Browsing by Author "Cabalak, Mehmet"

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A Case of Salmonella Typhi Mesenteric Lymphadenitis Accompanied by Acute Abdomen and Pancytopenia
(Aves, 2013) Bilici, Adnan; Cabalak, Mehmet; Sunnetcioglu, Mahmut; Ceylan, Mehmet Resat; Karahocagil, Mustafa Kasim
Presenting with abdominal pain in the right lower quadrant and mimicking acute appendicitis, mesenteric lymphadenitis can lead to unnecessary surgical interventions, especially in children. We present a case of a 16-year-old female with Salmonella typhi mesenteric lymphadenopathy, who was admitted to the hospital with symptoms of acute abdomen, including severe abdominal pain, fever, nausea and vomiting. In addition, because of the pancytopenia, the prolongation of the prothrombin time and the hypofibrinogenemia, the clinical picture was similar to disseminated intravascular coagulation. After the growth of S. typhi in blood cultures, she was successfully treated with ciprofloxacin.
Efficacy and Safety of Direct-Acting Antivirals in Elderly Patients With Chronic Hepatitis C: a Nationwide Real-Life, Observational, Multicenter Study From Turkey
(Aves, 2022) Onlen, Yusuf; Bal, Tayibe; Cabalak, Mehmet; Oztoprak, Nefise Cuvalci; Sari, Nagehan Didem; Kurtaran, Behice; Tabak, Fehmi
Background: The number and proportion of elderly patients living with chronic hepatitis C are expected to increase in the coming years. We aimed to compare the real-world efficacy and safety of direct-acting antiviral treatment in elderly and younger Turkish adults infected with chronic hepatitis C. Methods: In this multicenter prospective study, 2629 eligible chronic hepatitis C patients treated with direct-acting antivirals between April 2017 and December 2019 from 37 Turkish referral centers were divided into 2 age groups: elderly (>= 65 years) and younger adults (<65 years) and their safety was compared between 2 groups in evaluable population. Then, by matching the 2 age groups for demographics and pretreatment risk factors for a non-sustained virological response, a total of 1516 patients (758 in each group) and 1244 patients (622 in each group) from the modified evaluable population and per-protocol population were included in the efficacy analysis and the efficacy was compared between age groups. Results: The sustained virological response in the chronic hepatitis C patients was not affected by the age and the presence of cirrhosis both in the modified evaluable population and per-protocol population (P =.879, P =.508 for modified evaluable population and P =.058, P =.788 for per-protocol population, respectively). The results of the per-protocol analysis revealed that male gender, patients who had a prior history of hepatocellular carcinoma, patients infected with non-genotype 1 hepatitis C virus, and patients treated with sofosbuvir + ribavirin had a significantly lower sustained virological response 12 rates (P <.001, P =.047, P =.013, and P =.025, respectively). Conclusion: Direct-acting antivirals can be safely used to treat Turkish elderly chronic hepatitis C patients with similar favorable efficacy and safety as that in younger adults.