Browsing by Author "Bilici, M."

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The Effect of Currant (Ribes) on Human Health and Determination Certain Antioxidant Activities
(Yuzuncu Yil Universitesi Tip Fakultesi, 2021) Bilici, M.
This study aimed to determine some antioxidant activities at ribes fruit. Ribes is a strong reservoir of anti oxidants. It has many vitamins, proteins, and mineral matters in its composition. Many Ribes types, especially black ribes types with darker fruits contains polyphenolic compounds in high concentrations, especially due to their antioxidant activities they have increasing amounts of anthocyanins and flavonols that are increasingly sought after due to their antioxidant activities. The most significant anthocyanin found in black ribes are cyanidine-3-glucoside, cyanidine-3-rutinoside, delphinidine-3-glucoside, and delfinidine-3-rutinoside. Natural antioxidants have protecting the body against infections, preventing anemia by inhibiting decomposition of red blood cells, preventing synthesis of cancerous compounds, diluting the blood by increasing prostaglandin synthesis (antithrombotic effect), preventing arteriosclerosis, and preventing unwanted effects on metabolism of active forms with oxidation ability causing liver damage. Its protective effects such as healing effects on some cancer types are known. Level of Catalase (CAT) was found to be 0.00011 U/mI on average for fresh ribes. Level of Superoxide Dismutase (SOD) was found to be 11.6960 U/mI on average for fresh ribes. The level of Reduced Glutathione (GSH) was found to be 0.00011 mmol/dI on average for fresh ribes. In this study ribes was found to display a very strong antioxidant activity. Thus, ribes was demonstrated to be a protective antioxidant against oxidative damage against many diseases. © 2021, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Evaluation of Serum Levels of Trace Elements in Myeloproliferative Neoplasms: a Case-Control Study
(Yuzuncu Yil Universitesi Tip Fakultesi, 2021) Yetişgin, F.; Bilici, M.; Esen, R.
The lack or excess of some of trace elements or heavy metals could be associated with the r isk of hematologic malignancy. This study aimed to compare the patients with myeloproliferative neoplasm with the serum concentrations of Zinc (Zn), copper (Cu), manganese (Mn), nickel (Ni), lead (Pb), iron (Fe), cadmium (Cd) and cobalt (Co) in healthy ind ividuals. Healthy individuals in the control group and newly diagnosed patients with myeloproliferative neoplasm were involved in the research. The patient and control groups were similar in terms of socioeconomic status and eating habits. The serum levels of the trace elements were determined via Atomic Absorption Spectrophotometry. The myeloproliferative neoplasm group consisted of 60 patients while the control group consisted of 20 volunteers. In the patient group, serum Zn and Fe concentrations were significantly lower than the control group (p=0.001 and p=0.001). Serum Cu, Pb, Cd, Co, Ni and Mn concentrations were higher in the patient group (p=0.001, p=0.001, p=0.001, p=0.001, p=0.001, p=0.027, respectively). When a comparison was made between Mn serum level and the control group, Mn serum level was determined to be low in PMF (p>5%). Serum Cd and Ni levels were higher in PMF, ET, CML and PV (p=0.005). Pb serum level was higher in ET, CML and PV (p=0.001, p=0.001, p=0.001, respectively). Serum Fe and Zn levels were lower in the PMF, ET, CML and PV groups (p=0.001 and p >0.5, respectively, for Fe). Serum Zn and Fe levels were lower and Cu, Pb, Cd, Co, Ni and Mn levels were higher in patients with myeloproliferative neoplasm. In particular, Zn is a very strong antioxidant element, and the fact that Zn is low in patients suggests that it could be an important marker in PV, ET, CML and PMF cases. © 2021, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Is There Any Association Between Fetal Nervous System Anomalies and Heavy Metal-Trace Element Levels in Amniotic Fluid
(I R O G Canada, inc, 2018) Cim, N.; Tolunay, H. E.; Boza, B.; Bilici, M.; Karaman, E.; Cetin, O.; Sahin, H. G.
Aim: In this study the authors aimed to evaluate whether there are any causal relationship between heavy metals-trace elements and fetal malformations of central nervous system (CNS). Materials and Methods: The study group consisted of pregnancies with fetal congenital nervous system anomaly (anencephaly, acrania, neural tube defects, etc.) in 16-22 weeks (n=36). Pregnancies with the same weeks of pregnancy who underwent amniocentesis due to high risk in triple test with the result of normal karyotype constituted the control group (n=30). In the both groups the authors analyzed the heavy metals and trace elements in amniotic fluid. Metals and elements were measured by using atomic absorption spectrophotometer technique with a UNICAM-929 spectrophotometer. Results: When compared, the groups were similar in terms of age, parity, BMI, and gestational week (p > 0.05). In fetal congenital anomaly group the authors detected low levels of copper (Cu) and zinc (Zn) rather than control groups (p < 0.05). In fetal congenital anomaly group they detected high levels of lead (Pb) and cadmium (Cd) rather than control groups (p < 0.05). Iron (Fe), manganese (Mn), cobalt (Co), nickel (Ni), and Cd levels were similar and there was no significantly difference between the groups (p > 0.05). Conclusion: This study can contribute benefits to the literature in terms of clarifying the pathogenesis of fetal congenital nervous system anomalies.
Synthesis and Characterisation of Molecularly Imprinted Microspheres for the Determination of Kanamycin
(Yuzuncu Yil Universitesi Tip Fakultesi, 2025) Buran, C.; Bilici, M.
This study aims to propose a methodology based on molecularly imprinted polymer solid phase extraction (MISPE) prior to instrumental analysis of kanamycin, a type of antibiotic. Solid phase extraction of kanamycin antibiotic, which is in the aminoglycoside class of antibiotics, from commercially purchased milk samples was carried out by molecular imprinting technique. After this process, the amount of kanamycin was determined by UV-visible spectrophotometry. This antibiotic in milk was removed by molecular imprinting method. The molecular imprinting technique was aimed to form complexes of functional monomers around a mould molecule with covalent or non-covalent interactions and then to form imprinted polymers with chemical function through an appropriate processing process. By removing the imprinted molecule after the process, a hollow cavity specific to the imprinted molecule was formed in the polymeric structure. These molecularly imprinted polymers were used as an ideal material for processes such as separation, chemical determination and catalysis. Molecularly imprinted microspheres were prepared for the determination of kanamycin antibiotic, the active ingredient of the drug in milk. The results obtained show that the proposed method can determine kanamycin in milk with high recovery rates and low relative standard deviation. © 2025, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.