Browsing by Author "Bozkurt, Abdi"

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Coronary Artery Fistula Presenting as Unstable Angina Pectoris in Patients With Antiphospholipid Syndrome
(Hindawi Ltd, 2013) Demir, Serafettin; Yucel, Ceyhun; Tufenk, Mucahit; Tosu, Aydin Rodi; Selcuk, Murat; Bozkurt, Abdi
The cardiovascular system is one of the primary targets in patients with antiphospholipid syndrome. The valves are the most frequently affected. Atherosclerosis and coronary thrombosis are also seen. The risk of acute coronary syndrome is 10 times higher in patients with APS. We present an APS patient case who was hospitalized with acute coronary syndrome and who was later found to have coronary artery fistula.
Effects of Insuline on Oxidative Stress and Free Fatty Acid Level in Left Ventricular Muscles of Diabetic Rats
(Asian Journal of Chemistry, 2009) Kavak, Servet; Ayaz, Lokman; Emre, Mustafa; Bozkurt, Abdi
Studies were carried out to examine and compare the effects of streptozotocin-diabetes on 3-nitrotyrosine (3-NT), Malondialdhyde (MDA) and lipid profiles related parameters in the heart from male rats. Effects of insulin (INS) treatment were also evaluated. The diabetic state severely compromised the 3-NT, MDA and lipid profiles defense mechanism in the left ventricular muscle tissue and the effects were more pronounced in the male rats. Wistar albino male rats were randomly divided into an untreated control group (C), a diabetic group (D) that was treated with a single intraperitoneal injection of streptozotocin (STZ) (45 mg kg(-1)), D + INS group which were treated with INS one times a day by injection subcutaneous, respectively. Lipid profiles, HbA1c and blood glucose levels in the circulation and MDA and 3-NT levels in left ventricular muscle were measured. Treatment of diabetic rats with INS resulted in a time-dependent decrease in blood glucose. It is found that the lipid profile and HbA1c levels in D + INS group reached the untreated control group rat values at the end of the treatment period. It is found that the lipid profile and HbA1c levels in D + INS group reached the C rat values at the end of the treatment period. In group D, 3-NT and MDA levels were found to be increased when compared with C and D + INS groups. In the D + INS group, MDA levels were found to be decreased when compared with untreated control group. This study shows a direct correlation between hyperglycemia and the production of MDA and nitrotyrosine, a marker of oxidative stress, in diabetic rat left ventricular muscle.
Positive Inotropic Effect of Rosiglitazone in Papillary Muscles in Control and Diabetic Rats
(Asian Journal of Chemistry, 2009) Kavak, Servet; Emre, Mustafa; Bozkurt, Abdi; Demir, Halit
Peroxisome proliferator-activated receptor gamma activators or rosiglitazone (RSG) used as insulin sensitizers in the treatment of diabetes. The aim of this study is the effects of RSG on papillary muscle positive inotropic were studied in left ventricular papillary muscles from both control rats and rats diabetes. In this study, we used four groups: (1) untreated control (C) (2) rosiglitazone-treated control (C + RSG), (3) diabetes (D) and (4) rosiglitazone-treated diabetes groups (D + RSG). Diabetes was induced by a single intraperitoneal injection of streptozotocin (STZ) for 8 weeks STZ-treatment (STZ, 45 mg/kg). Papillary muscle from spontaneously diabetic hearts exhibited a depressed conraction force (CF), prolonged contraction time (CT) and half relaxation time (1/2 RT) and reduced contraction and relaxation velocities (+- dp/dt) (p < 0.05). It is found that the lipid profile and glycohemoglobin levels (HbA1c) levels in D + RSG group as it increase the C rats value at the end of the treatment period (p < 0.05). D + RSG and C + RSG groups exhibited a increased CF, shortened CT and 1/2 RT and increased dp/dt (p < 0.05). Treatment of rats with RSG also markedly decreased the insulin resistance of the hearts. Present data suggest that the beneficial effects of RSG treatment on the mechanical activities of the diabetic rat papillary appear to be due to the restoration of the diminished SR Ca2+ release triggering, partially, related to the restoration of the hyperglycemia.