study was to evaluate the oxidative status using an automated method in patients with hyperthyroidism. Thirty-six subjects with hyperthyroidism and 30 healthy controls were enrolled in this study. Serum oxidative status was determined via measurement of total antioxidant capacity (TAC) and total oxidant status (TOS) and calculation of oxidative stress index (OSI). Serum TAC levels were significantly lower in patients with hyperthyroidism than controls (P = 0.002), while serum TOS levels and OSI values were significantly higher (P = 0.008, 0.004; respectively). Serum TAC levels were correlated with TSH levels (rho = 0.223, P = 0.032), FT3 levels (rho = -0.434, P = 0.002) and FT4 levels (rho = -0.363, P = 0.003) in patients. Further, TOS levels and OSI values were correlated with TSH levels (rho = -0.245, P = 0.037; rho = -0.312, P = 0.011, respectively), FT3 levels (rho = 0.293, P = 0.017, rho = 0.505, P = 0.002, respectively), and FT4 levels (rho = 0.302, P = 0.006, rho = 0.321, P = 0.008, respectively) in patients. Duration of disease was significantly correlated with OSI values in patients (rho = 0.420, P = 0.011), while no correlation with serum TAC levels and TOS levels (P > 0.05). Oxidants are increased and antioxidants are decreased in patients with hyperthyroidism; as a result, the oxidative-antioxidative balance is shifted to the oxidative side. Increased oxidative stress may play a role in the pathogenesis of hyperthyroidism. It is believed that supplementation of antioxidant vitamins such as vitamins C and E may be helpful for these patients.
Fenofibrate-Induced Rhabdomyolysis in a Patient With Chronic Renal Failure Due To Nephrotic Syndrome: a Rare Case Report
(Pergamon-elsevier Science Ltd, 2012) Erdur, Fatih Mehmet; Soyoral, Yasemin Usul; Emre, Habib; Begenik, Huseyin; Canbaz, Esra Turan; Erkoc, Reha
Objectives: Fenofibrate is a fibric acid derivative that is used alone or combination with statins in the treatment of hyperlipidemia. These drugs have potential risks, including rhabdomyolysis and acute renal failure. Despite reports of rhabdomyolysis with the use of fenofibrate alone or with statin-fibrate combinations, there have been no cases of rhabdomyolysis described when fenofibrate was used alone to treat patients with chronic renal failure owing to nephrotic syndrome. Design and methods: We report on a 26-year-old male who presented with fenofibrate-induced rhabdomyolysis with chronic renal failure due to nephrotic syndrome. Results: After the discontinuation of fenofibrate, the patient was treated with intravenous fluid replacement and urine alkalization. Subsequently, his clinical and biochemical findings improved. Conclusions: Before starting fenofibrate therapy, the causes of secondary hyperlipidemia, especially nephrotic syndrome, should be investigated. In the presence of chronic renal failure and hypoalbuminemia, the fenofibrate dose should be adjusted. Physicians should be aware of the potential toxicities of fenofibrate, and patients should be informed about its potential side effects. (C) 2011 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
Fenofibrate-Induced Rhabdomyolysis in a Patient With Stage 4 Chronic Renal Failure Due To Diabetes Mellitus
(Pakistan Medical Assoc, 2012) Soyoral, Yasemin Usul; Canbaz, Esra Turan; Erdur, Mehmet Fatih; Emre, Habib; Begenik, Huseyin; Erkoc, Reha
Rhabdomyolysis is defined as a pathological condition of skeletal muscle cell damage leading to the release of toxic intracellular components into the circulation. Several factors may lead to rhabdomyolysis. Fenofibrate is a fibric acid derivative agent that is used in the treatment of hyperlipidaemia. Although several case reports of rhabdomyolysis have been reported due to the combination of statin and fenofibrate, fenofibrate alone rarely causes rhabdomyolysis. When administering fenofibrate in chronic renal failure, dose should be adjusted. Here, we report a case with fenofibrate-induced rhabdomyolysis in a patient with chronic renal failure.
A Flare of Ulcerative Colitis Accompanied With Cerebral Sinus Venous Thrombosis and Bilateral Thalamic Infarctus: A Case Report
(Elmer Press inc, 2012) Dulger, Ahmet Cumhur; Begenik, Huseyin; Demirtas, Levent; Esen, Ramazan; Emre, Habib
Ulcerative colitis (UC) is a chronic inflammatory and recurrent disorder that is characterized by bowel inflammation. Some patients with Inflammatory Bowel Disease (IBD) have acute, severe, and sometimes devastating intracranial complications that require immediate medical intervention. Cerebral sinus vein thrombosis is a rare but serious extraintestinal complication associated with ulcerative colitis. Herein we report a 30-year-old man with UC who presented with a flare of gastrointestinal symptoms with mental obtundation and apathy. Total colonoscopy revealed active colitis and cranial MRI showed extensive cerebral sinus venous thrombosis with thalamic infarcts. Because the patient was clinically unstable metilprednisolon with low molecular weight heparin were administered. Two days after treatment the patient was died despite all medical efforts.
Hepatic Encephalopathy in Connection With Budd-Chiari Syndrome Due To Infection With Echinococcus Multilocularis: a Case Report
(Elmer Press inc, 2011) Dulger, Ahmet Cumhur; Kemik, Ozgur; Selvi, Fatih; Begenik, Huseyin; Emre, Habib; Erdur, Fatih Mehmet
Budd-Chiari syndrome (BCS) is a hepatic venous outflow block generally resulting from disorders affecting hepatic venous system. Elevated hepatic venous pressure results in portal hypertension. BCS may also cause hepatic encephalopathy. Echinococcus multilocularis is a tapeworm parasite and the natural course of the disease may affect liver parenchyma as well as hepatic venous tree. It is the most terrible parasitic disease of the liver and is easily confused with hepatic malignancies. Albendazole therapy may suppress disease progression. Alveolar echinococcosis of the liver rarely causes Budd-Chiari syndrome-related hepatic encephalopathy (HE). We report a rare case of alveolar echinococcosis-related BCS with HE, who was successfully managed by rifaximin and albendazole.
Hydrocephaly Secondary To Central Vein Thrombosis in a Hemodialysis Patient
(Professional Medical Publications, 2012) Emre, Habib; Soyoral, Yasemin Usul; Erdur, Fatih Mehmet; Begenik, Huseyin; Sayin, Refah
Neurological disorders can be observed in hemodialysis patients due to uremic encephalopathy, electrolyte imbalance, infection, medications, glucose intolerance, hypoxia and psychiatric disorders. We present a case of hydrocephalus consequent to central vein thrombosis that is rarely seen in an adult hemodialysis patient and which causes neuro-psychiatric symptoms.
Levels of Matrix Metalloproteinase-1 and Tissue Inhibitors of Metalloproteinase-1 in Gastric Cancer
(Baishideng Publ Grp Co Ltd, 2011) Kemik, Ozgur; Kemik, Ahu Sarbay; Sumer, Aziz; Dulger, Ahmet Cumhur; Adas, Mine; Begenik, Huseyin; Kotan, Cetin
AIM: To evaluate the levels of preoperative serum matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in gastric cancer. METHODS: One hundred gastric cancer patients who underwent gastrectomy were enrolled in this study. The serum concentrations of MMP-1 and TIMP-1 in these patients and in fifty healthy controls were determined using an enzyme-linked immunosorbent assay. RESULTS: Higher serum MMP-1 and TIMP-1 levels were observed in patients than in controls (P < 0.001). Serum MMP-1 and TIMP-1 levels were positively associated with morphological appearance, tumor size, depth of wall invasion, lymph node metastasis, liver metastasis, perineural invasion, and pathological stage. They were not significantly associated with age, gender, tumor location, or histological type. CONCLUSION: Increased MMP-1 and TIMP-1 were associated with gastric cancer. Although these markers are not good markers for diagnosis, these markers show in advanced gastric cancer. (C) 2011 Baishideng. All rights reserved.
Non-Secretory Multiple Myeloma in a Hemodialysis Patient With Hypercalcemia
(Galenos Yayincilik, 2012) Erdur, Fatih Mehmet; Soyoral, Yasemin Usul; Emre, Habib; Begenik, Huseyin; Tasdemir, Mehmet; Erkoc, Reha