Browsing by Author "Cagan, Eren"

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Bilateral Brachial Plexus Palsy and Right Horner Syndrome Due To Congenital Cervicothoracal Syringomyelia
(Elsevier Science Bv, 2010) Cagan, Eren; Sayin, Refah; Dogan, Murat; Peker, Erdal; Cagan, Havva Hasret; Caksen, Hueseyin
Syringomyelia (SM) is a disorder in which a cyst forms within the spinal cord. This cyst, called a syrinx, expands and elongates over time, destroying the center of the cord. Horner syndrome is an infrequent illness caused by a lesion of the cervical sympathetic nerve fiber. Its clinical features are facial anhidrosis, ptosis, miosis, and hypochromia iridis of the affected side. A full-term male newborn infant was admitted with weakness in bilateral upper extremities and narrowing of the palpebral fissure on the right side. Ophthalmologic examination revealed a smaller right pupil. Muscle power in bilateral upper limbs was 1/5. Chest X-ray and cranial magnetic resonance imaging were normal. Magnetic resonance imaging of the cervicothoracic spine showed SM at C4-T2 level. Electromyographic examination revealed bilateral brachial plexus palsy. The diagnosis was of brachial plexus palsy and congenital Homer syndrome due to congenital cervicothoracic SM. According to our best knowledge, this association has not been reported in the literature. (C) 2009 Elsevier B.V. All rights reserved.
Ceftriaxone-Induced Toxic Hepatitis
(Baishideng Publishing Group inc, 2009) Peker, Erdal; Cagan, Eren; Dogan, Murat
Toxic hepatitis or drug-induced liver injury encompasses a spectrum of clinical disease ranging from mild biochemical abnormalities to acute liver failure. The advantages of along half-life, wide spectrum, high tissue penetration rate, and a good safety profile, make ceftriaxone, a third-generation cephalosporin, a frequent choice in the treatment of childhood infections. Previous studies have reported a few cases of high aspartate aminotransferase and alanine aminotransferase levels, along with three cases of hepatitis caused by ceftriaxone. Here, we report a case of drug-induced toxic hepatitis in a patient who was treated with ceftriaxone for acute tonsillitis. (C) 2009 The WJG Press and Baishideng. All rights reserved.
The Effect of Magnesium Sulfate on Uncontrollable Contractions in a Tetanus Case
(Lippincott Williams & Wilkins, 2012) Kati, Ismail; Goktas, Ugur; Cagan, Eren; Guzel, Abdulmenap; Bartin, Serap
Tetanus is a rare disease caused by the exotoxins of Clostridium tetani. Higher mortality rates have been reported among the elderly and in the newborn. In this report of a tetanus case, the treatment and prognosis of contractions resistant to diazepam, midazolam, and atracurium infusion has been evaluated.
Infant Botulism
(Aves, 2010) Cagan, Eren; Peker, Erdal; Dogan, Murat; Caksen, Huseyin
Infant botulism is a rare condition caused by intestinal colonization with Clostridium botulinum. The enteric toxin causes intestinal immobility and progressive descending paralysis due to the effect on acetylcholine release at the neuromuscular junction and other cholinergic nerve terminals, particularly in the gut. Herein, we report an infant with infantile botulism because of rare clinically entity, with early diagnosis and appropriate treatment recover no squeal.
Investigation of Oxidant and Antioxidant Pathway Changes in Acute Rheumatic Fever
(Taylor & Francis Ltd, 2010) Uner, Abdurrahman; Sal, Ertan; Dogan, Murat; Sanli, Fatih M.; Acikgoz, Mehmet; Cemek, Mustafa; Cagan, Eren
Aim - The purpose of this study was to investigate the role of oxidant stress in the clinical process and pathogenesis of acute rheumatic fever (ARF). Material and methods - The study included 33 children with ARF and 20 healthy control subjects. The diagnosis of ARF was established according to the Jones Criteria. Malondialdehyde (MDA), reduced glutathione (GSH), alpha-tocopherol, ascorbic acid, retinol and beta-carotene levels were measured as markers of oxidative stress together with some antioxidant markers. Results - Our study includes 33 (19 male, 14 female) children with ARF and 20 (11 male, 9 female) healthy control subjects. The mean age ranged between 5-16 years and 5-15 years in the study and control groups, respectively. MDA was measured as 2.1 +/- 0.9 nmol/mL in the control group, 3.3 +/- 2.7 nmol/mL in the study group before treatment, and 2.1 +/- 1.2 nmol/mL after treatment. Blood GSH levels were 48.2 +/- 12.7 mg/dL in the control group, 24.7 +/- 16 mg/dL in the study group before treatment, and 40.6 +/- 21.3 mg/dL in the study group after treatment. MDA and GSH levels prior to the treatment were found to be significantly high and low as compared with the levels of the control group, respectively (P < 0.05, P < 0.001). After treatment, statistically important decrements and increments were determined in the levels of MDA (P < 0.05) and GSH (P < 0.01), respectively. Furthermore, alpha-tocopherol, retinol and beta-carotene levels prior to treatment in the study group, were significantly lower in comparison with control group levels (P = 0.05, P < 0.05, P < 0.01, respectively). Conclusion - We suggested that tissue damage in ARF may not only occur in the presence of increased oxidative stress, but also as a consequence of decreased antioxidant markers.
Methemoglobinemia Due To Local Anesthesia With Prilocaine for Circumcision
(Wiley-blackwell, 2010) Peker, Erdal; Cagan, Eren; Dogan, Murat; Aktar, Fesih; Bektas, Selcuk; Kirimi, Ercan; Ceylan, Abdullah
Mirtazapine Intoxication in a Child
(Elsevier Science inc, 2012) Akbayram, Sinan; Dogan, Murat; Basaranoglu, Murat; Cagan, Eren; Aktar, Fesih; Kaya, Avni; Peker, Erdal
Necrotizing Fasciitis Caused by Staphylococcus Epidermidis in a Neonate With Extremely Low Birthweight
(Wiley, 2010) Peker, Erdal; Kirimi, Ercan; Tuncer, Oguz; Ceylan, Abdullah; Cagan, Eren; Dogan, Murat
Necrotizing fasciitis (NF) is a severe life-threatening soft tissue infection characterized by rapidly spreading necrosis of the fascia and the subcutaneous tissue. The initial skin presentation ranges from minimal rash to cellulites. The lesions subsequently spread rapidly. Even with appropriate medical and surgical therapy, the mortality rate in NF is more than 50%. In cases of neonates, mortality rate is higher than that ratio. High index of suspicion, prompt aggressive surgery, appropriate antibiotics and supportive care are the mainstays of management in the newborn infant with NF. Herein, we report a case of invasive and mortal NF caused by Staphylococcus epidermidis in an infant with extremely low birthweight.
Nitric Oxide, Lipid Peroxidation, and Antioxidant Enzyme Levels in Epileptic Children Using Valproic Acid
(Elsevier Science Bv, 2009) Peker, Erdal; Oktar, Sueleyman; An, Mustafa; Kozan, Ramazan; Dogan, Murat; Cagan, Eren; Soeguet, Sadik
In the present study, we investigated the effects of valproic acid (VPA) on nitric oxide (NO) level, lipid peroxidation, and antioxidant enzyme activities in 21 epileptic children and 26 healthy controls. The subjects were selected from those who visited for a checkup or medical treatment at the Mustafa Kemal University Research Hospital. Serum levels of NO-2, NO-3, malondialdehyde (MDA), superoxide dismutase (SOD), and catalase (CAT) were analyzed by redox or enzymatic reactions and spectrophotometry. Based on the NO-2 and NO-3 levels, the NO concentration was about 10% higher in VPA group than in the control group (p < 0.001). However, no significant difference was detected for serum MDA, SOD, and CAT levels. It is suggested that NO would play a role in the mechanism of antiepileptic effects by VPA treatment. (c) 2009 Elsevier B.V. All rights reserved.
Periorbital Cellulitis Caused by Bacillus Thuringiensis
(Wichtig Editore, 2010) Peker, Erdal; Cagan, Eren; Dogan, Murat; Kilic, Adil; Caksen, Huseyin; Yesilmen, Osman
PURPOSE. Periorbital cellulitis is an inflammation of the lids and periorbital tissues without signs of true involvement such as proptosis or limitation of eye movement. METHODS. Bacillus thuringiensis is a Gram-positive, spore-forming soil bacterium with the ability to produce insecticidal crystal proteins. B thuringiensis is an extremely rare causative organism of orbital and periorbital infections. However, it was rarely seen isolated in pediatric cases with preseptal cellulites. Ocular infections of this bacteria quickly progress, within 12-48 hours from inoculation, leading to endophthalmitis or panophthalmitis and irreversible vision loss. RESULTS. Periorbital cellulitis should be recognized promptly and treated carefully. Hospitalization, prompt systemic antibiotic therapy, and careful monitoring for signs of sepsis and local invasion are critical. CONCLUSIONS. We report a rare presentation of periorbital cellulitis caused by B thuringiensis. (Eur J Ophthalmol 2010, 20: 243-5)
Stroke and Dilated Cardiomyopathy Associated With Celiac Disease
(W J G Press, 2010) Dogan, Murat; Peker, Erdal; Cagan, Eren; Akbayram, Sinan; Acikgoz, Mehmet; Caksen, Huseyin; Cesur, Yasar
Celiac disease (CD) is manifested by a variety of clinical signs and symptoms that may begin either in childhood or adult life. Neurological symptoms without signs of malabsorption have been observed for a long time in CD. In this report, an 8-year-old girl with CD presented with rarely seen dilated cardiomyopathy and stroke. The girl was admitted with left side weakness. Her medical history indicated abdominal distention, chronic diarrhea, failure to thrive, and geophagia. On physical examination, short stature, pale skin and a grade 2 of 6 systolic murmur were detected. Muscle strength was 0/5 on the left side, and 5/5 on the right side. Coagulation examinations were normal. Tests for collagen tissue diseases were negative. Factor V Leiden and prothrombin GA20210 mutations were negative. Tandem mass spectrophotometry and blood carnitine profiles were normal. Brain magnetic resonance imaging and cerebral angiography showed an infarction area at the basal ganglia level. Examinations of serologic markers and intestinal biopsy revealed CD. We emphasize that in differential diagnosis of ischemic stroke, CD should be kept in mind. (C) 2010 Baishideng. All rights reserved.
Tar Syndrome and Esophagial Atresia: a Concomitant or Variant Condition
(informa Healthcare, 2011) Peker, Erdal; Cagan, Eren; Dogan, Murat; Sal, Ertan; Kirimi, Ercan
Thrombocytopenia with absent radii (TAR) is rare cause of neonatal thrombocytopenia. TAR syndrome and esophageal atresia with tracheoesophageal fistula has been reported in only two cases in literature. Our case was the first in literature with unilateral TAR syndrome and bilateral absence of thumbs accompanying EA.