Browsing by Author "Bilgili, S. G."

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Birt-Hogg Syndrome: a Case Report
(Medecine Et Hygiene, 2015) Karadag, A. S.; Bilgili, S. G.; Yavuz, I. H.; Demircan, Y. T.; Kosem, M.
Decreased Serum Paraoxonase and Arylesterase Activities in Patients With Rosacea
(Wiley, 2015) Takci, Z.; Bilgili, S. G.; Karadag, A. S.; Kucukoglu, M. E.; Selek, S.; Aslan, M.
Background: Recent evidence suggests that oxidative stress may be an important phenomenon in the pathophysiology of rosacea. Paraoxonase-1 (PON1) is an antioxidant enzyme with three activities: paraoxonase, arylesterase and dyazoxonase. In this study, we evaluated serum paraoxonase and arylesterase activities, and serum lipid hydroperoxide (LOOH) levels in patients with rosacea in comparison to healthy controls. Material and methodThe study included 39 rosacea patients and healthy controls, consisting of 40 age- and sex-matched healthy volunteers. Serum paraoxonase and arylesterase activities were measured using paraoxon and phenylacetate substrates. Serum LOOH levels were measured with the ferrous ion oxidation-xylenol orange assay. ResultsIn rosacea group mean serum paraoxonase and arylesterase activities were 74.5438.30UL(-1) and 141.29 +/- 22.27kUL(-1) respectively, which were significantly lower than controls (P=0.010, 0.005; respectively). Mean serum LOOH level of rosacea group was 8.17 +/- 1.91molL(-1) which was significantly higher than controls (P=0.009). There were no statistically significant differences between the clinical subtypes of the disease, menopause situation or ocular involvement with the respect to the serum paraoxonase and arylesterase activities and LOOH levels (all; P>0.05). ConclusionsSerum PON1 enzyme activities have decreased significantly in rosacea. These findings support that decreased PON1 activity and increased oxidative stress may play a role in the pathogenesis of rosacea. Further studies are needed to elucidate the role of PON1 activity in the pathophysiology of rosacea.
Effects of Isotretinoin Treatment on General Psychiatric Symptoms, Quality of Life and Social Phobia in Acne Vulgaris Patients
(Wiley-blackwell, 2013) Karadag, A. S.; Bilgili, S. G.; Selvi, Y.; Tutuncu, R.; Aydin, A.; Calka, O.; Dalkilic, A.
Elevated Insulin Resistance in Patients With Recurrent Aphthous Stomatitis
(Springer Heidelberg, 2015) Takci, Z.; Karadag, A. S.; Ertugrul, D. T.; Bilgili, S. G.
Objectives The role of glucose metabolism disorders in periodontal diseases including recurrent aphthous stomatitis (RAS) is currently attracting attention. The aim of this study is to investigate insulin resistance (IR) in patients with RAS in otherwise healthy individuals. Materials and methods The study enrolled 81 patients with RAS and 61 healthy control subjects. Blood glucose, insulin, C-peptide, hemoglobin A1c, total cholesterol (TC), high-density lipoprotein (HDL) cholesterol, and HOMA-IR were measured in each individual. Results Forty-two of the RAS group were in the active, and 39 of the RAS group were in the passive stage. The levels of c-peptide, insulin, and HOMA-IR were remarkably higher in the RAS group (p=0.015; p<0.0001; p<0.0001, respectively) than the control group. The levels of HbA1c, glucose (p=0,045), TC (p=0,008), HDL cholesterol (p=0,002), and HOMA-IR (p=0.022) were significantly higher in patients with RAS in the active stage. Conclusion The study revealed an elevated IR in patients with RAS that was not previously shown. IR was more prominent when the patients were in the active stage that elevated inflammatory cytokines may induce IR by interfering with insulin signaling. Further studies, investigating the interplay between RAS, inflammation, and IR are needed. Clinical relevance Patients who admitted the hospital with RAS might be screened for prediabetes.
Fixed Drug Eruption Induced by Topical Olopatadine Ophthalmic Solution
(Sage Publications Ltd, 2012) Bilgili, S. G.; Karadag, A. S.; Karadag, R.; Bulut, G.; Calka, O.
Fixed drug eruption (FDE) usually develops after oral administration and is described as a cutaneous reaction recurring at the same location each time the drug is taken. Olopatadine is both a H I histamine receptor antagonist and a mast cell stabilizer, indicated for the treatment of allergic conjunctivitis. Here, we report a 14-year-old male patient who developed FDE localised on the lateral side of periorbital rim bilaterally, whilst applying olopatadine 0.1% ophthalmic solution for the treatment of allergic conjunctivitis. As far as we know, FDE due to olopatadine has not been previously reported in the literature. We deem it appropriate to report this case because FDE that results from the application of topical drugs is a rare event in the literature.
Immunoregulatory Effects of Isotretinoin in Patients With Acne
(Wiley-blackwell, 2012) Karadag, A. S.; Ertugrul, D. T.; Bilgili, S. G.; Takci, Z.; Akin, K. O.; Calka, O.
Background In vitro studies have shown that retinoids influence T-cell differentiation. Objectives To study the effect of isotretinoin on T-cell differentiation markers in patients with acne. Methods A total of 37 patients with acne vulgaris (25 female, 12 male, age 19.6 +/- 3.7 years) and 30 age- and sex-matched healthy controls (19 female, 11 male, age 20.5 +/- 4.4 years) were included in the study. Screening for biochemical parameters in serum samples were done just before initiation (pretreatment) and after 3 months of isotretinoin treatment (post-treatment) in the acne group. Results Baseline levels of tumour necrosis factor (TNF)-alpha (P < 0.0001), interleukin (IL)-4 (P < 0.0001), IL-17 (P < 0.0001) and interferon (IFN)-gamma (P = 0.002) were significantly higher in the acne group compared with the control group. TNF-alpha (P < 0.0001), IL-4 (P < 0.0001), IL-17 (P < 0.0001) and IFN-gamma (P < 0.0001) levels decreased after isotretinoin treatment. TNF-alpha and IL-4 values after isotretinoin treatment were similar to those of the control group. However, levels of IL-17 (P < 0.0001) after isotretinoin treatment were higher than those of the control group, despite a significant decline after treatment. Levels of IFN-gamma (P < 0.0001) after isotretinoin treatment were lower than those of the control group. Conclusions This study shows that isotretinoin treatment significantly decreases TNF, IL-4, IL-17 and IFN-gamma levels in patients with acne. We failed to show that isotretinoin redirects naive T helper (Th) differentiation preferentially towards the Th2 cell lineage.
Incontinentia Pigmenti With Ocular Involvement: Two Cases
(Medecine Et Hygiene, 2012) Bilgili, S. G.; Karadag, A. S.; Karadag, R.; Akdeniz, N.; Bulut, G.; Calka, O.
Incontinentia pigmenti with ocular involvement: two cases: Incontinentia pigmenti (IP) is a rare, X-linked dominant disorder that presents at or soon after birth and presents with cutaneous signs and symptoms. Besides its typical skin signs presenting in all patients, central nervous system (CNS), ophthalmologic and dental involvement are encountered as well. In this report, we present two patients at the verrucous stage of IP and review the literature concerning the diagnosis and course of IP.
A Lamotrigine Induced Toxic Epidermal Necrolysis in a Child
(informa Healthcare, 2013) Calka, O.; Karadag, A. S.; Bilgili, S. G.; Bulut, G.; Altun, F.; Burakgazi, A. Z.
Toxic epidermal necrolysis (TEN) is rare, life-threatening skin disorder that usually is caused by an adverse drug reaction. The exact pathogenesis of TEN is still unknown. Many treatments including prednisolone, cyclosporine and intravenous immunoglobulin (IVIG) can be used to halt the disease process. We present a 12-year-old girl with epilepsy who developed TEN after about 14 days of lamotrigine treatment. Lamotrigine was immediately discontinued. After receiving systemic corticosteroid treatment, the patient had a complete recovery. Antiepileptic-induced TEN can be mortal in some cases. Thus, we would like to point out the importance of early diagnosis and treatment.
Nine Case Series With Phototoxic Dermatitis Related To Chenopodium Album
(Sage Publications Ltd, 2012) Ozkol, H. U.; Calka, O.; Karadag, A. S.; Akdeniz, N.; Bilgili, S. G.; Behcet, L.
Chenopodium album L. ssp. album is a common plant species worldwide, especially in humid areas. Sun exposure after oral intake of the plant can lead to sunburn-like rashes owing to its furocoumarin content. In this article, we reported nine patients who developed dermatitis with edema, erythema and necrosis on the face and dorsum of the hands. Each was exposed to sunlight after eating selemez (the vernacular name of C. album L. ssp. album). The plant samples analyzed by an expert botanist were described as C. album L. ssp. album belonging to Chenopodiacea family.
Nonsteroidal Anti-Inflammatory Drugs-Induced Generalized Fixed Drug Eruption: Two Cases
(Sage Publications Ltd, 2012) Bilgili, S. G.; Calka, O.; Karadag, A. S.; Akdeniz, N.; Kosem, M.
Fixed drug eruption (FDE) is a drug-induced cutaneous reaction that occurs at the same site with each exposure to a specific medication and usually manifests as round or oval, sharply demarcated erythematous or edematous plaques. The exact mechanism is unknown. The most common causative agent is co-trimoxazole. Other major categories of causative agents of FDE include antibiotics, antiepileptics, and nonsteroidal anti-inflammatory drugs (NSAIDs). FDE usually causes localized eruptions and very rarely generalized lesions. We report two cases of developing generalized FDEs after exposure to diclofenac and naproxen.
Response To 'letter To the Editor' by Agilli Et Al. Entitled 'assessment of Decreased Serum Paraoxonase Activity in Patients With Rosacea in Terms of Methodology
(Wiley-blackwell, 2016) Takci, Z.; Bilgili, S. G.; Karadag, A. S.; Kucukoglu, M. E.; Selek, S.; Aslan, M.
Serum Holotranscobalamine, Vitamin B12, Folic Acid and Homocysteine Levels in Patients With Vitiligo
(Wiley-blackwell, 2012) Karadag, A. S.; Tutal, E.; Ertugrul, D. T.; Akin, K. O.; Bilgili, S. G.
Few studies have investigated the role of vitamin B12 metabolism in vitiligo. We tested the hypothesis that vitamin B12 and folate metabolism might have an influence on the pathogenesis of vitiligo. Full blood count and levels of folic acid, vitamin B12, homocysteine and holotranscobalamine were examined for 69 patients with vitiligo and 52 controls. The vitiligo group had higher levels of homocysteine (P < 0.01) and haemoglobin (P < 0.01) levels, and lower levels of vitamin B12 (P < 0.01) and holotranscobalamine (P < 0.0001) than the control group. Folic acid levels were similar for both groups. In a risk analysis, hyperhomocysteinaemia (= 15 mu mol/L, P < 0.01) and vitamin B12 deficiency (< 200 pg/mL, P < 0.01) were significant risk factors for vitiligo. Patients with holotranscobalamine levels in the lowest quartile had an increased risk for co-occurrence of vitiligo (P < 0.005). Vitamin B12 deficiency and hyperhomocysteinaemia may share a common genetic background with vitiligo.
The Use of Complementary and Alternative Medicine Among Dermatology Outpatients in Eastern Turkey
(Sage Publications Ltd, 2014) Bilgili, S. G.; Ozkol, H. U.; Karadag, A. S.; Calka, O.
Introduction: Over the past decade, complementary and alternative medicine (CAM) has become increasingly popular around the world. Objectives: In this study, we aim to investigate how frequently CAM is used and the types of CAM methods used for dermatological disease in Eastern Turkey. Materials and methods: We recruited 1610 patients from our clinic for this study. The sociodemographic features and the CAM methods were investigated with a survey. Results: The most common dermatological disorders included contact dermatitis (21.4%), acne vulgaris (17.5%), fungal infections (10.9%), eczema (6.3%), and warts (5.7%). The ratio of patients using at least one CAM method was 43.7% and that of those using two or more CAM methods was 20.8%. The most commonly used CAM methods were those using henna, cologne, moisturizing cream, prayer, and herbal therapy. Some patients were found to use some interesting and unusual CAM methods, such as putting out a cigarette over the skin on the back for anthrax, applying raw meat for furuncle, using fuel oil and nitric acid for contact dermatitis. Conclusions: CAM methods are commonly used in our population. CAM methods often cause adverse reactions that may alter diagnostic skin findings and interfere with the efficacy of other medical therapies. Therefore, physicians should ask their patients about the use of CAM methods while collecting patient history. Physicians have a critical role in preventing improper use of CAM. In addition, further investigations into the efficacy, benefits, and risks of CAM methods should be carried out for better insight into those CAM methods.