Browsing by Author "Bulut, G."

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Acute Renal Failure Due To Light Chain Cast Nephropathy
(2011) Bulut, G.; Kösem, M.
Myeloma cast nephropathy, also known Bence Jones cast nephropathy or myeloma kidney is the most common form of renal disease associated with multiple myeloma. Clinically, it may present as progressive renal insufficieny or acute renal failure. We describe a case of multiple myeloma who presented with acute renal failure due to light chain cast nephropathy and had a primary diagnosis made by renal biopsy. A renal biopsy was performed for acute renal failure in a 44 year old female patient. The renal biopsy showed numerous dilated tubules filled with pink eosinophilic fractured casts surrounded at places by multinucleated giant cells and accompanied by moderate interstitial infiltrate consisting of lymphomononuclear cells. There was tubular atrophy with interstitial fibrosis. The renal biopsy is occasionally the first test indicative of myeloma in a patient with acute renal failure of seemingly unknown origin. Thus the microscopic appearance of the tubules in this biopsy is easy to appreciate and is diagnostic of light chain cast nephropathy.
Adenocarcinoma of Fallopian Tube Case Coexisting With Tuberculous Salpingitis
(2012) Güler, A.; Kolusari, A.; Bulut, G.; Kurdoǧlu, Z.
Primay fallopian tube cancers, the least frequently seen among female genital malignancies, are very similar to ovarian cancers in histological properties and behavior. Data on its etiology, risk factors and prognosis is limited probably as a result of its rarity. There are few case reports in literature about tubal cancers coexisting with tuberculous salpingitis. While etiology of the tumor is still unknown, probable relation of it with chronic inflammation, infertility, tuberculous salpingitis and tubal endometriosis was noted. A case of primary tubal adenocarcinoma diagnosed postoperatively in a patient having high levels of Ca 125 and a right adnexal mass that was found during investigations for her menometrorrhagia was presented. In countries where tuberculosis is still an important health problem, the relation of the tubal cancer with tuberculous salpingitis should be remembered and surgical and specific medical treatments of the disease should be made accordingly. Copyright © 2012 by Türkiye Klinikleri.
Alexander Type Primary Anetoderma: Case Report
(2012) Güneş Bilgili, S.; Karadaǧ, A.S.; Çalka, Ö.; Bulut, G.; Özdemir, S.
Anetoderma is a rare disease which is characterized by localized, atrophic, herniated macules caused by loss of elastic tissue in the skin. Anetoderma usually involves back, chest, neck upper parts of arms. Alexander-type anetoderma is a severe variant of primary anetoderma. Bullous lesions appears during its course and heals with postinflammatory lesions. A 20-year-old female patient admitted to our outpatient clinic with brown atrophic plaques located on the dorsum of both feet, lateral aspects of her right legs, extansor surfaces of both knees and elbows and on her buttocks for 6 years following preceding vesicles and bullae. The patient was diagnosed with Alexander-type anetoderma based on clinical and histopathologic findings. Our case has been reported because of the rarity of this type of anetoderma and atypical localization of its lesions. Copyright © 2012 by Türkiye Klinikleri.
Antioxidant and Renoprotective Effects of Paricalcitol on Experimental Contrast-Induced Nephropathy Model
(British inst Radiology, 2012) Ari, E.; Kedrah, A. E.; Alahdab, Y.; Bulut, G.; Eren, Z.; Baytekin, O.; Odabasi, D.
Objectives: The aim of the study was to assess the effect of paricalcitol on the experimental contrast-induced nephropathy (CIN) model. We hypothesised that paricalcitol may prevent CIN. Methods: 32 Wistar albino rats were divided into four groups (n=8 each): control group, paricalcitol group, CIN group and paricalcitol plus CIN group. Paricalcitol (0.4 mu g kg(-1) day(-1)) was given intraperitoneally for 5 consecutive days prior to induction of CIN. CIN was induced at day 4 by intravenous injection of indometacin (10 mg kg(-1)), N omega-nitro-L-arginine methyl ester (L-NAME, 10 mg kg(-1)) and meglumine amidotrizoate (6 ml kg(-1)). Renal function parameters, oxidative stress biomarkers, histopathological findings and vascular endothelial growth factor (VEGF) immunoexpression were evaluated. Results: The paricalcitol plus CIN group had lower mean serum creatinine levels (p=0.034) as well as higher creatinine clearance (p=0.042) than the CIN group. Serum malondialdehyde and kidney thiobarbituric acid-reacting substances levels were significantly lower in the paricalcitol plus CIN group than in the CIN group (p=0.024 and p=0.042, respectively). The mean scores of tubular necrosis (p=0.024), proteinaceous casts (p=0.038), medullary congestion (p=0.035) and VEGF immunoexpression (p=0.018) in the paricalcitol plus CIN group were also significantly lower. Conclusion: This study demonstrates the protective effect of paricalcitol in the prevention of CIN in an experimental model.
Conjunctival Lymphangiectasia: a Case Report
(Yuzuncu Yil Universitesi Tip Fakultesi, 2018) Seven, E.; Batur, M.; Tekin, S.; Bulut, G.; Yaşar, T.
In this article, a 51-year-old man with conjunctival lymphangiectasia who applied to the hospital with conjunctival swelling was presented. Conjunctival resection of lesion was performed and no recurrence was found in the follow-up examination at 9 months. This is an uncommon clinical condition in which conjunctival swelling occurs as a consequence of enlarged lymphatics of the bulbar conjunctiva. © 2018, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
The Diagnostic Importance of Matrix Metalloproteinase-7 and Nestin in Gastrointestinal Stromal Tumors
(International Scientific Literature Inc., 2014) Peker, K.; Sayar, I.; Gelincik, I.; Bulut, G.; Ünal, T.D.K.; Şenol, S.; Isik, A.
Background: The importance of the matrix metalloproteinase-7 (MMP-7) and nestin immunomarkers, C-kit proto-oncogene (CD117), and the efficiency of the Ki-67 proliferation index for gastrointestinal stromal tumors were evaluated. Material/Methods: This study was conducted by examining the microscope slides of 72 patients with gastrointestinal stromal tumors that were sent to the pathology laboratory between 2007 and 2012. Immunohistochemical staining for CD117, MMP-7, nestin, and marker of proliferation Ki-67 was performed. The correlations between the positive results for Ki-67, CD117, MMP-7, and nestin were evaluated relative to the tumor characteristics of size, localization, grade, cellular type, cellularity, cytology type, growth pattern, ulceration, necrosis, hemorrhage, invasion depth, and lymph node metastasis. Results: The tumor was localized in the stomach in 42 of the patients, the intestines in 19, the colon in 7, and the rectum in 4. Comparisons among the groups showed that MMP-7 was correlated with the tumor grade (p<0.001), cellularity (p<0.009), cytologic atypia (p<0.001), ulceration (p=0.002), necrosis (p<0.001), and tumor size (p=0.001). Nestin was correlated with the tumor grade (p=0.013), and tumor size (p=0.024). Correlations among CD117, MMP-7, nestin, and Ki-67 were examined. Nestin and Ki-67 were both significantly correlated with CD117 and MMP-7 [(r=0.279, p=0.018), (r=0.322, p=0.006), (r=0.386, p=0.001), (r=0.386, p=0.002)], respectively. Conclusions: MMP-7 and nestin may be beneficial as markers, given their sensitivity to gastrointestinal stromal tumors. © Med Sci Monit, 2014.
Fixed Drug Eruption Induced by Topical Olopatadine Ophthalmic Solution
(Sage Publications Ltd, 2012) Bilgili, S. G.; Karadag, A. S.; Karadag, R.; Bulut, G.; Calka, O.
Fixed drug eruption (FDE) usually develops after oral administration and is described as a cutaneous reaction recurring at the same location each time the drug is taken. Olopatadine is both a H I histamine receptor antagonist and a mast cell stabilizer, indicated for the treatment of allergic conjunctivitis. Here, we report a 14-year-old male patient who developed FDE localised on the lateral side of periorbital rim bilaterally, whilst applying olopatadine 0.1% ophthalmic solution for the treatment of allergic conjunctivitis. As far as we know, FDE due to olopatadine has not been previously reported in the literature. We deem it appropriate to report this case because FDE that results from the application of topical drugs is a rare event in the literature.
Gapo Syndrome Associated With Pyoderma Vegetans: an Unreported Co-Existence
(Medecine Et Hygiene, 2013) Karadag, A. S.; Calka, O.; Bilgil, S. G.; Karadag, R.; Bulut, G.
GAPO syndrome associated with pyoderma vegetans: an unreported co-existence: GAPO syndrome is a rare autosomal recessive disease and an acronym composed of growth retardation, alopecia, pseudoanodontia, optic atrophy. Approximately 38 cases have been reported in literature until now. Pyoderma vegetans is a chronic inflammatory disease characterized with vesicopustular, exudative and vegetative lesions usually localized on face, scalp, axilla and genitalia. Pyoderma vegetans is attributed to a bacterial infection frequently occurring in individuals with an underlying immunosuppressive condition. A 30-year-old female patient was admitted to our clinic with complaint of a hemorrhagic, crusted, exudative vegetative two plaques on the scalp. On her physical examination, she had a prematurely aged face, predominant lower lips, total tooth loss, frontal bossing, enlarged anterior fontanelle, marked scalp veins, micrognatia, depressed nasal bridge, short stature, growth retardation. She was diagnosed as GAPO syndrome as the result of her physical examination. Result of the biopsy taken from scalp was evaluated as pyoderma vegetans. And the diagnosis of pyoderma vegetans was established based on the correlate of both clinical and histopathologic findings. Pyoderma vegetans coexisting with GAPO syndrome has not been reported previously. Thus we wished to report it.
Histopathological and Mechanical Properties of Different Meshes in a Rat Model of Pelvic Prolapse Surgery
(Yuzuncu Yil Universitesi Tip Fakultesi, 2017) Elçi, G.G.; Elçi, E.; Kaya, C.; Çim, N.; Kolusarı, A.; Erten, R.; Bulut, G.
Different types of mesh materials are used to support pelvic structures in urogynecologic procedures. Our aim was to compare histopathological and mechanical effects of Prolene®, UltraPro®, Vypro II®, and Permacol® meshes used in pelvic organ prolapse. Thirty Sprague-Dawley rats were randomized into five groups. Group 1 served as a sham-operated control (n=6); Prolene® was used in group 2 (n=6), UltraPro® in group 3 (n=6), Vypro II® in group 4 (n=6), and Permacol® in group 5 (n=6). A 0.5 × 1 cm mesh was placed between the paravaginal tissue and bladder. After 12 weeks, the rats were reoperated and meshes were excised. Histopathological tissue reactions were compared. The muscle penetration rate was 67% in the Prolene® group, which was significantly higher than that in the other groups (p=0.026). Minimum preserved postoperative surface area was seen with Prolene® at 0.31 cm2 and maximum with UltraPro® at 0.45 cm2, which was statistically significant. UltraPro® had the most preserved postoperative surface area and less shrinkage than the other meshes. The mesh materials cause an inflammatory reaction in surrounding tissue. Prolene® mesh had superior muscle penetration and tensile strength compared to the other materials. © 2017, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Incontinentia Pigmenti With Ocular Involvement: Two Cases
(Medecine Et Hygiene, 2012) Bilgili, S. G.; Karadag, A. S.; Karadag, R.; Akdeniz, N.; Bulut, G.; Calka, O.
Incontinentia pigmenti with ocular involvement: two cases: Incontinentia pigmenti (IP) is a rare, X-linked dominant disorder that presents at or soon after birth and presents with cutaneous signs and symptoms. Besides its typical skin signs presenting in all patients, central nervous system (CNS), ophthalmologic and dental involvement are encountered as well. In this report, we present two patients at the verrucous stage of IP and review the literature concerning the diagnosis and course of IP.
Investigation of the Long-Acting Single-Dose Gnrh Vaccine (repro-Bloc™) Effect on the Germinative and Endocrine Testicular Function in Male Rats
(Wiley-blackwell, 2015) Eski, F.; Sendag, S.; Tasal, I.; Mis, L.; Comba, B.; Bulut, G.; Wehrend, A.
Is Immunohistochemical Sex Hormone Binding Globulin Expression Important in the Differential Diagnosis of Adenocarcinomas
(Asian Pacific Organization for Cancer Prevention, 2016) Bulut, G.; Kosem, M.; Bulut, M.D.; Erten, R.; Bayram, I.
Adenocarcinomas (AC) are the most frequently encountered carcinomas. It may be quite challenging to detect the primary origin when those carcinomas metastasize and the first finding is a metastatic tumor. This study evaluated the role of sex hormone binding globulin (SHBG) positivity in tumor cells in the subclassification and detection of the original organ of adenocarcinomas. Between 1994 and 2008, 64 sections of normal tissue belonging to ten organs, and 116 cases diagnosed as adenoid cystic carcinoma and mucoepidermoid carcinoma of the salivary gland, lung adenocarcinoma, invasive ductal carcinoma of the breast, adenocarcinoma of stomach, colon, gallbladder, pancreas and prostate, endometrial adenocarcinoma and serous adenocarcinoma and mucinous adenocarcinoma of the ovary, were sent to the laboratory at the Department of Pathology at the Yuzuncu Yil University School of Medicine, where they were stained immunohistochemically, using antibodies against SHBG. The SHBG immunoreactivity in both the tumor cells and normal cells, together with the type, diffuseness and intensity of the staining were then evaluated. In the differential diagnosis of the adenocarcinomas of the organs, including the glandular structures, impressively valuable results are encountered in the tumor cells, whether the SHBG immunopositivity is evaluated alone or together with other IHC markers. Further extensive research with a larger number of cases, including instances of cholangiocarcinoma and cervix uteri AC [which we could not include in the study for technical reasons] should be performed, in order to appropriately evaluate the role of SHBG in the differential diagnosis of AC.
A Lamotrigine Induced Toxic Epidermal Necrolysis in a Child
(informa Healthcare, 2013) Calka, O.; Karadag, A. S.; Bilgili, S. G.; Bulut, G.; Altun, F.; Burakgazi, A. Z.
Toxic epidermal necrolysis (TEN) is rare, life-threatening skin disorder that usually is caused by an adverse drug reaction. The exact pathogenesis of TEN is still unknown. Many treatments including prednisolone, cyclosporine and intravenous immunoglobulin (IVIG) can be used to halt the disease process. We present a 12-year-old girl with epilepsy who developed TEN after about 14 days of lamotrigine treatment. Lamotrigine was immediately discontinued. After receiving systemic corticosteroid treatment, the patient had a complete recovery. Antiepileptic-induced TEN can be mortal in some cases. Thus, we would like to point out the importance of early diagnosis and treatment.
Management of Haemangiopericytoma Located in the Spinal Cord Diagnosed During Pregnancy
(Taylor & Francis inc, 2015) Kurdoglu, Z.; Cetin, O.; Bulut, G.; Erten, R.; Gulsen, I.; Sahin, H. Guler
Mixed Type Adrenal Cyst: a Case Report
(Yuzuncu Yil Universitesi Tip Fakultesi, 2015) Bulut, G.; Bulut, M.D.; Yilmaz, D.; Celik, S.; Toprak, N.
Adrenal cysts are rare lesions that usually progress asymptomatically. They are often determined postmortem. Our case was a 50-year old-male who had presented to our clinic with upper right quadrant pain. The computed tomography demonstrated a cystic mass in the adrenal gland. No abnormalities were determined in the laboratory tests. According to the histopathological and immunohistochemical examination, the cyst was evaluated as a mixed-type adrenal cyst, the wall of which was covered with endothelium, mesothelium and cubic epithelium. We believed that the case was worth presenting, since it was the first diagnosed mixed-type adrenal cyst in the literature. © 2015, Yuzuncu Yil Universitesi Tip Fakultesi, Universitas Indonesia. All rights reserved.
Presented With Central Nervous System Involvement, Extra- Pulmonary and Intra-Pulmonary Tuberculosis Combined Infection in a Dialysis Patient
(Yuzuncu Yil Universitesi Tip Fakultesi, 2015) Gunbatar, H.; Bulut, G.; Soyoral, Y.; Sertogullarindan, B.; Ebinc, S.
The clinical appearance of Mycobacterium tuberculosis (TB) in patients on dialysis are substantially non-specific that makes diagnosis difficult. We report a case of extrapulmonary and intrapulmonary TB in end stage renal disease (ESRD). A 58- year-old female with ESRD was admitted to emergency with the complaints of intermittent fever, weakness, impairment of consciousness for last three days. Because of mental confusion she was entubated, transferred to the intensive care unit. Thorax CT showed widespreadcentryasinarnodules in both lungs. The empirically anti-TB therapy was initiated. There was in size of 4x5 cm palpable lymphadenopaty on left supraclavicular region, excisional biopsy revealed caseating granulomatous lymphadenitis. Lumbar puncture was performed and analysis was consistent with TB meningitis. The patient was diagnosed as miliary TB, TB meningitis and TB lymphadenitis and died on the tenth day on admission. Increased awareness of TB in the ESRD population, early diagnosis and treatment are very important. © 2015, Yuzuncu Yil Universitesi Tip Fakultesi, Universitas Indonesia. All rights reserved.
Retroperitoneal Castleman Disease With Paravertebral Localization Mimicking Nephrolithiasis: a Rare Case
(Yuzuncu Yil Universitesi Tip Fakultesi, 2014) Kaba, M.; Pirinççi, N.; Yavuz, A.; Bora, A.; Soyoral, L.; Bulut, G.
Castleman’s Disease (CD), is a rare condition of uncertain etiology, involves a massive proliferation of lymphoid tissues and typically presents as mediastinal masses. In general, CD is an incidentally diagnosed disease with an asymptomatic course in most cases. We aimed to present a 48-year old woman who presented with left flank pain and had calcifications at the localization of left kidney on abdomen x-ray. The retroperitoneal mass with paravertebral localization was evaluated, because the size of mass in our case was larger than traditional sizes seen in Castleman Disease and calcifications and localization of the mass on KUB x-ray can mimic renal stone disease. © 2014, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Squamous Cell Carcinoma Arising From Teratoma of the Ovary: Magnetic Resonance, Computed Tomography, and Pathological Findings
(I R O G Canada, inc, 2017) Celiker, F. Beyazal; Turan, A.; Beyazal, M.; Eroglu, H. Temel; Bulut, G.; Colcimen, N.; Polat, H. Beyazal
In the present case report, the authors investigated the clinicopathological characteristics of squamous cell carcinoma (SCC) arising from teratoma of the ovary and intended to report their clinical experience. Malignant transformation of ovarian teratoma is a quite rare condition with SCC observed to be the most common form of transformation. The present case was a 43-year-old female patient and her clinical presentation was abdominal pain, abdominal distension, and abdominal mass sensation. The patient underwent ultrasonography. After detection of a mass, magnetic resonance imaging (MRI) was performed. Surgery was performed on the patient and the pathological report revealed SCC arising from teratoma. The patient was evaluated retrospectively in terms of demographic characteristics, MRI, surgical findings, and prognosis.