Browsing by Author "Bektas, Mehmet Selcuk"

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Association of Pulmonary Hemosiderosis and Celiac Disease
(Nobel Ilac, 2011) Dogan, Murat; Bektas, Mehmet Selcuk; Dogan, Sekibe Zehra; Aktar, Fesih; Cesur, Yasar
Idiopathic pulmonary hemosiderosis (IPH) is a rare disease of unknown autoimmune etiology mainly affecting children and adolescents. We report the case of an 6-years-old boy with cough and tiredness. There were no gastrointestinal symptoms were not determined. Body weight and height were in normal percentiles. Physical examination revealed cutaneous and mucosal pallor, due to severe anemia (hemoglobin 3 g/dL). Infiltrations were seen at the chest X-rays at both lungs, but markedly at left lung. In sputum examinations, hemosiderin-laden macrophages were seen. The diagnosis of IPH was made. The association of IPH and Celiac disease (CD) is well known. Searching associated CD was performed and then confirmed by biological and histological examinations. A gluten-free diet was initiated. Evolution was favorable. Searching for CD in IPH should be done, even in the absence of gastrointestinal symptoms.
Biotidinase Deficiency Accompanied by Diffuse Demyelination and Cerebral Atrophy
(Modestum Ltd, 2012) Okur, Mesut; Bektas, Mehmet Selcuk; Temel, Hayrettin; Caksen, Huseyin; Acikgoz, Mehmet; Sal, Ertan
Biotinidase deficiency is an inherited disorder which has autosomal recessive pattern; it occurs in approximately 1 in 60,000 live births. Usually it manifests seborrheic dermatitis, alopecia, ataxia, convulsions, hypotonia, developmental delay, hearing loss, chronic lactic acidosis and immune deficiency. Its diagnosis is made by the measurement of serum biotinidase enzyme activity and determination of the enzyme. Herein presented that a two and half-month-old boy with biotinidase enzyme deficiency which had cerebral atrophy without any skin signs. In the patients presented with refractory convulsions with unexplainable etiology without any skin lesions, as in our patient, biotinidase enzyme deficiency should be considered and the treatment should be established in early period to prevent many complications that may develop.
A Case of Immune Thrombocytopenic Purpura Presenting With Intracranial Hemorrhage
(Elsevier Science Bv, 2013) Akbayrami, Sinan; Aktar, Fesih; Akgun, Cihangir; Bektas, Mehmet Selcuk; Caksen, Huseyin; Onert, Ahmet Faik
Immune thrombocytopenic purpura is an acute, generally considered a self-limiting benign disorder with a 60%-80% change of spontaneous recovery occurring usually within a few months after onset. Intracranial hemorrhage is a rare but life-threatening complication of childhood immune thrombocytopenic purpura. We report a 4-year-old girl who admitted with headache, vomiting, bleeding from noise and bruises on the extremities. Her neurological examination was normal. Based on laboratory finding she was diagnosed immune thrombocytopenic purpura and intracranial hemorrhage. We suggest that cranial imaging should be perform in patients with immune thrombocytopenic purpura admitted with bleeding symptoms, vomiting and headache even if they had no abnormal neurological signs.
A Case of Leptospirosis With Multiple Organ Dysfunction
(Aves Yayincilik, Ibrahim Kara, 2010) Okur, Mesut; Akgun, Cihangir; Bektas, Mehmet Selcuk; Kaya, Avni; Temel, Hayrettin; Acikgoz, Mehmet; Dogan, Sekibe Zehra
Leptospirosis is a zoonotic infection caused by a spirochete of the genus Leptospira, which may affect both humans and animals and is common worldwide. The disease may lead to distinct clinical pictures in humans varying from subclinical infection to multiple organ dysfunction and even death. In this paper, we presented a 8-year-old male patient admitted with the complaints of fever, malaise, fatigue and night sweating, who had been feeding a pet rabbit in the house, and who had jaundice of the sclera and skin, a rash, gastrointestinal bleeding and hepatosplenomegaly found on examination. He developed encephalopathy, bleeding diathesis, hepatic and renal failure; and was diagnosed with leptospirosis based on the clinical symptoms and laboratory tests. After 14-days of therapy with crystallized penicillin and intensive supportive treatment, the neurological and hematological anomalies improved as well as the renal and hepatic dysfunction. In conclusion, we would like to emphasize that the probability of leptospirosis should be considered in children presenting with jaundice, encephalopathy, multiple organ dysfunction and bleeding diathesis if there are any environmental risk factors.
Comparison of Effects of 2.4 Ghz Wi-Fi and Mobile Phone Exposure on Human Placenta and Cord Blood
(Taylor & Francis Ltd, 2020) Bektas, Hava; Dasdag, Suleyman; Bektas, Mehmet Selcuk
The aim of this study was to investigate the effects of radiofrequency radiation emitted from Wi-Fi systems and mobile phones on cord blood and placenta. The study included 149 pregnant women who were divided in subgroups: unexposed (control), mobile phone exposed, Wi-Fi exposed and mobile phone plus Wi-Fi exposed groups. Immediately after birth, placenta and cord blood samples were collected and protein carbonyl (PCO), malondialdehyde (MDA), total oxidant status (TOS), total antioxidant status, 8-hydroxy-2 '-deoxyguanosine (8-OHdG) levels and DNA single strand breaks were analysed. The results of the study showed an increase in 8-OHdG, MDA, PCO and TOS in cord blood and placenta in the group exposed to mobile phones during gestation. However, the group exposed to Wi-Fi did not show alterations in the studied oxidative stress parameters. On the other hand, tail intensity and tail moment of DNA in the mobile phone exposure groups were higher than those in the control and Wi-Fi exposure groups. In conclusion, the results of this study indicated that mobile phone exposure during pregnancy could have an important potential to cause oxidative stress and DNA damage in cord blood and placenta. The results of this study also indicated that combined effects of Wi-Fi plus mobile phone exposure have a higher potential to cause synergistic harmful effects.
Diagnostic Role of Inflammatory Markers in Pediatric Brucella Arthritis
(Bmc, 2016) Aktar, Fesih; Tekin, Recep; Bektas, Mehmet Selcuk; Gunes, Ali; Kosker, Muhammet; Ertugrul, Sabahattin; Yolbas, Ilyas
Background: As a multisystem infectious disease, there is an inflammation, which causes increase in acute phase reactants in brucellosis. The mean platelet volume (MPV), platelet distribution width (PDW), red cell distribution width (RDW), neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) have been identified as markers of inflammation. The present study aimed to evaluate diagnostic values of these biomarkers in brucella arthritis (BA). Methods: The study included 64 children with BA and 66 healthy control subjects. Demographic features, joint involvement, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and hematological variables were retrospectively recorded. In addition, results of synovial fluid and serum tube agglutination test for brucella together with treatment regimens were recorded. Results: The mean age of the patients (53.1 % male) was 92.3 +/- 41.2 months. The most commonly affected joint was ankle (53.1 %). Synovial fluid puncture-brucella agglutination test was positive in 22 (34.3 %) patients. Puncture culture was positive in 9 patients. Most of the patients (57.8 %) were treated with a combination of rifampicin plus sulfamethoxazole/trimethoprim and gentamicin. Significantly higher mean PDW, RDW, MPV, NLR and PLR values were found in children with BA compared to control subjects (p < 0.05). A positive correlation was found between MPV and NLR values (R-2 = 0.192, p < 0.001). Conclusion: Our findings indicated that NLR and PLR are indirect markers of inflammation that may be observed abnormally increased in children with brucella arthritis. Further longitudinal studies are needed to investigate this topic to establish the more clear associations.
Effect of Mobile Phone Usage Duration During Pregnancy on the General Motor Movements of Infants
(Taylor & Francis Ltd, 2022) Bektas, Hava; Bektas, Mehmet Selcuk; Dasdag, Suleyman
Radiofrequency radiation (RFR) emitted from wireless devices increases rapidly and the most sensitive groups are pregnant women and children. Therefore, we aimed to evaluate the fidgety movements (FMs) and motor repertoires of the infants of pregnant women with different durations of mobile phone usage (DOMFU) in the prenatal period by performing a general movement assessment (GMA) using the Prechtl method. Infants suitable for the study were divided into 4 groups according to their mothers' duration of mobile phone usage during pregnancy, comprising those who did not talk on a mobile phone (Control Group, n: 31), those with mobile phone usage (MFU) of similar to 20 min a day (Group 1, n: 33), those with MFU of similar to 40 min a day (Group 2, n: 31), and those with MFU of similar to 2 h a day (Group 3, n: 28). The analysis showed that the abnormal fidgety (AF) and absent fidgety (F-), suboptimal motor optimality score (MOS) and reduced motor repertoire were statistically higher in Group 3 compared to the other groups. Normal posture and the quality of other movements were statistically higher in the Control, and Groups 1 and 2 compared to Group 3. According to the findings, infants of mothers with different DOMFU during pregnancy differed with regard to the quality of FMs, MOS, repertoire, posture and other movements. In conclusion, the findings suggested that there may be a relationship between prenatal RFR exposure and motor development in infants. More long-term studies are needed to determine whether these changes are temporary or permanent.
Effects of Mobile Phone Exposure on Biochemical Parameters of Cord Blood: a Preliminary Study
(Taylor & Francis inc, 2018) Bektas, Hava; Bektas, Mehmet Selcuk; Dasdag, Suleyman
The purpose of this study is to investigate foetal impact of radiofrequencies (RFs) emitted from mobile phones in postnatal cord blood. The study carried on 149 pregnant women divided into four groups such as nonusers of mobile phone (n: 37; control group), 2-15min/d (n: 39; group 1), 15-60min/d (n: 37; group 2) and participants using mobile phone for more than 60min/d (n: 36; group 3). Cord blood of the infants was taken in all groups for biochemical analyses immediately after birth. The results of the study showed that the biggest foetal impact was observed in the third study group which was pregnant exposed RFRs (RF radiation) more than 1h/d (1hour per day). AST (aspartat aminotransferaz), ALT (alanine aminotransferase), LDH (lactate dehydrogenase), CK (creatine kinase), CK-MB (creatine kinase-miyocardial band), CRP (c-reactive protein), PCT (procalcitonin), TnT (troponin T), uric acid and lactate levels of third group were found higher than the other groups (p<0.001). However, Mean platelet volume values of third group were found lower than the other groups (p<0.001). Finally, this is the first human study which was performed on pregnant and infants because there is no previous work in this area. However, the results of this study revealed that long-term RFR exposure of pregnant may result in some biochemical changes in the infants. Therefore, our suggestion to pregnant is to avoid from RFR exposure emitted from mobile phones at least during pregnancy.
Evaluation of Children With Nutritional Rickets
(Walter de Gruyter Gmbh, 2011) Cesur, Yasar; Dogan, Murat; Ariyuca, Sevil; Basaranoglu, Murat; Bektas, Mehmet Selcuk; Peker, Erdal; Caksen, Huseyin
Aim: To evaluate the clinical findings, risk factors, therapy and outcome in 946 children with nutritional rickets. Patients and methods: This retrospective study included a review of medical records of patients with nutritional rickets between March 2004 and 2009. Patients who displayed both the biochemical inclusion criteria and the clinical signs/symptoms or radiological signs of rickets were included in the study. Results: The present study included 946 patients aged between 4 months and 15 years. Distribution of the cases showed a density between December and May. The age at diagnosis, showed two peaks and most of the patients were in the age range 0-23 months and 12.0-15 years. In infants and young children, most of the patients had been admitted to the hospital due to infectious diseases. In older children, short stature and obesity were the most common complaints. Conclusion: Children aged between 0-23 months and 12.0-15 years were under most risk for nutritional rickets, especially in winter and spring and vitamin D should be given to them as supplementation dose.
The Frequency of Hashimoto Thyroiditis in Children and the Relationship Between Urinary Iodine Level and Hashimoto Thyroiditis
(Walter de Gruyter Gmbh, 2011) Dogan, Murat; Acikgoz, Emel; Acikgoz, Mehmet; Cesur, Yasar; Ariyuca, Sevil; Bektas, Mehmet Selcuk
The aim of this study was to determine the frequency of thyroid autoimmunity in second grade primary school students and to examine the relationship between iodine and Hashimoto thyroiditis (HT). This was a cohort study performed with 1000 students. Urinary iodine levels, antithyroid peroxidase (anti-TPO) and antithyroglobulin (anti-Tg) antibodies were determined in all children. Children with anti-TPO or anti-Tg antibody positivity or with goiter were summoned for detailed examinations. In total, 36 cases (3.6%) were diagnosed as HT. The goiter frequency was found in 17.5% of the whole cohort. Additionally, iodine deficiency was found in 64.2% of all children. The median urinary iodine excretion was determined as 132 mu g/L (range 382 mu g/L) in the HT group, whereas it was 73 mu g/L (range 390 mu g/L) in children with goiter but without HT and 81 mu g/L (range 394 mu g/L) in normal children. The urinary iodine level of HT cases was significantly higher than the other two groups (p < 0.001). HT was also determined in 2% of patients with low urinary iodine levels, in 6.2% of patients with normal urinary iodine levels, and in 7.5% of patients with high urinary iodine levels. Our data demonstrates the close relationship between excessive iodine levels and autoimmunity.
Mycoplasma Pneumoniae Meningoencephalitis: a Case Report
(Wolters Kluwer Medknow Publications, 2013) Bektas, Mehmet Selcuk; Aktar, Fesih; Acikgoz, Mehmet; Sal, Ertan; Caksen, Huseyin
Nervous system is the most affected area in mycoplasma pneumoniae infections with exception of respiratory system. It is an important agent of childhood acute encephalitis and respiratory system infections in school-age children and young adults. Routine clinical and laboratory findings to identify spesific diagnosis is limited. Twelve-year-old female patient was admitted with fever, fatigue, sore throat, slipping the right eye, withdrawal of the mouth from the right and right hemiclonic seizures. Test of anti-Mycoplasma pneumoniae (M. pneumoniae) IgM was positive and IgG antibodies were found to be 4-fold increase in the sera of follow-up. This article was presented with the aim of remembering M. pneumoniae to be an differential diagnosis in children with acute encephalitis.
New Coagulant Agent (Ankaferd Blood Stopper) for Open Hemorrhages in Hemophilia With Inhibitor
(Sage Publications inc, 2010) Oner, Ahmet Faik; Dogan, Murat; Kaya, Avni; Sal, Ertan; Bektas, Mehmet Selcuk; Yesilmen, Osman; Acikgoz, Mehmet
The treatment of hemophilia A patients with inhibitor could be very expensive. Ankaferd blood stopper (ABS) is a unique folkloric medicinal plant extract, which has historically been used in Turkish traditional medicine as a hemostatic agent. In this article, a 16-year-old boy was presented with uncontrolled bleeding, despite the treatment of factor VIII, rVIIa, factor VIII inhibitor bypass activity (FEIBA), cyclophosphamide, and prednisolone at circumcision site that resolved with ABS in minutes. Our patient with hemophilia A and inhibitor is the first clinical pediatric case.
The Prevalence of Factor V 1691g-A Mutation in Van Region of Turkey
(Aves Yayincilik, 2010) Akbayram, Sinan; Akgun, Cihangir; Dogan, Murat; Bektas, Mehmet Selcuk; Oner, Ahmet Faik
Retrospective Clinical and Laboratory Evaluation of Children With Brucellosis
(Wiley, 2012) Okur, Mesut; Erbey, Fatih; Bektas, Mehmet Selcuk; Kaya, Avni; Dogan, Murat; Acar, Mehmet Nuri; Uzun, Hakan
Background: Acute brucellosis is a zoonotic disease seen in childhood, with non-specific complaints and clinical findings that can affect the locomotor, gastrointestinal, genitourinary, hematologic, cardiovascular, respiratory, and central nervous systems. Particularly in endemic regions, it occurs as a result of consumption of unpasteurized milk and dairy products. In this study, clinical and laboratory findings of children with acute brucellosis are presented. Methods: Data for 147 patients, aged 2-16 years, were evaluated retrospectively. Results: The most frequent complaints and clinical findings were abdominal pain and fever. Other complaints and clinical findings included arthralgia, myalgia, loss of appetite, weakness, sweating, fatigue, headache, arthritis, hepatomegaly, and splenomegaly. Anemia was the most frequent hematological abnormality detected; other abnormalities included leukopenia, thrombocytopenia, and pancytopenia. Conclusion: Childhood brucellosis can cause non-specific complaints and particularly anemia and leukopenia as hematological abnormalities. It is easily treated, however, with appropriate antibiotics.