Browsing by Author "Berberoglu, M"

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Does Long-Term Use of Valproate Cause Weight Gain in Prepubertal Epileptic Children
(Taylor & Francis Ltd, 2002) Çaksen, H; Deda, G; Berberoglu, M
In this experiment, we studied the effect of valproate (VPA) on weight gain, and serum leptin levels in prepubertal epileptic children receiving VPA. Our purpose was to determine whether or not long-term use of VPA causes weight gain in childhood, and to evaluate serum leptin levels in a group of prepubertal children receiving VPA. Our study included 15 patients (9 males, 6 females) with new diagnosed epilepsy and 16 healthy age-matched controls (9 males, 7 females). The subjects' ages ranged from 9 months to 12 years. Weight gain was noted in 9 (60%) of 15 patients in the study group, and 8 (50%) of 16 subjects in the control group (p > .05). There was no difference between the groups for body mass index (BMI) and serum leptin levels. Although higher serum leptin levels were found in the patients treated with VPA weight gaining (5.65 +/- 3.06 ng/ml vs. 3.28 +/- 1.69 ng/ml), we did not find a difference between the patients Weight gaining and nonweight gaining (p > .05). While a significant correlation between BMI and serum leptin levels was found in the study group (r = .704; p = .003), it was not significant in the control group (r = .330; p = .211). In conclusion, our findings showed that long-term use of VPA did not cause weight gain in a group of prepubertal children receiving VPA and, parallel to this, serum leptin levels were similar in both the control and study group.
The Effect of Co2 Insufflation Rate on the Postlaparoscopic Shoulder Pain
(Mary Ann Liebert inc Publ, 1998) Berberoglu, M; Dilek, ON; Ercan, F; Kati, I; Ozmen, M
Shoulder pain (SP) is frequently mentioned in recent literature following laparoscopic operations. In the literature, many causes have been declared to explain shoulder pain after CO2 insufflation, such as direct peritoneal irritation of the CO2 gas, excessive traction of the triangular ligament, and overstretching of the diaphragmatic muscle fibers due to the high rate of insufflation, This study was planned as multicentric, and 76 patients, aged between 35 to 45, were entered into the study. They were all selected by a randomized sampling method, with equal numbers of men and women, to achieve true evaluation. The low flowrate (LFR) group was insufflated with 2.5 L/min and the high flow-rate (HFR) group with 7.5 L/min. All cases were evaluated by subjective pain classification on postoperative day 3. According to the subjective pain scale method, shoulder pain average was 23.9 +/- 3.1 in the LFR group and 55.4 +/- 6.5 in the HFR group. The difference between these groups was significant (p > 0.01), There is no significant difference for the operation time (LFR%: 64 +/- 15 minutes, HFR: 61 +/- 20 minutes, p > 0.05), Our results suggest that there is a significant statistical relation between the postoperative shoulder pain levels and increased insufflation rates. For this reason, low insufflation rate significantly reduces the shoulder pain but does not increase the operation time. Therefore, a low insufflation rate should be applied in all cases for patients' comfort and safety.
Herniography and Ultrasonography - a Prospective Study Comparing the Effectiveness of Laparoscopic Hernia Repair With Extraperitoneal Balloon Dissection
(Springer verlag, 1997) Dilek, ON; Bozkurt, M; Arslan, H; Kisli, E; Poyraz, N; Berberoglu, M
Background: This study was designed to assess differences between pre- and postoperative herniography and ultrasonography in inguinal hernia performed laparoscopically with balloon dissection and mesh without suture, Methods: Pre- and postoperative herniographic and ultrasonographic findings were analyzed in ten consecutive patients, Postoperative ultrasonography was performed on the 3rd and 7th days and herniography was performed on the 7th day, Results: Following the operation both the herniography and ultrasonography were almost normalized to a great extent in nine patients, Overall, minimal impaired continence was recorded by herniography in one patient. Also, we detected nonspecific soft-tissue thickening at the operation site in ultrasonographic examination in four patients, Conclusions: As for inguinal hernias, compared with other operative modalities of treatment, laparoscopic hernia repair with extraperitoneal balloon dissection and mesh without suture is a highly successful procedure and its minimal morbidity is well accepted by the patient.