Browsing by Author "Bilgili, Serap Gunes"

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Acrodermatitis Enteropathica in Three Siblings
(Medknow Publications & Media Pvt Ltd, 2013) Karadag, Ayse Serap; Bilgili, Serap Gunes; Calka, Omer
Alopecia Areata Different View; Heavy Metals
(Wolters Kluwer Medknow Publications, 2019) Ozaydin-Yavuz, Goknur; Yavuz, Ibrahim Halil; Demir, Halit; Demir, Canan; Bilgili, Serap Gunes
Background: Alopecia areata (AA) is a noncicatricial alopecia affecting any hair-bearing area. Although AA is considered to be an autoimmune disease, oxidative stress has been shown to be an important factor in the etiology of AA. Trace elements are highly essential for humans since they form the building blocks of large molecules, function as the cofactors of enzymes, and have some key biological functions. The aim of this study was to investigate serum levels of heavy metals like iron (Fe), zinc (Zn), manganese (Mn), copper (Cu), magnesium (Mg), cobalt (Co), cadmium (Cd), and lead (Pb) in patients with AA. Materials and Methods: The study included a patient group of 30 with AA and a control group of 31 healthy individuals. Serum levels of heavy metals were measured using atomic absorption spectrophotometry. Results: The 30 patients included 17 (56.7%) men and 13 (43.3%) women with a mean age of 33.8 (range, 19-48) years. Serum Zn and Mn levels were significantly lower and serum Cd, Fe, Mg, Pb, Co, and Cu levels were significantly higher in the patient group compared to that of the control group (P<0.05 for all). Conclusion: The results indicated that low levels of Zn and Mn are associated with AA while other metals were normal. So Zn supplementation may have some beneficial effect in AA while Fe prescription is fruitless.
Angiokeratoma of Fordyce in a Children
(Turkish Soc dermatology venerology, 2014) Calka, Omer; Bilgili, Serap Gunes; Karadag, Ayse Serap; Bayram, Irfan; Ozdemir, Serhat
Angiokeratomas are benign tumors characterized by epidermal hyperkeratosis, acanthosis and multiple dilated blood vessels in the papillary dermis. Angiokeratoma of Fordyce is one of five types in the group of the angiokeratomas, which occurs on the scrotum, penis or vulva. It is usually observed in young adults or elderly men. A 6-year-old boy presented to the dermatology department because of papular and erythematous lesions on his scrotum and penis. These lesions were found at birth and were asymptomatic. There was a history of occasional bleeding on trauma from the lesions. Histological evaluation of a skin biopsy specimen showed hyperkeratosis and acanthosis of the epidermis and multiple dilated thin-walled vessels in the papillary dermis. Based on the clinical, histopathological and dermoscopic findings, the patient was diagnosed with Fordyce angiokeratoma. Herein, we report a case of angiokeratomas of Fordyce, which is very rare in childhood and the dermoscopic findings.
Assessment of Heavy Metal and Trace Element Levels in Patients With Telogen Effluvium
(Wolters Kluwer Medknow Publications, 2018) Yavuz, Ibrahim Halil; Yavuz, Goknur Ozaydin; Bilgili, Serap Gunes; Demir, Halit; Demir, Canan
Background: Despite a multitude of studies, etiology of primary chronic telogen effluvium (TE) remains incompletely understood. Essential heavy metals are associated with beneficial effects in humans as well as in other living organisms. However, they may lead to toxic effects when the exposure exceeds the higher tolerable limits. We wanted to assess the heavy metal and trace element levels in patients with chronic TE. Materials and Methods: A total of 40 subjects with chronic TE were included in the study, and 30 healthy women served as control. General and dermatological examinations were taken up in all individuals. Those patients with positive hair pull test were evaluated with the help of a trichogram. The presence of >20% telogen hair as documented by trichogram was a requirement for the study inclusion. UNICAM-929 spectrophotometry device was used for determining serum trace element and heavy metal concentrations. Results: In spite of an absence of significant differences in terms of average Zn concentration, weight, or height between patients and controls, significant differences were noted for Cd, Fe, Mg, Mn, Pb, Co, and Cu (P<0.05). Conclusion: Our results suggest that heavy metals may play a causative role in the development of chronic TE. However, contrary to previous reports, zinc did not appear to play an important etiological role, while these patients had elevated serum iron levels.
Assessment of the Effects of Antihistamine Drugs on Mood, Sleep Quality, Sleepiness, and Dream Anxiety
(Taylor & Francis Ltd, 2014) Ozdemir, Pinar Guzel; Karadag, Ayse Serap; Selvi, Yavuz; Boysan, Murat; Bilgili, Serap Gunes; Aydin, Adem; Onder, Sevda
Objective. There are limited comparative studies on classic and new-generation antihistamines that affect sleep quality and mood. The purpose of this study was to determine and compare the effects of classic and new-generation antihistamines on sleep quality, daytime sleepiness, dream anxiety, and mood. Methods. Ninety-two patients with chronic pruritus completed study in the dermatology outpatient clinic. Treatments with regular recommended therapeutic doses were administered. The effects of antihistaminic drugs on mood, daytime sleepiness, dream anxiety, and sleep quality were assessed on the first day and 1 month aft er. Results. Outpatients who received cetirizine and hydroxyzine treatments reported higher scores on the depression, anxiety, and fatigue sub-scales than those who received desloratadine, levocetirizine, and rupatadine. Pheniramine and rupatadine were found to be associated with daytime sleepiness and better sleep quality. UKU side effects scale scores were significantly elevated among outpatients receiving pheniramine. Classic antihistamines increased daytime sleepiness and decreased the sleep quality scores. New-generation antihistamines reduced sleep latency and dream anxiety, and increased daytime sleepiness and sleep quality. Conclusion. Both antihistamines, significantly increased daytime sleepiness and nocturnal sleep quality. Daytime sleepiness was significantly predicted by rupadatine and pheniramine treatment. Cetirizine and hydroxyzine, seem to have negative influences on mood states. Given the extensive use of antihistamines in clinical settings, these results should be more elaborately examined in further studies.
Assessment of the Serum Paraoxonase Activity and Oxidant/Antioxidant Status in Patients With Recurrent Aphthous Stomatitis
(Wiley, 2013) Bilgili, Serap Gunes; Ozkol, Halil; Takci, Zennure; Ozkol, Hatice Uce; Karadag, Ayse Serap; Aslan, Mehmet
ObjectivesSeveral studies have indicated that recurrent aphthous stomatitis (RAS) is associated with oxidative stress. The aim of this study was to investigate serum paraoxonase (PON) activity and oxidant/antioxidant status in patients with RAS. Design and methodsThirty-one patients with RAS and 31 healthy controls were enrolled. Serum PON1 and arylesterase activities, total antioxidant capacity, total oxidant status, and oxidative stress index were determined. ResultsSerum total antioxidant capacity levels, PON1, and arylesterase activities were significantly lower in RAS than controls (P<0.001), while total oxidant status levels andoxidative stress index were significantly higher (P<0.001). PON1 activity had a significant correlation with high-density lipoprotein cholesterol only (r=0.482, P<0.05),while there were no correlations with other lipids (P>0.05) in patients with RAS. ConclusionsOur results indicate that RAS is associated with decreased PON1 activity and increased oxidative stress that plays a crucial role in the pathogenesis of RAS. Further studies on a larger number of patients are needed to verify these results.
Biochemical and Histopathologic Assessment of Effects of Acitretin on Epiphyseal Growth Plate in Rats
(Termedia Publishing House Ltd, 2020) Onder, Sevda; Bilgili, Serap Gunes; Bulut, Gulay; Celik, Huseyin Tugrul; Oguztuzun, Serpil; Onder, Haci; Karadag, Ayse Serap
Introduction: Acitretin is a commonly used retinoid in dermatology. Although there are generally known side effects, the effects on the epiphyseal plaque and bone metabolism are not clear in the literature. Aim: To histopathologically investigate the effects on the epiphyseal plate and assess variations in bone metabolism caused by acitretin. Material and methods: Three groups were formed with 10 rats in each group. The 1st group (n = 10, 5 male, 5 female) were administered 10 mg/kg/day oral acitretin solution and the 2nd group (n = 10, 5 male, 5 female) were administered 3 mg/kg/day oral acitretin solution. The control group were given normal standard feed and water. Rats were sacrificed at the end of 4 weeks. The proximal tibias were excised and histopathologically and immunohistochemically assessed. Biochemical assessment was also carried out. Results: Staining with haematoxylin-eosin found reductions in the epiphyseal plate in the 1st and 2nd group compared to the control group, though this situation was not statistically significant. Immunohistochemical studies did not encounter Type II collagen in the epiphyseal bone, proliferative zone and hypertrophic zone in the control group, low dose acitretin solution group and high dose acitretin solution group. Type II collagen was not observed in osteoids and osteoblasts. Type I collagen was not observed in the hypertrophic zone and proliferative zone of any group. Conclusions: Our data show that though acitretin caused degeneration of the epiphyseal plate, it did not cause clear thinning and we identified no significant variations in bone metabolism markers.
A Case of Generalized Lichen Nitidus Successfully Treated With Narrow-Band Ultraviolet B Treatment
(Wiley-blackwell, 2013) Bilgili, Serap Gunes; Karadag, Ayse Serap; Calka, Omer; Ozdemir, Serhat; Kosem, Mustafa
Lichen nitidus (LN) is a rare skin disorder presenting with multiple, small and bright papules located on the chest, abdomen, penis glans and upper extremities. It usually presents with limited involvement; however, it can present as generalized involvement. There is no consensus on treatment. Corticosteroid, astemizole, phototherapy has been used; however, the results are controversial. A 15-year-old male with clinical and histopathological diagnosis of LN was treated with narrow-band ultraviolet B (NB-UVB). The lesions completely regressed with post-inflammatory hypopigmentation on the second month of the therapy (25 sessions). We believe that NB-UVB is an effective treatment on generalized LN.
A Case of Levetiracetam Induced Bullous Pemphigoid
(informa Healthcare, 2013) Karadag, Ayse Serap; Bilgili, Serap Gunes; Calka, Omer; Onder, Sevda; Kosem, Mustafa; Burakgazi-Dalkilic, Evren
Bullous pemphigoid is a chronic, acquired autoimmune skin disease. Certain drugs such as furosemide, penicillins, sulfonamides, ciprofloxacins, penicillamines, angiotensin converting enzyme inhibitors, chloroquine, and phenacetin were reported to cause bullous pemphigoid. This is a case report of a 70-year-old female, who presented with the formation of diffuse cutaneous blister in month after starting to use levetiracetam. Dermatological exam and histopathological findings were consistent with bullous pemphigoid. To the best of our knowledge this is the first case of bullous pemphigoid in the literature associated with levetiracetam use.
A Case of Linear Syringocystadenoma Papilliferum of the Axilla: A Rare Location
(deri Zuhrevi Hastaliklar dernegi, 2019) Bilgili, Serap Gunes; Yavuz, Ibrahim Halil; Yavuz, Goknur Ozaydin; Ozturk, Murat; Erten, Remzi
A Case of Sarcoidosis Diagnosed Via Skin Involvement
(deri Zuhrevi Hastaliklar dernegi, 2019) Yavuz, Goknur Ozaydin; Yavuz, Ibrahim Halil; Aktar, Rojda; Bulut, Gulay; Bilgili, Serap Gunes
A Case of Spider Bite Localized To the Eyelid
(informa Healthcare, 2013) Bilgili, Serap Gunes; Karadag, Ayse Serap; Karadag, Remzi; Cecen, Ilhan; Calka, Omer
Loxosceles Spiders have a worldwide distribution and are considered one of the most medically important groups of Spiders. The venom from Spiders of the genus Loxosceles, the most famous being Loxosceles reclusa (brown recluse Spider), can promote severe local and systemic damages. This report describes a girl presenting with a Spider bite over her right upper eyelid.
A Case of Tinea Capitis Favosa Which Persists Up To Adulthood
(Galenos Yayincilik, 2012) Bilgili, Serap Gunes; Calka, Omer; Karadag, Ayse Serap; Akdeniz, Necmettin
Tinea capitis favosa is a dermatophyte infection characterized by scutulum formation, and the causative agent is usually Trichophyton schoenleinii. It is seen most commonly in children, but may follow a lifelong course if remain untreated. The incidence has decreased considerably in recent years in Turkey. We report an 18-year-old female patient diagnosed with tinea capitis favosa. The disease had been present for 10 years owing to misdiagnosis and unsuccessful treatments. She was successfully treated with terbinafine. Since it is a rare condition we present this case.
A Case of Verru Plana on Tattoo
(Pakistan Medical Assoc, 2014) Karadag, Ayse Serap; Bilgili, Serap Gunes; Onder, Sevda; Kosem, Mustafa
Tattoo is a popular cosmetic decoration, however several different tattoo-induced complication have been described. Several tattoo related cutaneous reactions such as allergic, granulomatous, lichenoid reactions, and infections have been reported. A 20 year-old male presented with multiple papules on the dragon shaped tattoo. The clinical and histopathological assessments were consistent with verrucas. Tattoo has become increasingly popular among young people. People interested in tattoos should be informed on its related infections and complications during and following tattooing. Herein, we present this rare tattoo induced verru plane to point out tattoo related complications and its treatments.
Clinic Experience in Discoid Lupus Erythematosus: a Retrospective Study of 132 Cases
(Termedia Publishing House Ltd, 2019) Yavuz, Goknur Ozaydin; Yavuz, Ibrahim Halit; Bayram, Irfan; Aktar, Rojda; Bilgili, Serap Gunes
Introduction: Lupus erythematosus (LE) is an autoimmune disease characterized by a broad range of cutaneous manifestations. Discoid LE (DLE) is the most common chronic manifestation of LE. Literature reviews show that there are a limited number of large-series studies investigating DLE. Additionally, there is still no consensus on the etiological factors of DLE such as sun exposure and smoking. Aim: To evaluate the clinical and demographic characteristics of patients with DLE. Material and methods: The study included patients who were hospitalized in the inpatient and outpatient clinics at the Dermatology Department. Age, gender, treatment method, history of smoking, antinuclear antibody positivity, progression to systemic lupus erythematosus (SLE), photosensitivity, and laboratory findings were recorded for each patient. Results: The study included 132 patients comprising 67 (50.8%) men and 65 (49.2%) women. A family history was found in 3.8%, SLE was detected in 5.3%, and photosensitivity was revealed in 50.0% of the patients. ANA positivity was found in 23.7%, a history of smoking was revealed in 61.4%, and chronic sun exposure was detected in 42.4% of the patients. Conclusions: Discoid LE, though identified long ago, remains unelucidated and there are very few studies in the literature reporting on DLE. The results indicated that smoking and chronic UV exposure are important risk factors for DLE. Moreover, although ANA positivity was high in our patients, the rate of progression to SLE was remarkably low. The results also showed that, contrary to common belief, there is no female preponderance in DLE.
Clinical Evaluation of Inpatients With Acute Urticaria
(deri Zuhrevi Hastaliklar dernegi, 2011) Karadag, Ayse Serap; Bilgili, Serap Gunes; Calka, Omer; Akdeniz, Necmettin; Ozkol, Hatice Uce; Aktar, Sirac
Background and Design: To determine the clinical and etiological features of inpatients with acute urticaria and angioedema and to assess the need for laboratory tests. Material and Methods: We recruited 105 patients with acute urticaria and angioedema who were admitted to our inpatient unit. The lesions and the characteristics of the patients were analyzed. Routine diagnostic tests including complete blood count, thyroid function tests, hepatitis panel, stool parasite, total IgE levels, cultures, erythrocyte sedimentation rate, C-reactive protein, anti-nuclear antibody, and posterior anterior lung X-ray were ordered. A psychiatric consultation was obtained, when needed. The results were analyzed with SPSS 15.0 statistical software. Results: Among 105 patients, 28 (26.7%) had urticaria, 7 (6.7%) had angioedema, and 70 (66.70/0) suffered from both urticaria and angioedema. The most common accompanying symptoms were itching (91.40%) and burning (34.3%). The most common systemic symptoms were fatigue (15.2%) and headache (12.4%). The lesions usually appeared in the evening hours (24.8%). Twenty-five patients were waking up due to itching during the night. Some lesions were associated with physical activities. Systemic diseases accompanied the lesions in 12 patients (11%). In terms of etiological factors, 33 patients (22.5%) had infections. Food- related lesions were encountered in 14 (13%) patients. Thirty patients (28.5%) had history of medication use. Stress was detected in 37.1% of the patients; anxiety was diagnosed in 3% of patients. The stool was positive for parasites in 10 (9%) patients. Conclusion: Acute urticaria is a benign disorder. Although the underlying cause of urticaria can not always be identified, infections and medications are the most common causes. A comprehensive and detailed history is very important to discover the underlying cause. The diagnostic tests should be ordered according to the patient's history. Conducting diagnostic tests without considering the medical history of the patient leads to waste of time and resources. (Turkderm 2011; 45:179-83)
Comparison of Cutaneous Mastocytosis With Onset in Children and Adults
(Tubitak Scientific & Technological Research Council Turkey, 2014) Bilgili, Serap Gunes; Karadag, Ayse Serap; Takci, Zennure; Calka, Omer; Kosem, Mustafa
Background/aim: Mastocytosis is a heterogeneous group of diseases characterized by the abnormal infiltration of mast cells in the skin and sometimes other organs. This study aimed to compare the demographic, clinical, and histopathological findings of cutaneous mastocytosis with onset in children and in adults. Materials and methods: Patients diagnosed with cutaneous mastocytosis in 2 different dermatology clinics between 2007 and 2011 were included in the study. Demographic characteristics of the patients as well as localization and type of the cutaneous lesions, presence of symptoms, Darier's sign, family history, systemic involvement, and histopathological evaluations were retrospectively examined. Results: Out of the 30 cases of cutaneous mastocytosis, 60% of patients were male (n = 18) and 40% were female (n = 12). Twenty-two patients had childhood-onset mastocytosis (= 15 years) and 8 patients had adult-onset mastocytosis. The onset of the disease occurred before the age of 2 years in all cases of childhood onset. Patients with adult-onset mastocytosis had statistically significantly more systemic involvement than those with childhood-onset mastocytosis (P < 0.05). Conclusion: Cutaneous mastocytosis is a benign disease in children without systemic involvement and is usually sporadic.
Comparison of Efficacy of Narrow Band Uvb Therapies With Uvb Alone, in Combination With Calcipotriol, and With Betamethasoneand Calcipotriol in Vitiligo
(Taylor & Francis Ltd, 2014) Akdeniz, Necmettin; Yavuz, Ibrahim Halil; Bilgili, Serap Gunes; Yavuz, Goknur Ozaydin; Calka, Omer
Objective: The purpose of this study is to compare the efficacy of three therapies in the treatment of non-segmental vitiligo: a combination of topical calcipotriol, narrowband-ultraviolet B (NB-UVB), and betamethasone therapies; a combination of NB-UVB and topical calcipotriol; and NB-UVB alone. Material and methods: Forty-five patients with non-segmental vitiligo presenting to our Dermatology clinic were recruited to participate in the study. Patients were randomly divided into three groups. For each patient the size of the depigmented areas was assessed according to the rule of nines. The first group was treated with a combination of topical calcipotriol, NB-UVB, and betamethasone therapies. The second group was treated with a combination of NB-UVB and topical calcipotriol and third group was treated with NB-UVB alone. Since the patients' vitiligo lesions had similar phototypes, all patients were started with 0.1 j/cm(2), regardless of their skin phototype. The dose of NB-UVB was increased 10% in each session and no further increment was done after reaching 2.5 j/cm(2). Treatment effectiveness was evaluated according to the percentage improvement in repigmentation. The quality of life of the patients was measured by the Dermatology Life Quality Index (DLQI). Results: The patients were aged from 13 to 55 years (mean: 25.29). The duration of disease ranged from 3 months to 20 years. Family history was positive for vitiligo in 10 patients (22.2%). The percentage of recovery after treatment was 63.33% +/- 7.55 in group 1, 60.67% +/- 5.75 in group 2, and 46.67% +/- 7.98 in group 3. There was no statistically significant difference between groups 1 and 2, and groups 2 and 3, but there was a statistically significant difference between groups 1 and 3 (p = 0.0048). Conclusions: In conclusion, NB-UVB-alone therapy and the combined therapies are effective treatment options in the treatment of vitiligo. Future studies with larger groups are warranted to confirm our results.
Cutaneous Reactions Caused by Nitrofurazone
(Termedia Publishing House Ltd, 2019) Bilgili, Serap Gunes; Ozaydin Yavuz, Goknur; Yavuz, Ibrahim Halil; Bilgili, Mehmet Ali; Karadag, Ayse Serap
Introduction: Allergic contact dermatitis (ACD) is a form of dermatitis due to type 4 hypersensitivity reaction that occurs when the skin comes into contacts with the topical product. Topical nitrofurazone is a widely used antimicrobial drug in our country which is well known to cause ACD. Aim: In this study, ACD cases with different clinical features attributed to the use of nitrofurazone were evaluated. Material and methods: Patients hospitalized in our clinic between 2013 and 2017 with ACD diagnosis due to nitrofurazone were evaluated. The patient age, gender, atopy histories, clinical features, dissemination of the lesions, treatment given were reviewed. Results: In a 5-year period, 58 cases were identified and their data were analysed. Twelve patients were female (21%), 46 patients were male (79%). Clinical presentations were dyshidrosiform (45%), excoriated papules and plaques (33%), combined (21%), and erythroderma in one patient. The dissemination was generalized in 34 patients, localized in 14 patients, and local spread in 10 patients. The mean hospitalization time was 7 +/- 3 days, and ranged from 3 to 18 days. Conclusions: There may be widespread and severe ACD due to the use of nitrofurazone. Topical nitrofurazone should not be applied on damaged skin as sensitization may develop. Patients and physicians should be aware of the ACD risk associated with topical nitrofurazone, which is also commonly used as self-medication, physicians should take a detailed history of the drug use and products containing nitrofurazone should not be used in conditions where skin integrity is not intact, whenever possible.
Cutaneous Siderosis After Intramuscular Iron Injections: a Case Report
(informa Healthcare, 2014) Ozlu, Emin; Karadag, Ayse Serap; Bilgili, Serap Gunes; Bayram, Irfan
Skin reactions against injected or implanted foreign materials are not rare. Siderosis is a disease characterized by the accumulation of iron in various tissues. Brownish-gray discoloration of the skin can be seen as a side-effect on the injection area after the parenteral iron treatment. Here, we present cutaneous siderosis case developed after multiple intramuscular iron injection on the gluteal region for iron-deficiency anemia. Development of cutaneous siderosis after intramuscular iron injection rarely has been reported in the literature before.