Browsing by Author "Besiroglu, L."

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Dream Anxiety Is an Emotional Trigger for Acute Myocardial Infarction
(2011) Selvi, Y.; Aydin, A.; Gumrukcuoglu, H.A.; Gulec, M.; Besiroglu, L.; Ozdemir, P.G.; Kilic, S.
Objective: The aim of the present study was to investigate the relationship between nightmares and acute myocardial infarction (AMI) occurring during sleep, and also to evaluate the influence of several related factors. Method: The sample comprised AMI patients who had been admitted to the coronary care unit. The patients were grouped into two categories; the asleep-AMI group consisted of 36 patients who had the onset of symptoms of AMI during sleep, and the awake-AMI group included 183 patients who had AMI while they were awake. The sleep quality and dream anxiety for the 1-month interval before AMI were assessed with Pittsburgh Sleep Quality Index (PSQI) and Van Dream Anxiety Scale (VDAS), respectively. Results: Asleep-AMI patients reported significantly poorer subjective sleep quality, significantly higher global PSQI scores, and displayed significantly higher nightmare frequency, difficulty in falling asleep after a nightmare, higher autonomic hyperactivity, dream recall frequency, daytime anxiety, psychological problems, and higher global dream anxiety scores than awake-AMI patients. Conclusion: The present study suggests that sleep anxiety and related emotions are associated with AMI during sleep. © 2011 The Academy of Psychosomatic Medicine.
Influence of Pharmacological Treatment on Obsessive Beliefs in the Patients With Obsessive Compulsive Disorder
(Elsevier France-editions Scientifiques Medicales Elsevier, 2011) Selvi, Y.; Besiroglu, L.; Aydin, A.; Atli, A.; Gulec, M.
The Influence of Shift Work on Cognitive Functions and Oxidative Stress
(Cambridge Univ Press, 2013) Ozdemir, P. G.; Selvi, Y.; Ozkol, H.; Aydin, A.; Tuluce, Y.; Boysan, M.; Besiroglu, L.
The Involvement of Distinct Neural Systems in Patients With Obsessive-Compulsive Disorder With Autogenous and Reactive Obsessions
(Wiley, 2011) Besiroglu, L.; Sozen, M.; Ozbebit, O.; Avcu, S.; Selvi, Y.; Bora, A.; Bulut, M. D.
Objective: To investigate the regional metabolite abnormalities and changes after treatment in patients with OCD with autogenous and reactive obsessions. Method: We assessed right anterior cingulate cortex (ACC) and amygdala-hippocampal region (Am + Hpp) N-acetyl-aspartate (NAA), choline (Cho) and creatine (Cr) concentrations and NAA/Cr and Cho/Cr ratios using single-voxel proton magnetic resonance spectroscopy in 15 patients with autogenous obsessions (OCD-A), 15 patients with reactive obsessions (OCD-R) and 15 healthy controls (HC). Measurements were repeated after 16 weeks of fluoxetine treatment. Results: Baseline ACC NAA/Cr ratios of both OCD groups were significantly lower than HC. OCD-A group had significantly lower baseline NAA/Cr ratios in the Am + Hpp than other groups. These differences were more likely to be explained by higher Cr levels in ACC. We found no significant differences and changes for Cho levels and Cho/Cr ratios between groups and within groups. Significant increase in NAA/Cr ratios of OCD-A group found in the Am + Hpp was more likely to be explained by increased NAA levels. No significant changes were found in ACC NAA/Cr ratios. Conclusion: While disturbed energy metabolism in ACC might reflect a common pathology in patients with OCD regardless of symptom dimension, alterations in mesiotemporal lobe are more likely for autogenous obsessions.
Neuroendocrine and Behavioral Correlates of Sleep Deprivation: a Synthesis of Neurobiological and Psychological Mechanisms
(Springer US, 2006) Agargun, M.Y.; Besiroglu, L.
There is a burgeoning literature related to an alteration in mood and behavioral variables after total or partial sleep deprivation. For example, acute sleep manipulations usually are followed by a temporary improvement in mood in major depression; however, there is a regression to the previous status of depression after any subsequent sleep.1 It is may also be asserted that morning mood improves when REM sleep is intact but worsens after a night of sleep deprivation in normal volunteers2 Given that sleep deprivation results in different treatment responses in normal healthy or depressed subjects, emotional or behavioral concomitants of sleep deprivation correlate with its neuroendocrine bases. In this chapter, firstly, we briefly review neuroendocrine aspects of sleep deprivation in healthy and depressed subjects. Secondly, we look at emotional and behavioral results in response to sleep deprivation in clinical samples. Another aim of this chapter is to try to figure out how these correlates concomitantly interact with each other. Finally, we discuss the therapeutic consequences of sleep deprivation in a within-sleep mood regulation process © 2006 Springer Science+Business Media, Inc. All rights reserved.
Socio-Demographic and Clinical Risk Factors on the Non-Recovery of the Major Depressive Disorder: a 52-Week Follow-Up Study
(Cambridge Univ Press, 2012) Gulec, M.; Selvi, Y.; Boysan, M.; Aydin, A.; Besiroglu, L.; Agargun, M. Y.