Browsing by Author "Bercin, Sami"

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Changes in Serum Igf-1 and Igfbp-3 Levels and Growth in Children Following Adenoidectomy, Tonsillectomy or Adenotonsillectomy
(Elsevier Ireland Ltd, 2010) Kiris, Muzaffer; Muderris, Togay; Celebi, Sezgin; Cankaya, Hakan; Bercin, Sami
Objective: The aim of this study is to determine the effect of adenoidectomy, tonsillectomy or adenotonsillectomy on growth. For this purpose, we prospectively reviewed the postoperative changes in serum levels of insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3), weight and height in children that underwent adenoidectomy, tonsillectomy or adenotonsillectomy. Methods: Ninety-six children with symptoms of sleep disordered breathing (SDB) or recurrent adenotonsillitis were enrolled to study. Blood samples were taken preoperatively and repeated at 6 months following operation to determine the changes in serum IGF-1 and IGFBP-3 levels, pre- and postoperative values of weight and height were recorded for each operation. Results: Thirty-six patients underwent adenoidectomy, 52 patients underwent adenotonsillectomy and 8 patients underwent tonsillectomy. Seventy of the operations were performed for SDB and 26 were performed for recurrent adenotonsillitis. The mean serum levels of IGF-1 increased by 26%, from 126.74 +/- 112.13 ng/ml to 159.82 +/- 122.91 ng/ml (p < 0.001) and IGFBP-3 levels increased by 7%, from 3.34 +/- 1.17 mu g/l to 3.57 +/- 1.16 mu g/l (p < 0.05) 6 months after operation. The increase was independent from the preoperative diagnosis. There was a significant increase both in patients with SDB and in children with recurrent infections (p < 0.001 for IGF-1, p < 0.05 for IGFBP-3). Their Z scores (standard deviation scores) for body weights (mean Z score from -0.06 +/- 0.98 to 0.118 +/- 1.18, p < 0.001) and heights (mean Z score from 0.30 +/- 0.98 to 0.42 +/- 0.88, p < 0.001) were significantly higher 6 months after the operation compared to preoperative period. Conclusions: We found a significant increase in weight, height, and IGF-1 and IGFBP-3 levels of children with SDB or recurrent infections postoperatively. These results suggest that upper airway obstruction may not be the only mechanism that causes retardation on growth in children. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
Effects of Absorbable Gelatine Sponge on Middle Ear Mucosa Alone and With Corticosteroids and Antibiotics: an Animal Study
(Mediterranean Soc Otology & Audiology, 2011) Kiris, Muzaffer; Muderris, Togay; Icli, Murat; Bercin, Sami; Ozen, Suleyman; Yazici, Alper
Objective: The aim of this study is to investigate histopathologic changes that take place in middle ear mucosa after the use of absorbable gelatine sponge (AGS), and to find out if AGS combined with corticosteroids and/or antibiotics have an influence on these changes. Study design: Animal study Materials and Methods: Thirty-two adult guinea pigs were divided into four groups, with eight ears in each group. In control group, nothing was inserted to middle ear after traumatization of mucosa (group A). In study groups, sponges soaked with physiologic saline (group B), dexamethasone (group C) or dexamethasone and levofloxacin (group D) was inserted to middle ear after mucosal abrasion. Animals were sacrificed at the end of fourth week and fibrosis, inflammation, microscopic residue of AGS and the signs of foreign body reaction in middle ear mucosa were analyzed under light microscopy. Results: No fibrosis was observed in the study group and inflammation was visible in two ears. Sponge residue was seen in two ears in group B, in two ears in group C and in one ear in group D. Signs of inflammation, fibrosis and foreign body reaction was observed in all study groups more or less, and even if the difference between study groups is not statistically significant, all histopathologic changes were slighter in group D. Conclusion: Since we cannot avoid the use of AGS in otologic surgery, we believe soaking sponges with antibiotics and steroids is the best way to reduce its undesirable effects like fibrosis and foreign body reaction.
Prevalence and Risk Factors of Otitis Media With Effusion in School Children in Eastern Anatolia
(Elsevier Ireland Ltd, 2012) Kiris, Muzaffer; Muderris, Togay; Kara, Tolga; Bercin, Sami; Cankaya, Hakan; Sevil, Ergun
Objective: To investigate the prevalence and demographic, environmental and child associated risk factors of OME in schoolchildren in Eastern Anatolia, Turkey, and analyze the results with reference to the review of the literature. Methods: A total of 2355 children who were attending two different primary schools, one located in low, and the other located in a high socioeconomic district of city of Van were screened and 2320 children who met the inclusion criteria were enrolled to study. Standardized questionnaires that include nine questions for determination of risk factors were delivered to the parents to be filled before examination of each child. All of the children underwent both otoscopic examination and tympanometric evaluation to provide high accuracy on the diagnosis of OME. The association between children diagnosed as OME and the answers to the questionnaires were evaluated. Also, teachers of the children were asked to complete a questionnaire evaluating child's level of school success, and the success levels of children with or without OME were compared. Results: The prevalence of OME was found to be 10.43%. Second-hand smoking (p < 0.0001), low socioeconomic status (p < 0.001), living in a crowded house (p < 0.001), presence of atopy (p < 0.01), lack of breast-feeding (p < 0.05), presence of URTI (p < 0.0001), young age (p < 0.001) and snoring (p < 0.0001) were found to be associated with prevalence of OME. No significance was found for duration of breast-feeding, gender, birth history and previous otolaryngological operations. Also, children with OME were tended to be less successful in terms of school success. Conclusions: The potential of OME to cause serious sequelae and complications that may affect children's life long-term, makes the disease an important health problem. Environmental, epidemiologic and familial factors play an important role in pathogenesis of OME. Caretakers must be informed about these highly modifiable risk factors, by this way the development or delayed diagnosis of the disease that may cause serious consequences can be prevented. (C) 2012 Elsevier Ireland Ltd. All rights reserved.