Browsing by Author "Belge, F"

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Changes in Erythrocyte Parameters of Fluorotic Sheep
(int Soc Fluoride Research, 2003) Yur, F; Belge, F; Mert, N; Yörük, I
The aim of this study was to investigate changes in oxidative stress parameters of erythrocytes in twenty 3-4 year-old fluorotic sheep as compared to twenty controls. Malondialdehyde (MDA) levels (mean +/- SD) were significantly elevated in erthyrocytes of the fluorotic sheep (2.51 +/- 0.16 nmol/mL) in comparison to the control sheep (1.32 +/- 0.13 nmol/mL). Erythrocyte Na+-K+ adenosine-5'-triphosphatase (Na+-K+ ATPase) activity in the fluorotic sheep (0.003 +/- 0.0005 mumol Pi/mg protein/h) was significantly lower than in the controls (0.005 +/- 0.0005 mumol Pi/mg protein/h), as was the activity of glucose-6-phosphate dehydrogenase (G6PD) (510 +/- 23.30 mU/g Hb) compared to the controls (1418 +/- 85.40 mU/g Hb). The results are explained by fluoride-induced oxidative stress reflected in elevated erythrocyte MDA levels that cause decreased enzyme activity of Na+-K+ ATPase and G6PD by affecting membrane structure.
Effect of Nigella Sativa L. on Heart Rate and Some Haematological Values of Alloxan-Induced Diabetic Rabbits
(Scandinavian Federation Laboratory Animal Science, 2004) Meral, I; Donmez, N; Baydas, B; Belge, F; Kanter, M
This study was designed to investigate the effect of an extract of Nigella sativa L. on the heart rate and some haematological values in alloxan-induced diabetic rabbits. Fifteen New Zealand male rabbits were divided into three experimental groups: control, diabetic and N. sativa L.-treated diabetic. At the end of the experimental period (2 months), animals in all three groups were fasted for 12 hours and blood samples were taken for the determination of glucose levels, RBC and WBC (red and white blood cell) counts, packed cell volume (PCV), and haemoglobin (Hb) concentration. Heart rates were also measured by a direct-writing electrocardiograph before the blood withdrawals. It was found that N. sativa L. treatment increased the lowered RBC and WBC counts, PCV and neutrophil percentage in diabetic rabbits. However, the WBC count of the X sativa L. treated diabetic group was still lower than the control. N. sativa L. treatment also decreased the elevated heart rate and glucose concentration of diabetic rabbits. It is concluded that oral X sativa L. treatment might decrease the diabetes-induced disturbances of heart rate and some haematological parameters of alloxan-induced diabetic rabbits.
Effect of Protein Deficiency on Macroelement and Trace Element Levels of Weanling Rats' Small Intestine and Liver Tissues
(Humana Press inc, 2005) Kilicalp, D; Dede, S; Belge, F; Tatar, M
Protein energy malnutrition has become a major health issue in developing countries. In the present study, the effect of protein deficiency on the small intestine and liver tissue content of macroelements and trace elements was investigated in weanling rats. Forty-five male weanling Wistar albino rats were divided into three groups. The control group (C) was fed a standard diet containing 25% casein, whereas the two experimental groups E1 and E2 consumed 12% and 3% casein, respectively, over a period of 45 d. The tissue samples were analyzed for zinc, copper, iron, manganese, calcium, and magnesium by atomic absorption spectroscopy. The protein-deficient groups showed increased levels of iron in both tissues and decreased manganese in small intestine tissue from the E1 group. No other differences were found for the other elements. These results suggest that protein deficiency might cause iron accumulation in the liver and intestine and decreases of manganese in the small intestine.
Effects of Chronic Fluorosis on Electrocardiogram in Dogs
(int Soc Fluoride Research, 2004) Kilicalp, D; Cinar, A; Belge, F
The aim of this study was to determine the effects of chronic fluorosis on the electrocardiogram (ECG) in dogs. A total of sixteen mixed breed dogs (8 fluorotic and 8 healthy), 2 to 3 years old and weighing 18-30 kg, were used in this study. The eight dogs with chronic fluorosis were obtained from the Tendurek Mountain region (altitude about 2000 m) in Eastern Anatolia. All ECG waves were observed in all of the leads. Sinus bradycardia was seen in dogs with chronic fluorosis. Prolonged P-Q interval (P<0.05) was present. The duration and amplitude of T wave was higher and longer (P<0.05) in the fluorosis group. As a result, the number of heart beats/minute was decreased significantly (p<0.05) from 120.4+/-15 in the control group to 80.7+/-14 in dogs with fluorosis. The average electrical axis of the heart changes were between +60degrees and +100degrees in both groups. The average electrical axis was +80degrees in the control group and +75degrees in the fluorotic dogs.
Effects of Stress Produced by Adrenocorticotropin (Acth) on Lipid Peroxidation and Some Antioxidants in Vitamin C Treated and Nontreated Chickens
(South African Journal of Animal Sciences, 2003) Belge, F; Çinar, A; Selçuk, M
The aim of this study was to examine the effects of vitamin C on malonaldehyde (MDA) and glutathione (GSH) concentrations, and superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activity in chickens stressed by adrenocorticotropin (ACTH). Sixty Leghorn chickens (20 weeks old) were randomly allotted to a control and a vitamin C treated group. An isotonic sodium chloride solution was administrated intramuscularly for a period of five days to the control group at a dose of 2.5 mL per chicken per day, and the treatment group received a vitamin C solution (containing 250 mg vitamin C/2.5 mL) intramuscularly for five days. On the fifth day of the experiment the chickens in both groups received 50 IU ACTH intramuscularly. Three hours after ACTH application blood samples were collected to determine the concentrations of MDA and GSH, and activities of SOD and GSH-Px in the blood. The concentration of MDA in the control group increased compared to that in the vitamin C treated group. After the ACTH application the activity of SOD increased in both groups, thought significantly so in the vitamin C treated group. The GSH-Px activity did not differ significantly between the treatments after ACTH application. It was concluded that intramuscularly administrated vitamin C facilitated an adaptation against stress and decreased negative effects of stress in chickens.
The Electrocardiogram of the Pekin Duck
(Amer Assoc Avian Pathologists, 1996) Cinar, A; Bagci, C; Belge, F; Uzun, M
In this study, standard limb lead electrocardiograms (EGG) were recorded in 50 Pekin ducks. The ECG exhibited P, R, S, and T waves. A Q wave was observed in 30% of leads aVR aVL. All waves in lead I were of very low amplitude or almost isoelectric. The P wave was 20% negative, 80% positive in lead aVR and always positive in other leads. The duration and amplitude of P wave were 0.025 sec and 0.17 mV, respectively and the P-R interval was 0.06 sec in lead II. A Q wave was observed in 30% of leads aVR and aVL but was invisible in other leads. The duration of QRS complex was 0.036 sec and its amplitude was 0.069 mV. The S wave (rS) was greater than the R wave in leads III and aVE The R and S waves were equal in lead III (66%). The mean duration and amplitude of T wave were 0.05 sec and 0.22 mV, respectively. The T wave was negative in leads aVR and aVL and positive in other leads. The Q-T interval was 0.10 sec. The mean heart rate was 281.3 (220-375) beats/min. The average value of the mean electrical axis was +147 degrees (+95 degrees to -160 degrees).
Erythrocyte Membrane (na+-K+< Atpase Activities in Some Mammals
(indian veterinary Journal, 2002) Belge, F; Donmez, N; Bildik, A; Tatar, M
Metamizol Induced Anaemia in Dogs
(indian veterinary Journal, 2003) Bakir, B; Belge, F; Belge, A; Tutuncu, M; Ozen, S; Dilek, I
Possible Association Between Chronic Laminitis and Some Biochemical Parameters in Dairy
(Australian veterinary Assn, 2004) Belge, F; Bildik, A; Belge, A; Kiliçalp, D; Atasoy, N