Browsing by Author "Bozkurt, H."

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Anti-Tuberculous Drug Resistance of Mycobacterium Tuberculosis Strains Isolated From Van Region
(Elsevier Sci Ltd, 2008) Bozkurt, H.; Nalcacioglu, R. B.; Kurtoglu, M. G.; Kesli, R.; Berktas, M.
The Biofilm Production (Slime) and Fluconazole Sensitivity of the Candida Strains Isolated From the Mouth Flora of Newborns and Adults
(2005) Güdücüoǧlu, H.; Berktaş, M.; Bozkurt, H.; Aygül, K.; Bayram, Y.; Gülmez, S.; Andiç, S.
In this study we planned to investigate the differences of the Candida species in the newborns' and adults' mouth flora, their slime production and antimicrobial susceptibility. They were identified with conventional methods (germ tube production) and carbohydrate fermentation characteristics were evaluated by Api 20 C AUX (bioMerieux-France) kits. Stock solution of fluconazole was used for antibiotic susceptibility test. A total of 18 Candida isolates; 14 C. albicans, 2 C. tropicalis, 1 C. kefyr and1 C. lusitaneae were isolated from newborns and 18 Candida strains consisting of 13 C. albicans, 4 C. tropicalis and 1 C. ciferii were isolated from the adults with decayed teeth. Slime production and fluconazole susceptibility tests were performed on these strains. As a result, 4 of 18 (22%) Candida species from newborns and 2 of 18 (11%) strains from adults teeth were observed to be potent slime producer. None of the Candida strains isolated were resistant to fluconazole.
Chronic Hepatitis Delta Virus Infection in Van Region of Eastern Turkey
(2005) Türkdoǧan, M.K.; Bozkurt, H.; Uygan, I.; Tuncer, I.; Irmak, H.; Buzgan, T.; Akdeniz, H.
Background/aims: Hepatitis delta virus infection is an important cause of liver morbidity and mortality worldwide. In Eastern Turkey, hepatitis B virus infection is the major cause of chronic liver diseases. We aimed to research the role of hepatitis delta virus infection in chronic liver diseases related to hepatitis B virus infection in the Van region of Eastern Turkey. Methods: Serological markers of hepatitis B virus and hepatitis delta virus infection [HBsAg, HbeAg, Anti-HBe and Anti- hepatitis delta virus total (IgM+IgG)] were determined by ELISA test in patients with chronic hepatitis and cirrhosis. Serum hepatitis B virus DNA was determined by polymerase chain reaction (PCR) method in chronic hepatitis B patients. Results: Hepatitis delta virus infection was detected in 5% (7/138) of asymptomatic hepatitis B virus carriers, in 16% (24/148) of chronic hepatitis B patients and in 45% (34/75) of cirrhotic hepatitis B virus patients, hepatitis delta virus infection showed a three-fold increase in chronic hepatitis (p<0.01) and nine-fold increase in cirrhosis (p<0.001) compared to hepatitis delta virus carriers. Also, it was three times more frequent in cirrhosis (p< 0.001) compared to chronic hepatitis. Chronic hepatitis delta virus infection was equally distributed between sexes in patients with chronic hepatitis B virus infection, whereas chronic hepatitis B virus infection alone was three times more frequent in males (p<0.001). Mean ages of hepatitis delta virus carriers, chronic hepatitis D and hepatitis delta virus cirrhosis patients were 30.7±8 (14-65), 36±13 (19-70) and 44±16 (25-55), respectively. Conclusions: The higher prevalence of hepatitis delta virus infection in more severe form of hepatitis B virus infection suggests that hepatitis delta virus infection increases the severity of chronic hepatitis B virus infection in the Van region, hepatitis delta virus infection remains a second major cause of chronic liver diseases in Eastern Turkey in spite of its decreasing prevalence in Western countries and in Western Turkey.
Correlation of Slime Production Investigated Via Three Different Methods in Coagulase-Negative Staphylococci With Crystal Violet Reaction and Antimicrobial Resistance
(Sage Publications Ltd, 2009) Bozkurt, H.; Kurtoglu, M. G.; Bayram, Y.; Kesli, R.; Berktas, M.
This study investigated slime production by coagulase-negative staphylococci (CNS) using the standard tube (ST), Congo red agar (CRA) plate and Christensen's tube (CT) methods, and compared the results with those of the crystal violet reaction (CVR) test. The potential correlation between slime production and antimicrobial resistance was also evaluated. In total, 205 CNS strains were isolated from biological samples: 92 (44.9%) were shown to produce slime by the ST method; 96 (46.8%) by the CRA plate method; 90 (43.9%) by the CT method; and 89 (43.4%) strains were CVR positive. Eighty-three (40.5%) CNS strains were positive for slime production by the ST, CRA and CT methods. The findings of the ST, CRA and CT test methods were consistent with each other but were not related to CVR positivity. Based on the ST method, rates of antibiotic resistance to several antimicrobial agents were higher in slime-positive strains than in slime-negative strains and, in some cases, this was statistically significant.
Distribution of Hepatitis C Prevalence in Individuals According To Their Age Level in Eastern Turkey
(2008) Bozkurt, H.; Kurtoglu, M.G.; Bayram, Y.; Kesli, R.; Berktas, M.
Distribution, Optimum Detection Time and Antimicrobial Susceptibility Rates of the Microorganisms Isolated From Blood Cultures Over a 4-Year Time Period in a Turkish University Hospital and a Review of the International Literature
(Sage Publications Ltd, 2008) Kurtoglu, M. G.; Bozkurt, H.; Tuncer, O.; Kesli, R.; Berktas, M.
This study retrospectively examined 8986 blood cultures from patients over a 4-year time period in an eastern Turkish university hospital to determine the detection times and distribution of isolated microorganisms using the automated BACTEC (TM) 9050 and BACTEC (TM) 9120 systems. A total of 1914 (21.3%) blood cultures contained pathogenic microorganisms and 252 (2.8%) positive cultures were considered contaminated. Of all the cultures, 18 (0.2%) were false positives and 224 (2.5%) were false negatives. In cultures containing pathogenic microorganisms, Gram-positive and Gram-negative bacterial isolation rates were 436 (22.8%) and 1440 (75.2%), respectively, and yeasts (all Candida sp.) were found in 38 (2.0%) cultures. Coagulase-negative staphylococci occurred in 936 (48.9%) cultures and Staphylococcus aureus occurred in 302 (15.8%) cultures. The mean detection time for all of the pathogens was 21 h and Brucella spp were isolated within 10 days. This study helps in understanding the epidemiology of the region and in providing positive therapeutic approaches. A review of the international literature helps to place this understanding into a global context.
Evaluation of Related With Age of Ifn-Gamma Levels of Treated Leprosy Patients and Their Healthy Relatives Compared With a Control Group
(2006) Güdücüoglu, H.; Berktaş, M.; Bozkurt, H.; Akdeniz, N.; Kutluay, N.; Yaman, G.; Andiç, S.
OBJECTIVE: This study was to search how change with age of IFN-gamma (IFN-gamma) levels of leprosy patients who had received or still undergoing treatment, their healthy close relatives and healthy people. METHOD: From a total of 39 patients, 28 had received leprosy treatment and recovered with some defects [17 Lepromatous Leprosy(LL), 7 Borderline Lepromatous (BL), 3 Borderlien Tuberculoid (BT), 1 Tuberculoid form (TT)] and 11 (9 LL, 2 BL) were undergoing therapy in a hospital at that moment. Close relatives of the patients included 39 people living with treated patients in the same house and the control group consisted of 39 healthy people. Human IFN-gamma kits were used as a solid phase sandwich ELISA method. RESULTS: The IFN-gamma values of treated leprosy patients, therapy receiving patients, relatives group's and control group's were detected as 11-20 pg/mL, 11-18 pg/mL, 12-145 pg/mL and 12-65 pg/mL respectively. CONCLUSION: According to the statistical evaluation of these three groups, IFN-gamma levels of patients were detected lower than other two groups. According to the age, if IFN-gamma levels were compared, it was detected that significant relationship between relatives groups and interferon gamma levels.
The Evaluation of the Resistance Rates of Staphylococcus Aureus Strains To Antimicrobials According To the Years
(2007) Bozkurt, H.; Güzel Kurtoǧlu, M.; Bayram, Y.; Berktas, M.
In our hospital, sensitivity tests of 290 Staphylococcus aureus strains isolated in 1998-2000 years and 280 Staphylococcus aureus strains isolated in 2003-2004 years were performed and investigated the alterations on resistance rates. At two periods the resistance was not established to vancomycin; but, it was established an increase statistically unsignificant at the second period, amikacin, teicoplanin, gentamicin, tetracycline, oxacillin and eritromycin but increase in to ciprofloxacin and rifampicin significantly.