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Browsing by Author "Binbay, Tolga"

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    Covid 19 Pandemic and Psychotic Symptoms
    (Klinik Psikiyatri dergisi, 2020) Kirli, Umut; Binbay, Tolga; Elbi, Hayriye; Alptekin, Koksal
    COVID-19 pandemic causes substantial psychosocial stress on individuals and the community. Due to social isolation, neurotrophic potential of coronaviruses and the inflammatory processes, occurrence and relapse of psychotic symptoms may increase during the pandemic. Furthermore, pandemic has limited some protective factors for psychosis (i.e. social support, community mental health practices and physical activity). Additionally, admission of individuals suffering from psychotic symptoms may decrease due to risk of viral contamination. This may lead to under-detection of the problem, persistence of psychotic symptoms, poorer prognosis and more severe outcomes. Psychotic symptoms were reported among infected individuals during the recent coronavirus outbreaks (SARS CoV-1 and MERS CoV). Furthermore, mental problems were of the most substantial causes of long term disability associated with these outbreaks. In this paper, limited data on psychotic symptoms during the COVID-19 pandemic will be reviewed. Furthermore, psychosocial stress during the pandemic and plausible associations between the coronaviruses and psychotic symptoms will be discussed in light of the previous research.
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    Article
    Izmir Mental Health Cohort for Gene-Environment Interaction in Psychosis (Turksch): Assessment of the Extended and Transdiagnostic Psychosis Phenotype and Analysis of Attrition in a 6-Year Follow-Up of a Community-Based Sample
    (Frontiers Media Sa, 2019) Kirli, Umut; Binbay, Tolga; Elbi, Hayriye; Drukker, Marjan; Kayahan, Bulent; Ozkinay, Ferda; van Os, Jim
    Objective: TurkSch is a prospective, longitudinal study in a representative community sample (Izmir, Turkey), consisting of several data collection stages, to screen and follow-up mental health outcomes, with a special focus on the extended and transdiagnostic psychosis phenotype. The aim of the present paper is to describe the research methodology, data collection results, and associations with noncontact and refusal in the longitudinal arm. Methods: Households were contacted in a multistage clustered probability sampling frame, covering 11 districts and 302 neighborhoods at baseline (n = 4,011) and at 6-year follow-up (n = 2,185). Both at baseline and at follow-up, participants were interviewed with the Composite International Diagnostic Interview. Participants with probable psychotic disorder were reinterviewed with the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (SCID)-I either at the hospital or at the participant's residence. Relevant neighborhood-level measures were assessed in a separate sample (n = 5,124) in addition to individual-level measures. Candidate gene-by-environment interactions were investigated using two nested case-control studies. Results: Individuals with a mental health problem had lower refusal rates. Older and lower educated individuals had a lower probability of noncontact. Discussion: The TurkSch study has an advanced design to meet the challenges of evaluating the multidimensional etiological and phenomenological nature of the extended and transdiagnostic psychosis phenotype.