Browsing by Author "Bulduk, Bahattin"

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Akut Miyokard İnfarktüsü Sonrası Gelişen Ruhsal Bozukluklar
(2017) Bulduk, Mehmet; Aktaş, Mehmet Cihad; Bulduk, Bahattin
Miyokard İnfarktüs, kalbi besleyen koroner arterlerin tıkanmasına bağlı olarak kalp kasının yeterince kanlanmaması ve sonuçta kalp dokusunda nekroz oluşmasıdır. Akut Miyokard İnfarktüsü (AMİ), ölümle sonuçlanabilen bir hastalık olması, genellikle her yaş grubunda görülmesi ve sonrasında ciddi komplikasyonların oluşmasından dolayı önemli bir toplum sağlığı sorunudur. Psikolojik sorunlar insanların, kardiyovasküler sorunlar yaşamalarına neden olabileceği gibi, kalp hastalıklarının varlığının da psikiyatrik sorunların oluşumuna neden olacağı bilinmektedir. AMİ öncesi ve sonrası kişilerde ruhsal ve davranışsal tepkilerin olması beklenmektedir. Bu tepkilerin ciddiye alınması ve tıbbi açıdan tedavi edilmesi gerektiği unutulmamalıdır. Yapılan çalışmalar AMİ sonrası bireylerde anksiyete, depresyon ve stres belirtilerinin görüldüğünü bildirmektedir. Bu makalenin yazılma amacı, dünyadaki bir numaralı ölüm nedeni olan AMİ'nin insanlar üzerindeki oluşturabileceği ruhsal bozuklukları bir kez daha gündeme getirmektir
Artificial Intelligence-Assisted Virtual Reality for Reducing Anxiety in Pediatric Endoscopy
(Mdpi, 2025) Bulduk, Mehmet; Can, Veysel; Aktas, Emre; Ipekci, Belkis; Bulduk, Bahattin; Nas, Ibrahim
Background/Objectives: This study aimed to evaluate the effects of artificial intelligence (AI)-assisted virtual reality (VR) applications on preoperative anxiety levels and vital signs in children undergoing endoscopy. Methods: A randomized controlled trial design was employed, including a total of 80 children aged 8-17 years (40 in the intervention group and 40 in the control group). Children in the intervention group were exposed to VR applications featuring space and underwater themes, while the control group received standard procedures. Anxiety levels were assessed using the "State-Trait Anxiety Inventory for Children (STAIC)", and vital signs were evaluated through measurements of systolic and diastolic blood pressure, heart rate, temperature, and SpO(2) . Results: VR applications significantly reduced anxiety scores in the intervention group (36.3 +/- 1.9), while no significant changes were observed in the control group (45.4 +/- 2.74) (p < 0.001). Regarding vital signs, more favorable outcomes were observed in the intervention group. Systolic blood pressure was measured as 89 +/- 6.7 mmHg in the intervention group and 96.5 +/- 10.5 mmHg in the control group (p < 0.001). Diastolic blood pressure was 60.8 +/- 4.7 mmHg in the intervention group and 63.8 +/- 6 mmHg in the control group (p < 0.05). Heart rate was recorded as 88.7 +/- 10.1 bpm in the intervention group and 94.5 +/- 14.8 bpm in the control group (p < 0.05). SpO(2) levels were 98 +/- 1 in the intervention group and 96.2 +/- 1.3 in the control group (p < 0.001). Conclusions: AI-assisted VR applications emerge as an effective non-pharmacological method for reducing preoperative anxiety and promoting physiological stability in children. This approach holds the potential to enhance pediatric experiences during invasive procedures such as endoscopy.
The Effect of Boric Acid and Borax on Blood Pressure in the Benzo(A)pyrene (B and 3-Methylcholanthrene (3-Mc) Applied Rats
(Wiley-blackwell, 2015) Bulduk, Bahattin; Oto, Gokhan; Ozdemir, Hulya; Gunbatar, Nizamettin; Uyar, Hasan; Bulduk, Mehmet; Elaslan, Sadi
Effect of Boric Acid and Borax on Heart Rate in Rats Treated With Benzo(A)pyrene and 3-Methylcholanthrene
(Parlar Scientific Publications (p S P), 2021) Bulduk, Bahattin; Oto, Gokhan; Ozdemir, Hulya; Gunbatar, Nizamettin; Bulduk, Mehmet; Kocak, Yilmaz; Keskin, Siddik
In this study, the effects of boric acid (BA) and borax (BX) on the heart rate of rats treated with benzo(a)pyrene (B(a)P) and 3-methylcholanthrene (3-MC) were investigated. This research was conducted with the permission of Van Ytiztincti Yil University Animal Experiments Local Ethics Committee. Wistar albino rats weighing 250 +/- 50 g were used in the study and divided into nine groups, six in each group. Group 1 was assigned as the control group. B(a)P (100 mg/kg) was administered intraperitoneally to Group 2 and 3-MC (100 mg/kg) to Group 3. BA only was administered to Group 4 at 300 mg/L in drinking water and to Group 5, BX only at 300 mg/L. Group 6 received B(a)P (100 mg/kg) + BA (300 mg/L) and Group 7 3-MC (100 mg/kg) + BA (300 mg/L). B(a)P (100 mg/kg) + BX (300 mg/L) was administered to Group 8 and 3 -MC (100 mg/kg) BX (300 mg/L) to Group 9. At the end of the 150th day, the rats were anaesthetised and their ECGs recorded. The heart rate (beats/min) was found to be statistically significant in B(a)P, 3 -MC and groups compared to the control group. It was found that the heart rate increased by 3 -MC and B(a)P in the groups was regulated by BA and BX.
Effect of Exposure To Fluorine and 7, 12-Dimethyl Benzanthracene on Vascular Responses
(Parlar Scientific Publications (p S P), 2022) Bulduk, Bahattin; Uyar, Hasan; Oto, Gokhan; Ozdemir, Hulya; Gunbatar, Nizamettin; Bulduk, Mehmet; Elasan, Sadi
In this study, the effect of experimental administration of fluorine and DMBA, alone or in combination, on rats on vascular responses was investigated. After adaptation, the rats were randomly selected and divided into 9 groups, 10 male rats in each group. While sodium fluoride was applied daily in drinking water for 12 weeks to the groups to which fluoride will be applied; on the other hand, DMBA was dissolved in sesame oil and applied to the groups that needed it, once a week for a total of 12 weeks. The groups were determined as C, SO, 1NaF, 15NaF, 30NaF, DMBA, 1NaF+DMBA, 15NaF+DMBA and 30NaF+DMBA. Tensions in the thoracic aorta were provided with phenylephrine. Then, relaxation responses were recorded by giving ACh ((10-8'-7'-6'-5)) and SNP ((10-,-9,-8,-7,)(-6)(,)(-5)) at different cumulative concentrations. In the study, it was determined that fluorine caused the vessels to contract and DMBA to relax. Concurrent exposure to high amounts of fluorine and DMBA was observed to cause vasoconstriction.
The Effect of Moderate-Intensity Physical Exercise on Some Serum Inflammation Markers and the Immune System in Rats Fed Intermittent Fasting With a High-Fat Diet
(Mdpi, 2023) Gunbatar, Nizamettin; Bulduk, Bahattin; Bezgin, Selver; Oto, Gokhan; Bayiroglu, Fahri; Bulduk, Mehmet
Background and Objectives: This study aimed to investigate the impact of moderate-intensity physical exercise on serum inflammation markers and the immune system in rats that were fed a high-fat diet (HFD) with intermittent fasting. Materials and Methods: A total of 48 Wistar albino male rats were included in the study and divided into eight groups, each consisting of six rats. Group 1 served as the control group (CG), receiving a standard diet. Group 2 followed the standard nutrition program with intermittent fasting (CG + IF). Group 3 underwent exercise with a standard diet (CG + E). Group 4 underwent both a standard diet with intermittent fasting and exercise (CG + IF + E). Group 5 was fed a high-fat diet (HFD). Group 6 received a high-fat diet with intermittent fasting (HFD + IF). Group 7 followed a high-fat diet with exercise (HFD + E). Group 8 underwent both a high-fat diet with intermittent fasting and exercise (HFD + IF + E). The study lasted for 8 weeks. Results: The results of the analysis show that lymphocyte cell levels in groups HFD + IF, HFD + IF, and HFD + IF + E were higher compared to groups CG-HFD (p < 0.05). Additionally, B lymphocyte and monocyte cell levels were higher in group HFD + IF + E compared to groups CG, CG + IF, and CG + IF + E, as well as CG, CG + IF, and CG + E, respectively. TNF-alpha levels were significantly higher in group HFD compared to the other groups. Furthermore, IL 10 levels were higher in group HFD + IF + E compared to the other groups. Conclusions: These findings indicate that moderate exercise and intermittent fasting, particularly in groups fed a high-fat diet, increased anti-inflammatory cytokine levels, and certain immune system cell counts, while decreasing pro-inflammatory cytokine levels.
The Effect of Resveratrol on Toxicity Caused by Cisplatin in Rats With Experimentally Created Diabetes by Streptozotocin
(2022) Bulduk, Bahattin; Oto, Gokhan; Bulduk, Mehmet; Günbatar, Nizamettin; Elasan, Sadi; Koçak, Yılmaz
Aim: In our study, the therapeutic effect of resveratrol against the toxicity of cisplatin in rats with experimental diabetes mellitus with streptozotocin was investigated. Material and Method: 64 rats were used in the study. 8 groups were randomly formed, with 8 rats in each group. Group 1 was determined as the control group. Group 2 (STZ) was injected with 60 mg/kg streptozotocin intraperitoneally (ip) on the first day to induce diabetes. Group 3 (RES) was given 100 mg/kg of resveratrol orally every day. Group 4 (SIS), a single dose of cisplatin 7 mg/kg (ip) was administered 3 days later. Group 5 (STZ+RES), group 6 (STZ+SIS), group 7 (RES+SIS) and group 8 (STZ+SIS+RES) were determined. Results: While there was weight gain in the control and RES groups during the experiment, the STZ and STZ + SIS groups showed a significant decrease in body weights of the rats. In the groups given streptozotocin and cisplatin together with resveratrol, there was no decrease in body weight, but a small increase was observed. In groups with increased blood glucose values with streptozotocin, these values were found to have dropped significantly with resveratrol. The TAS level has increased significantly in groups RES, STZ+RES, SIS+RES and STZ+SIS+RES according to the control group; no significant difference has been found in the other groups compared to the control group. While the AST level was significantly higher in the STZ, SIS and STZ+SIS groups compared to the control group, the ALT level was found to be significantly higher in the STZ and STZ+SIS groups compared to the control group. Creatinine was found to be significantly higher in SIS, STZ+SIS, RES+SIS and STZ+SIS+RES groups compared to the control group. The SIS group and RES+SIS and STZ+SIS+RES groups were compared, the decrease in the RES+SIS and STZ+SIS+RES groups was statistically significant. QT (ms) values increased significantly in the STZ and STZ+SIS groups compared to the control group, but there was no significant difference in the other groups. According to the control group, the heart rate per minute was found to be significantly lower in the STZ and STZ+SIS groups. Conclusion: As a result, it was seen that the use of resveratrol would be effective in reducing the increased glucose levels in the treatment of diabetes and in the treatment of possible complications.
The Effect of Resveratrol Treatment on Ecg Values of Cronical Flourozis Induced Rats
(Wiley-blackwell, 2015) Bulduk, Bahattin; Oto, Gokhan; Ozdemir, Hulya; Gunbatar, Nizamettin; Bulduk, Mehmet; Elaslan, Sadi
The Effect of Resveratrol Treatment on Heart Rate and Qt Values in Rats With Chronic Fluorosis
(Parlar Scientific Publications (p S P), 2022) Bulduk, Bahattin; Oto, Gokhan; Ozdemir, Hulya; Gunbatar, Nizamettin; Kocak, Yilmaz; Gul, Cihan; Elasan, Sadi
With this study, it was investigated how the impact of sodium fluoride (NaF) exposure on the cardiac conduction system would be treated with resveratrol. A total of 8 rats, 4 female and 4 male, weighing 200-300 grams, were used in each group. The first group was separated as the control group. The second group was determined as the group given 10 melt/day NaF, the third group as the group given 50 mg/It/day resveratrol, and the fourth group as the group given 10 mg/It/day NaF + 50 mg/It/day resveratrol. In the study conducted for 12 weeks, resveratrol and NaF were mixed into the drinking water of rats. When the study was finished after 4 months, the rats were anesthetized. They were placed in the right lateral position for the recording of ECGs. ECG samples were evaluated in II. derivation. Heart rate numbers were found high and QT values were found low in the groups that were administered only NaF. The heart rate and QT values of the groups administered with resveratrol alone or in combination with NaF showed parallelism with the control group.
Perceived Social Support Levels Among Medical Staff Working at the Medical Faculty Hospital of Van Following the 2011 Van-Turkey Earthquake
(Sage Publications inc, 2014) Guner, Sukriye Ilkay; Sevimli, Sukran; Bulduk, Bahattin; Orakci, Hakan
The aim of the study was to evaluate the "perceived social support levels" of the medical staff after the earthquake. The sample of this study is made up of 300 of the 490 medical staff of the Medical Faculty Hospital of Van. The data were collected using a survey that included the personal information and the "multidimensional perceived social support scale." It was observed that since the houses of the medical staff were being repaired or rebuilt, 55% of the medical staff were not residing in their homes. It was determined that 41.3% of the staff were residing in different cities away from their families. Among those, 52.4% was obliged to live apart from their families for more than 6 months. The medical staff whose families did not relocate, those who stayed with their spouses, and those who lived in containers were reported to have high social support.
Terör Mağdurlarının Yaşadıkları Ruhsal Sorunlar
(2017) Orakcı, Hakan; Bulduk, Bahattin; Aktaş, Sakine
Terör, kişilerde yılgınlık yaratan ve büyük çaplı korku veren bir eylem durumunu ifade eder. Terörizm ise siyasal amaçlar için mevcut durumu kanun dışı yollardan değiştirmek amacıyla örgütlü, sistemli ve sürekli terör eylemlerini kullanmayı bir yöntem olarak benimseme durumudur. Terör olayları bireylerde yoğun travmaya neden olan olgulardır. Travma, ruh sağlığı alanında, kişinin günlük yaşamında bildiği ve kullandığı dengeyi bozan ve bir kriz reaksiyonu ortaya çıkaran durum olarak tanımlanmaktadır. Travmatik olayların ardından olaya doğrudan maruz kalanların yanı sıra, aileleri, yakınları, yardım çalışanları ve gönüllüler ile olayın etkilerini medyadan takip eden bireylerin de travma-ya dolaylı olarak maruz kaldığı söylenebilir. Terörist saldırılara tanık olmuş kişilerde Travma Sonrası Stres Bozukluğu (TSSB), panik atak ve benzeri ruhsal sorunlar yaşandığı ortaya konmuştur. Mağdurlarda şok, korku, öfke, suçluluk, kaygı, çaresizlik ve umutsuzluk, gerginlik, yorgunluk, uyku sorunları, yeme bozuklukları, kalp atışlarında düzensizlik ve ani irkilmeler, huzursuzluk, güvensizlik, gibi ruhsal sorunlar görülmektedir. Bu derlemede, terör olaylarına doğrudan veya dolaylı biçimde maruz kalmış bireylerin yaşadıkları ruhsal sorunlar ele alınmaktadır
The Effect of Daily Application of Crataegus Oxyacantha (Hawthorn) on the Values of Biochemical and ECG in Rats
(2013) Bulduk, Bahattin; Kılınç, Dide Kılıçalp
Bulduk B, günlük Crataegus oxyacantha (alıç) uygulamasının ratlarda biyokimyasal ve EKG değerlerine etkisi, Y.Y.Ü. Sağlık Bilimleri Enstitüsü Veteriner Fakültesi Fizyoloji Ana Bilim Dalı Doktora Tezi, Van, 2013. Bu çalışma 16'sı dişi 16'sı erkek olmak üzere toplam 32 sağlıklı rat üzerinde yapıldı. Dişi ve erkek sayıları eşit olan rastgele seçilmiş 4 grup oluşturuldu. Birinci grup kontrol grubu, 2. grup 25 mg/kg, 3. grup 50 mg/kg, 4. grup 100 mg/kg Crataegus oxyacantha ekstraktı verilen grup olarak belirlendi. Bir ay boyunca oral olarak Crataegus oxyacantha ekstraktı verilen bu ratlarda glukoz, trigliserit, kolesterol, VLDL, AST, ALT, CK, CK-MB, magnezyum, troponin I ve EKG değerlerine bakıldı. Bu çalışmada glukoz, trigliserit ve VLDL değerleri arasındaki fark cinsiyetler açısından anlamlı bulundu EKG bulgularının belirlenmesi için dalgaların süre ve amplitüdleri ?. derivasyonda, kalbin ortalama elektriksel ekseni ?. ve ?. derivasyonlarda değerlendirildi. Buna göre QT (sn) ve QTc (sn) değerleri arasındaki fark gruplar açısından, QRS (sn), R-R (sn) ve kalp atım sayısı (atım/dk) değerleri arasındaki fark ise hem gruplar hem de cinsiyetler açısından anlamlı bulundu. Crataegus oxyacantha tüketiminin yapılmasında doz, cinsiyet ve uygulama süresinin dikkate alınması tavsiye edilmektedir.Anahtar sözcükler: Alıç, Biyokimya, Crataegus Oxyacantha, EKG